PubRank

Andrew Wakeham

Author PubWeight™ 89.05‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell 2005 5.37
2 TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008 4.85
3 IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 2012 4.04
4 Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A 2006 3.85
5 Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A 2005 3.83
6 Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev 2003 3.79
7 Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 2002 3.74
8 The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol 2003 3.18
9 Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol 2002 3.08
10 Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 2011 2.97
11 Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 2003 2.63
12 RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 2005 2.59
13 HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev 2007 2.32
14 iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science 2012 2.14
15 D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev 2012 2.10
16 Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev 2010 2.06
17 Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med 2004 1.80
18 Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity 2008 1.77
19 Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol 2002 1.61
20 Cellular FLICE-inhibitory protein is required for T cell survival and cycling. J Exp Med 2005 1.52
21 Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One 2011 1.48
22 Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med 2012 1.48
23 Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol 2003 1.45
24 p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A 2004 1.43
25 Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A 2005 1.40
26 BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J Exp Med 2013 1.30
27 Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev 2013 1.30
28 Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A 2008 1.26
29 Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol 2005 1.20
30 Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A 2013 1.19
31 Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol 2006 1.18
32 Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Mol Cell Biol 2006 1.16
33 Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proc Natl Acad Sci U S A 2003 1.11
34 The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28. J Immunol 2004 1.08
35 Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway. Proc Natl Acad Sci U S A 2014 1.02
36 The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med 2012 1.02
37 Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis. Cancer Res 2002 1.00
38 HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proc Natl Acad Sci U S A 2010 0.98
39 Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol Cell Biol 2004 0.97
40 TAp73 is required for spermatogenesis and the maintenance of male fertility. Proc Natl Acad Sci U S A 2014 0.95
41 Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development. Proc Natl Acad Sci U S A 2011 0.92
42 The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo. Proc Natl Acad Sci U S A 2008 0.92
43 Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors. Proc Natl Acad Sci U S A 2010 0.89
44 Generation and characterization of the Anp32e-deficient mouse. PLoS One 2010 0.89
45 Role of SODD in regulation of tumor necrosis factor responses. Mol Cell Biol 2003 0.88
46 14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1. Proc Natl Acad Sci U S A 2011 0.87
47 ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol 2012 0.85
48 CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation. Mol Cell Biol 2007 0.85
49 Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development. Blood 2010 0.83
50 Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540-543. J Immunol 2017 0.75