Published in J Immunol on November 15, 2006
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity (2007) 9.26
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity (2007) 4.92
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity (2008) 4.25
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med (2008) 3.15
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest (2010) 1.92
A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation. J Immunol (2009) 1.50
B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections. PLoS Pathog (2009) 1.27
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Mol Immunol (2007) 1.12
Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory. Proc Natl Acad Sci U S A (2007) 1.10
Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold. PLoS Pathog (2010) 1.06
Immune memory and aging: an infinite or finite resource? Curr Opin Immunol (2010) 1.05
Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality. J Immunol (2008) 1.02
High frequencies of virus-specific CD8+ T-cell precursors. J Virol (2009) 0.98
Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy. Proc Natl Acad Sci U S A (2008) 0.95
Theiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J mice. J Virol (2009) 0.89
Dynamics of the CD8 T-cell response following yellow fever virus 17D immunization. Immunology (2009) 0.87
Extraction and characterization of the rhesus macaque T-cell receptor beta-chain genes. Immunol Cell Biol (2009) 0.87
Sizing up the key determinants of the CD8(+) T cell response. Nat Rev Immunol (2015) 0.87
Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function. J Immunol (2011) 0.85
A simple mathematical model helps to explain the immunodominance of CD8 T cells in influenza A virus infections. J Virol (2008) 0.85
The functional CD8 T cell memory recall repertoire responding to the influenza A M1(58-66) epitope is polyclonal and shows a complex clonotype distribution. Hum Immunol (2013) 0.82
CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. J Immunol (2010) 0.81
Cross-reactivity of T cells and its role in the immune system. Crit Rev Immunol (2012) 0.80
Assessing T cell clonal size distribution: a non-parametric approach. PLoS One (2014) 0.80
Subsisting H1N1 influenza memory responses are insufficient to protect from pandemic H1N1 influenza challenge in C57BL/6 mice. J Gen Virol (2013) 0.77
Modelling lymphoma therapy and outcome. Bull Math Biol (2013) 0.76
Analysis of TCR repertoires for tracking and evaluating distinct T cell subsets. Stem Cell Investig (2016) 0.75
Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol (2013) 4.98
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity (2009) 4.51
TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A (2009) 3.70
A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol (2007) 3.65
Cell-mediated protection in influenza infection. Emerg Infect Dis (2006) 3.62
Influenza and the challenge for immunology. Nat Immunol (2006) 3.24
Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice. J Virol (2002) 3.21
Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol (2006) 3.01
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nat Immunol (2005) 2.44
Characterization of birdshot chorioretinopathy using extramacular enhanced depth optical coherence tomography. JAMA Ophthalmol (2013) 2.36
Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity. J Immunol (2004) 2.26
Pause on avian flu transmission research. Science (2012) 2.24
Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A (2014) 2.17
Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. J Gen Virol (2005) 2.15
The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity (2004) 2.13
Protection and compensation in the influenza virus-specific CD8+ T cell response. Proc Natl Acad Sci U S A (2003) 2.13
Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections. J Exp Med (2003) 2.07
A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. Proc Natl Acad Sci U S A (2006) 2.00
Methods for comparing the diversity of samples of the T cell receptor repertoire. J Immunol Methods (2007) 1.98
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope. Proc Natl Acad Sci U S A (2004) 1.92
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest (2010) 1.92
Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. J Clin Invest (2010) 1.87
Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities. Proc Natl Acad Sci U S A (2014) 1.83
Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease. Virology (2010) 1.79
Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci U S A (2013) 1.74
Analysis of clonotype distribution and persistence for an influenza virus-specific CD8+ T cell response. Immunity (2003) 1.74
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol (2013) 1.66
Addition of a prominent epitope affects influenza A virus-specific CD8+ T cell immunodominance hierarchies when antigen is limiting. J Immunol (2006) 1.64
T cell antigen receptor recognition of antigen-presenting molecules. Annu Rev Immunol (2014) 1.64
Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses. Proc Natl Acad Sci U S A (2010) 1.63
Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59
A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol (2005) 1.59
Virus-specific CD8+ T cells in the liver: armed and ready to kill. J Immunol (2007) 1.58
Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res (2010) 1.57
T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection. Sci Transl Med (2012) 1.53
Division-linked differentiation can account for CD8+ T-cell phenotype in vivo. Eur J Immunol (2009) 1.51
Reduced functional capacity of CD8+ T cells expanded by post-exposure vaccination of gamma-herpesvirus-infected CD4-deficient mice. J Immunol (2002) 1.49
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol (2013) 1.47
A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nat Immunol (2011) 1.47
Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice. Respir Res (2008) 1.46
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis. J Exp Med (2011) 1.45
Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA. J Virol (2006) 1.44
Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity. Proc Natl Acad Sci U S A (2009) 1.44
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proc Natl Acad Sci U S A (2006) 1.43
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. J Virol (2010) 1.40
Very diverse CD8 T cell clonotypic responses after virus infections. J Immunol (2004) 1.40
An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions. J Exp Med (2003) 1.40
Origins, distribution, and local co-occurrence of polyploid cytotypes in Solidago altissima (Asteraceae). Am J Bot (2008) 1.35
Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol (2011) 1.35
Reversible topological organization within a polytopic membrane protein is governed by a change in membrane phospholipid composition. J Biol Chem (2003) 1.34
Reconstruction of the 1918 influenza virus: unexpected rewards from the past. MBio (2012) 1.34
Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells. Proc Natl Acad Sci U S A (2006) 1.33
Cascading host-associated genetic differentiation in parasitoids of phytophagous insects. Proc Biol Sci (2006) 1.32
Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest (2011) 1.32
Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL. J Immunol (2007) 1.31
An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses. Proc Natl Acad Sci U S A (2006) 1.29
Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses. J Virol (2005) 1.28
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses. J Immunol (2007) 1.28
Host-associated genetic differentiation in phytophagous insects: general phenomenon or isolated exceptions? Evidence from a goldenrod-insect community. Evolution (2005) 1.27
Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol (2014) 1.25
Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides. Proc Natl Acad Sci U S A (2008) 1.24
Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog (2009) 1.24
Immunity to seasonal and pandemic influenza A viruses. Microbes Infect (2011) 1.21
Killer T cells in influenza. Pharmacol Ther (2008) 1.18
Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells. Proc Natl Acad Sci U S A (2011) 1.18
Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. J Immunol (2010) 1.17
Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice. Virology (2008) 1.17
Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus. J Immunol (2002) 1.16
Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein. J Virol (2003) 1.16
Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses. Proc Natl Acad Sci U S A (2005) 1.16
Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance. J Immunol (2007) 1.15
A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned. Immunol Rev (2012) 1.14
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol (2005) 1.14
Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses. J Immunol (2006) 1.14
Functional implications of T cell receptor diversity. Curr Opin Immunol (2009) 1.13
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition. Proc Natl Acad Sci U S A (2010) 1.13
Establishment and recall of CD8+ T-cell memory in a model of localized transient infection. Immunol Rev (2006) 1.12