Published in Chest on May 01, 2003
Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother (2005) 3.87
Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother (2010) 2.34
Multidrug-resistant organisms in military wounds from Iraq and Afghanistan. Clin Orthop Relat Res (2008) 1.83
Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol (2011) 1.62
Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. Acad Emerg Med (2010) 1.54
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. Crit Care (2006) 1.43
Staphylococcus aureus bacteremia, Australia. Emerg Infect Dis (2005) 1.35
Impact of initial antibiotic choice and delayed appropriate treatment on the outcome of Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis (2006) 1.33
Molecular diagnosis of sepsis: New aspects and recent developments. Eur J Microbiol Immunol (Bp) (2014) 1.30
Accuracy and potential usefulness of triplex real-time PCR for improving antibiotic treatment of patients with blood cultures showing clustered gram-positive cocci on direct smears. J Clin Microbiol (2008) 1.29
Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection. Crit Care (2009) 1.23
A microfluidics approach towards high-throughput pathogen removal from blood using margination. Biomicrofluidics (2012) 1.23
Bacteraemia prediction in emergency medical admissions: role of C reactive protein. J Clin Pathol (2005) 1.18
Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2009) 1.18
Epidemiology of bacteremia episodes in a single center: increase in Gram-negative isolates, antibiotics resistance, and patient age. Eur J Clin Microbiol Infect Dis (2008) 1.13
Timing of specimen collection for blood cultures from febrile patients with bacteremia. J Clin Microbiol (2008) 1.13
Quantitative detection of Staphylococcus aureus and Enterococcus faecalis DNA in blood to diagnose bacteremia in patients in the intensive care unit. J Clin Microbiol (2007) 1.13
Immediate incubation of blood cultures outside routine laboratory hours of operation accelerates antibiotic switching. J Clin Microbiol (2009) 1.10
A comparative study of two different methods of sample preparation for positive blood cultures for the rapid identification of bacteria using MALDI-TOF MS. Eur J Clin Microbiol Infect Dis (2011) 1.10
Bench-to-bedside review: Rapid molecular diagnostics for bloodstream infection--a new frontier? Crit Care (2012) 1.08
Clinical sepsis and septic shock--definition, diagnosis and management principles. Langenbecks Arch Surg (2008) 1.08
The influence of infection sites on development and mortality of ARDS. Intensive Care Med (2010) 1.08
Multiresistant bacteria and current therapy - the economical side of the story. Eur J Med Res (2010) 1.07
Timing of vasopressor initiation and mortality in septic shock: a cohort study. Crit Care (2014) 1.05
Comparison of pathogen DNA isolation methods from large volumes of whole blood to improve molecular diagnosis of bloodstream infections. PLoS One (2013) 1.04
Impact of nosocomial polymicrobial bloodstream infections on the outcome in critically ill patients. Eur J Clin Microbiol Infect Dis (2011) 1.03
Antimicrobial peptides and their potential application in inflammation and sepsis. Crit Care (2012) 1.02
Impact of inactive empiric antimicrobial therapy on inpatient mortality and length of stay. Antimicrob Agents Chemother (2006) 1.02
Appropriateness of empirical treatment and outcome in bacteremia caused by extended-spectrum-β-lactamase-producing bacteria. Antimicrob Agents Chemother (2013) 0.99
Prediction of outcome from community-acquired severe sepsis and septic shock in tertiary-care university hospital in a developing country. Crit Care Res Pract (2012) 0.98
Truncated human cytidylate-phosphate-deoxyguanylate-binding protein for improved nucleic acid amplification technique-based detection of bacterial species in human samples. J Clin Microbiol (2009) 0.98
Survival analysis of 314 episodes of sepsis in medical intensive care unit in university hospital: impact of intensive care unit performance and antimicrobial therapy. Croat Med J (2006) 0.95
Inappropriate initial antimicrobial therapy as a risk factor for mortality in patients with community-onset Pseudomonas aeruginosa bacteraemia. Eur J Clin Microbiol Infect Dis (2008) 0.94
Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa. Clin Infect Dis (2015) 0.94
Nosocomial methicillin-resistant Staphylococcus aureus (MRSA) pneumonia: linezolid or vancomycin? - Comparison of pharmacology and clinical efficacy. Eur J Med Res (2010) 0.94
Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital. BMC Infect Dis (2014) 0.91
Infections of respiratory or abdominal origin in ICU patients: what are the differences? Crit Care (2010) 0.91
Role of plasma matrix-metalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients. Sci Rep (2014) 0.90
Developments for improved diagnosis of bacterial bloodstream infections. Eur J Clin Microbiol Infect Dis (2014) 0.90
Implementation of a computerized decision support system to improve the appropriateness of antibiotic therapy using local microbiologic data. Biomed Res Int (2014) 0.90
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates. Antimicrob Agents Chemother (2013) 0.88
Rapid intrinsic fluorescence method for direct identification of pathogens in blood cultures. MBio (2013) 0.88
Laboratory markers of systemic inflammation as predictors of bloodstream infection in acutely ill patients admitted to hospital in medical emergency. Eur J Clin Microbiol Infect Dis (2004) 0.87
The complex pathogenesis of bacteremia: from antimicrobial clearance mechanisms to the genetic background of the host. Virulence (2013) 0.87
Short- and long-term mortality in severe sepsis/septic shock in a setting with low antibiotic resistance: a prospective observational study in a Swedish university hospital. Front Public Health (2013) 0.86
An alternate pathophysiologic paradigm of sepsis and septic shock: implications for optimizing antimicrobial therapy. Virulence (2013) 0.86
First notification of positive blood cultures and the high accuracy of the gram stain report. J Clin Microbiol (2007) 0.86
Multiplex PCR performed of bronchoalveolar lavage fluid increases pathogen identification rate in critically ill patients with pneumonia: a pilot study. Ann Intensive Care (2014) 0.83
Revolutionising bacteriology to improve treatment outcomes and antibiotic stewardship. Infect Chemother (2013) 0.82
Ten-year surveillance of nosocomial bloodstream infections: trends of aetiology and antimicrobial resistance in a comprehensive cancer centre. Ecancermedicalscience (2011) 0.81
Prognostic value of venoarterial carbon dioxide gradient in patients with severe sepsis and septic shock. Croat Med J (2010) 0.81
Empiric antimicrobial therapy in severe sepsis and septic shock: optimizing pathogen clearance. Curr Infect Dis Rep (2015) 0.81
Epidemiology and outcome of primary community-acquired bacteremia in adult patients. Eur J Clin Microbiol Infect Dis (2007) 0.80
Mortality predictors of Staphylococcus aureus bacteremia: a prospective multicenter study. Ann Clin Microbiol Antimicrob (2016) 0.80
Should We Monitor ScVO(2) in Critically Ill Patients? Cardiol Res Pract (2011) 0.80
The impact of inappropriate antibiotics on bacteremia patients in a community hospital in Taiwan: an emphasis on the impact of referral information for cases from a hospital affiliated nursing home. BMC Infect Dis (2013) 0.79
Community-onset bacteraemia of unknown origin: clinical characteristics, epidemiology and outcome. Eur J Clin Microbiol Infect Dis (2014) 0.79
Clinical outcomes and risk factors of community-acquired pneumonia caused by gram-negative bacilli. Eur J Clin Microbiol Infect Dis (2008) 0.79
Impact of combination therapy with aminoglycosides on the outcome of ICU-acquired bacteraemias. Eur J Clin Microbiol Infect Dis (2012) 0.78
Bloodstream infections in the Intensive Care Unit. Virulence (2016) 0.78
Antimicrobial Non-Susceptibility of Escherichia coli from Outpatients and Patients Visiting Emergency Rooms in Taiwan. PLoS One (2015) 0.77
Incidence of bacteremia at the time of ICU admission and its impact on outcome. Indian J Anaesth (2011) 0.77
Rapid Detection of Vancomycin-Intermediate Staphylococcus aureus by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. J Clin Microbiol (2016) 0.77
The Reduction in Antibiotic Use in Hospitals. Dtsch Arztebl Int (2015) 0.77
