Published in J Enzyme Inhib Med Chem on December 01, 2002
Synthesis and biological evaluation of five-membered heterocycles fused to cyclopenta[c]thiophene as new antitumor agents. Bioorg Med Chem (2003) 1.14
Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor. Proc Natl Acad Sci U S A (2010) 1.08
New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization. J Med Chem (2003) 1.06
Selective ortho-bromination of substituted benzaldoximes using Pd-catalyzed C-H activation: application to the synthesis of substituted 2-bromobenzaldehydes. J Org Chem (2011) 1.00
Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives. J Enzyme Inhib Med Chem (2004) 0.95
Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity. J Cereb Blood Flow Metab (2008) 0.94
Synthesis of a novel class of non-peptide NK-2 receptor ligand, derived from 1-phenyl-3-pyrrol-1-ylindan-2-carboxamides. Bioorg Med Chem (2002) 0.92
2-(6-bromopyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane and (6-bromopyridin-3-yl)boronic acid, new bifunctional building blocks for combinatorial chemistry. Acta Crystallogr C (2003) 0.91
Nanocarriers for the targeted treatment of ovarian cancers. Biomaterials (2012) 0.86
3D Pharmacophore, hierarchical methods, and 5-HT4 receptor binding data. J Enzyme Inhib Med Chem (2008) 0.86
Synthesis of oxysterols and nitrogenous sterols with antileishmanial and trypanocidal activities. Eur J Med Chem (2006) 0.85
4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett (2007) 0.85
Introduction of jumping fragments in combination with QSARs for the assessment of classification in ecotoxicology. J Chem Inf Model (2010) 0.85
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Behav Brain Res (2012) 0.84
Targeting the proangiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening. Chem Biol (2011) 0.84
New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase. Bioorg Med Chem (2012) 0.84
1,2,3-Trimethoxy-4-[(E)-2-phenylvinyl]benzene and (E,E)-1,4-bis(2,3,4-trimethoxyphenyl)buta-1,3-diene. Acta Crystallogr C (2009) 0.83
2-bromo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, a new unexpected bifunctional building block for combinatorial chemistry. Acta Crystallogr C (2003) 0.83
Molecular modeling studies focused on 5-HT7 versus 5-HT1A selectivity. Discovery of novel phenylpyrrole derivatives with high affinity for 5-HT7 receptors. J Chem Inf Model (2005) 0.82
9-Ethyl-1,4-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole and 6-bromo-9-ethyl-1,4-dimethyl-9H-carbazole. Acta Crystallogr C (2008) 0.81
tert-Butyl 6-bromo-1,4-dimethyl-9H-carbazole-9-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2010) 0.80
MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity. Cancer Lett (2012) 0.80
New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines. Bioorg Med Chem (2008) 0.80
Synthesis of new 4-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors. J Enzyme Inhib Med Chem (2007) 0.80
Interpretation of honeybees contact toxicity associated to acetylcholinesterase inhibitors. Ecotoxicol Environ Saf (2012) 0.80
Synthesis of new L-ascorbic ferulic acid hybrids. Molecules (2007) 0.79
(6-bromo-1,4-dimethyl-9H-carbazol-3-yl-methylene)-hydrazine (carbhydraz) acts as a GPER agonist in breast cancer cells. Curr Top Med Chem (2015) 0.79
Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity. Eur J Med Chem (2009) 0.78
An efficient two-step total synthesis of the quaterpyridine nemertelline. J Org Chem (2003) 0.78
Two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles. J Org Chem (2010) 0.78
Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents. J Med Chem (2004) 0.78
Review of 5-HT4R ligands: state of art and clinical applications. Curr Top Med Chem (2010) 0.78
Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I. J Enzyme Inhib Med Chem (2011) 0.78
4-Thiophenoxy-2-trichloromethyquinazolines display in vitro selective antiplasmodial activity against the human malaria parasite Plasmodium falciparum. Bioorg Med Chem Lett (2011) 0.77
Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors. J Enzyme Inhib Med Chem (2004) 0.77
Molecular design based on 3D-pharmacophore. Application to 5-HT subtypes receptors. J Chem Inf Comput Sci (2002) 0.77
Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines. Bioorg Med Chem Lett (2007) 0.77
Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. Bioorg Med Chem (2008) 0.77
Molecular design based on 3D-pharmacophore. Application to 5-HT4 receptor. J Chem Inf Comput Sci (2002) 0.77
First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump. J Med Chem (2014) 0.77
Tripentones: a promising series of potent anti-cancer agents. Anticancer Agents Med Chem (2009) 0.77
Dual histamine H3R/serotonin 5-HT4R ligands with antiamnesic properties: pharmacophore-based virtual screening and polypharmacology. J Chem Inf Model (2014) 0.76
Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library. J Chem Inf Model (2010) 0.76
Molecular design based on 3D pharmacophores. Applications to 5-HT7 receptors. J Chem Inf Comput Sci (2004) 0.76
Solution-phase parallel synthesis of a 1140-member ureidothiophene carboxylic acid library. J Comb Chem (2005) 0.76
