Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism.

PubWeight™: 3.04‹?› | Rank: Top 1%

🔗 View Article (PMC 2863624)

Published in Antimicrob Agents Chemother on February 16, 2010

Authors

Benoit Witkowski1, Joel Lelièvre, María José López Barragán, Victor Laurent, Xin-zhuan Su, Antoine Berry, Françoise Benoit-Vical

Author Affiliations

1: CNRS, Laboratoire de Chimie de Coordination, UPR8241, Toulouse, France.

Articles citing this

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature (2013) 11.03

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect Dis (2013) 6.06

Intrahost modeling of artemisinin resistance in Plasmodium falciparum. Proc Natl Acad Sci U S A (2010) 4.50

Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science (2014) 3.41

Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia. Antimicrob Agents Chemother (2012) 3.01

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A (2011) 2.94

Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure. J Infect Dis (2010) 2.89

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics (2011) 2.53

Malaria biology and disease pathogenesis: insights for new treatments. Nat Med (2013) 2.38

Artemisinin-resistant malaria: research challenges, opportunities, and public health implications. Am J Trop Med Hyg (2012) 1.97

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell (2014) 1.91

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin. Proc Natl Acad Sci U S A (2013) 1.83

Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum. Curr Opin Infect Dis (2011) 1.68

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance. PLoS Biol (2015) 1.67

Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum. Antimicrob Agents Chemother (2011) 1.57

Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum. Mol Microbiol (2012) 1.42

Microbial persistence and the road to drug resistance. Cell Host Microbe (2013) 1.37

The interplay between drug resistance and fitness in malaria parasites. Mol Microbiol (2013) 1.35

Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotechnol (2011) 1.29

Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition. Antimicrob Agents Chemother (2011) 1.26

Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure. Malar J (2011) 1.19

Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy? Int J Parasitol Drugs Drug Resist (2012) 1.14

Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrob Agents Chemother (2010) 1.14

Artesunate tolerance in transgenic Plasmodium falciparum parasites overexpressing a tryptophan-rich protein. Antimicrob Agents Chemother (2011) 1.12

Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax. Antimicrob Agents Chemother (2012) 1.09

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state. Proc Natl Acad Sci U S A (2012) 1.05

Malaria drug resistance: new observations and developments. Essays Biochem (2011) 1.03

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. Malar J (2012) 1.03

Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites. Antimicrob Agents Chemother (2010) 1.03

Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei. PLoS One (2011) 1.01

Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins. Antimicrob Agents Chemother (2012) 1.01

Fitness costs of disrupting circadian rhythms in malaria parasites. Proc Biol Sci (2011) 1.00

The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread. FEMS Microbiol Rev (2016) 0.99

Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol (2014) 0.95

Open-label trial with artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria three years after its broad introduction in Jimma Zone, Ethiopia. Malar J (2012) 0.94

Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi. Proc Biol Sci (2012) 0.94

Waking the sleeping beauty. J Infect Dis (2010) 0.93

Artemisinin Action and Resistance in Plasmodium falciparum. Trends Parasitol (2016) 0.93

Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking. Malar J (2013) 0.90

The Cinderella syndrome: why do malaria-infected cells burst at midnight? Trends Parasitol (2012) 0.89

Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum. Antimicrob Agents Chemother (2014) 0.88

War and peace: social interactions in infections. Philos Trans R Soc Lond B Biol Sci (2014) 0.88

Genome wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressure. PLoS One (2012) 0.85

A key role for Plasmodium subtilisin-like SUB1 protease in egress of malaria parasites from host hepatocytes. J Biol Chem (2013) 0.85

Rapid response to selection, competitive release and increased transmission potential of artesunate-selected Plasmodium chabaudi malaria parasites. PLoS Pathog (2014) 0.84

Molecular epidemiology of malaria in Cameroon. XXX. sequence analysis of Plasmodium falciparum ATPase 6, dihydrofolate reductase, and dihydropteroate synthase resistance markers in clinical isolates from children treated with an artesunate-sulfadoxine-pyrimethamine combination. Am J Trop Med Hyg (2011) 0.83

Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure. Emerg Infect Dis (2015) 0.82

