Published in Nucleic Acids Res on August 09, 2006
The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol (2008) 1.33
Oxidation of a single active site suffices for the functional inactivation of the dimeric Bacillus subtilis OhrR repressor in vitro. Nucleic Acids Res (2009) 0.95
Synthetic mammalian trigger-controlled bipartite transcription factors. Nucleic Acids Res (2013) 0.84
New architectures for Tet-on and Tet-off regulation in Staphylococcus aureus. Appl Environ Microbiol (2009) 0.83
Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion. Biochemistry (2011) 0.81
Tetracycline regulated systems in functional oncogenomics. Transl Oncogenomics (2007) 0.79
Tetracycline-tet repressor binding specificity: insights from experiments and simulations. Biophys J (2009) 0.75
Transcription activation by catabolite activator protein (CAP). J Mol Biol (1999) 6.08
The TetR family of transcriptional repressors. Microbiol Mol Biol Rev (2005) 6.02
The regulation of bacterial transcription initiation. Nat Rev Microbiol (2004) 5.94
Homology requirements for recombination in Escherichia coli. Proc Natl Acad Sci U S A (1985) 4.46
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res (2005) 4.00
Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat Struct Biol (2000) 3.90
The MerR family of transcriptional regulators. FEMS Microbiol Rev (2003) 3.30
Structural mechanisms of QacR induction and multidrug recognition. Science (2001) 3.10
A chimeric transactivator allows tetracycline-responsive gene expression in whole plants. Plant J (1994) 2.73
Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem (2003) 2.03
Prokaryotic transcription regulators: more than just the helix-turn-helix motif. Curr Opin Struct Biol (2002) 1.94
Optimizing the stability of single-chain proteins by linker length and composition mutagenesis. Proc Natl Acad Sci U S A (1998) 1.87
The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance. J Mol Biol (1995) 1.78
Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. Nucleic Acids Res (2004) 1.38
The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. J Mol Biol (1998) 1.37
Activity reversal of Tet repressor caused by single amino acid exchanges. Mol Microbiol (2004) 1.20
Tetracycline-dependent conditional gene knockout in Bacillus subtilis. Appl Environ Microbiol (2005) 1.09
Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer. Protein Sci (2003) 1.03
Characterization of non-inducible Tet repressor mutants suggests conformational changes necessary for induction. Nat Struct Biol (1995) 1.01
The structure of full-length LysR-type transcriptional regulators. Modeling of the full-length OxyR transcription factor dimer. Nucleic Acids Res (2003) 1.01
Tet repressor induction without Mg2+. Biochemistry (2000) 1.00
Combinations of the alpha-helix-turn-alpha-helix motif of TetR with respective residues from LacI or 434Cro: DNA recognition, inducer binding, and urea-dependent denaturation. Biochemistry (1997) 1.00
Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor. EMBO J (1998) 0.99
Structure-based design of Tet repressor to optimize a new inducer specificity. Biochemistry (2004) 0.97
Single-chain Tet transregulators. Nucleic Acids Res (2003) 0.97
Fast large-scale purification of tetracycline repressor variants from overproducing Escherichia coli strains. J Chromatogr A (1996) 0.95
Tet repressor mutants with altered effector binding and allostery. FEBS J (2005) 0.91
Mutagenesis of the cysteines in the metalloregulatory protein MerR indicates that a metal-bridged dimer activates transcription. Biochemistry (1989) 0.91
Single-chain repressors containing engineered DNA-binding domains of the phage 434 repressor recognize symmetric or asymmetric DNA operators. J Mol Biol (1997) 0.90
Tet repressor residues indirectly recognizing anhydrotetracycline. Eur J Biochem (2004) 0.84
High-level expression of the mycobacterial porin MspA in Escherichia coli and purification of the recombinant protein. J Chromatogr B Analyt Technol Biomed Life Sci (2003) 0.84
Single-chain lambda Cro repressors confirm high intrinsic dimer-DNA affinity. Biochemistry (1998) 0.84
Identification of a stability determinant on the edge of the Tet repressor four-helix bundle dimerization motif. Biochemistry (2001) 0.83
Kinetic and thermodynamic studies of tet repressor-tetracycline interaction. Biochemistry (2005) 0.80
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nat Med (2007) 2.76
Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur J Biochem (2003) 2.03
Global control of sugar metabolism: a gram-positive solution. Antonie Van Leeuwenhoek (2002) 1.98
Stringent doxycycline-dependent control of gene activities using an episomal one-vector system. Nucleic Acids Res (2005) 1.74
