Published in J Biol Chem on March 19, 2003
Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci U S A (2004) 4.28
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol (2007) 3.86
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A (2006) 2.45
Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci U S A (2007) 1.96
Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation. Invest Ophthalmol Vis Sci (2008) 1.96
The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. Proc Natl Acad Sci U S A (2007) 1.78
Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration. Proc Natl Acad Sci U S A (2004) 1.74
Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J Lipid Res (2009) 1.69
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J Biol Chem (2008) 1.61
Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4. Mol Vis (2007) 1.49
Complement activation by bisretinoid constituents of RPE lipofuscin. Invest Ophthalmol Vis Sci (2008) 1.47
How much blue light should an IOL transmit? Br J Ophthalmol (2003) 1.41
Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 1.40
Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression. Mol Vis (2010) 1.35
Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli. Invest Ophthalmol Vis Sci (2009) 1.32
Spatial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci (2011) 1.19
ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull's-eye maculopathy. Br J Ophthalmol (2007) 1.15
Ocular fundus auto-fluorescence observations at different wavelengths in patients with age-related macular degeneration and diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol (2007) 1.14
The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell Mol Neurobiol (2006) 1.06
(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci (2005) 1.06
Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70. BMC Res Notes (2008) 1.02
Treatment of geographic atrophy by the topical administration of OT-551: results of a phase II clinical trial. Invest Ophthalmol Vis Sci (2010) 0.98
Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity. Vision Res (2009) 0.96
Mechanisms involved in A2E oxidation. Exp Eye Res (2008) 0.96
Toward an understanding of bisretinoid autofluorescence bleaching and recovery. Invest Ophthalmol Vis Sci (2012) 0.95
Anatomic alterations in aging and age-related diseases of the eye. Invest Ophthalmol Vis Sci (2013) 0.94
Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. Adv Exp Med Biol (2008) 0.94
C20-D3-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of Stargardt disease. J Biol Chem (2010) 0.88
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults. Oxid Med Cell Longev (2016) 0.88
Photodecomposition and phototoxicity of natural retinoids. Int J Environ Res Public Health (2005) 0.88
Ageing of the retinal pigment epithelium: implications for transplantation. Graefes Arch Clin Exp Ophthalmol (2003) 0.87
Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light. Apoptosis (2009) 0.86
Light damage in Abca4 and Rpe65rd12 mice. Invest Ophthalmol Vis Sci (2014) 0.84
Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration. Proc Natl Acad Sci U S A (2016) 0.82
Synthesis of antioxidants for prevention of age-related macular degeneration. J Nat Prod (2013) 0.81
Light-induced release of A2E photooxidation toxic products from lipofuscin granules of human retinal pigment epithelium. Dokl Biochem Biophys (2009) 0.80
Morphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits. Dis Model Mech (2014) 0.79
Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells. Proc Natl Acad Sci U S A (2007) 0.79
Clinical applications of fundus autofluorescence in retinal disease. Int J Retina Vitreous (2016) 0.78
Formation and growth of lipofuscin in the retinal pigment epithelium cells. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 0.77
The Benefits of Calorie Restriction and Calorie Restriction Mimetics as Related to the Eye. Open Longev Sci (2009) 0.77
Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J Biol Chem (2013) 0.76
[Effect of resveratrol on the fundus oculi. An overview]. Ophthalmologe (2013) 0.76
Light filtering in a retinal pigment epithelial cell culture model. Optom Vis Sci (2011) 0.76
Structures and biogenetic analysis of lipofuscin bis-retinoids. J Zhejiang Univ Sci B (2013) 0.76
Vitamin A-aldehyde adducts: AMD risk and targeted therapeutics. Proc Natl Acad Sci U S A (2016) 0.75
Effects of flavone on the oxidation-induced injury of retinal pigment epithelium cells. Int J Ophthalmol (2010) 0.75
Effects of organic solvents on two retinal pigment epithelial lipofuscin fluorophores, A2E and all-trans-retinal dimer. J Zhejiang Univ Sci B (2014) 0.75
