Published in Science on April 11, 2003
The global distribution and population at risk of malaria: past, present, and future. Lancet Infect Dis (2004) 14.42
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet (2008) 6.06
How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet (2005) 5.79
Microevolution and history of the plague bacillus, Yersinia pestis. Proc Natl Acad Sci U S A (2004) 5.04
Evolutionary analysis of the dynamics of viral infectious disease. Nat Rev Genet (2009) 4.56
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature (2012) 4.37
Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis. PLoS Pathog (2005) 3.73
From evolutionary genetics to human immunology: how selection shapes host defence genes. Nat Rev Genet (2009) 2.98
The origin of malignant malaria. Proc Natl Acad Sci U S A (2009) 2.67
On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from Bonobos. PLoS Pathog (2010) 2.60
A new malaria agent in African hominids. PLoS Pathog (2009) 2.47
Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques. PLoS Pathog (2011) 2.45
A monkey's tale: the origin of Plasmodium vivax as a human malaria parasite. Proc Natl Acad Sci U S A (2005) 2.25
Human infections and detection of Plasmodium knowlesi. Clin Microbiol Rev (2013) 2.05
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Mol Cell (2004) 2.02
Population genetics of malaria resistance in humans. Heredity (Edinb) (2011) 1.85
Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen. Genetics (2003) 1.82
Malaria research in the post-genomic era. Nature (2008) 1.78
Population genomics of the immune evasion (var) genes of Plasmodium falciparum. PLoS Pathog (2007) 1.74
The origin and age of Plasmodium vivax. Trends Parasitol (2006) 1.62
Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites. PLoS Genet (2012) 1.55
Malaria in selected non-Amazonian countries of Latin America. Acta Trop (2011) 1.53
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Multilocus haplotypes reveal variable levels of diversity and population structure of Plasmodium falciparum in Papua New Guinea, a region of intense perennial transmission. Malar J (2010) 1.47
Global phylogeographic limits of Hawaii's avian malaria. Proc Biol Sci (2006) 1.45
Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax. Mol Biol Evol (2005) 1.45
Contrasting population structures of the genes encoding ten leading vaccine-candidate antigens of the human malaria parasite, Plasmodium falciparum. PLoS One (2009) 1.43
Malaria in India: the center for the study of complex malaria in India. Acta Trop (2011) 1.42
Allele frequency-based and polymorphism-versus-divergence indices of balancing selection in a new filtered set of polymorphic genes in Plasmodium falciparum. Mol Biol Evol (2010) 1.38
The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan. PLoS Med (2010) 1.34
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Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. Genome Res (2010) 1.27
Genomic epidemiology of artemisinin resistant malaria. Elife (2016) 1.27
Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system. Antimicrob Agents Chemother (2005) 1.24
Meager genetic variability of the human malaria agent Plasmodium vivax. Proc Natl Acad Sci U S A (2004) 1.20
Prospective identification of malaria parasite genes under balancing selection. PLoS One (2009) 1.18
Timing the origin of human malarias: the lemur puzzle. BMC Evol Biol (2011) 1.17
Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity. PLoS One (2010) 1.17
On the origin and spread of the Scab disease of apple: out of central Asia. PLoS One (2008) 1.15
Bayesian analysis of new and old malaria parasite DNA sequence data demonstrates the need for more phylogenetic signal to clarify the descent of Plasmodium falciparum. Parasitol Res (2007) 1.12
Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity. Mol Biol Evol (2014) 1.11
Genetic distance in housekeeping genes between Plasmodium falciparum and Plasmodium reichenowi and within P. falciparum. J Mol Evol (2004) 1.11
Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya. Malar J (2012) 1.09
A comparative study of the genetic diversity of the 42kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax. Infect Genet Evol (2006) 1.07
Pleistocene glacial refugia across the Appalachian Mountains and coastal plain in the millipede genus Narceus: evidence from population genetic, phylogeographic, and paleoclimatic data. BMC Evol Biol (2009) 1.06
