Published in J Enzyme Inhib Med Chem on December 01, 2004
New highlights of the syntheses of pyrrolo[1,2-a]quinoxalin-4-ones. Beilstein J Org Chem (2014) 0.90
A one-pot catalyst-free synthesis of functionalized pyrrolo[1,2-a]quinoxaline derivatives from benzene-1,2-diamine, acetylenedicarboxylates and ethyl bromopyruvate. Beilstein J Org Chem (2013) 0.89
Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother (2005) 3.16
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) (2009) 2.58
Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives. J Med Chem (2002) 2.16
Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb) (2009) 1.94
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. Antimicrob Agents Chemother (2007) 1.58
A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. Cancer Prev Res (Phila) (2009) 1.51
Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus. Proc Natl Acad Sci U S A (2013) 1.47
Multidrug resistance reversal agents. J Med Chem (2003) 1.42
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. PLoS One (2007) 1.41
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ. J Antimicrob Chemother (2002) 1.39
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds. Tuberculosis (Edinb) (2004) 1.33
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Mol Cancer Ther (2009) 1.31
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J Mol Biol (2004) 1.10
Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery. Chem Biol (2013) 1.10
Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models. PLoS One (2013) 1.01
Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery. Pharm Res (2013) 0.99
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Mol Microbiol (2009) 0.99
Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100. Vaccine (2003) 0.99
Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydr Res (2002) 0.97
8-O-Azeloyl-14-benzoylaconine: a new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities. Bioorg Med Chem (2005) 0.95
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors. Bioorg Med Chem (2011) 0.95
Synthesis of new pyrrolo[1,2-a]quinoxaline derivatives as potential inhibitors of Akt kinase. J Enzyme Inhib Med Chem (2008) 0.93
Synthesis of a novel class of non-peptide NK-2 receptor ligand, derived from 1-phenyl-3-pyrrol-1-ylindan-2-carboxamides. Bioorg Med Chem (2002) 0.92
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis. Bioorg Med Chem Lett (2006) 0.90
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis. PLoS One (2012) 0.89
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology (2010) 0.89
Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis. J Chem Inf Model (2014) 0.88
Probing the role of the covalent linkage of ferrocene into a chloroquine template. J Med Chem (2006) 0.87
Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis. J Chem Inf Model (2014) 0.87
Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cell Signal (2012) 0.87
Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents. Bioorg Med Chem (2006) 0.86
A novel quinoline derivative that inhibits mycobacterial FtsZ. Tuberculosis (Edinb) (2013) 0.85
Fusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation. J Chem Inf Model (2013) 0.85
Antimycobacterial agents. 1. Thio analogues of purine. J Med Chem (2004) 0.85
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Behav Brain Res (2012) 0.84
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis. Protein Expr Purif (2007) 0.84
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. Biochem J (2008) 0.84
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis. Bioorg Med Chem Lett (2002) 0.84
Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis. Bioorg Med Chem (2007) 0.84
Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists. Bioorg Med Chem (2005) 0.81
Hemisynthesis and antiproliferative properties of mono-[O-(14-benzoylaconine-8-yl)]esters and bis-[O-(14-benzoylaconine-8-yl)]esters. Eur J Med Chem (2012) 0.81
A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila) (2010) 0.80
MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity. Cancer Lett (2012) 0.80
Synthesis of new 4-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors. J Enzyme Inhib Med Chem (2007) 0.80
Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of the multidrug efflux pump NorA of Staphylococcus aureus. Antimicrob Agents Chemother (2006) 0.79
Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity. Bioorg Med Chem (2002) 0.79
Parallel solution-phase synthesis of an adenosine antibiotic analog library. ACS Comb Sci (2013) 0.79
Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II. J Enzyme Inhib Med Chem (2010) 0.79
Modulation of cell proliferation in rat liver cell cultures by new calix[4]arenes. J Enzyme Inhib Med Chem (2006) 0.79
