Published in Mech Ageing Dev on May 01, 2003
The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet (2009) 2.17
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila) (2011) 1.86
Do US Black Women Experience Stress-Related Accelerated Biological Aging?: A Novel Theory and First Population-Based Test of Black-White Differences in Telomere Length. Hum Nat (2010) 1.66
Blood cell telomere length is a dynamic feature. PLoS One (2011) 1.41
Telomere biology in healthy aging and disease. Pflugers Arch (2009) 1.41
Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J (2007) 1.38
Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev Res (Phila) (2009) 1.22
Telomere length in blood cells and breast cancer risk: investigations in two case-control studies. Breast Cancer Res Treat (2009) 1.18
Allele-specific relative telomere lengths are inherited. Hum Genet (2006) 1.18
Genome-wide association study of relative telomere length. PLoS One (2011) 1.16
Chromosome 9 arm-specific telomere length and breast cancer risk. Carcinogenesis (2009) 1.03
Human subtelomeric duplicon structure and organization. Genome Biol (2007) 1.01
Modulation of telomere length dynamics by the subtelomeric region of tetrahymena telomeres. Mol Biol Cell (2004) 0.93
Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline. Genome Res (2014) 0.88
Telomere deficiencies on chromosomes 9p, 15p, 15q and Xp: potential biomarkers for breast cancer risk. Hum Mol Genet (2010) 0.88
Telomeres and telomere dynamics: relevance to cancers of the GI tract. Expert Rev Gastroenterol Hepatol (2013) 0.87
Leukocyte telomere length and age at menopause. Epidemiology (2014) 0.87
The distribution pattern of critically short telomeres in human osteoarthritic knees. Arthritis Res Ther (2012) 0.87
Telomere length: a review of methods for measurement. Nurs Res (2014) 0.86
Human subtelomeric copy number variations. Cytogenet Genome Res (2009) 0.84
Telomere attrition in cancer cells and telomere length in tumor stroma cells predict chromosome instability in esophageal squamous cell carcinoma: a genome-wide analysis. Cancer Res (2009) 0.83
Chromosome arm-specific long telomeres: a new clonal event in primary chronic myelogenous leukemia cells. Neoplasia (2011) 0.82
Short telomere lengths in peripheral blood leukocytes are associated with an increased risk of oral premalignant lesion and oral squamous cell carcinoma. Cancer (2013) 0.82
Individual telomere lengths in chronic myeloid leukemia. Neoplasia (2009) 0.82
Human telomere length correlates to the size of the associated chromosome arm. PLoS One (2009) 0.82
Early-Life Telomere Dynamics Differ between the Sexes and Predict Growth in the Barn Swallow (Hirundo rustica). PLoS One (2015) 0.81
Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis. Mutat Res Rev Mutat Res (2014) 0.78
Characterization of telomeric repeats in metaphase chromosomes and interphase nuclei of Syrian Hamster Fibroblasts. Mol Cytogenet (2012) 0.77
Mesenchymal stem cells with high telomerase expression do not actively restore their chromosome arm specific telomere length pattern after exposure to ionizing radiation. BMC Mol Biol (2007) 0.76
A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study. Oncol Rep (2014) 0.75
High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres. Nucleic Acids Res (2017) 0.75
Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med (2004) 7.91
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet (2008) 4.04
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat Genet (2010) 3.63
Smoking habits, nicotine use, and congenital malformations. Obstet Gynecol (2006) 3.63
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
Effect of Availability of Transcatheter Aortic-Valve Replacement on Clinical Practice. N Engl J Med (2015) 3.29
Genetic influence on human lifespan and longevity. Hum Genet (2006) 3.27
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol (2008) 2.85
Predictors of mortality in 2,249 nonagenarians--the Danish 1905-Cohort Survey. J Am Geriatr Soc (2003) 2.79
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Academic performance in adolescence after inguinal hernia repair in infancy: a nationwide cohort study. Anesthesiology (2011) 2.64
Magnetic resonance imaging and low back pain in adults: a diagnostic imaging study of 40-year-old men and women. Spine (Phila Pa 1976) (2005) 2.63
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell (2004) 2.60
Rising prevalence of diabetes: evidence from a Danish pharmaco-epidemiological database. Lancet (2003) 2.57
System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention. JAMA (2010) 2.53
The Danish Twin Registry: 127 birth cohorts of twins. Twin Res (2002) 2.53
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50
The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37
No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33
Men: good health and high mortality. Sex differences in health and aging. Aging Clin Exp Res (2008) 2.33
Potential impact of myocardial perfusion scintigraphy as gatekeeper for invasive examination and treatment in patients with stable angina pectoris: observational study without post-test referral bias. Eur Heart J (2005) 2.31
Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Res (2003) 2.16
Risk of suicide in twins: 51 year follow up study. BMJ (2003) 2.08
Apolipoprotein e genotypes: relationship to cognitive functioning, cognitive decline, and survival in nonagenarians. J Am Geriatr Soc (2006) 2.02
Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102. Ann Epidemiol (2006) 1.97
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance. J Med Genet (2009) 1.89
Selective serotonin reuptake inhibitors and the risk of stroke: a population-based case-control study. Stroke (2002) 1.86
Association between height and coronary heart disease mortality: a prospective study of 35,000 twin pairs. Am J Epidemiol (2006) 1.85
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
Cancer risk in persons with oral cleft--a population-based study of 8,093 cases. Am J Epidemiol (2005) 1.82
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am J Epidemiol (2009) 1.81
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet (2008) 1.80
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark. Clin Infect Dis (2008) 1.75
Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY) (2011) 1.74
Risk of stroke associated with nonsteroidal anti-inflammatory drugs: a nested case-control study. Stroke (2003) 1.74
Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. Diabetes (2005) 1.73
Social activity and healthy aging: a study of aging Danish twins. Twin Res Hum Genet (2007) 1.73
Genetic liability in stroke: a long-term follow-up study of Danish twins. Stroke (2002) 1.72
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70
Modic changes and their associations with clinical findings. Eur Spine J (2006) 1.69
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
Responsiveness and minimal clinically important difference for pain and disability instruments in low back pain patients. BMC Musculoskelet Disord (2006) 1.68
Longevity studies in GenomEUtwin. Twin Res (2003) 1.66
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci (2010) 1.65
[¹⁸F]FDG-PET is superior to [¹²³I]IBZM-SPECT for the differential diagnosis of parkinsonism. Neurology (2012) 1.64
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64
Mediating the effect of self-care management intervention in type 2 diabetes: a meta-analysis of 47 randomised controlled trials. Patient Educ Couns (2009) 1.64
Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A (2003) 1.64
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Functional and structural nerve fiber findings in heterozygote patients with Fabry disease. Pain (2009) 1.62
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study. Eur J Endocrinol (2013) 1.61
Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. Am J Hum Genet (2006) 1.59
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res (2005) 1.59
Genetic influences on growth traits of BMI: a longitudinal study of adult twins. Obesity (Silver Spring) (2008) 1.56
Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia. PLoS One (2009) 1.56
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell (2012) 1.55
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Hum Mol Genet (2009) 1.55
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging (2005) 1.52
The heritability of level and rate-of-change in cognitive functioning in Danish twins aged 70 years and older. Exp Aging Res (2002) 1.51
Genetic influence on prolonged gestation: a population-based Danish twin study. Am J Obstet Gynecol (2004) 1.51
Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? BMC Med (2007) 1.50
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48
Use of myocardial perfusion imaging to predict the effectiveness of coronary revascularisation in patients with stable angina pectoris. Eur J Nucl Med Mol Imaging (2005) 1.48
Graves' disease and toxic nodular goiter are both associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study. Thyroid (2013) 1.48
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Characterization of fetal cells from the maternal circulation by microarray gene expression analysis--could the extravillous trophoblasts be a target for future cell-based non-invasive prenatal diagnosis? Fetal Diagn Ther (2013) 1.47
Diagnostic accuracy of myocardial perfusion imaging in a study population without post-test referral bias. J Nucl Cardiol (2005) 1.47
Neurosurgical conditions and procedures in infancy are associated with mortality and academic performances in adolescence: a nationwide cohort study. Paediatr Anaesth (2014) 1.47
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. Genet Epidemiol (2011) 1.47
The antiplatelet effect of clopidogrel is not attenuated by statin treatment in stable patients with ischemic heart disease. Thromb Haemost (2005) 1.46
Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet (2003) 1.46
Hand grip strength: a phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning. Genet Epidemiol (2002) 1.46
Cognitive Functioning after Surgery in Middle-aged and Elderly Danish Twins. Anesthesiology (2016) 1.45
Increased prevalence of congenital heart defects in monozygotic and dizygotic twins. Circulation (2013) 1.45
Psychiatric hospitalisation and suicide among the very old in Denmark: population-based register study. Br J Psychiatry (2005) 1.44
[18F]-fluorocholine positron-emission/computed tomography for lymph node staging of patients with prostate cancer: preliminary results of a prospective study. BJU Int (2010) 1.43
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells (2008) 1.43
Frequent change of procedure during coronary artery bypass surgery suggests insufficient preoperative diagnostic strategy. Interact Cardiovasc Thorac Surg (2007) 1.42
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging Cell (2004) 1.42