Genome sequences reveal divergence times of malaria parasite lineages. Parasitology (2010) 1.06
Multiple independent introductions of Plasmodium falciparum in South America. Proc Natl Acad Sci U S A (2011) 1.06
The remarkable journey of adaptation of the Plasmodium falciparum malaria parasite to New World anopheline mosquitoes. Mem Inst Oswaldo Cruz (2014) 1.04
The fragmented mitochondrial ribosomal RNAs of Plasmodium falciparum. PLoS One (2012) 1.04
A novel locus of resistance to severe malaria in a region of ancient balancing selection. Nature (2015) 1.03
The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum. Trends Parasitol (2009) 1.02
Plasmodium vivax: recent world expansion and genetic identity to Plasmodium simium. Proc Natl Acad Sci U S A (2005) 1.02
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. Mol Biol Evol (2012) 1.00
The changing disease-scape in the third epidemiological transition. Int J Environ Res Public Health (2010) 0.99
A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa. PLoS One (2011) 0.98
Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. PLoS Negl Trop Dis (2015) 0.98
PlasmoView: a web-based resource to visualise global Plasmodium falciparum genomic variation. J Infect Dis (2013) 0.97
Evidence for negative selection on the gene encoding rhoptry-associated protein 1 (RAP-1) in Plasmodium spp. Infect Genet Evol (2010) 0.96
Malaria parasitaemia among long distance truck drivers in the Niger delta of Nigeria. Afr Health Sci (2012) 0.96
High levels of genetic diversity of Plasmodium falciparum populations in Papua New Guinea despite variable infection prevalence. Am J Trop Med Hyg (2013) 0.96
The origins of African Plasmodium vivax; insights from mitochondrial genome sequencing. PLoS One (2011) 0.96
The limits of theoretical population genetics. Genetics (2005) 0.95
Genetic relatedness of Plasmodium falciparum isolates and the origin of allelic diversity at the merozoite surface protein-1 (MSP-1) locus in Brazil and Vietnam. Malar J (2003) 0.95
Paraphyly of organelle DNAs in Cycas Sect. Asiorientales due to ancient ancestral polymorphisms. BMC Evol Biol (2009) 0.94
Malarial parasite diversity in chimpanzees: the value of comparative approaches to ascertain the evolution of Plasmodium falciparum antigens. Malar J (2013) 0.93
Niche construction on Bali: the gods of the countryside. Philos Trans R Soc Lond B Biol Sci (2011) 0.93
Hypervariable antigen genes in malaria have ancient roots. BMC Evol Biol (2013) 0.90
Pooled sequencing and rare variant association tests for identifying the determinants of emerging drug resistance in malaria parasites. Mol Biol Evol (2014) 0.89
Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites. BMC Evol Biol (2010) 0.89
Sexual recombination is a signature of a persisting malaria epidemic in Peru. Malar J (2011) 0.89
Using mitochondrial genome sequences to track the origin of imported Plasmodium vivax infections diagnosed in the United States. Am J Trop Med Hyg (2014) 0.88
Plasmodium vivax populations revisited: mitochondrial genomes of temperate strains in Asia suggest ancient population expansion. BMC Evol Biol (2012) 0.88
A quantitative synthesis of the medicinal ethnobotany of the Malinké of Mali and the Asháninka of Peru, with a new theoretical framework. J Ethnobiol Ethnomed (2007) 0.87
Molecular evolutionary signatures reveal the role of host ecological dynamics in viral disease emergence and spread. Philos Trans R Soc Lond B Biol Sci (2013) 0.87
Long- and short-term selective forces on malaria parasite genomes. PLoS Genet (2010) 0.86
Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites. Parasitol Res (2005) 0.86
Uncertainty in mapping malaria epidemiology: implications for control. Epidemiol Rev (2010) 0.85
Microsatellite markers reveal low levels of population sub-structuring of Plasmodium falciparum in southwestern Nigeria. Malar J (2014) 0.85
Phylogeographic Evidence for 2 Genetically Distinct Zoonotic Plasmodium knowlesi Parasites, Malaysia. Emerg Infect Dis (2016) 0.84
Recurrent bottlenecks in the malaria life cycle obscure signals of positive selection. Parasitology (2014) 0.84
Sequence analysis of Plasmodium falciparum cytochrome b in multiple geographic sites. Malar J (2007) 0.83
Population Structure Shapes Copy Number Variation in Malaria Parasites. Mol Biol Evol (2015) 0.82
Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases. Sci Rep (2013) 0.82
