Published in J Cell Biol on April 28, 2003
XMAP215 is a processive microtubule polymerase. Cell (2008) 3.33
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol Biol Cell (2004) 2.65
Mechanochemical model of microtubule structure and self-assembly kinetics. Biophys J (2005) 2.31
Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Trends Cell Biol (2011) 1.67
Stu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol (2006) 1.57
Differential functional interplay of TOGp/XMAP215 and the KinI kinesin MCAK during interphase and mitosis. EMBO J (2004) 1.55
EB1 accelerates two conformational transitions important for microtubule maturation and dynamics. Curr Biol (2014) 1.55
Mini spindles, the XMAP215 homologue, suppresses pausing of interphase microtubules in Drosophila. EMBO J (2005) 1.51
Deciphering protein function during mitosis in PtK cells using RNAi. BMC Cell Biol (2006) 1.49
Yeast kinetochores do not stabilize Stu2p-dependent spindle microtubule dynamics. Mol Biol Cell (2003) 1.45
A TOG Protein Confers Tension Sensitivity to Kinetochore-Microtubule Attachments. Cell (2016) 1.44
The XMAP215 homologue Stu2 at yeast spindle pole bodies regulates microtubule dynamics and anchorage. EMBO J (2003) 1.39
Mitotic spindle form and function. Genetics (2012) 1.38
Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. Mol Biol Cell (2004) 1.25
Microtubule-associated proteins in higher plants. J Plant Res (2007) 1.13
CLIP-170 homologue and NUDE play overlapping roles in NUDF localization in Aspergillus nidulans. Mol Biol Cell (2006) 1.09
Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase. Mol Biol Cell (2012) 1.08
Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. Mol Biol Cell (2009) 1.08
MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics. Mol Cell Biol (2008) 1.08
TMBP200, a XMAP215 homologue of tobacco BY-2 cells, has an essential role in plant mitosis. Protoplasma (2010) 1.07
Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. PLoS One (2012) 1.05
The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics. Mol Biol Cell (2011) 1.02
A tethered delivery mechanism explains the catalytic action of a microtubule polymerase. Elife (2014) 0.98
Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth. Neural Dev (2013) 0.96
Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics. Mol Cell Biol (2013) 0.93
Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation. Nat Cell Biol (2013) 0.89
The tobacco MAP215/Dis1-family protein TMBP200 is required for the functional organization of microtubule arrays during male germline establishment. J Exp Bot (2009) 0.87
Kinetic analysis of tubulin assembly in the presence of the microtubule-associated protein TOGp. J Biol Chem (2006) 0.86
Kinesin-5 is a microtubule polymerase. Nat Commun (2015) 0.83
TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J Cell Biol (2015) 0.82
Three-dimensional microtubule behavior in Xenopus egg extracts reveals four dynamic states and state-dependent elastic properties. Biophys J (2008) 0.81
Ahead of the Curve: New Insights into Microtubule Dynamics. F1000Res (2016) 0.79
A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Sci Rep (2015) 0.79
Alp7/TACC-Alp14/TOG generates long-lived, fast-growing MTs by an unconventional mechanism. Sci Rep (2016) 0.79
XMAP215: a tip tracker that really moves. Cell (2008) 0.78
GTP is required for the microtubule catastrophe-inducing activity of MAP200, a tobacco homolog of XMAP215. Plant Physiol (2009) 0.78
An unconventional interaction between Dis1/TOG and Mal3/EB1 promotes the fidelity of chromosome segregation. J Cell Sci (2016) 0.77
TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics. PLoS One (2015) 0.76
Lessons from in vitro reconstitution analyses of plant microtubule-associated proteins. Front Plant Sci (2014) 0.76
Probing the biology of cell boundary conditions through confinement of Xenopus cell-free cytoplasmic extracts. Genesis (2017) 0.75
Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies. J Cell Biol (1988) 9.32
Kin I kinesins are microtubule-destabilizing enzymes. Cell (1999) 6.07
XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell (1996) 5.21
Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study. J Cell Biol (1991) 5.16
Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts. Cell (1990) 4.92
Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell (1996) 4.32
The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol (1999) 4.31
Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Nat Cell Biol (2000) 4.31
Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. Mol Biol Cell (1992) 4.02
Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell (1993) 3.95
Structure of growing microtubule ends: two-dimensional sheets close into tubes at variable rates. J Cell Biol (1995) 3.83
A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end. J Cell Biol (1987) 3.30
Yeast Bim1p promotes the G1-specific dynamics of microtubules. J Cell Biol (1999) 3.20
Cell cycle-dependent changes in microtubule dynamics in living cells expressing green fluorescent protein-alpha tubulin. Mol Biol Cell (2001) 3.15
EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell (2002) 2.92
Reconstitution of physiological microtubule dynamics using purified components. Science (2001) 2.83
The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev (2003) 2.75
Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific. J Cell Biol (1993) 2.68
XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover. J Cell Biol (1994) 2.50
Dynamic instability of microtubules as an efficient way to search in space. Proc Natl Acad Sci U S A (1994) 2.25
The free energy for hydrolysis of a microtubule-bound nucleotide triphosphate is near zero: all of the free energy for hydrolysis is stored in the microtubule lattice. J Cell Biol (1994) 2.20
Preparation of marked microtubules for the assay of the polarity of microtubule-based motors by fluorescence. J Cell Sci Suppl (1991) 2.12
The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells. Mol Biol Cell (2002) 1.88
The structure of microtubule ends during the elongation and shortening phases of dynamic instability examined by negative-stain electron microscopy. J Cell Sci (1990) 1.86
XMAP215 is a long thin molecule that does not increase microtubule stiffness. J Cell Sci (2001) 1.85
Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint. EMBO J (2001) 1.83
Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin. J Biol Chem (2001) 1.78
Stu2p, the budding yeast member of the conserved Dis1/XMAP215 family of microtubule-associated proteins is a plus end-binding microtubule destabilizer. J Cell Biol (2003) 1.77
Evidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules. Mol Biol Cell (1996) 1.77
M phase-specific kinetochore proteins in fission yeast: microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase. Curr Biol (2001) 1.77
The minimum GTP cap required to stabilize microtubules. Curr Biol (1994) 1.76
Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast. EMBO J (2002) 1.70
Dis1/TOG universal microtubule adaptors - one MAP for all? J Cell Sci (2001) 1.66
XMAP215 regulates microtubule dynamics through two distinct domains. EMBO J (2001) 1.57
The interaction of TOGp with microtubules and tubulin. J Biol Chem (2000) 1.56
Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue. J Cell Biol (1992) 1.54
Localization of an exchangeable GTP binding site at the plus end of microtubules. Science (1993) 1.40
A metastable intermediate state of microtubule dynamic instability that differs significantly between plus and minus ends. J Cell Biol (1997) 1.27
Identification of ribonucleotide reductase protein R1 as an activator of microtubule nucleation in Xenopus egg mitotic extracts. Mol Biol Cell (2000) 0.84
Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science (2011) 4.26
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol (2003) 3.01
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res (2008) 2.56
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun (2013) 1.66
Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome. Proteomics (2004) 1.19
Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Mol Biol Cell (2009) 1.11
Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol (2011) 0.87
A decade of molecular cell biology: achievements and challenges. Nat Rev Mol Cell Biol (2011) 0.76