Published in J Org Chem on May 16, 2003
Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med (2008) 3.92
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med (2012) 2.49
Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal (2010) 2.04
Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Proc Natl Acad Sci U S A (2006) 1.59
Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers. Mol Cell Proteomics (2009) 1.39
The innate immune response to products of phospholipid peroxidation. Biochim Biophys Acta (2012) 1.20
A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. Mol Neurobiol (2010) 1.10
Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids. Chem Res Toxicol (2011) 1.05
Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration. Bioorg Med Chem (2009) 0.97
Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs). Chem Res Toxicol (2014) 0.95
Improved synthesis of the epoxy isoprostane phospholipid PEIPC and its reactivity with amines. Org Lett (2008) 0.93
Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues. Chem Res Toxicol (2011) 0.92
CEP biomarkers as potential tools for monitoring therapeutics. PLoS One (2013) 0.92
Lysophosphatidylcholine is generated by spontaneous deacylation of oxidized phospholipids. Chem Res Toxicol (2010) 0.91
Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids. J Lipid Res (2007) 0.89
Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane. FASEB J (2010) 0.89
4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids. Chem Res Toxicol (2015) 0.82
An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine. Bioorg Med Chem (2010) 0.81
The proteomics of drusen. Cold Spring Harb Perspect Med (2014) 0.80
Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells. Chem Res Toxicol (2016) 0.78
A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA. Chem Res Toxicol (2010) 0.77
An (1)O2 route to γ-hydroxyalkenal phospholipids by vitamin E-induced fragmentation of hydroperoxydiene-derived endoperoxides. Chem Res Toxicol (2011) 0.76
Carboxyethylpyrrole plasma biomarkers in age-related macular degeneration. Drugs Future (2011) 0.75
Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation. Chem Res Toxicol (2016) 0.75
Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products. Chem Res Toxicol (2016) 0.75
Biological and pathophysiological roles of end-products of DHA oxidation. Biochim Biophys Acta (2016) 0.75
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A (2002) 6.47
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med (2007) 4.11
Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med (2008) 3.92
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature (2010) 3.70
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 3.63
A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem (2002) 3.17
Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol (2002) 3.13
Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem (2002) 2.94
Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med (2006) 2.51
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med (2012) 2.49
The lipid whisker model of the structure of oxidized cell membranes. J Biol Chem (2007) 2.31
Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J Biol Chem (2003) 2.30
Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Invest Ophthalmol Vis Sci (2002) 2.03
Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork. J Biol Chem (2004) 2.00
Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1. Exp Cell Res (2006) 1.82
SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci (2007) 1.77
Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration. Proc Natl Acad Sci U S A (2006) 1.59
Retinal pigment epithelium lipofuscin proteomics. Mol Cell Proteomics (2008) 1.50
Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers. Mol Cell Proteomics (2009) 1.39
Rapid and selective oxygen-regulated protein tyrosine denitration and nitration in mitochondria. J Biol Chem (2004) 1.37
Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Invest Ophthalmol Vis Sci (2006) 1.32
Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem (2002) 1.31
Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis. Circ Res (2012) 1.24
Dynamics of protein nitration in cells and mitochondria. Am J Physiol Heart Circ Physiol (2004) 1.24
Evidence that light modulates protein nitration in rat retina. Mol Cell Proteomics (2002) 1.22
Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes. Mol Cell Proteomics (2010) 1.22
Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse. Exp Eye Res (2005) 1.20
Intense light exposure changes the crystallin content in retina. Exp Eye Res (2003) 1.20
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. Cancer Res (2005) 1.17
Crystallin distribution in Bruch's membrane-choroid complex from AMD and age-matched donor eyes. Exp Eye Res (2005) 1.16
Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36. Biochemistry (2007) 1.16
Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification. Biochemistry (2003) 1.15
Interaction between the photoreceptor-specific tubby-like protein 1 and the neuronal-specific GTPase dynamin-1. Invest Ophthalmol Vis Sci (2007) 1.14
Bestrophin interacts physically and functionally with protein phosphatase 2A. J Biol Chem (2002) 1.13