A new method for estimating species age supports the coexistence of malaria parasites and their Mammalian hosts. Mol Biol Evol (2015) 0.81
Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy. Parasit Vectors (2015) 0.81
Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites. Mol Biol Evol (2016) 0.80
Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene. Malar J (2010) 0.80
Arab gene geography: From population diversities to personalized medical genomics. Glob Cardiol Sci Pract (2014) 0.80
A comparative molecular survey of malaria prevalence among Eastern chimpanzee populations in Issa Valley (Tanzania) and Kalinzu (Uganda). Malar J (2016) 0.80
Evidence of gene conversion in the evolutionary process of the codon 41/42 (-CTTT) mutation causing beta-thalassemia in southern China. J Mol Evol (2008) 0.79
Whole mitochondrial genome sequence of an Indian Plasmodium falciparum field isolate. Korean J Parasitol (2014) 0.79
From branch to bedside: Youyou Tu is awarded the 2011 Lasker~DeBakey Clinical Medical Research Award for discovering artemisinin as a treatment for malaria. J Clin Invest (2011) 0.79
Post-Pleistocene range expansion of the recently imperiled eastern little brown bat (Myotis lucifugus lucifugus) from a single southern refugium. Ecol Evol (2011) 0.78
Modeling the evolution of drug resistance in malaria. J Comput Aided Mol Des (2012) 0.78
Genetic structure of Plasmodium vivax using the merozoite surface protein 1 icb5-6 fragment reveals new hybrid haplotypes in southern Mexico. Malar J (2014) 0.78
Potential antimalarials from African natural products: A reviw. J Intercult Ethnopharmacol (2015) 0.77
Five-year tracking of Plasmodium falciparum allele frequencies in a holoendemic area with indistinct seasonal transitions. J Multidiscip Healthc (2014) 0.77
Tracing the geographic origins of Plasmodium falciparum malaria parasites. Pathog Glob Health (2014) 0.77
Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2009) 33.25
Typhoid fever. N Engl J Med (2002) 12.96
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum. Nature (2002) 12.09
Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2014) 11.87
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet (2012) 11.82
Vivax malaria: neglected and not benign. Am J Trop Med Hyg (2007) 10.16
Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med (2004) 10.14
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet (2010) 8.52
Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa. PLoS Med (2005) 8.36
Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect Dis (2012) 6.94
Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol (2006) 6.34
A major genome region underlying artemisinin resistance in malaria. Science (2012) 6.25
Mixed-species malaria infections in humans. Trends Parasitol (2004) 6.01
Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment. PLoS One (2009) 5.81
Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator. Malar J (2011) 5.65
BEAGLE: an application programming interface and high-performance computing library for statistical phylogenetics. Syst Biol (2011) 5.40
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat Genet (2013) 5.22
Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med (2005) 4.65
Artemisinin-based combination treatment of falciparum malaria. Am J Trop Med Hyg (2007) 4.58
Intrahost modeling of artemisinin resistance in Plasmodium falciparum. Proc Natl Acad Sci U S A (2010) 4.50
Comparison of three fluid solutions for resuscitation in dengue shock syndrome. N Engl J Med (2005) 4.47
Manslaughter by fake artesunate in Asia--will Africa be next? PLoS Med (2006) 4.46
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature (2012) 4.37
Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites. J Infect Dis (2007) 4.35
Access to artemisinin combination therapy for malaria in remote areas of Cambodia. Malar J (2008) 4.33
In vivo parasitological measures of artemisinin susceptibility. J Infect Dis (2010) 4.25
The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia. Malar J (2009) 4.25
Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin Infect Dis (2006) 4.14
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial. Lancet (2004) 4.14
Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc Natl Acad Sci U S A (2012) 4.10
Counterfeit anti-infective drugs. Lancet Infect Dis (2006) 3.91
Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison. Lancet (2006) 3.90
Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis (2006) 3.87
