Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice.

PubWeight™: 0.86‹?›

🔗 View Article (PMID 16688529)

Published in Mamm Genome on May 01, 2006

Authors

Isabelle Angers1, Vanessa Sancho-Shimizu, Albert Descoteaux, Andrew T Gewirtz, Danielle Malo

Author Affiliations

1: Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3G 1A4. danielle.malo@mcgill.ca

Articles cited by this

Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res (1995) 21.22

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med (2001) 8.60

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell (1990) 8.00

Finding genes that underlie complex traits. Science (2002) 7.39

Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell (1993) 6.99

Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol (2001) 6.62

Toll-like receptor signaling pathways. Science (2003) 5.86

Dendritic cell regulation of TH1-TH2 development. Nat Immunol (2000) 5.13

The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med (1995) 3.86

Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol (1980) 3.31

A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30

MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature (2002) 3.10

Wild mice: an ever-increasing contribution to a popular mammalian model. Trends Genet (2003) 2.93

The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol (2003) 2.73

Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. J Clin Invest (2001) 2.67

Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J Immunol (2001) 2.44

Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol (2003) 2.43

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6. J Immunol (1994) 2.22

Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol (2002) 2.22

Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response. J Immunol (2004) 2.13

Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5. Am J Respir Cell Mol Biol (2003) 2.09

Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Clin Exp Immunol (2004) 1.94

Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cell Microbiol (2004) 1.89

PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J Biol Chem (2000) 1.87

Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kappaB pathway. J Clin Invest (2000) 1.74

Species-specific regulation of Toll-like receptor 3 genes in men and mice. J Biol Chem (2003) 1.73

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. J Biol Chem (2000) 1.65

Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock (2003) 1.64

Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. Blood (1993) 1.50

Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics (2000) 1.49

In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain. J Biol Chem (2004) 1.49

Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science (2004) 1.46

Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophages. J Immunol (2002) 1.40

Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5. J Biol Chem (2002) 1.37

Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics (1998) 1.24

The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells. J Biol Chem (2002) 1.22

Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin. J Immunol (2004) 1.19

Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Infect Immun (2002) 1.13

A high-resolution map in the chromosomal region surrounding the Lps locus. Genomics (1996) 0.99

Immunity to Salmonella from a dendritic point of view. Cell Microbiol (2004) 0.97

Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. J Infect Dis (2005) 0.96

Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infect Immun (2002) 0.95

Sequencing, expression, and functional analyses support the candidacy of Ncf2 in susceptibility to Salmonella typhimurium infection in wild-derived mice. J Immunol (2006) 0.94

Essential roles of NF-kappaB and C/EBP in the regulation of intercellular adhesion molecule-1 after respiratory syncytial virus infection of human respiratory epithelial cell cultures. J Virol (1998) 0.87

Articles by these authors

(truncated to the top 100)

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (2010) 12.54

TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86

Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18

Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe (2013) 3.05

Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe (2012) 2.48

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity (2010) 2.47

Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol (2003) 2.43

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut (2013) 2.32

Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol (2002) 2.22

Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol (2008) 2.07

Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog (2009) 2.07

Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest (2009) 2.06

Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol (2010) 2.05

Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology (2005) 2.03

Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One (2012) 1.90

p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. J Biol Chem (2011) 1.82

Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am J Pathol (2006) 1.77

A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J Exp Med (2005) 1.74

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity. J Exp Med (2011) 1.71

In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res (2009) 1.67

Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A (2004) 1.63

Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J Clin Invest (2010) 1.59

Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm Bowel Dis (2007) 1.57

Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J Immunol (2006) 1.54

Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology (2012) 1.52

TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. J Immunol (2006) 1.50

Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol (2005) 1.49

Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses. Immunol Rev (2007) 1.47

Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol (2006) 1.45

IL-6 induces NF-kappa B activation in the intestinal epithelia. J Immunol (2003) 1.42

RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon-gamma-primed macrophages. Eur J Immunol (2006) 1.41

Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol (2004) 1.41

Shanthi V. Sitaraman, MD, PhD: physician, scientist, educator, and humanitarian. Gastroenterology (2011) 1.39

Toll-like receptor-gut microbiota interactions: perturb at your own risk! Annu Rev Physiol (2011) 1.38

In"sight" into immune blindness: Helicobacter pylori-induced gastritis requires T cells primed in the small intestine Peyer's patches. Gastroenterology (2007) 1.38

TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol (2003) 1.38

Toll-like receptors 4 and 5 induce distinct types of vasculitis. Circ Res (2009) 1.37

TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. Eur J Immunol (2010) 1.37

Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease. Infect Immun (2008) 1.37

The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. J Pediatr (2010) 1.36

Overexpression of Toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice. J Immunol (2003) 1.36

