Bench-to-bedside review: Rapid molecular diagnostics for bloodstream infection--a new frontier?

PubWeight™: 1.08‹?› | Rank: Top 10%

🔗 View Article (PMC 3580598)

Published in Crit Care on May 29, 2012

Authors

Arash Afshari, Jacques Schrenzel, Margareta Ieven, Stephan Harbarth

Articles citing this

Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum. Antimicrob Resist Infect Control (2013) 2.29

Evaluation of three rapid diagnostic methods for direct identification of microorganisms in positive blood cultures. J Clin Microbiol (2014) 1.16

Evaluation of the Broad-Range PCR/ESI-MS Technology in Blood Specimens for the Molecular Diagnosis of Bloodstream Infections. PLoS One (2015) 1.05

Improving the diagnosis of bloodstream infections: PCR coupled with mass spectrometry. Biomed Res Int (2014) 0.98

Rapid identification of pathogens in positive blood culture of patients with sepsis: review and meta-analysis of the performance of the sepsityper kit. Int J Microbiol (2015) 0.94

Emerging rapid resistance testing methods for clinical microbiology laboratories and their potential impact on patient management. Biomed Res Int (2014) 0.84

A systematic review of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry compared to routine microbiological methods for the time taken to identify microbial organisms from positive blood cultures. Eur J Clin Microbiol Infect Dis (2015) 0.84

Challenges and solutions for clinical development of new antibacterial agents: results of a survey among pharmaceutical industry professionals. Antimicrob Agents Chemother (2015) 0.81

The development and application of a molecular community profiling strategy to identify polymicrobial bacterial DNA in the whole blood of septic patients. BMC Microbiol (2015) 0.80

Monitoring of patients supported by extracorporeal membrane oxygenation for systemic infections by broad-range rRNA gene PCR amplification and sequence analysis. J Clin Microbiol (2013) 0.80

Use of rapid diagnostic techniques in ICU patients with infections. BMC Infect Dis (2014) 0.78

Assessment of a semi-automated protocol for multiplex analysis of sepsis-causing bacteria with spiked whole blood samples. Microbiologyopen (2013) 0.76

Perceptions of point-of-care infectious disease testing among European medical personnel, point-of-care test kit manufacturers, and the general public. Patient Prefer Adherence (2013) 0.75

Beyond Blood Culture and Gram Stain Analysis: A Review of Molecular Techniques for the Early Detection of Bacteremia in Surgical Patients. Surg Infect (Larchmt) (2016) 0.75

Bench-to-bedside review: Challenges of diagnosis, care and prevention of central catheter-related bloodstream infections in children. Crit Care (2013) 0.75

Elasto-inertial microfluidics for bacteria separation from whole blood for sepsis diagnostics. J Nanobiotechnology (2017) 0.75

Articles cited by this

(truncated to the top 100)

Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am J Med (2003) 4.56

Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study. Lancet (2009) 4.53

Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest (2009) 4.51

Comparison of two matrix-assisted laser desorption ionization-time of flight mass spectrometry methods with conventional phenotypic identification for routine identification of bacteria to the species level. J Clin Microbiol (2010) 4.14

An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia. Clin Infect Dis (2010) 4.06

Accuracy of phenotypic and genotypic testing for identification of Streptococcus pneumoniae and description of Streptococcus pseudopneumoniae sp. nov. J Clin Microbiol (2004) 3.96

Ibis T5000: a universal biosensor approach for microbiology. Nat Rev Microbiol (2008) 3.41

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, a revolution in clinical microbial identification. Clin Microbiol Infect (2010) 3.01

Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med (2007) 2.97

The era of molecular and other non-culture-based methods in diagnosis of sepsis. Clin Microbiol Rev (2010) 2.90

MALDI-TOF-mass spectrometry applications in clinical microbiology. Future Microbiol (2010) 2.79

Quantitative aspects of septicemia. Clin Microbiol Rev (1990) 2.79

A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol (2007) 2.64

Impact of rapid in situ hybridization testing on coagulase-negative staphylococci positive blood cultures. J Antimicrob Chemother (2006) 2.57

Society's failure to protect a precious resource: antibiotics. Lancet (2011) 2.51

