Published in J Biol Chem on April 02, 2003
Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 6.10
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A (2003) 3.29
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS One (2010) 3.14
Sensing of viral infection and activation of innate immunity by toll-like receptor 3. Clin Microbiol Rev (2008) 2.39
Vaccine immunogenetics: bedside to bench to population. Vaccine (2008) 2.01
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol (2008) 1.93
Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology (2005) 1.75
Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. J Clin Invest (2011) 1.50
Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility. PLoS Pathog (2012) 1.48
Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am J Pathol (2006) 1.28
Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling. J Immunol (2010) 1.17
High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression. J Virol (2011) 1.16
Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells. Proc Natl Acad Sci U S A (2004) 1.14
Division of labor between IRF1 and IRF2 in regulating different stages of transcriptional activation in cellular antiviral activities. Cell Biosci (2015) 1.08
Molecular mechanisms of autoimmunity triggered by microbial infection. Arthritis Res Ther (2005) 1.05
Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther (2010) 0.98
Characterization of Toll-like receptor 3 gene in rainbow trout (Oncorhynchus mykiss). Immunogenetics (2005) 0.93
Localization of type I interferon receptor limits interferon-induced TLR3 in epithelial cells. J Interferon Cytokine Res (2009) 0.92
Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery. J Biol Chem (2009) 0.91
Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice. Free Radic Biol Med (2012) 0.90
IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly(I:C) partly in a TRAIL-dependent manner. PLoS One (2013) 0.89
Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections. Mol Vis (2009) 0.88
Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung. PLoS One (2012) 0.87
Toll-like receptor 3 and TICAM genes in catfish: species-specific expression profiles following infection with Edwardsiella ictaluri. Immunogenetics (2006) 0.86
Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice. Mamm Genome (2006) 0.86
Toll-like receptor 3 ligand and retinoic acid enhance germinal center formation and increase the tetanus toxoid vaccine response. Clin Vaccine Immunol (2009) 0.85
TLR3 activation efficiency by high or low molecular mass poly I:C. Innate Immun (2012) 0.85
Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J Immunol (2011) 0.85
Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig. J Neuroinflammation (2015) 0.84
Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers. Hepatol Int (2008) 0.84
Bacterial LPS up-regulated TLR3 expression is critical for antiviral response in human monocytes: evidence for negative regulation by CYLD. Int Immunol (2011) 0.84
C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity. J Biol Chem (2010) 0.84
The role of stress mediators in modulation of cytokine production by ethanol. Toxicol Appl Pharmacol (2009) 0.83
Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. BMC Bioinformatics (2006) 0.83
Animal models to study acute and chronic intestinal inflammation in mammals. Gut Pathog (2015) 0.83
Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther (2011) 0.82
Promoter region polymorphism & expression profile of toll like receptor-3 (TLR-3) gene in chronic hepatitis C virus (HCV) patients from India. Indian J Med Res (2011) 0.81
Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells. Cell Death Dis (2013) 0.81
Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice. Endocrinology (2014) 0.80
Early activation of teleost B cells in response to rhabdovirus infection. J Virol (2014) 0.80
Transcriptional regulation of Tlr11 gene expression in epithelial cells. J Biol Chem (2009) 0.79
Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis. Oncoimmunology (2015) 0.78
Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain. J Biol Chem (2010) 0.78
A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis. Br J Pharmacol (2014) 0.77
RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells. Virology (2015) 0.76
Toll-like receptor 3 regulates Mx expression in rare minnow Gobiocypris rarus after viral infection. Immunogenetics (2008) 0.76
Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models. Am J Physiol Lung Cell Mol Physiol (2014) 0.76
Sodium methyldithiocarbamate exerts broad inhibition of cellular signaling and expression of effector molecules of inflammation. Toxicol Sci (2013) 0.75
Critical Role of IRF-3 in the Direct Regulation of dsRNA-Induced Retinoic Acid-Inducible Gene-I (RIG-I) Expression. PLoS One (2016) 0.75
Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms. Nucleic Acids Res (2016) 0.75
A comparative analysis of protein targets of withdrawn cardiovascular drugs in human and mouse. J Clin Bioinforma (2012) 0.75
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem (2002) 6.16
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad trial). Clin Infect Dis (2007) 5.15
Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV. J Clin Oncol (2013) 4.50
The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity (2008) 4.44
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol (2011) 4.18
The yin and yang of type I interferon activity in bacterial infection. Nat Rev Immunol (2005) 3.65
Tolerability-adapted imatinib 800 mg/d versus 400 mg/d versus 400 mg/d plus interferon-α in newly diagnosed chronic myeloid leukemia. J Clin Oncol (2011) 3.09
Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Res (2009) 2.87
Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vector. Epigenetics (2006) 2.68
Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood (2007) 2.64
IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism. J Immunol (2004) 2.60
Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes. J Immunol (2002) 2.54
Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. Immunity (2003) 2.51