Anticancer Effect of AntiMalarial Artemisinin Compounds. Ann Med Health Sci Res (2015) 0.82

Artemisone uptake in Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother (2010) 0.80

Observing in real time the evolution of artemisinin resistance in Plasmodium falciparum. BMC Med (2015) 0.80

Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy. Malar J (2010) 0.80

The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites. Antimicrob Agents Chemother (2016) 0.79

Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model. Antimicrob Agents Chemother (2013) 0.79

In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate. Malar J (2017) 0.79

Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity. Malar J (2016) 0.78

Plasmodium falciparum: multifaceted resistance to artemisinins. Malar J (2016) 0.78

No evidence of decreased artemisinin efficacy in a high-transmission malaria setting in Mali. Am J Trop Med Hyg (2012) 0.78

Plasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia. Am J Trop Med Hyg (2016) 0.78

Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. PLoS One (2014) 0.77

An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum. BMC Genomics (2015) 0.77

Disrupting rhythms in Plasmodium chabaudi: costs accrue quickly and independently of how infections are initiated. Malar J (2013) 0.76

Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study. BMC Genomics (2015) 0.76

In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin. Malar J (2016) 0.75

Reduced ex vivo susceptibility of Plasmodium falciparum after oral artemether-lumefantrine treatment in Mali. Malar J (2017) 0.75

Muddled mechanisms: recent progress towards antimalarial target identification. F1000Res (2016) 0.75

Correlation between Cyclin Dependent Kinases and Artemisinin-Induced Dormancy in Plasmodium falciparum In Vitro. PLoS One (2016) 0.75

Insight into k13-propeller gene polymorphism and ex vivo DHA-response profiles from Cameroonian isolates. Malar J (2016) 0.75

Molecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo. PLoS One (2017) 0.75

In Vivo Efficacy and Parasite Clearance of Artesunate + Sulfadoxine-Pyrimethamine Versus Artemether-Lumefantrine in Mali. Am J Trop Med Hyg (2016) 0.75

Plasmodium falciparum Maf1 Confers Survival upon Amino Acid Starvation. MBio (2017) 0.75

Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle. Int J Parasitol Drugs Drug Resist (2017) 0.75

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance. BMC Genomics (2017) 0.75

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream. Pathogens (2017) 0.75

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

Human malaria parasites in continuous culture. Science (1976) 59.70

Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2009) 33.25

Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol (1979) 23.90

Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med (2008) 17.65

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother (1979) 17.49

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol (2003) 11.86

Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet (2005) 8.30

Qinghaosu (artemisinin): the price of success. Science (2008) 8.25

Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science (2004) 7.01

The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother (1999) 4.64

Artemisinin-resistant malaria in Asia. N Engl J Med (2009) 3.58

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat Struct Mol Biol (2005) 3.18

Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species. Malar J (2008) 2.30

Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes. Antimicrob Agents Chemother (2007) 1.96

In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs. Int J Parasitol (1996) 1.90

Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiae and Anopheles funestus. Proc Natl Acad Sci U S A (2007) 1.40

Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate. BMC Genomics (2008) 1.23

Mirk regulates the exit of colon cancer cells from quiescence. J Biol Chem (2009) 1.20

Targeting malaria with specific CDK inhibitors. Biochim Biophys Acta (2005) 1.09

PfPK6, a novel cyclin-dependent kinase/mitogen-activated protein kinase-related protein kinase from Plasmodium falciparum. Biochem J (2000) 1.06

Resistance to antimalarial compounds: methods and applications. Drug Resist Updat (2009) 1.02

Glyceraldehyde 3-phosphate dehydrogenase depletion induces cell cycle arrest and resistance to antimetabolites in human carcinoma cell lines. J Pharmacol Exp Ther (2009) 1.02

Nucleotide sequence of a Plasmodium falciparum stress protein with similarity to mammalian 78-kDa glucose-regulated protein. Mol Biochem Parasitol (1992) 1.00

Reversal of mefloquine resistance with penfluridol in isolates of Plasmodium falciparum from south-west Nigeria. Trans R Soc Trop Med Hyg (1993) 0.95

Vital staining of Plasmodium falciparum with cationic fluorescent rhodamine dyes. J Parasitol (1987) 0.92

Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2009) 0.90

Articles by these authors

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect Dis (2012) 6.94

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc Natl Acad Sci U S A (2012) 4.10

Early origin and recent expansion of Plasmodium falciparum. Science (2003) 4.07

Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nat Genet (2006) 3.45

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (2011) 3.30

Dissecting the loci of low-level quinine resistance in malaria parasites. Mol Microbiol (2004) 3.30

Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol Microbiol (2003) 3.26

Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia. Antimicrob Agents Chemother (2012) 3.01

Malaria in the Greater Mekong Subregion: heterogeneity and complexity. Acta Trop (2011) 2.70

Recombination hotspots and population structure in Plasmodium falciparum. PLoS Biol (2005) 2.67

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nat Genet (2010) 2.48

Host switch leads to emergence of Plasmodium vivax malaria in humans. Mol Biol Evol (2005) 2.45

Malaria biology and disease pathogenesis: insights for new treatments. Nat Med (2013) 2.38

Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species. Malar J (2008) 2.30

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria. Mol Biochem Parasitol (2006) 2.24

Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes. Antimicrob Agents Chemother (2007) 1.96

The antimalarial drug artemisinin alkylates heme in infected mice. Proc Natl Acad Sci U S A (2005) 1.81

Effects of Plasmodium falciparum mixed infections on in vitro antimalarial drug tests and genotyping. Am J Trop Med Hyg (2008) 1.79

Polymorphism in a Plasmodium falciparum erythrocyte-binding ligand changes its receptor specificity. J Exp Med (2002) 1.73

Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro. Mol Biochem Parasitol (2004) 1.71

Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity. Proc Natl Acad Sci U S A (2004) 1.66

Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum. BMC Genomics (2011) 1.60

Local adaptation and vector-mediated population structure in Plasmodium vivax malaria. Mol Biol Evol (2008) 1.57

African monkeys are infected by Plasmodium falciparum nonhuman primate-specific strains. Proc Natl Acad Sci U S A (2011) 1.56

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol (2009) 1.52

Routine identification of medical fungi by the new Vitek MS matrix-assisted laser desorption ionization-time of flight system with a new time-effective strategy. J Clin Microbiol (2012) 1.52

Upregulation of expression of the reticulocyte homology gene 4 in the Plasmodium falciparum clone Dd2 is associated with a switch in the erythrocyte invasion pathway. Mol Biochem Parasitol (2005) 1.50

Indole and aminoimidazole moieties appear as key structural units in antiplasmodial molecules. Phytomedicine (2011) 1.43

Mechanisms of in vitro resistance to dihydroartemisinin in Plasmodium falciparum. Mol Microbiol (2012) 1.42

Discovery, mechanisms of action and combination therapy of artemisinin. Expert Rev Anti Infect Ther (2009) 1.41

Schistosomiasis haematobium, Corsica, France. Emerg Infect Dis (2014) 1.39

Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene. PLoS One (2008) 1.36

cDNA sequences reveal considerable gene prediction inaccuracy in the Plasmodium falciparum genome. BMC Genomics (2007) 1.35

PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum. Eukaryot Cell (2007) 1.31

Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine. Malar J (2010) 1.27

High recombination rates and hotspots in a Plasmodium falciparum genetic cross. Genome Biol (2011) 1.27

Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer. Cancer Res (2013) 1.24

Challenges and prospects for malaria elimination in the Greater Mekong Subregion. Acta Trop (2011) 1.21

Imported Plasmodium knowlesi malaria in a French tourist returning from Thailand. Am J Trop Med Hyg (2011) 1.20

Adipose tissue and breast epithelial cells: a dangerous dynamic duo in breast cancer. Cancer Lett (2012) 1.16

Diversity, host switching and evolution of Plasmodium vivax infecting African great apes. Proc Natl Acad Sci U S A (2013) 1.13

IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. Eur J Immunol (2007) 1.11

Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis. Proc Natl Acad Sci U S A (2005) 1.08

Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants? Malar J (2011) 1.08

Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers. Antimicrob Agents Chemother (2013) 1.08

Acute Plasmodium falciparum malaria following splenectomy for suspected lymphoma in 2 patients. Clin Infect Dis (2005) 1.07

