Published in ACS Chem Biol on October 21, 2011
Mitosis as an anti-cancer drug target. Chromosoma (2013) 0.88
Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem (2012) 0.87
A Cell Biologist's Field Guide to Aurora Kinase Inhibitors. Front Oncol (2015) 0.80
Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem (2013) 0.80
Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. Cancer Res (2015) 0.78
Potent antiproliferative cembrenoids accumulate in tobacco upon infection with Rhodococcus fascians and trigger unusual microtubule dynamics in human glioblastoma cells. PLoS One (2013) 0.75
Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors. ACS Med Chem Lett (2016) 0.75
A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol (2005) 12.22
Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell (2002) 6.59
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med (2004) 6.40
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell (2002) 5.91
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell (2003) 5.68
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell (1995) 5.56
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature (2011) 5.32
Correcting improper chromosome-spindle attachments during cell division. Nat Cell Biol (2004) 5.18
Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell (2004) 4.90
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell (2003) 4.51
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell (2007) 3.98
Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J Cell Biol (2001) 3.86
AIM-1: a mammalian midbody-associated protein required for cytokinesis. EMBO J (1998) 3.73
Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol (2010) 3.50
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell (2009) 3.44
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell (2008) 3.38
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A (2007) 3.27
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell (2005) 3.14
Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J Cell Biol (2002) 3.05
Functional interrogation of the kinome using nucleotide acyl phosphates. Biochemistry (2007) 3.01
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol (2011) 2.91
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol (2003) 2.86
HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol (2006) 2.74
A novel mechanism for activation of the protein kinase Aurora A. Curr Biol (2003) 2.68
Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev Cell (2006) 2.57
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res (2008) 2.56
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell (2002) 2.56
Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. J Biol Chem (1997) 2.44
Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J Biol Chem (2002) 2.40
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Dev Cell (2007) 2.25
Molecular basis of drug resistance in aurora kinases. Chem Biol (2008) 2.03
Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem (2004) 1.97
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J Cell Biol (2008) 1.92
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep (2006) 1.82
Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J Med Chem (2007) 1.81
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol (2006) 1.69
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J (2011) 1.62
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun (2011) 1.59
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes Cells (2004) 1.35
Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells. J Biol Chem (2002) 1.35
LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. FEBS Lett (2006) 1.30
Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models. Clin Cancer Res (2011) 1.23
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem (2009) 1.09
Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis and tumour growth. J Cell Mol Med (2009) 0.94
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1. ACS Med Chem Lett (2011) 0.92
Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91
ESEfinder: A web resource to identify exonic splicing enhancers. Nucleic Acids Res (2003) 12.81
Large-scale sequence analysis of avian influenza isolates. Science (2006) 9.87
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell (2006) 6.46
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell (2008) 5.87
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res (2002) 4.92
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell (2011) 4.89
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov (2011) 4.80
GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol (2003) 4.60
The life and miracles of kinetochores. EMBO J (2009) 4.59
An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Hum Mol Genet (2006) 4.56
Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science (2011) 4.26
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell (2012) 4.04
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr Biol (2005) 3.77
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat Rev Drug Discov (2009) 3.64
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem (2004) 3.57
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol (2010) 3.50
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J (2002) 3.42
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell (2005) 3.14
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell (2006) 3.06
The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint. Cell (2007) 3.04
The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature (2010) 2.90
Structural analysis of multiprotein complexes by cross-linking, mass spectrometry, and database searching. Mol Cell Proteomics (2007) 2.78
MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J (2008) 2.75
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol (2011) 2.62
GenomeComp: a visualization tool for microbial genome comparison. J Microbiol Methods (2003) 2.62
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res (2008) 2.56
Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol (2010) 2.50
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A (2008) 2.42
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Nat Genet (2013) 2.38
In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics. Curr Biol (2006) 2.37
Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov (2012) 2.35
Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J Biol Chem (2005) 2.35
Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem (2005) 2.31
PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials (2010) 2.31
Response and acquired resistance to everolimus in anaplastic thyroid cancer. N Engl J Med (2014) 2.09
Decreasing catheter-related bloodstream infections in the intensive care unit: interventions in a medical center in central Taiwan. J Microbiol Immunol Infect (2012) 2.05
Molecular basis of drug resistance in aurora kinases. Chem Biol (2008) 2.03
Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing. Nucleic Acids Res (2006) 2.00
The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J Cell Biol (2010) 1.96
Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis. Hum Mol Genet (2013) 1.95
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J (2006) 1.89
The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Curr Biol (2011) 1.86
Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Structure (2010) 1.81
Sister chromatid tension and the spindle assembly checkpoint. Curr Opin Cell Biol (2009) 1.80
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia. Blood (2008) 1.79
Homeostatic control of mitotic arrest. Mol Cell (2011) 1.76
FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res (2010) 1.73
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell (2010) 1.72
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem (2004) 1.72
Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies. Blood (2011) 1.67
Self-assembly of the plant cell wall requires an extensin scaffold. Proc Natl Acad Sci U S A (2008) 1.67
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun (2013) 1.66
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem (2007) 1.65
Genome-wide promoter extraction and analysis in human, mouse, and rat. Genome Biol (2005) 1.64
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J (2011) 1.62
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell (2012) 1.61
A role for mammalian Sin3 in permanent gene silencing. Mol Cell (2008) 1.59
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. EMBO J (2006) 1.57
Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. EMBO Rep (2011) 1.55
MAD contortions: conformational dimerization boosts spindle checkpoint signaling. Curr Opin Struct Biol (2007) 1.52
Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling. Elife (2013) 1.52
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron (2004) 1.51
Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification. J Cell Biol (2003) 1.49
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. Drug Resist Updat (2009) 1.47
A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol (2006) 1.47
A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia. Blood (2013) 1.44
mTOR Mediated Anti-Cancer Drug Discovery. Drug Discov Today Ther Strateg (2009) 1.41
Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol (2012) 1.41
The influence of catalysis on mad2 activation dynamics. PLoS Biol (2009) 1.40
Regulation of cytoplasmic dynein ATPase by Lis1. J Neurosci (2006) 1.37
Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers. Nat Mater (2010) 1.37
Improving image quality in portal venography with spectral CT imaging. Eur J Radiol (2011) 1.37
Structural organization of the kinetochore-microtubule interface. Curr Opin Cell Biol (2011) 1.36
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. Structure (2007) 1.36
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem (2012) 1.33
Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc Natl Acad Sci U S A (2009) 1.31
Novel aminoglycosides increase SMN levels in spinal muscular atrophy fibroblasts. Hum Genet (2006) 1.31
Sgt1 is required for human kinetochore assembly. EMBO Rep (2004) 1.30
Identification of gmhA, a Yersinia pestis gene required for flea blockage, by using a Caenorhabditis elegans biofilm system. Infect Immun (2005) 1.30
The Ndc80 complex: hub of kinetochore activity. FEBS Lett (2007) 1.28
Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Res (2011) 1.27
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol (2011) 1.27