Impact of time to antibiotics on outcomes of chemotherapy-induced febrile neutropenia. Support Care Cancer (2015) 0.76
A novel, multiplex, real-time PCR-based approach for the detection of the commonly occurring pathogenic fungi and bacteria. BMC Microbiol (2013) 0.76
A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection. Int J Nanomedicine (2017) 0.75
Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing. Open Forum Infect Dis (2016) 0.75
The IRIDICA BAC BSI Assay: Rapid, Sensitive and Culture-Independent Identification of Bacteria and Candida in Blood. PLoS One (2016) 0.75
Bacterial etiology of bloodstream infections and antimicrobial resistance in Dhaka, Bangladesh, 2005-2014. Antimicrob Resist Infect Control (2017) 0.75
Antimicrobial use and microbiological testing in district general hospital ICUs of the Veneto region of north-east Italy. Eur J Clin Microbiol Infect Dis (2016) 0.75
International study of the prevalence and outcomes of infection in intensive care units. JAMA (2009) 11.57
Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest (2003) 5.64
DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients? Clin Infect Dis (2014) 3.99
An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin Infect Dis (2003) 3.93
Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit Care Med (2002) 3.63
A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med (2014) 3.56
Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med (2004) 3.49
Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Crit Care (2009) 3.48
Microbial aetiology of healthcare associated pneumonia in Spain: a prospective, multicentre, case-control study. Thorax (2013) 3.05
Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: an observational, multicenter study comparing monotherapy with combination antibiotic therapy. Crit Care Med (2007) 2.94
Prevalence, risk factors, and mortality for ventilator-associated pneumonia in middle-aged, old, and very old critically ill patients*. Crit Care Med (2014) 2.86
Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock. Crit Care Med (2007) 2.44
Patients with New York Heart Association class III heart failure may benefit with high flow nasal cannula supportive therapy: high flow nasal cannula in heart failure. J Crit Care (2013) 2.43
Recruitment maneuvers during lung protective ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med (2002) 2.43
Clinical cure and survival in Gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin. Intensive Care Med (2004) 2.30
Management of community-acquired pneumonia in adults. Am J Respir Crit Care Med (2010) 2.29
Effects of delayed oxygenation assessment on time to antibiotic delivery and mortality in patients with severe community-acquired pneumonia. Crit Care Med (2007) 2.22
Clinical impact of pneumonia caused by Acinetobacter baumannii in intubated patients: a matched cohort study. Crit Care Med (2003) 2.13
A worldwide perspective of atypical pathogens in community-acquired pneumonia. Am J Respir Crit Care Med (2007) 2.08
A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically ill patients. Am J Respir Crit Care Med (2012) 2.06
Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Crit Care Med (2003) 1.98
Acinetobacter baumannii: a threat for the ICU? Intensive Care Med (2003) 1.93
Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia. J Infect Dis (2003) 1.90
Pseudomonas aeruginosa virulence and therapy: evolving translational strategies. Crit Care Med (2009) 1.89
A randomized trial of dental brushing for preventing ventilator-associated pneumonia. Chest (2009) 1.87
Drug-resistant pneumococcal pneumonia: clinical relevance and related factors. Clin Infect Dis (2004) 1.85
New issues and controversies in the prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med (2010) 1.84
Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents (2011) 1.80
Global prospective epidemiologic and surveillance study of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Crit Care Med (2014) 1.77
Bacteremia in patients with ventilator-associated pneumonia is associated with increased mortality: A study comparing bacteremic vs. nonbacteremic ventilator-associated pneumonia. Crit Care Med (2007) 1.66
Host adaptive immunity deficiency in severe pandemic influenza. Crit Care (2010) 1.64