Synthesis and antimalarial activity of trioxaquine derivatives. Chemistry (2004) 1.06

Are West African plants a source of future antimalarial drugs? J Ethnopharmacol (2007) 1.05

Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae. Int J Parasitol (2012) 1.05

Plasmodium falciparum gametocyte development 1 (Pfgdv1) and gametocytogenesis early gene identification and commitment to sexual development. PLoS Pathog (2012) 1.05

pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: implications for efficacy of artemisinin combination therapies. J Clin Microbiol (2010) 1.05

Schistosomiasis Screening of Travelers to Corsica, France. Emerg Infect Dis (2016) 1.03

Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii. Proc Natl Acad Sci U S A (2011) 1.03

Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa. Antimicrob Agents Chemother (2010) 1.02

Accuracy of a routine real-time PCR assay for the diagnosis of Pneumocystis jirovecii pneumonia. J Microbiol Methods (2008) 1.02

Resistance to antimalarial compounds: methods and applications. Drug Resist Updat (2009) 1.02

Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine. Antimicrob Agents Chemother (2007) 1.01

Antiplasmodial and cytotoxic activity of galipinine and other tetrahydroquinolines from Galipea officinalis. Planta Med (2002) 1.00

Nucleotide sequencing for diagnosis of sinusal infection by Schizophyllum commune, an uncommon pathogenic fungus. J Clin Microbiol (2006) 0.99

An extraction method of positive blood cultures for direct identification of Candida species by Vitek MS matrix-assisted laser desorption ionization time of flight mass spectrometry. Med Mycol (2013) 0.99

Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A (2011) 0.99

Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria. PLoS Pathog (2011) 0.96

n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells. Biochim Biophys Acta (2007) 0.95

Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaoundé, Cameroon: implications for the future. Malar J (2012) 0.94

Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum. Malar J (2012) 0.94

In vitro and in vivo properties of ellagic acid in malaria treatment. Antimicrob Agents Chemother (2008) 0.94

Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011. Malar J (2013) 0.93

Effects of antimalarial molecules on the gametocyte stage of Plasmodium falciparum: the debate. J Med Chem (2012) 0.93

Pneumocystis jirovecii pneumonia in patients with or without AIDS, France. Emerg Infect Dis (2014) 0.92

The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice. Antimicrob Agents Chemother (2008) 0.92

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality. Proc Natl Acad Sci U S A (2014) 0.91

Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs. PLoS One (2012) 0.90

Hundreds of microsatellites for genotyping Plasmodium yoelii parasites. Mol Biochem Parasitol (2009) 0.90

Modulation of malaria infection in Anopheles gambiae mosquitoes exposed to natural midgut bacteria. PLoS One (2013) 0.89

Artemisinin and chloroquine: do mode of action and mechanism of resistance involve the same protagonists? Curr Opin Investig Drugs (2007) 0.87

Use of magnetically purified Plasmodium falciparum parasites improves the accuracy of erythrocyte invasion assays. Exp Parasitol (2010) 0.87

Use of a locked-nucleic-acid oligomer in the clamped-probe assay for detection of a minority Pfcrt K76T mutant population of Plasmodium falciparum. J Clin Microbiol (2005) 0.86

Genetic diversity of Plasmodium vivax population in Anhui province of China. Malar J (2014) 0.85

Assessment of Aspergillus sensitization or persistent carriage as a factor in lung function impairment in cystic fibrosis patients. Scand J Infect Dis (2012) 0.85

Real-time PCR assay for the diagnosis of Pneumocystis jirovecii pneumonia. Methods Mol Biol (2013) 0.84

Detection by real-time PCR of the Pfcrt T76 mutation, a molecular marker of chloroquine-resistant Plasmodium falciparum strains. Parasitol Res (2004) 0.84

[Anaphylactic shock revealing anisakiasis]. Presse Med (2002) 0.84

Human malaria parasites: are we ready for a new species? J Infect Dis (2010) 0.83

Pfs 16 pivotal role in Plasmodium falciparum gametocytogenesis: a potential antiplasmodial drug target. Exp Parasitol (2008) 0.83

Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure. Emerg Infect Dis (2015) 0.82

Protocol for production of a genetic cross of the rodent malaria parasites. J Vis Exp (2011) 0.81