Blue-Light Filtering Spectacle Lenses: Optical and Clinical Performances. PLoS One (2017) 0.75
Molecular Structures of Isolevuglandin-Protein Cross-Links. Chem Res Toxicol (2016) 0.75
Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases. Oxid Med Cell Longev (2016) 0.75
Nutritional and Lifestyle Interventions for Age-Related Macular Degeneration: A Review. Oxid Med Cell Longev (2017) 0.75
Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo. PLoS One (2016) 0.75
Quercetin and cyanidin-3-glucoside protect against photooxidation and photodegradation of A2E in retinal pigment epithelial cells. Exp Eye Res (2017) 0.75
Foveal sparing in patients with Japanese Stargardt's disease and good visual acuity. Jpn J Ophthalmol (2012) 0.75
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell (2006) 7.33
Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE. Invest Ophthalmol Vis Sci (2002) 2.41
Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol (2006) 2.21
Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin. J Biol Chem (2001) 2.14
A2E, a byproduct of the visual cycle. Vision Res (2003) 2.05
The bisretinoids of retinal pigment epithelium. Prog Retin Eye Res (2011) 2.02
Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed Engl (2002) 1.95
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A (2004) 1.80
Light-switching excimer probes for rapid protein monitoring in complex biological fluids. Proc Natl Acad Sci U S A (2005) 1.80
The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. Proc Natl Acad Sci U S A (2007) 1.78
Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A (2005) 1.75
Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet (2013) 1.71
Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J Lipid Res (2009) 1.69
Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin. J Biol Chem (2005) 1.65
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J Biol Chem (2008) 1.61
Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations. Am J Med Genet A (2006) 1.54
Fluorescent chlorophyll catabolites in bananas light up blue halos of cell death. Proc Natl Acad Sci U S A (2009) 1.32
Structural analysis and dynamics of retinal chromophore in dark and meta I states of rhodopsin from 2H NMR of aligned membranes. J Mol Biol (2007) 1.31
Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells. Exp Eye Res (2005) 1.31
A2-rhodopsin: a new fluorophore isolated from photoreceptor outer segments. Org Biomol Chem (2003) 1.31
Ultra-stable organic fluorophores for single-molecule research. Chem Soc Rev (2014) 1.31
Blue luminescence of ripening bananas. Angew Chem Int Ed Engl (2008) 1.28
Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin. Exp Eye Res (2005) 1.26
DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination. Invest Ophthalmol Vis Sci (2003) 1.25
Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese. J Clin Endocrinol Metab (2008) 1.24
Subtyping of avian influenza viruses H1 to H15 on the basis of hemagglutinin genes by PCR assay and molecular determination of pathogenic potential. J Clin Microbiol (2008) 1.24
Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone. Am J Med Sci (2005) 1.21
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis (2005) 1.21
Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc (2007) 1.20
DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity. Cell Cycle (2009) 1.18
The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. J Clin Endocrinol Metab (2005) 1.17
Controlling photoreactions with restricted spaces and weak intermolecular forces: exquisite selectivity during oxidation of olefins by singlet oxygen. J Am Chem Soc (2007) 1.17
Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8. J Biol Chem (2008) 1.15
Reversible surface oxidation and efficient luminescence quenching in semiconductor single-wall carbon nanotubes. J Am Chem Soc (2004) 1.12
A cleavable affinity biotinylating agent reveals a retinoid binding role for RPE65. Biochemistry (2003) 1.12
Deuterium NMR structure of retinal in the ground state of rhodopsin. Biochemistry (2004) 1.10
Pyrene binary probes for unambiguous detection of mRNA using time-resolved fluorescence spectroscopy. Nucleic Acids Res (2006) 1.08
Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway. Biochemistry (2007) 1.07
Solid-state 2H NMR structure of retinal in metarhodopsin I. J Am Chem Soc (2006) 1.07
Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol (2005) 1.05
Fundus autofluorescence and the bisretinoids of retina. Photochem Photobiol Sci (2010) 1.04
Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. Mol Aspects Med (2012) 1.03
A2E, a fluorophore of RPE lipofuscin, can destabilize membrane. Adv Exp Med Biol (2006) 1.02
Use of reverse transcriptase PCR to subtype N1 to N9 neuraminidase genes of avian influenza viruses. J Clin Microbiol (2009) 1.02
Molecular beacons with intrinsically fluorescent nucleotides. Nucleic Acids Res (2006) 1.01
Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments. Chirality (2004) 1.00
On the Mechanisms of Cyanine Fluorophore Photostabilization. J Phys Chem Lett (2012) 1.00
Photocleavage of a 2-nitrobenzyl linker bridging a fluorophore to the 5' end of DNA. Proc Natl Acad Sci U S A (2003) 1.00
Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic Biol Med (2012) 1.00
SYBR green-based real-time reverse transcription-PCR for typing and subtyping of all hemagglutinin and neuraminidase genes of avian influenza viruses and comparison to standard serological subtyping tests. J Clin Microbiol (2011) 0.99
The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells. Invest Ophthalmol Vis Sci (2008) 0.99
Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro. J Cataract Refract Surg (2004) 0.98
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. Phytochemistry (2004) 0.98
A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration. PLoS One (2012) 0.97
Absolute stereochemistry of allylic alcohols, amines, and other ene moieties: a microscale cross metathesis/exciton chirality protocol. J Am Chem Soc (2003) 0.96
Inherited bone marrow failure syndromes in 2012. Int J Hematol (2012) 0.96
Mechanisms involved in A2E oxidation. Exp Eye Res (2008) 0.96
Fluorescent hybridization probes for sensitive and selective DNA and RNA detection. Acc Chem Res (2007) 0.95
Chemistry and biology of terpene trilactones from Ginkgo biloba. Angew Chem Int Ed Engl (2004) 0.95
Toward an understanding of bisretinoid autofluorescence bleaching and recovery. Invest Ophthalmol Vis Sci (2012) 0.95
Metabolic improvement of male prisoners with type 2 diabetes in Fukushima Prison, Japan. Diabetes Res Clin Pract (2007) 0.95
Type 1 diabetes and interferon therapy: a nationwide survey in Japan. Diabetes Care (2011) 0.95
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. J Biol Chem (2003) 0.95
Bilateral iliopsoas hematomas under sedation: a complication of postoperative therapy after coronary artery bypass grafting. Acta Med Okayama (2010) 0.94
Solution and biologically relevant conformations of enantiomeric 11-cis-locked cyclopropyl retinals. J Am Chem Soc (2002) 0.93
Association of HLA-DQ genotype in autoantibody-negative and rapid-onset type 1 diabetes. Diabetes Care (2002) 0.93
Charge transfer chemical doping of few layer graphenes: charge distribution and band gap formation. Nano Lett (2009) 0.91
Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes. J Clin Endocrinol Metab (2007) 0.91
Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols. Mol Vis (2011) 0.90
Preparation of alkyl-modified silicon nanosheets by hydrosilylation of layered polysilane (Si6H6). J Am Chem Soc (2012) 0.90
Stereoselective photooxidation of enecarbamates: reactivity of ozone vs singlet oxygen. Org Lett (2005) 0.89
Silicon nanosheets and their self-assembled regular stacking structure. J Am Chem Soc (2010) 0.89
Association of the SNP-19 genotype 22 in the calpain-10 gene with elevated body mass index and hemoglobin A1c levels in Japanese. Clin Chim Acta (2003) 0.89
Atrial natriuretic peptide protects against ischemia-reperfusion injury in the isolated rat heart. Ann Thorac Surg (2004) 0.89
The reaction of singlet oxygen with enecarbamates: a mechanistic playground for investigating chemoselectivity, stereoselectivity, and vibratioselectivity of photooxidations. Acc Chem Res (2008) 0.89
Absolute configuration of actinophyllic acid as determined through chiroptical data. J Nat Prod (2009) 0.89
Retinal conformation and dynamics in activation of rhodopsin illuminated by solid-state H NMR spectroscopy. Photochem Photobiol (2009) 0.88
Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese. J Autoimmun (2007) 0.88
Design and characterization of two-dye and three-dye binary fluorescent probes for mRNA detection. Tetrahedron (2007) 0.88
Synthesis of 11-cis-locked bicyclo[5.1.0]octanyl retinal and an enantioselective binding to bovine opsin. Chirality (2002) 0.88
Synthesis and optical properties of monolayer organosilicon nanosheets. J Am Chem Soc (2010) 0.87
Enantioselective organo-photocatalysis mediated by atropisomeric thiourea derivatives. Angew Chem Int Ed Engl (2014) 0.87
Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis. Intern Med (2007) 0.87