Published in DNA Repair (Amst) on May 26, 2009
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
ATR signalling: more than meeting at the fork. Biochem J (2011) 2.37
DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out. Immunol Rev (2012) 1.74
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell (2010) 1.68
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nat Med (2016) 1.42
DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae. PLoS One (2015) 1.41
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J Biol Chem (2010) 1.37
Roles of Chk1 in cell biology and cancer therapy. Int J Cancer (2013) 1.37
Evolution of networks and sequences in eukaryotic cell cycle control. Philos Trans R Soc Lond B Biol Sci (2011) 1.30
The regulation of the p53-mediated stress response by MDM2 and MDM4. Cold Spring Harb Perspect Biol (2010) 1.23
A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1. Genome Biol (2011) 1.21
CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycle. Mol Interv (2011) 1.14
NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell (2011) 1.09
Preclinical models for neuroblastoma: establishing a baseline for treatment. PLoS One (2011) 1.09
The intersection between DNA damage response and cell death pathways. Exp Oncol (2012) 1.06
Functional analysis of the Aspergillus nidulans kinome. PLoS One (2013) 1.05
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res (2011) 1.04
Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet (2010) 1.01
Hereditary breast cancer: the era of new susceptibility genes. Biomed Res Int (2013) 1.01
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem (2012) 0.97
Coupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viability. J Biol Chem (2012) 0.97
Phosphatases in the cellular response to DNA damage. Cell Commun Signal (2010) 0.97
Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways. J Virol (2013) 0.96
Aberrant signaling pathways in glioma. Cancers (Basel) (2011) 0.96
CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Mol Cell Biol (2012) 0.95
Time-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines. Exp Mol Med (2011) 0.95
Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proc Natl Acad Sci U S A (2012) 0.93
Posttranslational modifications of the retinoblastoma tumor suppressor protein as determinants of function. Genes Cancer (2012) 0.93
Molecular targets and mechanisms of radiosensitization using DNA damage response pathways. Future Oncol (2013) 0.93
A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Hum Mol Genet (2010) 0.93
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
The role of post-translational modifications in fine-tuning BLM helicase function during DNA repair. DNA Repair (Amst) (2014) 0.91
Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. Transplantation (2010) 0.91
DNA damage response in plants: conserved and variable response compared to animals. Biology (Basel) (2013) 0.90
Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex. Genes Dev (2015) 0.90
The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle. Viruses (2015) 0.89
Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1. Cancer Res (2012) 0.89
Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant. Mol Cell Biol (2012) 0.89
Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res (2014) 0.88
The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation. J Biol Chem (2014) 0.87
The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. Cell Death Differ (2013) 0.87
Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors. Oncogene (2014) 0.87
Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis (2010) 0.86
The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins. J Cell Sci (2014) 0.86
Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition. PLoS One (2011) 0.84
Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. PLoS Genet (2011) 0.84
Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint. PLoS Genet (2012) 0.83
Targeting DNA Repair in Cancer: Beyond PARP Inhibitors. Cancer Discov (2016) 0.82
Glutathione depletion and carbon ion radiation potentiate clustered DNA lesions, cell death and prevent chromosomal changes in cancer cells progeny. PLoS One (2012) 0.82
HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acids Res (2014) 0.82
Development of synthetic lethality anticancer therapeutics. J Med Chem (2014) 0.82
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1. PLoS Genet (2013) 0.81
Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res (2014) 0.81
The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells. PLoS One (2014) 0.81
VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest (2011) 0.81
Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis. J Biol Chem (2009) 0.81
A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk. Oncogene (2015) 0.81
Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus. Int J Mol Sci (2016) 0.80
Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan. Mech Ageing Dev (2013) 0.80
DNA damage induced by oridonin involves cell cycle arrest at G2/M phase in human MCF-7 cells. Contemp Oncol (Pozn) (2013) 0.80
Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation. J Clin Med (2015) 0.79
Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell Cycle (2014) 0.79
DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol (2015) 0.79
Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining. Mol Cell Biol (2015) 0.79
Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans. PLoS One (2014) 0.79
The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One (2013) 0.79
DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression. J Oncol (2011) 0.79
The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair. Biomolecules (2015) 0.78
Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses. Mol Biol Evol (2014) 0.78
Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization. J Biol Chem (2014) 0.78
Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics. Environ Health Perspect (2015) 0.77
Rad53 homologue forkhead-associated kinase A (FhkA) and Ca2+-binding protein 4a (CBP4a) are nucleolar proteins that differentially redistribute during mitosis in Dictyostelium. Cell Div (2013) 0.77
Proteasome activity is important for replication recovery, CHK1 phosphorylation and prevention of G2 arrest after low-dose formaldehyde. Toxicol Appl Pharmacol (2015) 0.77
Functional DNA repair signature of cancer cell lines exposed to a set of cytotoxic anticancer drugs using a multiplexed enzymatic repair assay on biochip. PLoS One (2012) 0.77
Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families. Fam Cancer (2010) 0.77
X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket. FEBS Lett (2011) 0.77
Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress. Front Genet (2016) 0.76
Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response. PLoS One (2015) 0.76
CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2. Oncogene (2016) 0.76
Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress. Stem Cell Res Ther (2016) 0.75
Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Mol Cell (2015) 0.75
Prevention of DNA Rereplication Through a Meiotic Recombination Checkpoint Response. G3 (Bethesda) (2016) 0.75
Inhibitory effects of trehalose on malignant melanoma cell growth: implications for a novel topical anticancer agent on the ocular surface. ISRN Ophthalmol (2012) 0.75
Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle (2014) 0.75
Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway. Oncotarget (2017) 0.75
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science (1997) 8.43
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell (2003) 7.48
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A (2000) 5.64
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell (1998) 5.37
53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev (2000) 4.38
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell (2008) 4.14
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell (2008) 4.04
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet (2004) 3.89
PML is essential for multiple apoptotic pathways. Nat Genet (1998) 3.75
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol Cell (2001) 3.74
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene (2007) 3.68
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell (2000) 3.65
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature (2003) 3.54
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J (2002) 3.45