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood. J Exp Med (2012) 1.35

Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps. J Immunol (2010) 1.33

Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1alpha in long-lived Mclk1+/- mouse mutants. J Immunol (2009) 1.33

Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B. J Biol Chem (2002) 1.32

Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.31

Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol (2008) 1.30

Latent cytomegalovirus infection exacerbates experimental colitis. Am J Pathol (2009) 1.30

Microbiota-liver axis in hepatic disease. Hepatology (2013) 1.27

Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis. J Immunol (2006) 1.25

Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut (2011) 1.25

Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome. Am J Physiol Regul Integr Comp Physiol (2007) 1.23

Human primary immunodeficiencies of type I interferons. Biochimie (2007) 1.23

TLR3 immunity to infection in mice and humans. Curr Opin Immunol (2013) 1.22

Allelic variation in TLR4 is linked to susceptibility to Salmonella enterica serovar Typhimurium infection in chickens. Infect Immun (2003) 1.22

Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol (2012) 1.22

The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells. J Biol Chem (2002) 1.22

Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood. J Pediatr (2010) 1.21

Leishmania donovani lipophosphoglycan blocks NADPH oxidase assembly at the phagosome membrane. Cell Microbiol (2006) 1.20

Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol (2009) 1.19

Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens. J Immunol (2007) 1.18

Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP. J Immunol (2003) 1.15

Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice. Gastroenterology (2009) 1.15

Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway. J Cell Sci (2004) 1.15

The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V. PLoS Pathog (2009) 1.11

ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels. J Neurosci (2002) 1.11

Polarized fibronectin secretion induced by adenosine regulates bacterial-epithelial interaction in human intestinal epithelial cells. Biochem J (2004) 1.11

Toll like receptor-5: protecting the gut from enteric microbes. Semin Immunopathol (2007) 1.10

Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view. PLoS Negl Trop Dis (2012) 1.09

Intestinal epithelial cell regulation of mucosal inflammation. Immunol Res (2004) 1.08

Modulation of phagolysosome biogenesis by the lipophosphoglycan of Leishmania. Clin Immunol (2005) 1.05

TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. J Leukoc Biol (2006) 1.05

Flagellin administration protects gut mucosal tissue from irradiation-induced apoptosis via MKP-7 activity. Gut (2011) 1.05

Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium. Infect Immun (2004) 1.04

Identification of proinflammatory flagellin proteins in supernatants of Vibrio cholerae O1 by proteomics analysis. Mol Cell Proteomics (2006) 1.03

Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. Cancer Res (2010) 1.03

Gut microbiota, low-grade inflammation, and metabolic syndrome. Toxicol Pathol (2013) 1.02

Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8. Cell Host Microbe (2013) 1.02

Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus. J Immunol (2005) 1.02

Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation. Gastroenterology (2007) 1.01

Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation. J Biol Chem (2007) 1.00

Phagocytosis of Leishmania donovani amastigotes is Rac1 dependent and occurs in the absence of NADPH oxidase activation. Eur J Immunol (2006) 0.98

N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium. J Immunol (2010) 0.97

Adenosine 2B receptor expression is post-transcriptionally regulated by microRNA. J Biol Chem (2010) 0.97

Toll-like receptor 5-dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection. Infect Immun (2009) 0.97

Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice. J Exp Med (2007) 0.97

Proteomic analysis reveals a role for protein kinase C-alpha in phagosome maturation. Biochem Biophys Res Commun (2004) 0.96

Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem (2004) 0.96

NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus. J Allergy Clin Immunol (2011) 0.96

Leishmania donovani promastigotes induce periphagosomal F-actin accumulation through retention of the GTPase Cdc42. Cell Microbiol (2005) 0.96

Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infect Immun (2002) 0.95

IFN-gamma-induced MHC class II expression: transactivation of class II transactivator promoter IV by IFN regulatory factor-1 is regulated by protein kinase C-alpha. J Immunol (2003) 0.95

Sequencing, expression, and functional analyses support the candidacy of Ncf2 in susceptibility to Salmonella typhimurium infection in wild-derived mice. J Immunol (2006) 0.94

Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity. J Immunol (2011) 0.93

Leishmania donovani lipophosphoglycan inhibits phagosomal maturation via action on membrane rafts. Microbes Infect (2008) 0.93

R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea. Nat Commun (2013) 0.93

Influence of Slc11a1 on the outcome of Salmonella enterica serovar Enteritidis infection in mice is associated with Th polarization. Infect Immun (2006) 0.92

Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice. J Inflamm (Lond) (2011) 0.92

The exocytosis regulator synaptotagmin V controls phagocytosis in macrophages. J Immunol (2008) 0.92

The C3H/HeJ inbred mouse is a model of vesico-ureteric reflux with a susceptibility locus on chromosome 12. Kidney Int (2010) 0.91