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol (2003) 2.44
Postanalytical external quality assessment of urine albumin in primary health care: an international survey. Clin Chem (2008) 2.27
Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia. Cancer Res (2006) 2.22
Ultra high resolution linear ion trap Orbitrap mass spectrometer (Orbitrap Elite) facilitates top down LC MS/MS and versatile peptide fragmentation modes. Mol Cell Proteomics (2011) 2.13
miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J Invest Dermatol (2009) 2.06
IFNs and STATs in innate immunity to microorganisms. J Clin Invest (2002) 2.04
Global, comparative analysis of tissue-specific promoter CpG methylation. Genomics (2007) 2.01
Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity (2010) 1.90
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov (2013) 1.81
Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequences. Genome Res (2009) 1.80
Of mice and men: species variations of Toll-like receptor expression. Trends Immunol (2002) 1.69
General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells. Cancer Res (2010) 1.64
High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial. J Clin Oncol (2013) 1.60
Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biol (2015) 1.58
Interferons limit inflammatory responses by induction of tristetraprolin. Blood (2006) 1.53
Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. PLoS Pathog (2009) 1.50
Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology (2015) 1.49
Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis. ISME J (2012) 1.43
Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages. J Immunol (2002) 1.40
Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation. J Biol Chem (2003) 1.39
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol (2009) 1.37
Transcription factor PU.1 controls transcription start site positioning and alternative TLR4 promoter usage. J Biol Chem (2007) 1.36
Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states. Blood (2012) 1.36
The regulation of inflammation by interferons and their STATs. JAKSTAT (2013) 1.35
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest (2013) 1.32
Transcriptomic profiling identifies a PU.1 regulatory network in macrophages. Biochem Biophys Res Commun (2009) 1.31
CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity (2013) 1.28
Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLoS Pathog (2012) 1.26
Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming. Immunobiology (2010) 1.25
Primary prophylaxis of invasive fungal infections in patients with hematologic malignancies. Recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Haematologica (2008) 1.24
Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. Mol Syst Biol (2011) 1.23
Induction of maturation and cytokine release of human dendritic cells by Helicobacter pylori. Infect Immun (2004) 1.21
Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels. Genome Biol (2010) 1.20
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood (2008) 1.20
A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity. Proc Natl Acad Sci U S A (2003) 1.19
A gene necessary for reproductive suppression in termites. Science (2009) 1.19
Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia. Cancer Res (2012) 1.18
UME6 is a crucial downstream target of other transcriptional regulators of true hyphal development in Candida albicans. FEMS Yeast Res (2008) 1.18
Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of rituximab: mechanism of antibody-dependent cellular cytotoxicity and impact of human serum. J Immunother (2006) 1.17
PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes. PLoS One (2012) 1.16
A brief review of parallel magnetic resonance imaging. Eur Radiol (2003) 1.15
Transcription and enhancer profiling in human monocyte subsets. Blood (2014) 1.12
Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg. Eur J Immunol (2011) 1.09
Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence. Cell Microbiol (2007) 1.09
Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Res (2010) 1.08
The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood (2014) 1.08
Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun (2009) 1.06
Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood (2011) 1.06
The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Mol Immunol (2010) 1.05
An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattle. PLoS One (2011) 1.05
Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol (2009) 1.05
Mitochondrial DNA heteroplasmy in ovine fetuses and sheep cloned by somatic cell nuclear transfer. BMC Dev Biol (2007) 1.04
PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. J Leukoc Biol (2007) 1.04
Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1. Nucleic Acids Res (2013) 1.04
Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol (2005) 1.03
CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep (2013) 1.02
Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins. Mol Cell Biol (2013) 1.00
Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity. Vaccine (2009) 1.00
Impact of Helicobacter pylori virulence factors and compounds on activation and maturation of human dendritic cells. Infect Immun (2005) 1.00
Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling. J Immunol (2011) 0.99
Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog (2012) 0.99
Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. FASEB J (2012) 0.99
CCAAT enhancer-binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage differentiation. J Biol Chem (2007) 0.99
Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis. Diabetes (2011) 0.98
Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV. Ann Hematol (2013) 0.98
Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2. FEBS Lett (2008) 0.97
Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression. J Immunol (2011) 0.97
Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation. J Leukoc Biol (2007) 0.97
Rapid and sensitive detection of CpG-methylation using methyl-binding (MB)-PCR. Nucleic Acids Res (2006) 0.97