PubRank

Wolfgang Hillen

Author PubWeight™ 79.04‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nat Med 2007 2.76
2 Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem 2003 2.03
3 Global control of sugar metabolism: a gram-positive solution. Antonie Van Leeuwenhoek 2002 1.98
4 Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res 2005 1.74
5 Silencing Mycobacterium smegmatis by using tetracycline repressors. J Bacteriol 2007 1.66
6 A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo. Nucleic Acids Res 2004 1.66
7 Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. Am J Physiol Cell Physiol 2005 1.59
8 Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell 2004 1.58
9 Conditional gene expression by controlling translation with tetracycline-binding aptamers. Nucleic Acids Res 2003 1.57
10 Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators. Hum Gene Ther 2002 1.50
11 Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. J Antimicrob Chemother 2004 1.42
12 An optimized conditional suicide switch using doxycycline-dependent expression of human tBid. Cancer Biol Ther 2005 1.39
13 Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. Nucleic Acids Res 2004 1.38
14 Inducible DNA-loop formation blocks transcriptional activation by an SV40 enhancer. EMBO J 2005 1.33
15 The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol 2008 1.33
16 Activity reversal of Tet repressor caused by single amino acid exchanges. Mol Microbiol 2004 1.20
17 Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes. J Bacteriol 2006 1.18
18 Teaching TetR to recognize a new inducer. J Mol Biol 2003 1.17
19 Tetracycline-dependent conditional gene knockout in Bacillus subtilis. Appl Environ Microbiol 2005 1.09
20 Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res 2005 1.04
21 Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis. FEBS J 2005 1.04
22 Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. J Mol Biol 2007 1.02
23 Mycoplasma pneumoniae HPr kinase/phosphorylase. Eur J Biochem 2004 1.02
24 Single-chain Tet transregulators. Nucleic Acids Res 2003 0.97
25 Structure-based design of Tet repressor to optimize a new inducer specificity. Biochemistry 2004 0.97
26 HPr kinase/phosphatase of Bacillus subtilis: expression of the gene and effects of mutations on enzyme activity, growth and carbon catabolite repression. Microbiology 2002 0.96
27 A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting. MAbs 2011 0.95
28 Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. J Biol Chem 2005 0.95
29 Quantification of the influence of HPrSer46P on CcpA-cre interaction. J Mol Biol 2002 0.95
30 Engineered Tet repressors with recognition specificity for the tetO-4C5G operator variant. Gene 2007 0.95
31 Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors. Cancer Res 2004 0.94
32 A gene regulation system with four distinct expression levels. J Gene Med 2006 0.93
33 High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis. BMC Genomics 2012 0.93
34 Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Res 2010 0.92
35 Tet repressor mutants with altered effector binding and allostery. FEBS J 2005 0.91
36 CcpA forms complexes with CodY and RpoA in Bacillus subtilis. FEBS J 2012 0.91
37 A novel mode of control of Mycoplasma pneumoniae HPr kinase/phosphatase activity reflects its parasitic lifestyle. Microbiology 2002 0.90
38 The transcription regulator RbsR represents a novel interaction partner of the phosphoprotein HPr-Ser46-P in Bacillus subtilis. FEBS J 2006 0.90
39 Adjusting transgene expression levels in lymphocytes with a set of inducible promoters. J Gene Med 2010 0.90
40 An exclusive α/β code directs allostery in TetR-peptide complexes. J Mol Biol 2011 0.89
41 How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor. J Mol Biol 2007 0.89
42 Gene regulation by tetracyclines. Genet Eng (N Y) 2004 0.89
43 An RNA aptamer that induces transcription. Chem Biol 2009 0.89
44 Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes. J Bacteriol 2006 0.89
45 Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae. J Mol Biol 2003 0.88
46 Cloning, sequencing, and characterization of the genetic region relevant to biosynthesis of the lipopeptides iturin A and surfactin in Bacillus subtilis. Curr Microbiol 2003 0.87
47 Transactivator mutants with altered effector specificity allow selective regulation of two genes by tetracycline variants. Gene 2004 0.87
48 Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex. J Biol Inorg Chem 2008 0.87