Severity of pneumococcal pneumonia associated with genomic bacterial load. Chest (2009) 2.46

Bacterial adhesins in host-microbe interactions. Cell Host Microbe (2009) 2.43

Peptide nucleic acid fluorescent in situ hybridization for hospital-acquired enterococcal bacteremia: delivering earlier effective antimicrobial therapy. Antimicrob Agents Chemother (2008) 2.32

Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest (2003) 2.31

Detection of bloodstream infections in adults: how many blood cultures are needed? J Clin Microbiol (2007) 2.28

Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis. Clin Microbiol Infect (2009) 2.28

Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis. J Clin Microbiol (2009) 2.19

Rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in wound specimens and blood cultures: multicenter preclinical evaluation of the Cepheid Xpert MRSA/SA skin and soft tissue and blood culture assays. J Clin Microbiol (2009) 2.07

Use of PCR coupled with electrospray ionization mass spectrometry for rapid identification of bacterial and yeast bloodstream pathogens from blood culture bottles. J Clin Microbiol (2010) 2.06

The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data. Crit Care (2009) 1.99

New technology for rapid molecular diagnosis of bloodstream infections. Expert Rev Mol Diagn (2010) 1.94

Does antibiotic selection impact patient outcome? Clin Infect Dis (2006) 1.88

Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis (2009) 1.83

Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit. Crit Care (2010) 1.81

Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time. Ther Clin Risk Manag (2008) 1.79

Rapid methods for diagnosis of bloodstream infections. Clin Chem Lab Med (2008) 1.79

Rapid identification of emerging infectious agents using PCR and electrospray ionization mass spectrometry. Ann N Y Acad Sci (2007) 1.79

Detection of microorganisms in blood specimens using matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a review. Clin Microbiol Infect (2010) 1.76

Renal and neurological side effects of colistin in critically ill patients. Ann Intensive Care (2011) 1.72

Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis (2007) 1.70

Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. J Antimicrob Chemother (2007) 1.64

The regulation of medical devices. BMJ (2011) 1.64

How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children's hospital. Pediatrics (2007) 1.63

Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. J Clin Microbiol (2009) 1.63

Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol (2011) 1.62

Multicenter evaluation of the Candida albicans/Candida glabrata peptide nucleic acid fluorescent in situ hybridization method for simultaneous dual-color identification of C. albicans and C. glabrata directly from blood culture bottles. J Clin Microbiol (2007) 1.57

Europeans are left to their own devices. BMJ (2011) 1.57

Quantifying uncertainty: physicians' estimates of infection in critically ill neonates and children. Clin Infect Dis (2004) 1.57

Blood culture negative endocarditis: analysis of 63 cases presenting over 25 years. Heart (2003) 1.55

Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria. Int J Antimicrob Agents (2007) 1.45

Rapid detection of mecA and nuc genes in staphylococci by real-time multiplex polymerase chain reaction. Diagn Microbiol Infect Dis (2005) 1.43

Identification of bacteria in blood culture broths using matrix-assisted laser desorption-ionization Sepsityper™ and time of flight mass spectrometry. PLoS One (2011) 1.42

Comparative analysis of PCR-electrospray ionization/mass spectrometry (MS) and MALDI-TOF/MS for the identification of bacteria and yeast from positive blood culture bottles. Clin Chem (2011) 1.41

Clinical validation of the molecular BD GeneOhm StaphSR assay for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in positive blood cultures. J Clin Microbiol (2007) 1.39

Detection and identification of Ehrlichia species in blood by use of PCR and electrospray ionization mass spectrometry. J Clin Microbiol (2009) 1.35

Cost and mortality prediction using polymerase chain reaction pathogen detection in sepsis: evidence from three observational trials. Crit Care (2010) 1.33

Rapid molecular genotyping and clonal complex assignment of Staphylococcus aureus isolates by PCR coupled to electrospray ionization-mass spectrometry. J Clin Microbiol (2009) 1.31

Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis. Crit Care Med (2009) 1.29

The clinical importance of microbiological findings in the diagnosis and management of bloodstream infections. Clin Infect Dis (2009) 1.28