Nursing adherence with evidence-based guidelines for preventing ventilator-associated pneumonia. Crit Care Med (2003) 1.61
Severe 2009 A/H1N1v influenza in pregnant women in Spain. Crit Care Med (2011) 1.61
Clinical resolution in patients with suspicion of ventilator-associated pneumonia: a cohort study comparing patients with and without acute respiratory distress syndrome. Crit Care Med (2005) 1.60
Prospective observational study of bacteremic pneumococcal pneumonia: Effect of discordant therapy on mortality. Crit Care Med (2004) 1.58
A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med (2015) 1.54
Evolution over a 15-year period of clinical characteristics and outcomes of critically ill patients with community-acquired bacteremia. Crit Care Med (2013) 1.50
Centers for Disease Control and Prevention guidelines for preventing central venous catheter-related infection: results of a knowledge test among 3405 European intensive care nurses. Crit Care Med (2009) 1.48
Validation of predictors of adverse outcomes in hospital-acquired pneumonia in the ICU. Crit Care Med (2013) 1.48
Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study. Intensive Care Med (2012) 1.47
Risk factors for respiratory failure in pneumococcal pneumonia: the importance of pneumococcal serotypes. Eur Respir J (2013) 1.45
Effect of high-flow nasal cannula and body position on end-expiratory lung volume: a cohort study using electrical impedance tomography. Respir Care (2013) 1.42
Severity of illness assessment for managing community-acquired pneumonia. Intensive Care Med (2007) 1.42
Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-Acquired Pneumonia Organization International cohort study results. Arch Intern Med (2009) 1.40
Late admission to the ICU in patients with community-acquired pneumonia is associated with higher mortality. Chest (2009) 1.40
The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients. Clin Pharmacokinet (2011) 1.39
Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza. CMAJ (2010) 1.33
Hybrid pathogenicity island PAGI-5 contributes to the highly virulent phenotype of a Pseudomonas aeruginosa isolate in mammals. J Bacteriol (2008) 1.33
C-reactive protein correlates with bacterial load and appropriate antibiotic therapy in suspected ventilator-associated pneumonia. Crit Care Med (2008) 1.25
Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection. PLoS One (2012) 1.23
Spectrum of practice in the diagnosis of nosocomial pneumonia in patients requiring mechanical ventilation in European intensive care units. Crit Care Med (2009) 1.21
Patterns of colonization by Pseudomonas aeruginosa in intubated patients: a 3-year prospective study of 1,607 isolates using pulsed-field gel electrophoresis with implications for prevention of ventilator-associated pneumonia. Intensive Care Med (2004) 1.19
C-reactive protein used as an early indicator of infection in patients with systemic inflammatory response syndrome. Intensive Care Med (2004) 1.17
Better outcomes through continuous infusion of time-dependent antibiotics to critically ill patients? Curr Opin Crit Care (2008) 1.17
Ventilator-associated pneumonia: issues related to the artificial airway. Respir Care (2005) 1.13
Impact of obesity in patients infected with 2009 influenza A(H1N1). Chest (2010) 1.13
Genomic islands of Pseudomonas aeruginosa. FEMS Microbiol Lett (2008) 1.12
Bacteremia is an independent risk factor for mortality in nosocomial pneumonia: a prospective and observational multicenter study. Crit Care (2011) 1.10
Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia across five sites in Italy and Spain. J Clin Microbiol (2013) 1.10
The ventilator-associated pneumonia PIRO score: a tool for predicting ICU mortality and health-care resources use in ventilator-associated pneumonia. Chest (2008) 1.09
Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors. Intensive Care Med (2013) 1.09
Treatment options for 2009 H1N1 influenza: evaluation of the published evidence. Int J Antimicrob Agents (2010) 1.07
Legionnaires' disease: a rational approach to therapy. J Antimicrob Chemother (2003) 1.06
Ventilator-associated pneumonia: impact of organisms on clinical resolution and medical resources utilization. Chest (2008) 1.04