Silencing Mycobacterium smegmatis by using tetracycline repressors. J Bacteriol (2007) 1.66
A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo. Nucleic Acids Res (2004) 1.66
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. Am J Physiol Cell Physiol (2005) 1.59
Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell (2004) 1.58
Conditional gene expression by controlling translation with tetracycline-binding aptamers. Nucleic Acids Res (2003) 1.57
Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate. FEMS Microbiol Lett (2013) 1.54
Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators. Hum Gene Ther (2002) 1.50
Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. J Antimicrob Chemother (2004) 1.42
An optimized conditional suicide switch using doxycycline-dependent expression of human tBid. Cancer Biol Ther (2005) 1.39
Two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor. Nucleic Acids Res (2004) 1.38
Inducible DNA-loop formation blocks transcriptional activation by an SV40 enhancer. EMBO J (2005) 1.33
The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol (2008) 1.33
Staphylococcus aureus persisters tolerant to bactericidal antibiotics. J Mol Microbiol Biotechnol (2012) 1.25
Activity reversal of Tet repressor caused by single amino acid exchanges. Mol Microbiol (2004) 1.20
Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes. J Bacteriol (2006) 1.18
Marker removal in staphylococci via Cre recombinase and different lox sites. Appl Environ Microbiol (2007) 1.18
Teaching TetR to recognize a new inducer. J Mol Biol (2003) 1.17
Small-colony variant selection as a survival strategy for Staphylococcus aureus in the presence of Pseudomonas aeruginosa. Appl Environ Microbiol (2009) 1.16
Tetracycline-dependent conditional gene knockout in Bacillus subtilis. Appl Environ Microbiol (2005) 1.09
Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucleic Acids Res (2005) 1.04
Quantitative interdependence of coeffectors, CcpA and cre in carbon catabolite regulation of Bacillus subtilis. FEBS J (2005) 1.04
Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. J Mol Biol (2007) 1.02
Mycoplasma pneumoniae HPr kinase/phosphorylase. Eur J Biochem (2004) 1.02
Structure-based design of Tet repressor to optimize a new inducer specificity. Biochemistry (2004) 0.97
Single-chain Tet transregulators. Nucleic Acids Res (2003) 0.97
HPr kinase/phosphatase of Bacillus subtilis: expression of the gene and effects of mutations on enzyme activity, growth and carbon catabolite repression. Microbiology (2002) 0.96
Vectors for improved Tet repressor-dependent gradual gene induction or silencing in Staphylococcus aureus. Microbiology (2011) 0.96
A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting. MAbs (2011) 0.95
Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. J Biol Chem (2005) 0.95
Engineered Tet repressors with recognition specificity for the tetO-4C5G operator variant. Gene (2007) 0.95
Quantification of the influence of HPrSer46P on CcpA-cre interaction. J Mol Biol (2002) 0.95
Characterization of a mazEF toxin-antitoxin homologue from Staphylococcus equorum. J Bacteriol (2012) 0.95
Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors. Cancer Res (2004) 0.94
A gene regulation system with four distinct expression levels. J Gene Med (2006) 0.93
High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis. BMC Genomics (2012) 0.93
Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Res (2010) 0.92
CcpA forms complexes with CodY and RpoA in Bacillus subtilis. FEBS J (2012) 0.91
Tet repressor mutants with altered effector binding and allostery. FEBS J (2005) 0.91
A novel mode of control of Mycoplasma pneumoniae HPr kinase/phosphatase activity reflects its parasitic lifestyle. Microbiology (2002) 0.90
Adjusting transgene expression levels in lymphocytes with a set of inducible promoters. J Gene Med (2010) 0.90
The transcription regulator RbsR represents a novel interaction partner of the phosphoprotein HPr-Ser46-P in Bacillus subtilis. FEBS J (2006) 0.90
An RNA aptamer that induces transcription. Chem Biol (2009) 0.89
Gene regulation by tetracyclines. Genet Eng (N Y) (2004) 0.89
Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes. J Bacteriol (2006) 0.89
How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor. J Mol Biol (2007) 0.89
An exclusive α/β code directs allostery in TetR-peptide complexes. J Mol Biol (2011) 0.89
Two paralogous yefM-yoeB loci from Staphylococcus equorum encode functional toxin-antitoxin systems. Microbiology (2013) 0.89
Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae. J Mol Biol (2003) 0.88
Cloning, sequencing, and characterization of the genetic region relevant to biosynthesis of the lipopeptides iturin A and surfactin in Bacillus subtilis. Curr Microbiol (2003) 0.87
