Published in J Mol Biol on May 30, 2003
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res (2005) 4.00
Laboratory-directed protein evolution. Microbiol Mol Biol Rev (2005) 1.69
Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut. Cell (2017) 1.40
Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. Nucleic Acids Res (2004) 1.38
The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol (2008) 1.33
Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Sci Transl Med (2009) 1.30
Tetracycline-dependent conditional gene knockout in Bacillus subtilis. Appl Environ Microbiol (2005) 1.09
Selection of biocatalysts for chemical synthesis. Proc Natl Acad Sci U S A (2006) 0.95
Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone. Appl Environ Microbiol (2007) 0.94
Engineering an allosteric transcription factor to respond to new ligands. Nat Methods (2015) 0.87
Synthetic mammalian trigger-controlled bipartite transcription factors. Nucleic Acids Res (2013) 0.84
Improved single-chain transactivators of the Tet-On gene expression system. BMC Biotechnol (2007) 0.81
The chbG gene of the chitobiose (chb) operon of Escherichia coli encodes a chitooligosaccharide deacetylase. J Bacteriol (2012) 0.81
Generating tetracycline-inducible auxotrophy in Escherichia coli and Salmonella enterica serovar Typhimurium by using an insertion element and a hyperactive transposase. Appl Environ Microbiol (2006) 0.79
Independent regulation of two genes in Escherichia coli by tetracyclines and Tet repressor variants. J Bacteriol (2004) 0.79
Directed evolution of the transcriptional regulator DntR: isolation of mutants with improved DNT-response. PLoS One (2012) 0.77
Characterization of tetracycline modifying enzymes using a sensitive in vivo reporter system. BMC Biochem (2010) 0.77
Tetracycline-tet repressor binding specificity: insights from experiments and simulations. Biophys J (2009) 0.75
A microbial sensor for organophosphate hydrolysis exploiting an engineered specificity switch in a transcription factor. Nucleic Acids Res (2016) 0.75
Tailor-made transcriptional biosensors for optimizing microbial cell factories. J Ind Microbiol Biotechnol (2016) 0.75
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nat Med (2007) 2.76
Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem (2003) 2.03
Global control of sugar metabolism: a gram-positive solution. Antonie Van Leeuwenhoek (2002) 1.98
Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res (2005) 1.74
Silencing Mycobacterium smegmatis by using tetracycline repressors. J Bacteriol (2007) 1.66
A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo. Nucleic Acids Res (2004) 1.66
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. Am J Physiol Cell Physiol (2005) 1.59
Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell (2004) 1.58
Conditional gene expression by controlling translation with tetracycline-binding aptamers. Nucleic Acids Res (2003) 1.57
Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators. Hum Gene Ther (2002) 1.50
Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. J Antimicrob Chemother (2004) 1.42
An optimized conditional suicide switch using doxycycline-dependent expression of human tBid. Cancer Biol Ther (2005) 1.39
Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. Nucleic Acids Res (2004) 1.38
Inducible DNA-loop formation blocks transcriptional activation by an SV40 enhancer. EMBO J (2005) 1.33
The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol (2008) 1.33
Activity reversal of Tet repressor caused by single amino acid exchanges. Mol Microbiol (2004) 1.20
Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes. J Bacteriol (2006) 1.18
Tetracycline-dependent conditional gene knockout in Bacillus subtilis. Appl Environ Microbiol (2005) 1.09
Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res (2005) 1.04
Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis. FEBS J (2005) 1.04
Mycoplasma pneumoniae HPr kinase/phosphorylase. Eur J Biochem (2004) 1.02
Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. J Mol Biol (2007) 1.02
Single-chain Tet transregulators. Nucleic Acids Res (2003) 0.97
Structure-based design of Tet repressor to optimize a new inducer specificity. Biochemistry (2004) 0.97
HPr kinase/phosphatase of Bacillus subtilis: expression of the gene and effects of mutations on enzyme activity, growth and carbon catabolite repression. Microbiology (2002) 0.96
A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting. MAbs (2011) 0.95
Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. J Biol Chem (2005) 0.95
Quantification of the influence of HPrSer46P on CcpA-cre interaction. J Mol Biol (2002) 0.95
Engineered Tet repressors with recognition specificity for the tetO-4C5G operator variant. Gene (2007) 0.95
Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors. Cancer Res (2004) 0.94
A gene regulation system with four distinct expression levels. J Gene Med (2006) 0.93
High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis. BMC Genomics (2012) 0.93
Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Res (2010) 0.92
The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol (2007) 0.92
CcpA forms complexes with CodY and RpoA in Bacillus subtilis. FEBS J (2012) 0.91
Tet repressor mutants with altered effector binding and allostery. FEBS J (2005) 0.91
The transcription regulator RbsR represents a novel interaction partner of the phosphoprotein HPr-Ser46-P in Bacillus subtilis. FEBS J (2006) 0.90