Novel aminoethylbiphenyls as 5-HT7 receptor ligands. Bioorg Med Chem Lett (2007) 0.76
Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands. Bioorg Med Chem Lett (2005) 0.76
Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family. J Ovarian Res (2013) 0.76
First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. J Med Chem (2015) 0.76
Inhibitory effects and spectral interactions of isomeric methoxyindazoles on recombinant nitric oxide synthases. Nitric Oxide (2003) 0.76
Discovery of a new antileishmanial hit in 8-nitroquinoline series. Eur J Med Chem (2012) 0.75
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers. J Med Chem (2012) 0.75
Synthesis, pharmacological study and modeling of 7-methoxyindazole and related substituted indazoles as neuronal nitric oxide synthase inhibitors. J Enzyme Inhib Med Chem (2003) 0.75
An inter-molecular dative B←N bond in 5-(4,4,5,5-tetra-methyl-1,3,2-dioxa-borolan-2-yl)-1,3-thia-zole. Acta Crystallogr Sect E Struct Rep Online (2009) 0.75
Synthesis, inhibition of NO production and antiproliferative activities of some indole derivatives. J Enzyme Inhib Med Chem (2009) 0.75
[Study of in vitro cytotoxic activity of cyclopentanones derivatives]. Tunis Med (2004) 0.75
Synthesis and biological evaluation of cyclopenta[c]thiophene related compounds as new antitumor agents. Bioorg Med Chem (2002) 0.75
7-Methoxy-1H-indazole, a new inhibitor of neuronal nitric oxide synthase. Acta Crystallogr C (2002) 0.75
Conformation control of abiotic α-helical foldamers. J Chem Inf Model (2013) 0.75
Towards Understanding Mcl-1 Promiscuous and Specific Binding Mode. J Chem Inf Model (2017) 0.75
Structural characterizations of oligopyridyl foldamers, α-helix mimetics. J Chem Inf Model (2012) 0.75
Prediction of acute toxicity in fish by using QSAR methods and chemical modes of action. J Enzyme Inhib Med Chem (2010) 0.75
Synthesis, reactivity and biological evaluation of novel halogenated tripentones. Bioorg Med Chem (2009) 0.75
The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouse. Steroids (2009) 0.75
Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines. Eur J Med Chem (2010) 0.75
Synthesis and preliminary in vivo evaluation of new 2-Aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and 2-Aryl-6-methylpiperidin-4-ols, as potential anti-amnesiant agents. J Enzyme Inhib Med Chem (2005) 0.75
Synthesis and characterization of a iodine-125-labeled pyrrolo[1,2-a]thieno[3,2-e]pyrazine and evaluation as a potential 5-HT4R SPECT tracer. Eur J Med Chem (2010) 0.75
Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil. Eur J Med Chem (2005) 0.75
Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors. J Enzyme Inhib Med Chem (2008) 0.75
N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines. Chem Biol Drug Des (2013) 0.75
Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats. Mol Imaging (2014) 0.75
Synthesis and initial results for MAO-B inhibition by new N-propargyl-3-pyrrol-1-ylindanamine derivatives, analogues of rasagiline. J Enzyme Inhib Med Chem (2003) 0.75
Synthesis of new bisaryl cyclopentathiophene and thienocyclopentoxazolidine derivatives as potential cytotoxic agents. J Enzyme Inhib Med Chem (2007) 0.75
Receptor- and ligand-based study on novel 2,2'-bithienyl derivatives as non-peptidic AANAT inhibitors. J Chem Inf Model (2010) 0.75
A new synthetic route to original sulfonamide derivatives in 2-trichloromethylquinazoline series: a structure-activity relationship study of antiplasmodial activity. Molecules (2012) 0.75
3D-QSAR and docking studies of selective GSK-3beta inhibitors. Comparison with a thieno[2,3-b]pyrrolizinone derivative, a new potential lead for GSK-3beta ligands. J Chem Inf Model (2005) 0.75
Pharmacological studies and synthesis of morpholino alkyl derivatives. Chem Pharm Bull (Tokyo) (2002) 0.75
Targeting the human malaria parasite Plasmodium falciparum: in vitro identification of a new antiplasmodial hit in 4-phenoxy-2-trichloromethylquinazoline series. Eur J Med Chem (2011) 0.75
N-arylsulfonyl-2-vinyltryptamines as new 5-HT6 serotonin receptor ligands. J Enzyme Inhib Med Chem (2006) 0.75
First synthesis of 7alpha- and 7beta-amino-DHEA, dehydroepiandrosterone (DHEA) analogues and preliminary evaluation of their cytotoxicity on Leydig cells and TM4 Sertoli cells. Bioorg Med Chem (2007) 0.75
Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors. Eur J Med Chem (2008) 0.75
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect. Bioorg Med Chem (2012) 0.75
Definition of new pharmacophores for nonpeptide antagonists of human urotensin-II. Comparison with the 3D-structure of human urotensin-II and URP. J Chem Inf Model (2007) 0.75
Simultaneous tritium labelling of two potent 5-HT4 ligands. Eur J Med Chem (2009) 0.75
Intramolecular cyclisation of β-aryl-β-amino acids in the design of novel heterocyclic systems with therapeutic interest: an unfailing source of diversity. Curr Med Chem (2010) 0.75
Cyclopropyl-tryptamine analogues: synthesis and biological evaluation as 5-HT(6) receptor ligands. ChemMedChem (2012) 0.75