Impact of diversity of antibiotic use on the development of antimicrobial resistance. J Antimicrob Chemother (2006) 1.03
Radiologic progression of pulmonary infiltrates predicts a worse prognosis in severe community-acquired pneumonia than bacteremia. Chest (2008) 1.03
Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A. J Antimicrob Chemother (2011) 1.02
Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics. J Antimicrob Chemother (2010) 1.02
Ventilator-associated pneumonia caused by ESKAPE organisms: cause, clinical features, and management. Curr Opin Pulm Med (2012) 1.01
Management of ventilator-associated pneumonia caused by multiresistant bacteria. Curr Opin Crit Care (2007) 1.00
Effects of immunocompromise and comorbidities on pneumococcal serotypes causing invasive respiratory infection in adults: implications for vaccine strategies. Clin Infect Dis (2013) 0.99
Gram-negative bacterial pneumonia: aetiology and management. Curr Opin Pulm Med (2006) 0.98
Mortality in ICU patients with bacterial community-acquired pneumonia: when antibiotics are not enough. Intensive Care Med (2008) 0.98
Impact of antibiotic guideline compliance on duration of mechanical ventilation in critically ill patients with community-acquired pneumonia. Chest (2006) 0.97
The role of mannose-binding lectin in pneumococcal infection. Eur Respir J (2012) 0.96
Temporal trends, risk factors and outcomes in albicans and non-albicans candidaemia: an international epidemiological study in four multidisciplinary intensive care units. Int J Antimicrob Agents (2009) 0.95
Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza. J Infect (2012) 0.95
Is Candida really a threat in the ICU? Curr Opin Crit Care (2008) 0.95
Bacteraemic pneumococcal pneumonia: impact of HIV on clinical presentation and outcome. J Infect (2007) 0.95
Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort. Crit Care (2014) 0.94
Ventilator-associated pneumonia in trauma patients is associated with lower mortality: results from EU-VAP study. J Trauma (2010) 0.94
A 7-year study of severe hospital-acquired pneumonia requiring ICU admission. Intensive Care Med (2003) 0.93
Impact of infection on the prognosis of critically ill cirrhotic patients: results from a large worldwide study. Liver Int (2014) 0.93
Therapy of ventilator-associated pneumonia. A patient-based approach based on the ten rules of "The Tarragona Strategy". Intensive Care Med (2003) 0.92
Why should we measure bacterial load when treating community-acquired pneumonia? Curr Opin Infect Dis (2011) 0.92
Human mesenchymal stem cells overexpressing the IL-33 antagonist soluble IL-1 receptor-like-1 attenuate endotoxin-induced acute lung injury. Am J Respir Cell Mol Biol (2013) 0.92
What is new in the prevention of ventilator-associated pneumonia? Curr Opin Pulm Med (2011) 0.92
Effects of high-dose of intravenous immunoglobulin and antibiotics on survival for severe sepsis undergoing surgery. Shock (2005) 0.91
The spectrum of pneumococcal empyema in adults in the early 21st century. Clin Infect Dis (2011) 0.91
Combination antibiotic therapy for community-acquired pneumonia. Ann Intensive Care (2011) 0.91
Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study. Crit Care (2011) 0.90
Update in community-acquired and nosocomial pneumonia 2009. Am J Respir Crit Care Med (2010) 0.90
Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis. Infect Drug Resist (2011) 0.90
Severe pandemic (H1N1)v influenza A infection: report on the first deaths in Spain. Respirology (2011) 0.89
Prevention of VAP: is zero rate possible? Clin Chest Med (2011) 0.88
New treatment options for infections caused by multiresistant strains of Pseudomonas aeruginosa and other nonfermenting gram-negative bacilli. Semin Respir Crit Care Med (2011) 0.88
The relevance of drug volume of distribution in antibiotic dosing. Curr Pharm Biotechnol (2011) 0.87
Effectiveness and safety of neuraminidase inhibitors in reducing influenza complications: a meta-analysis of randomized controlled trials. J Antimicrob Chemother (2010) 0.87
Elevation of creatine kinase is associated with worse outcomes in 2009 pH1N1 influenza A infection. Intensive Care Med (2012) 0.87