Published in Immunity on April 01, 2003
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med (2008) 3.15
Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity (2010) 2.52
A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. Proc Natl Acad Sci U S A (2006) 2.00
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope. Proc Natl Acad Sci U S A (2004) 1.92
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest (2010) 1.92
Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. J Clin Invest (2010) 1.87
Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape. J Exp Med (2004) 1.79
The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research. Proc Am Thorac Soc (2007) 1.65
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest (2006) 1.64
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proc Natl Acad Sci U S A (2006) 1.43
Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells. Proc Natl Acad Sci U S A (2006) 1.33
An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses. Proc Natl Acad Sci U S A (2006) 1.29
Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides. Proc Natl Acad Sci U S A (2008) 1.24
Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses. Proc Natl Acad Sci U S A (2005) 1.16
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition. Proc Natl Acad Sci U S A (2010) 1.13
Mapping the life histories of T cells. Nat Rev Immunol (2010) 1.12
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Mol Immunol (2007) 1.12
Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory. Proc Natl Acad Sci U S A (2007) 1.10
Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses. J Virol (2005) 1.06
Immune memory and aging: an infinite or finite resource? Curr Opin Immunol (2010) 1.05
CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections. J Immunol (2010) 1.05
Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells. Proc Natl Acad Sci U S A (2004) 1.03
Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc Natl Acad Sci U S A (2011) 0.98
Dynamics of the cytotoxic T cell response to a model of acute viral infection. J Virol (2015) 0.96
Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations. Proc Natl Acad Sci U S A (2013) 0.96
Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection. Infect Immun (2006) 0.95
Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function. PLoS Pathog (2012) 0.95
Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology. Front Immunol (2013) 0.93
Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses. J Immunol (2008) 0.91
Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool. Immunology (2010) 0.89
Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression. Proc Natl Acad Sci U S A (2005) 0.89
Transience of MHC Class I-restricted antigen presentation after influenza A virus infection. Proc Natl Acad Sci U S A (2009) 0.86
Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials. Viruses (2010) 0.86
Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function. J Immunol (2011) 0.85
Mucosal polyinosinic-polycytidylic acid improves protection elicited by replicating influenza vaccines via enhanced dendritic cell function and T cell immunity. J Immunol (2014) 0.85
In vivo compartmentalization of functionally distinct, rapidly responsive antigen-specific T-cell populations in DNA-immunized or Salmonella enterica serovar Typhimurium-infected mice. Infect Immun (2004) 0.84
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. J Immunol (2012) 0.83
Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection. Proc Natl Acad Sci U S A (2014) 0.83
Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoire. Immunol Cell Biol (2015) 0.83
Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice. Proc Natl Acad Sci U S A (2016) 0.79
Profile of a serial killer: cellular and molecular approaches to study individual cytotoxic T-cells following therapeutic vaccination. J Biomed Biotechnol (2010) 0.79
Analysis of T-cell receptor BV gene sequences in cattle reveals extensive duplication within the BV9 and BV20 subgroups. Immunogenetics (2005) 0.78
Identification of T cell clones without the need for sequencing. J Immunol Methods (2015) 0.76
TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J Leukoc Biol (2015) 0.75
Effect of Hejie decoction on T cell immune state of chronic hepatitis B patients. World J Gastroenterol (2004) 0.75
The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity (2009) 4.51
TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A (2009) 3.70
A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol (2007) 3.65
Cell-mediated protection in influenza infection. Emerg Infect Dis (2006) 3.62
Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers. Hepatology (2008) 3.60
Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice. J Virol (2002) 3.21
Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol (2006) 3.01
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat Immunol (2005) 2.44
Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity. J Immunol (2004) 2.26
Pause on avian flu transmission research. Science (2012) 2.24
Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. J Gen Virol (2005) 2.15
The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity (2004) 2.13
Protection and compensation in the influenza virus-specific CD8+ T cell response. Proc Natl Acad Sci U S A (2003) 2.13
Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections. J Exp Med (2003) 2.07
A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. Proc Natl Acad Sci U S A (2006) 2.00
Methods for comparing the diversity of samples of the T cell receptor repertoire. J Immunol Methods (2007) 1.98
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope. Proc Natl Acad Sci U S A (2004) 1.92
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest (2010) 1.92
Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. J Clin Invest (2010) 1.87
Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities. Proc Natl Acad Sci U S A (2014) 1.83
Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci U S A (2013) 1.74
Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease. Gastroenterology (2008) 1.71
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol (2013) 1.66
Addition of a prominent epitope affects influenza A virus-specific CD8+ T cell immunodominance hierarchies when antigen is limiting. J Immunol (2006) 1.64
Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses. Proc Natl Acad Sci U S A (2010) 1.63