49 A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR. Nucleic Acids Res 2008 0.87
50 A peptide triggers allostery in tet repressor by binding to a unique site. J Biol Chem 2005 0.87
51 Short peptides act as inducers, anti-inducers and corepressors of Tet repressor. J Mol Biol 2011 0.86
52 Random insertion of a TetR-inducing peptide tag into Escherichia coli proteins allows analysis of protein levels by induction of reporter gene expression. Appl Environ Microbiol 2006 0.84
53 Tet repressor residues indirectly recognizing anhydrotetracycline. Eur J Biochem 2004 0.84
54 Induction of single chain tetracycline repressor requires the binding of two inducers. Nucleic Acids Res 2006 0.84
55 Integrative elements for Bacillus subtilis yielding tetracycline-dependent growth phenotypes. Nucleic Acids Res 2005 0.84
56 CcpA mutants with differential activities in Bacillus subtilis. J Mol Microbiol Biotechnol 2007 0.82
57 Improved single-chain transactivators of the Tet-On gene expression system. BMC Biotechnol 2007 0.81
58 Subtype selective tetracycline agonists and their application for a two-stage regulatory system. Chembiochem 2006 0.81
59 Tetracycline derivatives: alternative effectors for Tet transregulators. Biotechniques 2004 0.80
60 Residues His-15 and Arg-17 of HPr participate differently in catabolite signal processing via CcpA. J Biol Chem 2006 0.80
61 Efficient and exclusive induction of Tet repressor by the oligopeptide Tip results from co-variation of their interaction site. Nucleic Acids Res 2007 0.80
62 A short autonomous repression motif is located within the N-terminal domain of CTCF. FEBS Lett 2004 0.80
63 Phenotypes of combined tet repressor mutants for effector and operator recognition and allostery. J Mol Microbiol Biotechnol 2004 0.80
64 Generating tetracycline-inducible auxotrophy in Escherichia coli and Salmonella enterica serovar Typhimurium by using an insertion element and a hyperactive transposase. Appl Environ Microbiol 2006 0.79
65 Independent regulation of two genes in Escherichia coli by tetracyclines and Tet repressor variants. J Bacteriol 2004 0.79
66 Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis. FEMS Microbiol Lett 2006 0.79
67 Functionally important residues of the Tet repressor inducing peptide TIP determined by a complete mutational analysis. Gene 2008 0.79
68 Promoter strength driving TetR determines the regulatory properties of Tet-controlled expression systems. PLoS One 2012 0.78
69 Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations. Chembiochem 2009 0.78
70 Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae. Acta Crystallogr D Biol Crystallogr 2002 0.78
71 Cross communication between components of carbon catabolite repression of Lactobacillus casei and Bacillus megaterium. J Mol Microbiol Biotechnol 2002 0.78
72 A novel method to analyze nucleocytoplasmic transport in vivo by using short peptide tags. J Mol Biol 2013 0.77
73 Complementation of a Delta ccpA mutant of Lactobacillus casei with CcpA mutants affected in the DNA- and cofactor-binding domains. Microbiology 2004 0.77
74 In vivo activation of tetracycline repressor by Cre/lox-mediated gene assembly. J Mol Microbiol Biotechnol 2009 0.77
75 Carbon source control of the phosphorylation state of the Bacillus subtilis carbon-flux regulator Crh in vivo. FEMS Microbiol Lett 2011 0.76
76 Protein expression can be monitored in yeast by peptide-mediated induction of TetR-controlled gene expression. J Biotechnol 2012 0.75
77 Tetracycline sensing using novel doxycycline derivatives immobilized on different surface plasmon resonance biosensor surfaces. Bioanalysis 2010 0.75
78 How does Mg(2+) affect the binding of anhydrotetracycline in the TetR protein? Photochem Photobiol Sci 2004 0.75
79 Pressure effect on the structure of the Tet repressor protein TetR(B). Photochem Photobiol Sci 2002 0.75
80 Conditional cell suicide using dox-dependent caspase-2 expression. J Gene Med 2003 0.75
81 Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems. Bioorg Med Chem 2010 0.75
82 Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. FEBS J 2009 0.75
83 Click-chemistry-derived tetracycline-amino acid conjugates exhibiting exceptional potency and exclusive recognition of the reverse tet repressor. Chembiochem 2010 0.75
84 Complex formation between malate dehydrogenase and isocitrate dehydrogenase from Bacillus subtilis is regulated by tricarboxylic acid cycle metabolites. FEBS J 2014 0.75