Comparison of different methods of isolation of DNA of commonly encountered Candida species and its quantitation by using a real-time PCR-based assay. J Clin Microbiol (2004) 1.28

Assessment of impact of peptide nucleic acid fluorescence in situ hybridization for rapid identification of coagulase-negative staphylococci in the absence of antimicrobial stewardship intervention. J Clin Microbiol (2011) 1.25

Usefulness of multilocus polymerase chain reaction followed by electrospray ionization mass spectrometry to identify a diverse panel of bacterial isolates. Diagn Microbiol Infect Dis (2009) 1.25

Activity and DNA contamination of commercial polymerase chain reaction reagents for the universal 16S rDNA real-time polymerase chain reaction detection of bacterial pathogens in blood. Diagn Microbiol Infect Dis (2008) 1.25

Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection. Crit Care (2009) 1.23

Evaluation of the BD GeneOhm StaphSR assay for detection of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates from spiked positive blood culture bottles. J Clin Microbiol (2009) 1.23

Novel multiplex PCR assay for simultaneous identification of community-associated methicillin-resistant Staphylococcus aureus strains USA300 and USA400 and detection of mecA and Panton-Valentine leukocidin genes, with discrimination of Staphylococcus aureus from coagulase-negative staphylococci. J Clin Microbiol (2007) 1.23

Sample preparation: a challenge in the development of point-of-care nucleic acid-based assays for resource-limited settings. Analyst (2007) 1.22

Prevalence, duration and aetiology of bacteraemia following dental extractions. Oral Dis (2007) 1.21

Impact of an assay that enables rapid determination of Staphylococcus species and their drug susceptibility on the treatment of patients with positive blood culture results. Infect Control Hosp Epidemiol (2010) 1.17

Blood and urine samples as useful sources for the direct detection of tuberculosis by polymerase chain reaction. Diagn Microbiol Infect Dis (2006) 1.16

Quantitative detection of Staphylococcus aureus and Enterococcus faecalis DNA in blood to diagnose bacteremia in patients in the intensive care unit. J Clin Microbiol (2007) 1.13

Adverse drug events in intensive care units: risk factors, impact, and the role of team care. Crit Care Med (2010) 1.12

Evaluation of the Hyplex BloodScreen Multiplex PCR-Enzyme-linked immunosorbent assay system for direct identification of gram-positive cocci and gram-negative bacilli from positive blood cultures. J Clin Microbiol (2004) 1.12

Diagnostics as essential tools for containing antibacterial resistance. Drug Resist Updat (2011) 1.12

Rapid detection of pathogens in blood culture bottles by real-time PCR in conjunction with the pre-analytic tool MolYsis. J Infect (2008) 1.10

StaphPlex system for rapid and simultaneous identification of antibiotic resistance determinants and Panton-Valentine leukocidin detection of staphylococci from positive blood cultures. J Clin Microbiol (2007) 1.10

Evaluation of a commercial multiplex PCR test (SeptiFast) in the etiological diagnosis of community-onset bloodstream infections. Eur J Clin Microbiol Infect Dis (2011) 1.08

Diagnostic accuracy and potential clinical value of the LightCycler SeptiFast assay in the management of bloodstream infections occurring in neutropenic and critically ill patients. Int J Infect Dis (2011) 1.05

Therapeutic impact and diagnostic performance of multiplex PCR in patients with malignancies and suspected sepsis. J Infect (2010) 1.03

Aspergillus PCR formidable challenges and progress. Med Mycol (2009) 1.02

Laboratory diagnosis of late-onset sepsis in newborns by multiplex real-time PCR. J Med Microbiol (2009) 1.02

Failure of the BD GeneOhm StaphSR assay for direct detection of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates in positive blood cultures collected in the United States. J Clin Microbiol (2009) 1.02

Molecular identification of bloodstream pathogens in patients presenting to the emergency department with suspected sepsis. Shock (2010) 1.01

Molecular diagnosis of bloodstream infections: planning to (physically) reach the bedside. Curr Opin Infect Dis (2010) 0.98

Truncated human cytidylate-phosphate-deoxyguanylate-binding protein for improved nucleic acid amplification technique-based detection of bacterial species in human samples. J Clin Microbiol (2009) 0.98