Pharmaceutical development and optimization of azithromycin suppository for paediatric use. Int J Pharm (2012) 0.79
Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity. Eur J Med Chem (2009) 0.78
Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine. Int Immunopharmacol (2002) 0.78
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity. Bioorg Med Chem (2008) 0.78
Binding mode analysis of 2,4-diamino-5-methyl-5-deaza-6-substituted pteridines with Mycobacterium tuberculosis and human dihydrofolate reductases. J Biomol Struct Dyn (2008) 0.78
6-Oxo and 6-thio purine analogs as antimycobacterial agents. Bioorg Med Chem (2013) 0.77
Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis. Carbohydr Res (2004) 0.77
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity--Part II. Eur J Med Chem (2011) 0.77
Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes. J Enzyme Inhib Med Chem (2010) 0.77
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett (2012) 0.77
Tripentones: a promising series of potent anti-cancer agents. Anticancer Agents Med Chem (2009) 0.77
Synthesis of novel peptidyl adenosine antibiotic analogs. Nucleosides Nucleotides Nucleic Acids (2014) 0.77
Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors. J Enzyme Inhib Med Chem (2004) 0.77
Parallel solution-phase synthesis and general biological activity of a uridine antibiotic analog library. ACS Comb Sci (2014) 0.77
Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes. Part II. J Enzyme Inhib Med Chem (2010) 0.76
Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library. J Chem Inf Model (2010) 0.76
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis. Bioorg Med Chem Lett (2007) 0.76
Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamides. ACS Comb Sci (2014) 0.75
Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis. Bioorg Med Chem (2008) 0.75
1-Allyl-3-phenyl-quinoxalin-2(1H)-one. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
2-(3H-1,3-Benzothia-zol-2-yl-idene)-propane-dial. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
[Study of in vitro cytotoxic activity of cyclopentanones derivatives]. Tunis Med (2004) 0.75
Synthesis and initial results for MAO-B inhibition by new N-propargyl-3-pyrrol-1-ylindanamine derivatives, analogues of rasagiline. J Enzyme Inhib Med Chem (2003) 0.75
Synthesis and preliminary in vivo evaluation of new 2-Aryl-6-methyl-1,2-dihydro-1H-pyridin-4-ones and 2-Aryl-6-methylpiperidin-4-ols, as potential anti-amnesiant agents. J Enzyme Inhib Med Chem (2005) 0.75
A first cyclopenta[c]thiophene dimer as a new bivalent potent cytotoxic derivative. J Enzyme Inhib Med Chem (2002) 0.75
Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil. Eur J Med Chem (2005) 0.75
Synthesis of new bisaryl cyclopentathiophene and thienocyclopentoxazolidine derivatives as potential cytotoxic agents. J Enzyme Inhib Med Chem (2007) 0.75
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors. Bioorg Med Chem Lett (2012) 0.75
Anti-leukemia activity of 7-hydroxy-2-substituted-methyl-5H-oxazolo[3,2-a]pyrimidin-5-one derivatives. J Enzyme Inhib Med Chem (2002) 0.75
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett (2012) 0.75
Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors. Bioorg Med Chem Lett (2012) 0.75
Intramolecular cyclisation of β-aryl-β-amino acids in the design of novel heterocyclic systems with therapeutic interest: an unfailing source of diversity. Curr Med Chem (2010) 0.75
Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors. Eur J Med Chem (2008) 0.75
Derivatization of (+/-)-5-[(2-methylphenoxy)methyl]-2-amino-2-oxazoline, an imidazoline binding sites ligand, with (+)-(R)-alpha-methylbenzyl isocyanate for drug monitoring purposes. J Enzyme Inhib Med Chem (2002) 0.75
Tripodal ligand incorporating dual fluorescent ionophore: a coordinative control of photoinduced electron transfer. Photochem Photobiol Sci (2003) 0.75
Synthesis, reactivity and biological evaluation of novel halogenated tripentones. Bioorg Med Chem (2009) 0.75
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect. Bioorg Med Chem (2012) 0.75
Novel substituted pyrimidines as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett (2011) 0.75
Enantioselective synthesis of spirocyclic aminochroman derivatives according to the CN(R,S) strategy. J Org Chem (2003) 0.75
Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors. J Enzyme Inhib Med Chem (2008) 0.75
N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines. Chem Biol Drug Des (2013) 0.75
Synthesis and general biological activity of a small adenosine-5'-(carboxamide and sulfanilamide) library. Nucleosides Nucleotides Nucleic Acids (2014) 0.75