Published in J Biol Chem on April 22, 2003
Crystal structure of C-terminal truncated apolipoprotein A-I reveals the assembly of high density lipoprotein (HDL) by dimerization. J Biol Chem (2011) 1.72
High density lipoprotein structure-function and role in reverse cholesterol transport. Subcell Biochem (2010) 1.69
Apolipoprotein E: from lipid transport to neurobiology. Prog Lipid Res (2010) 1.63
Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.50
Three-dimensional models of HDL apoA-I: implications for its assembly and function. J Lipid Res (2008) 1.47
Conformational adaptation of apolipoprotein A-I to discretely sized phospholipid complexes. Biochemistry (2007) 1.42
Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides. J Biol Chem (2008) 1.41
Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nat Chem Biol (2012) 1.27
Characterization and properties of pre beta-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I. J Lipid Res (2008) 1.18
Conformational flexibility of the N-terminal domain of apolipoprotein a-I bound to spherical lipid particles. Biochemistry (2008) 1.14
Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I. J Lipid Res (2009) 1.14
Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I. Biochemistry (2009) 1.12
Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs. Mol Cell Proteomics (2011) 1.07
Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoforms. Biochemistry (2008) 1.06
Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano. Arterioscler Thromb Vasc Biol (2009) 1.03
New insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolism. J Lipid Res (2012) 1.01
Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2012) 1.00
Apolipoprotein modulation of streptococcal serum opacity factor activity against human plasma high-density lipoproteins. Biochemistry (2009) 0.97
Influence of C-terminal α-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality. Biochim Biophys Acta (2011) 0.96
Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles. J Lipid Res (2009) 0.95
Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution. J Biol Chem (2010) 0.95
Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4. Biochemistry (2010) 0.93
Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol (2010) 0.92
Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan. J Lipid Res (2009) 0.91
Effects of the Iowa and Milano mutations on apolipoprotein A-I structure and dynamics determined by hydrogen exchange and mass spectrometry. Biochemistry (2012) 0.90
Impact of apolipoprotein E on Alzheimer's disease. Curr Alzheimer Res (2013) 0.90
Impact of self-association on function of apolipoprotein A-I. J Biol Chem (2011) 0.89
A gel-based method for purification of apolipoprotein A-I from small volumes of plasma. J Lipid Res (2010) 0.88
Influence of N-terminal helix bundle stability on the lipid-binding properties of human apolipoprotein A-I. Biochim Biophys Acta (2010) 0.88
Apolipoprotein-induced conversion of phosphatidylcholine bilayer vesicles into nanodisks. Biochim Biophys Acta (2010) 0.88
Role of secondary structure in protein-phospholipid surface interactions: reconstitution and denaturation of apolipoprotein C-I:DMPC complexes. Biochemistry (2007) 0.87
Function and comorbidities of apolipoprotein e in Alzheimer's disease. Int J Alzheimers Dis (2011) 0.87
Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4. Biochemistry (2012) 0.86
Apolipoprotein A-I binding to anionic vesicles and lipopolysaccharides: role for lysine residues in antimicrobial properties. Biochim Biophys Acta (2013) 0.86
Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake. Biochemistry (2012) 0.85
Interactions of apolipoprotein A-I with high-density lipoprotein particles. Biochemistry (2013) 0.85
Surface behavior of apolipoprotein A-I and its deletion mutants at model lipoprotein interfaces. J Lipid Res (2013) 0.85
Comparison of apoA-I helical structure and stability in discoidal and spherical HDL particles by HX and mass spectrometry. J Lipid Res (2013) 0.85
Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia. Biochemistry (2008) 0.84
A novel folding intermediate state for apolipoprotein A-I: role of the amino and carboxy termini. Biophys J (2005) 0.84
Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation. J Biol Chem (2012) 0.83
Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy. Beilstein J Nanotechnol (2011) 0.83
The conformation of lipid-free human apolipoprotein A-I in solution. Biochemistry (2013) 0.83
Lipid-free Apolipoprotein A-I Structure: Insights into HDL Formation and Atherosclerosis Development. Arch Med Res (2015) 0.83
The roles of C-terminal helices of human apolipoprotein A-I in formation of high-density lipoprotein particles. Biochim Biophys Acta (2013) 0.82
Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-IIowa) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate. J Biol Chem (2015) 0.82
Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I. J Lipid Res (2013) 0.82
The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux. Biochim Biophys Acta (2009) 0.81
Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein. J Lipid Res (2012) 0.80
Influence of domain stability on the properties of human apolipoprotein E3 and E4 and mouse apolipoprotein E. Biochemistry (2014) 0.79
Secondary structure changes in ApoA-I Milano (R173C) are not accompanied by a decrease in protein stability or solubility. PLoS One (2014) 0.79
An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding. J Biol Chem (2016) 0.79
Identification of sites in apolipoprotein A-I susceptible to chymase and carboxypeptidase A digestion. Biosci Rep (2012) 0.78
ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease. Lab Invest (2016) 0.77
Structural Insights into High Density Lipoprotein: Old Models and New Facts. Front Pharmacol (2016) 0.77
Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes. J Biol Chem (2015) 0.76
Conservation of apolipoprotein A-I's central domain structural elements upon lipid association on different high-density lipoprotein subclasses. Biochemistry (2013) 0.76
Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I. J Lipid Res (2014) 0.76
Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes. Sci Rep (2016) 0.75
Distinctive structure and interfacial activity of the human apolipoprotein A-IV 347S isoprotein. J Lipid Res (2010) 0.75
Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2017) 0.75
Probing the C-terminal domain of lipid-free apoA-I demonstrates the vital role of the H10B sequence repeat in HDL formation. J Lipid Res (2016) 0.75
A model of lipid-free apolipoprotein A-I revealed by iterative molecular dynamics simulation. PLoS One (2015) 0.75
A Tribute to the Philadelphia Lipid Group on the Occasion of Their Retirement. J Lipid Res (2013) 0.75
Methods for Monitoring ABCA1-Dependent Sterol Release. Methods Mol Biol (2017) 0.75
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med (2005) 4.11
Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterioscler Thromb Vasc Biol (2002) 3.51
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation (2012) 3.38
Importance of different pathways of cellular cholesterol efflux. Arterioscler Thromb Vasc Biol (2003) 2.70
Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles. J Biol Chem (2007) 2.53
The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res (2007) 2.38
High-density lipoprotein heterogeneity and function in reverse cholesterol transport. Curr Opin Lipidol (2010) 2.23
Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol (2007) 2.21
Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nat Mater (2004) 2.03
Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins. Prog Lipid Res (2004) 1.83
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. J Lipid Res (2006) 1.73
Requirement of heat shock protein 90 for human hepatitis B virus reverse transcriptase function. J Virol (2004) 1.72
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest (2012) 1.71
High density lipoprotein structure-function and role in reverse cholesterol transport. Subcell Biochem (2010) 1.69
Metabolic syndrome and the risk of cardiovascular disease in older adults. J Am Coll Cardiol (2006) 1.66
The importance of catch-up growth after early malnutrition for the programming of obesity in male rat. Obesity (Silver Spring) (2006) 1.53
Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem (2003) 1.53
ABCA1-induced cell surface binding sites for ApoA-I. Arterioscler Thromb Vasc Biol (2007) 1.52
Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.50
Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements. PLoS Biol (2007) 1.49
MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. Cardiovasc Res (2013) 1.49
Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol. Biochemistry (2005) 1.48
Pioglitazone improves myocardial blood flow and glucose utilization in nondiabetic patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled study. J Am Coll Cardiol (2007) 1.47
Oxidative stress and insulin resistance: the coronary artery risk development in young adults study. Diabetes Care (2009) 1.46
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol. J Lipid Res (2011) 1.45
Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res (2008) 1.45
CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem (2008) 1.41
MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. FASEB J (2011) 1.39
Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase. Circulation (2003) 1.38
The vicious circle between oxidative stress and inflammation in atherosclerosis. J Cell Mol Med (2009) 1.35
Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Rep (2012) 1.34
Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipids. J Biol Chem (2004) 1.32
Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI. Cardiovasc Res (2003) 1.29
Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study. Diabetes Metab Res Rev (2009) 1.28
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochim Biophys Acta (2007) 1.28
Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization. J Lipid Res (2002) 1.27
Contributions of the N- and C-terminal helical segments to the lipid-free structure and lipid interaction of apolipoprotein A-I. Biochemistry (2006) 1.27
Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol (2007) 1.26
The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry (2007) 1.24
High density lipoprotein structure. Front Biosci (2003) 1.22
Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. J Biol Chem (2004) 1.22
Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse model of metabolic syndrome. Arterioscler Thromb Vasc Biol (2006) 1.21
Beta-actin cannot be used as a control for gene expression in ovine interstitial cells derived from heart valves. J Heart Valve Dis (2004) 1.20
Characterization and properties of pre beta-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I. J Lipid Res (2008) 1.18
Effects of polymorphism on the lipid interaction of human apolipoprotein E. J Biol Chem (2003) 1.17
Fabrication and characterization of cross-linkable hydrogel particles based on hyaluronic acid: potential application in vocal fold regeneration. J Biomater Sci Polym Ed (2008) 1.17
Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids. J Biol Chem (2004) 1.15
Aromatic residue position on the nonpolar face of class a amphipathic helical peptides determines biological activity. J Biol Chem (2004) 1.15
Conformational flexibility of the N-terminal domain of apolipoprotein a-I bound to spherical lipid particles. Biochemistry (2008) 1.14
Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I. J Lipid Res (2009) 1.14
Secretion of genome-free hepatitis B virus--single strand blocking model for virion morphogenesis of para-retrovirus. PLoS Pathog (2011) 1.14
Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer. Prostate (2003) 1.13
Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4. Biochemistry (2006) 1.13
Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1. J Biol Chem (2004) 1.13
Influence of tertiary structure domain properties on the functionality of apolipoprotein A-I. Biochemistry (2008) 1.12