High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia. J Infect Dis (2010) 3.81
Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial. Lancet (2004) 3.72
A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites. Mol Biol Evol (2003) 3.67
Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect Dis (2002) 3.46
Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nat Genet (2006) 3.45
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (2011) 3.30
Dissecting the loci of low-level quinine resistance in malaria parasites. Mol Microbiol (2004) 3.30
Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol Microbiol (2003) 3.26
Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. J Infect Dis (2010) 3.21
The global threat of counterfeit drugs: why industry and governments must communicate the dangers. PLoS Med (2005) 3.15
A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria. Clin Infect Dis (2005) 3.15
In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam. Malar J (2012) 3.13
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Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial. Lancet Infect Dis (2010) 3.08
The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis (2008) 3.05
Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients. Clin Infect Dis (2009) 3.05
Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism. Antimicrob Agents Chemother (2010) 3.04
How do patients use antimalarial drugs? A review of the evidence. Trop Med Int Health (2005) 2.95
Spurious amplification of a Plasmodium vivax small-subunit RNA gene by use of primers currently used to detect P. knowlesi. J Clin Microbiol (2009) 2.85
Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand. J Infect Dis (2004) 2.82
Central role of the spleen in malaria parasite clearance. J Infect Dis (2002) 2.80
In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. Antimicrob Agents Chemother (2004) 2.77
Antimalarial drug toxicity: a review. Drug Saf (2004) 2.76
Malaria in the Greater Mekong Subregion: heterogeneity and complexity. Acta Trop (2011) 2.70
Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum. Antimicrob Agents Chemother (2010) 2.68
Clinical research in resource-limited settings: enhancing research capacity and working together to make trials less complicated. PLoS Negl Trop Dis (2010) 2.68
Recombination hotspots and population structure in Plasmodium falciparum. PLoS Biol (2005) 2.67
Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion. Cell Host Microbe (2008) 2.66
A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand. PLoS Negl Trop Dis (2007) 2.65
Counterfeit artesunate antimalarials in southeast Asia. Lancet (2003) 2.59
Editorial: clinical trials in tropical diseases: a politically incorrect view. Trop Med Int Health (2006) 2.59
Reduced microcirculatory flow in severe falciparum malaria: pathophysiology and electron-microscopic pathology. Acta Trop (2004) 2.58
Community-acquired bacterial bloodstream infections in developing countries in south and southeast Asia: a systematic review. Lancet Infect Dis (2012) 2.58
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol Pharmacol (2002) 2.57
Short communication: An assessment of the use of malaria rapid tests by village health volunteers in rural Laos. Trop Med Int Health (2004) 2.56
Murder by fake drugs. BMJ (2002) 2.54
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics (2011) 2.53
Artemisinin-based combinations. Curr Opin Infect Dis (2005) 2.51
Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nat Genet (2010) 2.48
An ultrastructural study of the brain in fatal Plasmodium falciparum malaria. Am J Trop Med Hyg (2003) 2.47
Host switch leads to emergence of Plasmodium vivax malaria in humans. Mol Biol Evol (2005) 2.45
Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors. Genome Res (2010) 2.41
Contrasting genetic structure in Plasmodium vivax populations from Asia and South America. Int J Parasitol (2007) 2.41
Antimalarial dosing regimens and drug resistance. Trends Parasitol (2008) 2.40
Stage-dependent production and release of histidine-rich protein 2 by Plasmodium falciparum. Trans R Soc Trop Med Hyg (2005) 2.38
Malaria biology and disease pathogenesis: insights for new treatments. Nat Med (2013) 2.38
The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitis. J Infect Dis (2005) 2.38
Risk factors and clinical features associated with severe dengue infection in adults and children during the 2001 epidemic in Chonburi, Thailand. Trop Med Int Health (2004) 2.37