Published in Cancer Res on March 15, 2003
Reactive oxygen species in cancer. Free Radic Res (2010) 3.20
Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics (2008) 2.09
Heterotopic pancreas in the stomach: a case report and literature review. World J Gastroenterol (2007) 1.80
Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat Protoc (2009) 1.74
Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res (2008) 1.64
Quercetin and cancer chemoprevention. Evid Based Complement Alternat Med (2011) 1.49
Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma. Cancer Genomics Proteomics (2008) 1.34
Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. Mol Cell Biol (2005) 1.26
A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev (2013) 1.09
Novel signaling axis for ROS generation during K-Ras-induced cellular transformation. Cell Death Differ (2014) 1.08
Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells. Pancreas (2010) 1.08
Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines. Br J Cancer (2007) 1.08
Manganese superoxide dismutase: beyond life and death. Amino Acids (2010) 1.06
Reactive oxygen species signaling in cancer: comparison with aging. Aging Dis (2010) 1.02
Manganese superoxide dismutase: guardian of the powerhouse. Int J Mol Sci (2011) 1.02
Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. BMC Cancer (2010) 0.98
Metastatic progression of pancreatic cancer: changes in antioxidant enzymes and cell growth. Clin Exp Metastasis (2006) 0.95
The bidirectional interation between pancreatic cancer and diabetes. World J Surg Oncol (2012) 0.95
Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. Carcinogenesis (2010) 0.95
Regulation of pancreatic cancer growth by superoxide. Mol Carcinog (2012) 0.94
Cell proliferation, reactive oxygen and cellular glutathione. Dose Response (2006) 0.94
Radical decisions in cancer: redox control of cell growth and death. Cancers (Basel) (2012) 0.90
Manganese superoxide dismutase regulates a redox cycle within the cell cycle. Antioxid Redox Signal (2013) 0.90
Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase. Mol Cancer Res (2012) 0.87
Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases. Antioxid Redox Signal (2014) 0.86
Sequence variants in antioxidant defense and DNA repair genes, dietary antioxidants, and pancreatic cancer risk. Int J Mol Epidemiol Genet (2011) 0.85
Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect? Mitochondrion (2012) 0.84
Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells. J Steroid Biochem Mol Biol (2009) 0.83
Identification of proteins responsible for the multiple drug resistance in 5-fluorouracil-induced breast cancer cell using proteomics analysis. J Cancer Res Clin Oncol (2010) 0.82
Pharmacologic approaches to the aging athlete. Sports Health (2014) 0.82
Mechanisms of superoxide signaling in epigenetic processes: relation to aging and cancer. Aging Dis (2015) 0.82
Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis. Mol Cell Proteomics (2011) 0.82
Heterotopic pancreatic tissue in the gastric cardia: a case report and literature review. World J Gastroenterol (2014) 0.81
The functional role of MnSOD as a biomarker of human diseases and therapeutic potential of a new isoform of a human recombinant MnSOD. Biomed Res Int (2014) 0.81
Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clin Cancer Res (2015) 0.80
Genomic analysis of pterostilbene predicts its antiproliferative effects against pancreatic cancer in vitro and in vivo. J Gastrointest Surg (2012) 0.80
The organotelluride catalyst LAB027 prevents colon cancer growth in the mice. Cell Death Dis (2011) 0.79
Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells. PLoS One (2013) 0.79
Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC. Mol Cancer Ther (2013) 0.79
A novel mechanism of protein thermostability: a unique N-terminal domain confers heat resistance to Fe/Mn-SODs. Sci Rep (2014) 0.78
Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer. Oxid Med Cell Longev (2016) 0.77
Combination of ZD55-MnSOD therapy with 5-FU enhances antitumor efficacy in colorectal cancer. J Cancer Res Clin Oncol (2007) 0.77
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxid Med Cell Longev (2015) 0.77
Superior therapeutic index of calmangafodipir in comparison to mangafodipir as a chemotherapy adjunct. Transl Oncol (2012) 0.76
Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification. Oncotarget (2016) 0.76
Ectopic pancreas: a diagnostic dilemma. Int J Angiol (2012) 0.75
Improving the thermostability and stress tolerance of an archaeon hyperthermophilic superoxide dismutase by fusion with a unique N-terminal domain. Springerplus (2016) 0.75
Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue. Oncotarget (2017) 0.75
Gene-by-Environment Interactions in Pancreatic Cancer: Implications for Prevention. Yale J Biol Med (2015) 0.75
Manganese superoxide dismutase expression is negatively associated with microRNA-301a in human pancreatic ductal adenocarcinoma. Cancer Gene Ther (2015) 0.75
Superoxide Dismutases in Pancreatic Cancer. Antioxidants (Basel) (2017) 0.75
Role for DNA methylation in the control of cell type specific maspin expression. Nat Genet (2002) 4.72
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet (2008) 4.04
Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2005) 2.42
Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler Thromb Vasc Biol (2004) 2.39
Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J (2009) 2.35
Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res (2006) 2.27
Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. Arterioscler Thromb Vasc Biol (2002) 2.01
Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem (2004) 1.94
Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol (2003) 1.80
Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Mol Endocrinol (2002) 1.67
Social support, psychological distress, and natural killer cell activity in ovarian cancer. J Clin Oncol (2005) 1.61
Epigenetic silencing of DSC3 is a common event in human breast cancer. Breast Cancer Res (2005) 1.50
Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression. Oncogene (2003) 1.48
Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. J Biol Chem (2002) 1.47
Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth. Aging Cell (2008) 1.47
Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Mol Cancer Ther (2003) 1.45
MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells. Carcinogenesis (2005) 1.39
An epigenetic perspective on the free radical theory of development. Free Radic Biol Med (2007) 1.35
Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase. Cancer Res (2007) 1.30
Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells. Oncogene (2005) 1.30
Quality of life and mood in women with gynecologic cancer: a one year prospective study. Cancer (2002) 1.28
A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis. Blood (2005) 1.28
Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer (2010) 1.27
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene (2005) 1.26
Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Res (2006) 1.25
Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radic Res (2004) 1.25
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Res (2003) 1.23
Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells. Free Radic Biol Med (2008) 1.20
Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts. J Biol Chem (2005) 1.19
Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer. Mol Carcinog (2005) 1.18
Modulation of reactive oxygen species in pancreatic cancer. Clin Cancer Res (2007) 1.18
DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage. BMC Med Genomics (2008) 1.17
A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J Biol Chem (2006) 1.16
Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth. Free Radic Biol Med (2006) 1.16
Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels. J Neurochem (2007) 1.16
Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts. Cancer Biol Ther (2009) 1.15
Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Radiat Res (2004) 1.15
Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med (2010) 1.13
Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Mol Cancer Ther (2006) 1.13
ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells. J Biol Chem (2010) 1.12
Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol (2002) 1.11
Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells. Epigenetics (2006) 1.11
Metabolic defects provide a spark for the epigenetic switch in cancer. Free Radic Biol Med (2009) 1.10
Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J Biol Chem (2005) 1.09
Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environ Int (2009) 1.09
Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion. Cancer Res (2009) 1.08
A role for manganese superoxide dismutase in apoptosis after photosensitization. Biochem Biophys Res Commun (2005) 1.07
A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency. J Lipid Res (2003) 1.05
Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells. J Biol Chem (2006) 1.05
Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells. Cancer Res (2006) 1.05
Aberrant methylation of the maspin promoter is an early event in human breast cancer. Neoplasia (2004) 1.05
Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiat Res (2009) 1.04
Initial clinical experience with frameless radiosurgery for patients with intracranial metastases. Int J Radiat Oncol Biol Phys (2005) 1.04
Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control. Neoplasia (2003) 1.04
Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect (2014) 1.03
Extracellular redox state regulates features associated with prostate cancer cell invasion. Cancer Res (2008) 1.03
Human Chondrosarcoma Cells Acquire an Epithelial-Like Gene Expression Pattern via an Epigenetic Switch: Evidence for Mesenchymal-Epithelial Transition during Sarcomagenesis. Sarcoma (2011) 1.03
Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide. Cancer Res (2008) 1.02
Epigenetic regulation of maspin expression in human ovarian carcinoma cells. Gynecol Oncol (2006) 1.01
Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype. Hum Gene Ther (2004) 1.01
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma. Cancer (2006) 1.01
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. Cancer Res (2002) 1.01
Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal. Antioxid Redox Signal (2004) 1.01
Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. Cancer Biol Ther (2005) 1.01
Delayed radioprotection by nuclear transcription factor kappaB -mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR1065. Free Radic Biol Med (2005) 1.00
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1. Oncogene (2003) 1.00
Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Pancreas (2003) 1.00
Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. FASEB J (2004) 1.00
Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine. Radiat Res (2002) 0.99
Heat-induced liver injury in old rats is associated with exaggerated oxidative stress and altered transcription factor activation. FASEB J (2003) 0.98
Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. Clin Cancer Res (2009) 0.98
NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. Toxicol Appl Pharmacol (2013) 0.97
A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns. Hear Res (2007) 0.97
Intrinsic radiation resistance in human chondrosarcoma cells. Biochem Biophys Res Commun (2006) 0.96
Dominant negative interference of transcription factor AP-2 causes inhibition of ErbB-3 expression and suppresses malignant cell growth. Breast Cancer Res Treat (2002) 0.96
Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses. J Immunol (2014) 0.96
Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia. Free Radic Res (2004) 0.95
Metastatic progression of pancreatic cancer: changes in antioxidant enzymes and cell growth. Clin Exp Metastasis (2006) 0.95
Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis. Mol Cancer Res (2011) 0.95
The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells. Neoplasia (2004) 0.94
AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells. Neoplasia (2006) 0.94
Inhibition of oral cancer cell growth by adenovirusMnSOD plus BCNU treatment. Free Radic Biol Med (2003) 0.93
Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species. Radiat Res (2010) 0.93
AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma. Exp Mol Pathol (2007) 0.92
Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism. Am J Physiol Cell Physiol (2002) 0.92