Published in J Biol Chem on June 29, 2007
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation (2012) 3.38
Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol (2009) 2.64
High-density lipoprotein heterogeneity and function in reverse cholesterol transport. Curr Opin Lipidol (2010) 2.23
Intracellular sterol dynamics. Biochim Biophys Acta (2009) 1.79
High density lipoprotein structure-function and role in reverse cholesterol transport. Subcell Biochem (2010) 1.69
Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.50
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol. J Lipid Res (2011) 1.45
Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res (2008) 1.45
Molecular mechanisms of cellular cholesterol efflux. J Biol Chem (2014) 1.44
Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly. Structure (2015) 1.43
Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metab (2013) 1.42
Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides. J Biol Chem (2008) 1.41
ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A (2011) 1.41
ABC transporters, atherosclerosis and inflammation. Atherosclerosis (2010) 1.41
Apolipoprotein A-I mimetic peptide helix number and helix linker influence potentially anti-atherogenic properties. J Lipid Res (2008) 1.39
An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. J Clin Invest (2010) 1.36
Cell cholesterol homeostasis: mediation by active cholesterol. Trends Cell Biol (2010) 1.26
Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol. Prog Lipid Res (2008) 1.21
Role of ABC transporters in lipid transport and human disease. Trends Endocrinol Metab (2013) 1.20
ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments. J Biol Chem (2008) 1.20
Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. J Biol Chem (2010) 1.19
Characterization and properties of pre beta-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I. J Lipid Res (2008) 1.18
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration. Biochim Biophys Acta (2010) 1.17
The ABCs of sterol transport. J Lipid Res (2008) 1.17
Conformational flexibility of the N-terminal domain of apolipoprotein a-I bound to spherical lipid particles. Biochemistry (2008) 1.14
Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I. J Lipid Res (2009) 1.14
Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res (2012) 1.13
Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I. Biochemistry (2009) 1.12
Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocr Rev (2012) 1.11
Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport. Biochim Biophys Acta (2012) 1.09
Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export. J Lipid Res (2010) 1.09
Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants. J Biol Chem (2013) 1.08
Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I. Biochim Biophys Acta (2008) 1.05
Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano. Arterioscler Thromb Vasc Biol (2009) 1.03
Reverse cholesterol transport: from classical view to new insights. World J Gastroenterol (2010) 1.03
ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation. J Lipid Res (2008) 1.02
New insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolism. J Lipid Res (2012) 1.01
Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2012) 1.00
Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered. Biochemistry (2008) 0.99
Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation. J Lipid Res (2009) 0.98
ATP-binding cassette transporter A1: from metabolism to neurodegeneration. Neurobiol Dis (2014) 0.98
An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux. J Biol Chem (2008) 0.97
Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI. J Lipid Res (2011) 0.97
Influence of C-terminal α-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality. Biochim Biophys Acta (2011) 0.96
Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution. J Biol Chem (2010) 0.95
Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles. J Lipid Res (2009) 0.95
Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol (2010) 0.92
Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins. Biochemistry (2008) 0.92
Mechanisms responsible for the compositional heterogeneity of nascent high density lipoprotein. J Biol Chem (2013) 0.91
Discoidal HDL and apoA-I-derived peptides improve glucose uptake in skeletal muscle. J Lipid Res (2013) 0.91
Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan. J Lipid Res (2009) 0.91
Impact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathway. J Proteomics (2011) 0.90
Regulation of ABCA1 functions by signaling pathways. Biochim Biophys Acta (2011) 0.90
The interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipids. Mol Med (2012) 0.89
A-Subclass ATP-Binding Cassette Proteins in Brain Lipid Homeostasis and Neurodegeneration. Front Psychiatry (2012) 0.89
Carboxyl terminus of apolipoprotein A-I (ApoA-I) is necessary for the transport of lipid-free ApoA-I but not prelipidated ApoA-I particles through aortic endothelial cells. J Biol Chem (2011) 0.89
