Published in Proc Natl Acad Sci U S A on June 11, 2010
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Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus. Cell Death Dis (2010) 0.89
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Investigating the putative glycine hinge in Shaker potassium channel. J Gen Physiol (2005) 1.50
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Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Eur Arch Psychiatry Clin Neurosci (2009) 1.23
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Cloning and characterization of a novel RING finger protein that interacts with class V myosins. J Biol Chem (1999) 1.18
The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells. Oncogene (2000) 1.09
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Circadian regulation of GABAA receptor function by CKI epsilon-CKI delta in the rat suprachiasmatic nuclei. Nat Neurosci (2004) 0.89
Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury. J Neurochem (2009) 0.88
Myosin-V: head to tail. Cell Mol Life Sci (1999) 0.88
BERP, a novel ring finger protein, binds to alpha-actinin-4. Biochem Biophys Res Commun (2000) 0.87
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TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe (2009) 4.20
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature (2012) 4.04
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest (2004) 3.92
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2006) 3.85
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A (2005) 3.83
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev (2003) 3.79
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55
Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol (2007) 3.48
Making the case for a paradigm shift in trauma surgery. J Am Coll Surg (2006) 3.42
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med (2007) 3.36
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol (2003) 3.18
Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Hepatology (2015) 3.10
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity (2003) 2.63
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev (2005) 2.59
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32
Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest (2010) 2.23
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev (2005) 2.18
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med (2003) 2.16
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (2012) 2.14
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev (2012) 2.10
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev (2010) 2.06
Ivabradine significantly improves cardiac function in patients with ischemic heart disease: a meta-analysis of randomized controlled trials. Int J Cardiol (2013) 1.96
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol (2009) 1.93
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
Tomato transcription factors pti4, pti5, and pti6 activate defense responses when expressed in Arabidopsis. Plant Cell (2002) 1.86
Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nat Med (2006) 1.82
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med (2004) 1.80
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity (2008) 1.77
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood (2002) 1.76
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res (2003) 1.75
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS One (2008) 1.73
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes (2010) 1.71
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci U S A (2009) 1.71
Abdominal compartment syndrome in the open abdomen. Arch Surg (2002) 1.70
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A (2011) 1.70
Adiponectin and mortality in patients with chronic kidney disease. J Am Soc Nephrol (2006) 1.70
Retracted Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Nat Med (2004) 1.69
Glial scar and neuroregeneration: histological, functional, and magnetic resonance imaging analysis in chronic spinal cord injury. J Neurosurg Spine (2010) 1.63
Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites. J Neurosci (2006) 1.63
Generation and characterization of Smac/DIABLO-deficient mice. Mol Cell Biol (2002) 1.61
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. Proc Natl Acad Sci U S A (2003) 1.60
Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A (2010) 1.59
Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci U S A (2010) 1.55
Neutrophil gelatinase-associated lipocalin is instrumental in the pathogenesis of antibody-mediated nephritis in mice. Arthritis Rheum (2012) 1.53
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med (2011) 1.52
Cellular FLICE-inhibitory protein is required for T cell survival and cycling. J Exp Med (2005) 1.52
Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. J Clin Invest (2003) 1.52
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS One (2011) 1.48
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med (2012) 1.48
NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure. J Am Soc Nephrol (2006) 1.46
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol (2003) 1.45
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
Portrait of PTEN: messages from mutant mice. Cancer Sci (2008) 1.44
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A (2004) 1.43
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A (2005) 1.40
Pitfalls in percutaneous dilational tracheostomy using the Ciaglia one-step technique. South Med J (2008) 1.39
Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci U S A (2006) 1.37
Physiological functions of Pten in mouse tissues. Cell Struct Funct (2003) 1.36
Direct-current electrical field guides neuronal stem/progenitor cell migration. Stem Cells (2008) 1.34
Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines. Hepatology (2005) 1.31
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J Exp Med (2013) 1.30
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev (2013) 1.30
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res (2006) 1.29
Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. J Neurosci (2004) 1.28
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A (2008) 1.26
Telemedicine for anger management therapy in a rural population of combat veterans with posttraumatic stress disorder: a randomized noninferiority trial. J Clin Psychiatry (2010) 1.21
Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J Immunol (2002) 1.21
Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol (2005) 1.20
Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A (2013) 1.19
Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis. Proc Natl Acad Sci U S A (2010) 1.19
Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res (2008) 1.19
Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol (2006) 1.18
The use of photon beams of a flattening filter-free linear accelerator for hypofractionated volumetric modulated arc therapy in localized prostate cancer. Int J Radiat Oncol Biol Phys (2012) 1.16
Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Mol Cell Biol (2006) 1.16
Phosphatase PTEN in neuronal injury and brain disorders. Trends Neurosci (2007) 1.14
Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors. Cancer Res (2005) 1.11
Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proc Natl Acad Sci U S A (2003) 1.11