Emerging moulds: epidemiological trends and antifungal resistance. Mycoses (2011) 0.98

How long does it take to "rule out" bacteremia in children with central venous catheters? Pediatrics (2008) 0.95

Time to positivity in blood cultures of adults with Streptococcus pneumoniae bacteremia. BMC Infect Dis (2006) 0.95

Detection of bacterial DNA in blood samples from febrile patients: underestimated infection or emerging contamination? FEMS Immunol Med Microbiol (2004) 0.95

Detection of metallo-β-lactamase genes in clinical specimens by a commercial multiplex PCR system. J Microbiol Methods (2010) 0.94

Intact cell MALDI-TOF mass spectrometry-based approaches for the diagnosis of bloodstream infections. Expert Rev Mol Diagn (2011) 0.92

PNA FISH: present and future impact on patient management. Expert Rev Mol Diagn (2007) 0.92

G-CSF and IL-8 for early diagnosis of sepsis in neonates and critically ill children - safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled trial [ISRCTN91123847]. Crit Care (2004) 0.90

Validation of a PCR for diagnosis of typhoid fever and salmonellosis by amplification of the hilA gene in clinical samples from Colombian patients. J Med Microbiol (2004) 0.90

Comparison of conventional culture with SeptiFast real-time PCR for microbial pathogen detection in clinical specimens other than blood. J Med Microbiol (2011) 0.89

Epidemiology of invasive fungal infections in the mediterranean area. Mediterr J Hematol Infect Dis (2011) 0.89

Multiparametric determination of genes and their point mutations for identification of beta-lactamases. Biochemistry (Mosc) (2010) 0.89

Direct identification of gram-positive cocci from routine blood cultures by using AccuProbe tests. J Clin Microbiol (2004) 0.89

Analytical validation of a novel high multiplexing real-time PCR array for the identification of key pathogens causative of bacterial ventilator-associated pneumonia and their associated resistance genes. J Antimicrob Chemother (2012) 0.88

Utility of peptide nucleic acid fluorescence in situ hybridization for rapid detection of Acinetobacter spp. and Pseudomonas aeruginosa. J Clin Microbiol (2008) 0.87

Rapid qualitative urinary tract infection pathogen identification by SeptiFast real-time PCR. PLoS One (2011) 0.87

Use of the LightCycler SeptiFast test for rapid etiologic diagnosis of nosocomial infection in gynecological sepsis. Gynecol Obstet Invest (2010) 0.86

Prevention of primary bacteraemia. Int J Antimicrob Agents (2007) 0.84

Evaluation of the BD GeneOhm StaphSR assay for detection of Staphylococcus aureus in patients in intensive care units. J Microbiol Immunol Infect (2011) 0.83

Performance of the LightCycler SeptiFast test Mgrade in detecting microbial pathogens in purulent fluids. J Clin Microbiol (2011) 0.83

Articles by these authors

De novo bacterial genome sequencing: millions of very short reads assembled on a desktop computer. Genome Res (2008) 14.90

Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA (2008) 7.60

The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol (2005) 5.86

Awake fiberoptic or awake video laryngoscopic tracheal intubation in patients with anticipated difficult airway management: a randomized clinical trial. Anesthesiology (2012) 5.57

Metagenomic study of the oral microbiota by Illumina high-throughput sequencing. J Microbiol Methods (2009) 4.32

Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. Am J Respir Crit Care Med (2006) 4.15

Comparison of two matrix-assisted laser desorption ionization-time of flight mass spectrometry methods with conventional phenotypic identification for routine identification of bacteria to the species level. J Clin Microbiol (2010) 4.14

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol (2013) 4.04

Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries. Lancet Infect Dis (2010) 3.65

Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding. Antimicrob Agents Chemother (2007) 3.54

Rapid detection of methicillin-resistant Staphylococcus aureus directly from sterile or nonsterile clinical samples by a new molecular assay. J Clin Microbiol (2003) 3.27

Meticillin-resistant Staphylococcus aureus. Lancet Infect Dis (2005) 3.18

Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action. Antimicrob Resist Infect Control (2012) 3.02

Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am J Respir Crit Care Med (2007) 2.88

Health-care workers: source, vector, or victim of MRSA? Lancet Infect Dis (2008) 2.79

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection. Blood (2010) 2.69

Society's failure to protect a precious resource: antibiotics. Lancet (2011) 2.51

Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes (2011) 2.46

Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ (2013) 2.40

Adequacy of antimicrobial treatment and outcome of Staphylococcus aureus bacteremia in 9 Western European countries. Clin Infect Dis (2009) 2.39

Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. Crit Care Med (2015) 2.37

Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes. Emerg Infect Dis (2004) 2.35

Livestock-associated methicillin-resistant Staphylococcus aureus in humans, Europe. Emerg Infect Dis (2011) 2.35

Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation. Crit Care Med (2004) 2.33

A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection. Clin Infect Dis (2004) 2.22

Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia. BMC Infect Dis (2007) 2.11

Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypes. Infect Immun (2002) 2.08

Use of PCR coupled with electrospray ionization mass spectrometry for rapid identification of bacterial and yeast bloodstream pathogens from blood culture bottles. J Clin Microbiol (2010) 2.06

Study of inter- and intra-individual variations in the salivary microbiota. BMC Genomics (2010) 2.01

Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus. J Clin Microbiol (2007) 1.97

Evaluating the probability of previously unknown carriage of MRSA at hospital admission. Am J Med (2006) 1.90

A call for action: the application of The International Health Regulations to the global threat of antimicrobial resistance. PLoS Med (2011) 1.88

Use of an automated multiple-locus, variable-number tandem repeat-based method for rapid and high-throughput genotyping of Staphylococcus aureus isolates. J Clin Microbiol (2005) 1.88

Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study. Crit Care (2006) 1.86

Current trends in rapid diagnostics for methicillin-resistant Staphylococcus aureus and glycopeptide-resistant enterococcus species. J Clin Microbiol (2008) 1.81

A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation. Nucleic Acids Res (2009) 1.81

Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains. Antimicrob Agents Chemother (2009) 1.76

A global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cells. BMC Genomics (2007) 1.73

Robustness of a loop-mediated isothermal amplification reaction for diagnostic applications. FEMS Immunol Med Microbiol (2011) 1.71

Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii. Antimicrob Agents Chemother (2011) 1.71

Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia [ISRCTN04176397]. Crit Care (2006) 1.70

Noma: an "infectious" disease of unknown aetiology. Lancet Infect Dis (2003) 1.70

CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression. J Bacteriol (2009) 1.68

Trends in the treatment of orthopaedic prosthetic infections. J Antimicrob Chemother (2003) 1.64

A novel multiplex real-time PCR assay for rapid typing of major staphylococcal cassette chromosome mec elements. J Clin Microbiol (2004) 1.63

Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study. Clin Infect Dis (2011) 1.62

Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile. J Antimicrob Chemother (2008) 1.60

Isolation and characterization of biofilm formation-defective mutants of Staphylococcus aureus. Infect Immun (2006) 1.58

Quantifying uncertainty: physicians' estimates of infection in critically ill neonates and children. Clin Infect Dis (2004) 1.57

Differentiating osteoarticular infections caused by Kingella kingae from those due to typical pathogens in young children. Pediatr Infect Dis J (2011) 1.55

Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, Switzerland. J Antimicrob Chemother (2011) 1.54

Small risk of osteoarticular infections in children with asymptomatic oropharyngeal carriage of Kingella kingae. Pediatr Infect Dis J (2012) 1.54

Emergence of unusual bloodstream infections associated with pig-borne-like Staphylococcus aureus ST398 in France. Clin Infect Dis (2011) 1.53

Is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit? J Clin Microbiol (2007) 1.51

Use of benchmarking and public reporting for infection control in four high-income countries. Lancet Infect Dis (2011) 1.50

Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care (2005) 1.49

Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism. J Virol (2013) 1.47

Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus. BMC Microbiol (2009) 1.46

Cartography of methicillin-resistant S. aureus transcripts: detection, orientation and temporal expression during growth phase and stress conditions. PLoS One (2010) 1.46

Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue. Front Microbiol (2011) 1.46

The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression. PLoS Pathog (2012) 1.46

Exploring glycopeptide-resistance in Staphylococcus aureus: a combined proteomics and transcriptomics approach for the identification of resistance-related markers. BMC Genomics (2006) 1.45

Detection of Mycoplasma pneumoniae in respiratory samples by real-time PCR using an inhibition control. J Microbiol Methods (2003) 1.44

Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus. J Infect Dis (2010) 1.43

De novo finished 2.8 Mbp Staphylococcus aureus genome assembly from 100 bp short and long range paired-end reads. Bioinformatics (2013) 1.43

Comparative analysis of PCR-electrospray ionization/mass spectrometry (MS) and MALDI-TOF/MS for the identification of bacteria and yeast from positive blood culture bottles. Clin Chem (2011) 1.41

A generic approach for the design of whole-genome oligoarrays, validated for genomotyping, deletion mapping and gene expression analysis on Staphylococcus aureus. BMC Genomics (2005) 1.41

A recA-LexA-dependent pathway mediates ciprofloxacin-induced fibronectin binding in Staphylococcus aureus. J Biol Chem (2003) 1.41

A type III-like restriction endonuclease functions as a major barrier to horizontal gene transfer in clinical Staphylococcus aureus strains. Proc Natl Acad Sci U S A (2010) 1.40

Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact. Am J Respir Crit Care Med (2004) 1.40

Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid identification of Beta-hemolytic streptococci. J Clin Microbiol (2011) 1.39

Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitis. J Infect Dis (2005) 1.39

Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance. BMC Genomics (2009) 1.39

'The body gets used to them': patients' interpretations of antibiotic resistance and the implications for containment strategies. J Gen Intern Med (2011) 1.39

[Circulatory collapse in bodybuilder during anaesthesia]. Ugeskr Laeger (2010) 1.38

Haemostasis and safety measures before lumbar puncture in the haematology ward: the Danish routines. Acta Haematol (2014) 1.38

A sensitive assay for virus discovery in respiratory clinical samples. PLoS One (2011) 1.33

Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new specific real-time PCR assay to the diagnosis. J Pediatr Orthop (2010) 1.32

Comparison of four chromogenic media for culture-based screening of meticillin-resistant Staphylococcus aureus. J Med Microbiol (2007) 1.31

Reliability of nucleic acid amplification methods for detection of Chlamydia trachomatis in urine: results of the first international collaborative quality control study among 96 laboratories. J Clin Microbiol (2003) 1.30

Correlation of daptomycin resistance in a clinical Staphylococcus aureus strain with increased cell wall teichoic acid production and D-alanylation. Antimicrob Agents Chemother (2011) 1.30

Evaluation of chromogenic media for detection of methicillin-resistant Staphylococcus aureus. J Clin Microbiol (2010) 1.30

High prevalence of the arginine catabolic mobile element in carriage isolates of methicillin-resistant Staphylococcus epidermidis. J Antimicrob Chemother (2010) 1.28

Prevalence and prediction of previously unknown MRSA carriage on admission to a geriatric hospital. Age Ageing (2005) 1.27

Should this event be notified to the World Health Organization? Reliability of the international health regulations notification assessment process. Bull World Health Organ (2011) 1.27

Methicillin-susceptible ST398 Staphylococcus aureus responsible for bloodstream infections: an emerging human-adapted subclone? PLoS One (2011) 1.25

Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of Clostridium difficile-associated diarrhea in hospitalized patients. Antimicrob Agents Chemother (2009) 1.22

Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005. Emerg Infect Dis (2008) 1.21

Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidis. FEMS Immunol Med Microbiol (2003) 1.21

Comparative efficacy of daptomycin and vancomycin in the therapy of experimental foreign body infection due to Staphylococcus aureus. J Antimicrob Chemother (2003) 1.21

The CodY pleiotropic repressor controls virulence in gram-positive pathogens. FEMS Immunol Med Microbiol (2011) 1.20

Gram-negative bacteremia upon hospital admission: when should Pseudomonas aeruginosa be suspected? Clin Infect Dis (2009) 1.19