Novel bioactive phospholipids: practical total syntheses of products from the oxidation of arachidonic and linoleic esters of 2-lysophosphatidylcholine(1). J Org Chem (2002) 1.13
Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria. J Gerontol A Biol Sci Med Sci (2002) 1.12
Clusterin is present in drusen in age-related macular degeneration. Exp Eye Res (2002) 1.10
A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. Mol Neurobiol (2010) 1.10
Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration. Mol Cell Proteomics (2009) 1.08
A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products. J Lipid Res (2006) 1.08
Tubby-like protein 1 (TULP1) interacts with F-actin in photoreceptor cells. Invest Ophthalmol Vis Sci (2005) 1.08
Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters. J Biol Chem (2008) 1.06
Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts. Free Radic Biol Med (2009) 1.06
Protein database, human retinal pigment epithelium. Mol Cell Proteomics (2003) 1.05
Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells. Vascul Pharmacol (2002) 1.05
Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration. Int J Inflam (2013) 1.04
Disease-causing mutations in the cellular retinaldehyde binding protein tighten and abolish ligand interactions. J Biol Chem (2003) 1.03
Duplication and divergence of zebrafish CRALBP genes uncovers novel role for RPE- and Muller-CRALBP in cone vision. Invest Ophthalmol Vis Sci (2008) 1.03
Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo. FASEB J (2003) 1.03
Proteomic analysis of vitreous from diabetic macular edema. Exp Eye Res (2005) 1.03
Cellular retinaldehyde-binding protein interacts with ERM-binding phosphoprotein 50 in retinal pigment epithelium. Invest Ophthalmol Vis Sci (2004) 1.03
Platelet activation by low concentrations of intact oxidized LDL particles involves the PAF receptor. Arterioscler Thromb Vasc Biol (2008) 1.02
Quantitative proteomics: TGFβ₂ signaling in trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 1.02
Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork. Biochemistry (2007) 1.02
Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice. Free Radic Biol Med (2009) 1.01
Retracted Targets of tyrosine nitration in diabetic rat retina. Mol Cell Proteomics (2007) 1.00
Phospholipid hydroxyalkenals, a subset of recently discovered endogenous CD36 ligands, spontaneously generate novel furan-containing phospholipids lacking CD36 binding activity in vivo. J Biol Chem (2006) 0.97
Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration. Bioorg Med Chem (2009) 0.97
Protein s-glutathionylation in retinal pigment epithelium converts heat shock protein 70 to an active chaperone. Exp Eye Res (2004) 0.95
Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs). Chem Res Toxicol (2014) 0.95
Characterization of semenogelin proteins in the human retina. Exp Eye Res (2006) 0.94
Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry (2005) 0.92
CEP biomarkers as potential tools for monitoring therapeutics. PLoS One (2013) 0.92
Fe2+ catalyzes vitamin E-induced fragmentation of hydroperoxy and hydroxy endoperoxides that generates gamma-hydroxy alkenals. J Am Chem Soc (2007) 0.92
Cardiolipin: characterization of distinct oxidized molecular species. J Lipid Res (2010) 0.91
Lysophosphatidylcholine is generated by spontaneous deacylation of oxidized phospholipids. Chem Res Toxicol (2010) 0.91
Preparative singlet oxygenation of linoleate provides doubly allylic dihydroperoxides: putative intermediates in the generation of biologically active aldehydes in vivo. J Org Chem (2006) 0.91
Oxidative fragmentation of hydroxy octadecadienoates generates biologically active gamma-hydroxyalkenals. J Am Chem Soc (2004) 0.90
Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids. J Lipid Res (2007) 0.89
Proteomic characterization of isolated retinal pigment epithelium microvilli. Mol Cell Proteomics (2004) 0.89
Glucose-modulated tyrosine nitration in beta cells: targets and consequences. Arch Biochem Biophys (2009) 0.89
Focus on molecules: cellular retinaldehyde-binding protein (CRALBP). Exp Eye Res (2005) 0.89
Genetic, age and light mediated effects on crystallin protein expression in the retina. Photochem Photobiol (2007) 0.88
Identification of oxidatively truncated ethanolamine phospholipids in retina and their generation from polyunsaturated phosphatidylethanolamines. Chem Res Toxicol (2006) 0.88
Identification of CRALBP ligand interactions by photoaffinity labeling, hydrogen/deuterium exchange, and structural modeling. J Biol Chem (2004) 0.88
Clathrin and adaptin accumulation in drusen, Bruch's membrane and choroid in AMD and non-AMD donor eyes. Exp Eye Res (2006) 0.87
Age-related changes in the retinal pigment epithelium (RPE). PLoS One (2012) 0.87
Proteomic similarities in steroid responsiveness in normal and glaucomatous trabecular meshwork cells. Mol Vis (2012) 0.87
Support for a proposed retinoid-processing protein complex in apical retinal pigment epithelium. Exp Eye Res (2004) 0.87
Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE. Chem Res Toxicol (2008) 0.87
Cochlin and glaucoma: a mini-review. Vis Neurosci (2005) 0.87