Adjusting transgene expression levels in lymphocytes with a set of inducible promoters. J Gene Med (2010) 0.90
A novel mode of control of Mycoplasma pneumoniae HPr kinase/phosphatase activity reflects its parasitic lifestyle. Microbiology (2002) 0.90
Gene regulation by tetracyclines. Genet Eng (N Y) (2004) 0.89
An exclusive α/β code directs allostery in TetR-peptide complexes. J Mol Biol (2011) 0.89
How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor. J Mol Biol (2007) 0.89
Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes. J Bacteriol (2006) 0.89
An RNA aptamer that induces transcription. Chem Biol (2009) 0.89
Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae. J Mol Biol (2003) 0.88
Cloning, sequencing, and characterization of the genetic region relevant to biosynthesis of the lipopeptides iturin A and surfactin in Bacillus subtilis. Curr Microbiol (2003) 0.87
Transactivator mutants with altered effector specificity allow selective regulation of two genes by tetracycline variants. Gene (2004) 0.87
A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR. Nucleic Acids Res (2008) 0.87
Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex. J Biol Inorg Chem (2008) 0.87
A peptide triggers allostery in tet repressor by binding to a unique site. J Biol Chem (2005) 0.87
Short peptides act as inducers, anti-inducers and corepressors of Tet repressor. J Mol Biol (2011) 0.86
Random insertion of a TetR-inducing peptide tag into Escherichia coli proteins allows analysis of protein levels by induction of reporter gene expression. Appl Environ Microbiol (2006) 0.84
Integrative elements for Bacillus subtilis yielding tetracycline-dependent growth phenotypes. Nucleic Acids Res (2005) 0.84
Tet repressor residues indirectly recognizing anhydrotetracycline. Eur J Biochem (2004) 0.84
Induction of single chain tetracycline repressor requires the binding of two inducers. Nucleic Acids Res (2006) 0.84
CcpA mutants with differential activities in Bacillus subtilis. J Mol Microbiol Biotechnol (2007) 0.82
Subtype selective tetracycline agonists and their application for a two-stage regulatory system. Chembiochem (2006) 0.81
Improved single-chain transactivators of the Tet-On gene expression system. BMC Biotechnol (2007) 0.81
A short autonomous repression motif is located within the N-terminal domain of CTCF. FEBS Lett (2004) 0.80
Tetracycline derivatives: alternative effectors for Tet transregulators. Biotechniques (2004) 0.80
Residues His-15 and Arg-17 of HPr participate differently in catabolite signal processing via CcpA. J Biol Chem (2006) 0.80
Phenotypes of combined tet repressor mutants for effector and operator recognition and allostery. J Mol Microbiol Biotechnol (2004) 0.80
Efficient and exclusive induction of Tet repressor by the oligopeptide Tip results from co-variation of their interaction site. Nucleic Acids Res (2007) 0.80
Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis. FEMS Microbiol Lett (2006) 0.79
Generating tetracycline-inducible auxotrophy in Escherichia coli and Salmonella enterica serovar Typhimurium by using an insertion element and a hyperactive transposase. Appl Environ Microbiol (2006) 0.79
Functionally important residues of the Tet repressor inducing peptide TIP determined by a complete mutational analysis. Gene (2008) 0.79
Independent regulation of two genes in Escherichia coli by tetracyclines and Tet repressor variants. J Bacteriol (2004) 0.79
Promoter strength driving TetR determines the regulatory properties of Tet-controlled expression systems. PLoS One (2012) 0.78
Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae. Acta Crystallogr D Biol Crystallogr (2002) 0.78
Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations. Chembiochem (2009) 0.78
Cross communication between components of carbon catabolite repression of Lactobacillus casei and Bacillus megaterium. J Mol Microbiol Biotechnol (2002) 0.78
A novel method to analyze nucleocytoplasmic transport in vivo by using short peptide tags. J Mol Biol (2013) 0.77
Complementation of a Delta ccpA mutant of Lactobacillus casei with CcpA mutants affected in the DNA- and cofactor-binding domains. Microbiology (2004) 0.77
In vivo activation of tetracycline repressor by Cre/lox-mediated gene assembly. J Mol Microbiol Biotechnol (2009) 0.77
Carbon source control of the phosphorylation state of the Bacillus subtilis carbon-flux regulator Crh in vivo. FEMS Microbiol Lett (2011) 0.76
Tetracycline sensing using novel doxycycline derivatives immobilized on different surface plasmon resonance biosensor surfaces. Bioanalysis (2010) 0.75
Protein expression can be monitored in yeast by peptide-mediated induction of TetR-controlled gene expression. J Biotechnol (2012) 0.75
Conditional cell suicide using dox-dependent caspase-2 expression. J Gene Med (2003) 0.75
How does Mg(2+) affect the binding of anhydrotetracycline in the TetR protein? Photochem Photobiol Sci (2004) 0.75
Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems. Bioorg Med Chem (2010) 0.75
Pressure effect on the structure of the Tet repressor protein TetR(B). Photochem Photobiol Sci (2002) 0.75
Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. FEBS J (2009) 0.75
Click-chemistry-derived tetracycline-amino acid conjugates exhibiting exceptional potency and exclusive recognition of the reverse tet repressor. Chembiochem (2010) 0.75
Complex formation between malate dehydrogenase and isocitrate dehydrogenase from Bacillus subtilis is regulated by tricarboxylic acid cycle metabolites. FEBS J (2014) 0.75