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (2006) 3.41
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 3.19
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell (2008) 3.15
Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol (2003) 3.12
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer (2004) 3.06
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature (2003) 3.00
Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell (2005) 2.98
Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell (2004) 2.94
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev (2005) 2.85
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell (2006) 2.75
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell (2005) 2.75
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol (2004) 2.63
Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex. DNA Repair (Amst) (2004) 2.55
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem (2003) 2.54
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 2.39
Tel2 regulates the stability of PI3K-related protein kinases. Cell (2007) 2.30
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29
The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol (2006) 2.28
Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes. Oncogene (2005) 2.26
CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Nat Rev Cancer (2007) 2.21
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol (2006) 2.20
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J (2004) 2.19
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell (2008) 2.17
Asf1 links Rad53 to control of chromatin assembly. Genes Dev (2001) 2.16
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr Biol (2005) 2.13
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat Cell Biol (2002) 2.10
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev (2004) 2.07
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death Differ (2005) 1.98
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J (2005) 1.94
Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. Curr Biol (2001) 1.90
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A (2005) 1.90
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem (2004) 1.89
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell (2003) 1.88
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res (2003) 1.87
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol (2007) 1.87
The Chk2 protein kinase. DNA Repair (Amst) (2004) 1.85
Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell Biol (2006) 1.84
Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol Cell (2008) 1.82
Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev (2008) 1.80
Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol Cell Biol (2007) 1.77
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol (2007) 1.77
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell (2009) 1.73
The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst) (2004) 1.72
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat Cell Biol (2003) 1.68
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J (2006) 1.67
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J (2003) 1.67
Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell (2006) 1.65
Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. EMBO J (1999) 1.65
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J (2004) 1.63
The CHEK2 gene and inherited breast cancer susceptibility. Oncogene (2006) 1.62
Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J Biol Chem (2006) 1.62
Targeted cancer therapies based on the inhibition of DNA strand break repair. Oncogene (2007) 1.57
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol (2004) 1.57
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. Science (2008) 1.56
Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO J (2008) 1.56
Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. Proc Natl Acad Sci U S A (2005) 1.55
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J (2007) 1.52
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci U S A (2007) 1.52
The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation. Exp Cell Res (2006) 1.52
Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev (2008) 1.51
Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene (2006) 1.50
DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1. Proc Natl Acad Sci U S A (2008) 1.46
Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. Mol Biol Cell (2004) 1.46
Activation segment exchange: a common mechanism of kinase autophosphorylation? Trends Biochem Sci (2007) 1.45
Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. J Cell Biol (2006) 1.43
Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Mol Cell Biol (2003) 1.42
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J (2004) 1.38
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell (2006) 1.38
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J (2006) 1.38
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol (2008) 1.38
The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol (2011) 3.83
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature (2002) 3.48
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet (2002) 2.97
The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst) (2004) 2.68
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol Cancer Res (2003) 2.23
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23
The Rad50 hook domain is a critical determinant of Mre11 complex functions. Nat Struct Mol Biol (2005) 2.08
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell (2003) 2.08
A murine model of Nijmegen breakage syndrome. Curr Biol (2002) 1.96
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev (2002) 1.87
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell (2009) 1.73
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature (2007) 1.58
Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst) (2002) 1.57
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev (2005) 1.37
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell (2008) 1.30
The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol (2007) 1.23
Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage. Mol Cell Biol (2011) 1.23
The mre11 complex and the response to dysfunctional telomeres. Mol Cell Biol (2009) 1.22
Functional interactions between Sae2 and the Mre11 complex. Genetics (2008) 1.20
ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. PLoS Genet (2008) 1.18
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. Nat Struct Mol Biol (2011) 1.16
Methods for studying the cellular response to DNA damage: influence of the Mre11 complex on chromosome metabolism. Methods Enzymol (2006) 1.15
Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol (2008) 1.13
Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res (2009) 1.10
A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet (2013) 1.05
Rad50S alleles of the Mre11 complex: questions answered and questions raised. Exp Cell Res (2006) 1.02
Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication. DNA Repair (Amst) (2007) 0.99
DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions. Cancer Res (2008) 0.97
The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53. Proc Natl Acad Sci U S A (2007) 0.97
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genet (2012) 0.92
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol (2008) 0.92
Regulation of homologous integration in yeast by the DNA repair proteins Ku70 and RecQ. Mol Genet Genomics (2005) 0.90
Homologous recombination via synthesis-dependent strand annealing in yeast requires the Irc20 and Srs2 DNA helicases. Genetics (2012) 0.88
The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis. Mol Cell (2013) 0.87
Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression. Proc Natl Acad Sci U S A (2012) 0.86
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev (2014) 0.83
Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression. Cell Cycle (2008) 0.83
Modeling disease in the mouse: lessons from DNA damage response and cell cycle control genes. J Cell Biochem (2006) 0.83
The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep (2013) 0.82
Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex. Cell Cycle (2009) 0.80
At the end, remodeling leads to eviction. Nat Struct Mol Biol (2005) 0.79
NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. DNA Repair (Amst) (2009) 0.78
TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding. Mol Cell (2016) 0.75