Virus-specific CD8+ T cells in the liver: armed and ready to kill. J Immunol (2007) 1.58
Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease. J Hepatol (2010) 1.57
Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res (2010) 1.57
Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage. J Immunol (2006) 1.56
T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection. Sci Transl Med (2012) 1.53
Division-linked differentiation can account for CD8+ T-cell phenotype in vivo. Eur J Immunol (2009) 1.51
Reduced functional capacity of CD8+ T cells expanded by post-exposure vaccination of gamma-herpesvirus-infected CD4-deficient mice. J Immunol (2002) 1.49
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol (2013) 1.47
Evaluation of the aspartate aminotransferase/platelet ratio index and enhanced liver fibrosis tests to detect significant fibrosis due to chronic hepatitis C. J Clin Gastroenterol (2014) 1.44
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity. Proc Natl Acad Sci U S A (2009) 1.44
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proc Natl Acad Sci U S A (2006) 1.43
An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions. J Exp Med (2003) 1.40
Reconstruction of the 1918 influenza virus: unexpected rewards from the past. MBio (2012) 1.34
Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells. Proc Natl Acad Sci U S A (2006) 1.33
Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL. J Immunol (2007) 1.31
An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses. Proc Natl Acad Sci U S A (2006) 1.29
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses. J Immunol (2007) 1.28
Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses. J Virol (2005) 1.28
Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides. Proc Natl Acad Sci U S A (2008) 1.24
Immunity to seasonal and pandemic influenza A viruses. Microbes Infect (2011) 1.21
Killer T cells in influenza. Pharmacol Ther (2008) 1.18
Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells. Proc Natl Acad Sci U S A (2011) 1.18
Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses. Proc Natl Acad Sci U S A (2005) 1.16
Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance. J Immunol (2007) 1.15
Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses. J Immunol (2006) 1.14
Functional implications of T cell receptor diversity. Curr Opin Immunol (2009) 1.13
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition. Proc Natl Acad Sci U S A (2010) 1.13
Establishment and recall of CD8+ T-cell memory in a model of localized transient infection. Immunol Rev (2006) 1.12
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Mol Immunol (2007) 1.12
Clustering of Th cell epitopes on exposed regions of HIV envelope despite defects in antibody activity. J Immunol (2003) 1.11
IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells. Eur J Immunol (2007) 1.10
Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory. Proc Natl Acad Sci U S A (2007) 1.10
Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression. J Immunol (2009) 1.09
Method for assessing the similarity between subsets of the T cell receptor repertoire. J Immunol Methods (2007) 1.09
A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses. Eur J Immunol (2006) 1.08
Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection. Semin Immunol (2004) 1.08
Transmission studies resume for avian flu. Science (2013) 1.07
Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold. PLoS Pathog (2010) 1.06
Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells. J Immunol (2008) 1.03
Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells. Proc Natl Acad Sci U S A (2004) 1.03
IFN-gamma production by innate immune cells is sufficient for development of hypersensitivity pneumonitis. Eur J Immunol (2005) 1.01
Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides. Nat Commun (2013) 1.00
Chemokine production during hypersensitivity pneumonitis. Eur J Immunol (2004) 1.00
T cell epitope "hotspots" on the HIV Type 1 gp120 envelope protein overlap with tryptic fragments displayed by mass spectrometry. AIDS Res Hum Retroviruses (2005) 1.00
Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. J Immunol (2007) 0.99
Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals. Proc Natl Acad Sci U S A (2011) 0.99
Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses. J Immunol (2011) 0.99
Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles. J Immunol (2007) 0.99
Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc Natl Acad Sci U S A (2011) 0.98
WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. Exp Hematol (2005) 0.98
Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection. J Immunol Methods (2008) 0.98
The context of epitope presentation can influence functional quality of recalled influenza A virus-specific memory CD8+ T cells. J Immunol (2007) 0.97
Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus? J Biol (2009) 0.96
Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques. J Virol (2009) 0.96
Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations. Proc Natl Acad Sci U S A (2013) 0.96
Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels. Am J Physiol Lung Cell Mol Physiol (2013) 0.95
Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function. PLoS Pathog (2012) 0.95
Use it or lose it: establishment and persistence of T cell memory. Front Immunol (2012) 0.95
Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy. Proc Natl Acad Sci U S A (2008) 0.95
Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-A(b-/-) mice. J Gen Virol (2003) 0.94
Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral Immunol (2008) 0.94
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection. Eur J Immunol (2009) 0.93
An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells. J Immunol (2007) 0.92
Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses. J Immunol (2008) 0.91
Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses. PLoS One (2013) 0.91
Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model. J Gen Virol (2013) 0.91
The limits of protection by "memory" T cells in Ig-/- mice persistently infected with a gamma-herpesvirus. Proc Natl Acad Sci U S A (2004) 0.91
Memory precursor phenotype of CD8+ T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection. Eur J Immunol (2011) 0.90
Protective memory responses are modulated by priming events prior to challenge. J Virol (2009) 0.89