Site-specific oxidation of apolipoprotein A-I impairs cholesterol export by ABCA1, a key cardioprotective function of HDL. Biochim Biophys Acta (2011) 0.89
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun (2015) 0.88
ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding. J Lipid Res (2011) 0.88
Influence of N-terminal helix bundle stability on the lipid-binding properties of human apolipoprotein A-I. Biochim Biophys Acta (2010) 0.88
Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability. FASEB J (2013) 0.87
ABCA1 and nascent HDL biogenesis. Biofactors (2014) 0.86
Evidence for the presence of lipid-free monomolecular apolipoprotein A-1 in plasma. J Lipid Res (2013) 0.86
ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein. Arterioscler Thromb Vasc Biol (2013) 0.86
Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4. Biochemistry (2012) 0.86
Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase. J Lipid Res (2011) 0.86
Interactions of apolipoprotein A-I with high-density lipoprotein particles. Biochemistry (2013) 0.85
Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis. J Lipid Res (2011) 0.84
Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum. J Biol Chem (2015) 0.84
Expression of apolipoprotein A-I in rabbit carotid endothelium protects against atherosclerosis. Mol Ther (2011) 0.83
Reevaluation of the role of HDL in the anticoagulant activated protein C system in humans. J Clin Invest (2010) 0.83
ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development. J Immunol (2012) 0.83
Origins of intestinal ABCA1-mediated HDL-cholesterol. J Lipid Res (2008) 0.83
Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1. PLoS One (2014) 0.82
Brefeldin A inhibits cholesterol efflux without affecting the rate of cellular uptake and re-secretion of apolipoprotein A-I in adipocytes. Arch Biochem Biophys (2008) 0.82
Characterization of apoA-I-dependent lipid efflux from adipocytes and role of ABCA1. Mol Cell Biochem (2010) 0.82
Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide. J Pharmacol Exp Ther (2015) 0.82
The roles of C-terminal helices of human apolipoprotein A-I in formation of high-density lipoprotein particles. Biochim Biophys Acta (2013) 0.82
A novel model of cholesterol efflux from lipid-loaded cells. Acta Pharmacol Sin (2010) 0.81
The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux. Biochim Biophys Acta (2009) 0.81
Cholesterol determines and limits rHDL formation from human plasma apolipoprotein A-II and phospholipid membranes. Biochemistry (2012) 0.81
Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro. PLoS One (2015) 0.81
microRNAs and HDL life cycle. Cardiovasc Res (2014) 0.80
Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake. J Biol Chem (2015) 0.80
ABCA1 contributes to macrophage deposition of extracellular cholesterol. J Lipid Res (2015) 0.80
Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. PLoS One (2011) 0.80
Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults. Lipids Health Dis (2013) 0.80
The β-subunit of ATP synthase is involved in cellular uptake and resecretion of apoA-I but does not control apoA-I-induced lipid efflux in adipocytes. Mol Cell Biochem (2010) 0.80
Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry. Biochemistry (2014) 0.80
Structural Features of the ATP-Binding Cassette (ABC) Transporter ABCA3. Int J Mol Sci (2015) 0.79
ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation. J Lipid Res (2015) 0.79
A novel compound inhibits reconstituted high-density lipoprotein assembly and blocks nascent high-density lipoprotein biogenesis downstream of apolipoprotein AI binding to ATP-binding cassette transporter A1-expressing cells. Arterioscler Thromb Vasc Biol (2011) 0.79
ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis. J Lipid Res (2015) 0.79
FAMP, a novel apoA-I mimetic peptide, suppresses aortic plaque formation through promotion of biological HDL function in ApoE-deficient mice. J Am Heart Assoc (2013) 0.79
Multimarker screening of oxidative stress in aging. Oxid Med Cell Longev (2014) 0.78
Free cholesterol determines reassembled high-density lipoprotein phospholipid phase structure and stability. Biochemistry (2013) 0.78
Vinegar-baked Radix Bupleuri modulates the cell membrane constituents and inhibits the P-gp activity in rat hepatocytes. BMC Complement Altern Med (2014) 0.78
ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease. Lab Invest (2016) 0.77
Phospholipids mediated conversion of HDLs generates specific apoA-II pre-beta mobility particles. J Lipid Res (2008) 0.77
MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease. Biochim Biophys Acta (2016) 0.77
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med (2011) 13.55
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature (2010) 12.07
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest (2007) 4.20
The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. J Lipid Res (2008) 3.71
Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterioscler Thromb Vasc Biol (2002) 3.51
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation (2012) 3.38
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation (2005) 3.25
Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation (2003) 3.24
The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol (2010) 3.20
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc Natl Acad Sci U S A (2006) 3.00
Inflammation impairs reverse cholesterol transport in vivo. Circulation (2009) 2.86
Importance of different pathways of cellular cholesterol efflux. Arterioscler Thromb Vasc Biol (2003) 2.70
Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest (2005) 2.47
The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res (2007) 2.38
High-density lipoprotein heterogeneity and function in reverse cholesterol transport. Curr Opin Lipidol (2010) 2.23
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell (2008) 2.17
Early outcome of folding mitral valve repair technique without resection for mitral valve prolapse in 60 patients. J Thorac Cardiovasc Surg (2012) 2.06
Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nat Mater (2004) 2.03
Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun (2005) 2.01
Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo. Circ Res (2006) 1.85
A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan. J Gastroenterol (2004) 1.83
Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins. Prog Lipid Res (2004) 1.83
Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux. J Lipid Res (2005) 1.83
Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model. J Biol Chem (2003) 1.76
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. J Lipid Res (2006) 1.73
Requirement of heat shock protein 90 for human hepatitis B virus reverse transcriptase function. J Virol (2004) 1.72
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest (2012) 1.71
Cholesterol depletion increases membrane stiffness of aortic endothelial cells. Biophys J (2004) 1.71
High density lipoprotein structure-function and role in reverse cholesterol transport. Subcell Biochem (2010) 1.69
Hepatic proprotein convertases modulate HDL metabolism. Cell Metab (2007) 1.68
Use of rocuronium-sugammadex, an alternative to succinylcholine, as a muscle relaxant during electroconvulsive therapy. J Anesth (2011) 1.67
Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circ Res (2005) 1.66
Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J (2004) 1.56
Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol. Biophys J (2002) 1.53
Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem (2003) 1.53
ABCA1-induced cell surface binding sites for ApoA-I. Arterioscler Thromb Vasc Biol (2007) 1.52
Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.50
Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements. PLoS Biol (2007) 1.49
Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol. Biochemistry (2005) 1.48
Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol (2004) 1.46
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol. J Lipid Res (2011) 1.45
Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res (2008) 1.45
CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem (2008) 1.41
Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase. Circulation (2003) 1.38
The einkorn wheat (Triticum monococcum) mutant, maintained vegetative phase, is caused by a deletion in the VRN1 gene. Genes Genet Syst (2007) 1.38
Outbreak of gastroenteritis due to sapovirus. J Clin Microbiol (2007) 1.36
Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Rep (2012) 1.34
Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice. Cytokine (2002) 1.34
Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipids. J Biol Chem (2004) 1.32
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochim Biophys Acta (2007) 1.28
Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization. J Lipid Res (2002) 1.27
Contributions of the N- and C-terminal helical segments to the lipid-free structure and lipid interaction of apolipoprotein A-I. Biochemistry (2006) 1.27
Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol (2007) 1.26
The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry (2007) 1.24
High density lipoprotein structure. Front Biosci (2003) 1.22
Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. J Biol Chem (2004) 1.22
Pulmonary abnormalities due to ABCA1 deficiency in mice. Am J Physiol Lung Cell Mol Physiol (2005) 1.21
Adipocyte modulation of high-density lipoprotein cholesterol. Circulation (2010) 1.21
Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages. Arterioscler Thromb Vasc Biol (2006) 1.21
Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circulation (2006) 1.20
Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo. Circulation (2009) 1.20
OxLDL increases endothelial stiffness, force generation, and network formation. J Lipid Res (2006) 1.20