A protein functional leap: how a single mutation reverses the function of the transcription regulator TetR. Nucleic Acids Res (2008) 0.87
Transactivator mutants with altered effector specificity allow selective regulation of two genes by tetracycline variants. Gene (2004) 0.87
Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex. J Biol Inorg Chem (2008) 0.87
A peptide triggers allostery in tet repressor by binding to a unique site. J Biol Chem (2005) 0.87
Short peptides act as inducers, anti-inducers and corepressors of Tet repressor. J Mol Biol (2011) 0.86
Random insertion of a TetR-inducing peptide tag into Escherichia coli proteins allows analysis of protein levels by induction of reporter gene expression. Appl Environ Microbiol (2006) 0.84
Tet repressor residues indirectly recognizing anhydrotetracycline. Eur J Biochem (2004) 0.84
Integrative elements for Bacillus subtilis yielding tetracycline-dependent growth phenotypes. Nucleic Acids Res (2005) 0.84
New architectures for Tet-on and Tet-off regulation in Staphylococcus aureus. Appl Environ Microbiol (2009) 0.83
Intracellular monitoring of target protein production in Staphylococcus aureus by peptide tag-induced reporter fluorescence. Microb Biotechnol (2011) 0.83
Bovine mastitis associated with Prototheca blaschkeae. J Clin Microbiol (2008) 0.82
Catabolite control protein E (CcpE) is a LysR-type transcriptional regulator of tricarboxylic acid cycle activity in Staphylococcus aureus. J Biol Chem (2013) 0.82
CcpA mutants with differential activities in Bacillus subtilis. J Mol Microbiol Biotechnol (2007) 0.82
Interplay between population dynamics and drug tolerance of Staphylococcus aureus persister cells. J Mol Microbiol Biotechnol (2013) 0.82
An update on the molecular genetics toolbox for staphylococci. Microbiology (2013) 0.81
Subtype selective tetracycline agonists and their application for a two-stage regulatory system. Chembiochem (2006) 0.81
Improved single-chain transactivators of the Tet-On gene expression system. BMC Biotechnol (2007) 0.81
Glycodelin protein and mRNA is downregulated in human first trimester abortion and partially upregulated in mole pregnancy. J Histochem Cytochem (2008) 0.80
Residues His-15 and Arg-17 of HPr participate differently in catabolite signal processing via CcpA. J Biol Chem (2006) 0.80
Efficient and exclusive induction of Tet repressor by the oligopeptide Tip results from co-variation of their interaction site. Nucleic Acids Res (2007) 0.80
Phenotypes of combined tet repressor mutants for effector and operator recognition and allostery. J Mol Microbiol Biotechnol (2004) 0.80
A short autonomous repression motif is located within the N-terminal domain of CTCF. FEBS Lett (2004) 0.80
Tetracycline derivatives: alternative effectors for Tet transregulators. Biotechniques (2004) 0.80
Regulated expression of HPrK/P does not affect carbon catabolite repression of the xyn operon and of rocG in Bacillus subtilis. FEMS Microbiol Lett (2006) 0.79
Generating tetracycline-inducible auxotrophy in Escherichia coli and Salmonella enterica serovar Typhimurium by using an insertion element and a hyperactive transposase. Appl Environ Microbiol (2006) 0.79
Independent regulation of two genes in Escherichia coli by tetracyclines and Tet repressor variants. J Bacteriol (2004) 0.79
Functionally important residues of the Tet repressor inducing peptide TIP determined by a complete mutational analysis. Gene (2008) 0.79
Promoter strength driving TetR determines the regulatory properties of Tet-controlled expression systems. PLoS One (2012) 0.78
Cross communication between components of carbon catabolite repression of Lactobacillus casei and Bacillus megaterium. J Mol Microbiol Biotechnol (2002) 0.78
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of YvoA from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.78
Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae. Acta Crystallogr D Biol Crystallogr (2002) 0.78
Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations. Chembiochem (2009) 0.78
A novel method to analyze nucleocytoplasmic transport in vivo by using short peptide tags. J Mol Biol (2013) 0.77
Complementation of a Delta ccpA mutant of Lactobacillus casei with CcpA mutants affected in the DNA- and cofactor-binding domains. Microbiology (2004) 0.77
Characterization of multi-drug tolerant persister cells in Streptococcus suis. BMC Microbiol (2014) 0.77
In vivo activation of tetracycline repressor by Cre/lox-mediated gene assembly. J Mol Microbiol Biotechnol (2009) 0.77
Carbon source control of the phosphorylation state of the Bacillus subtilis carbon-flux regulator Crh in vivo. FEMS Microbiol Lett (2011) 0.76
Tetracycline sensing using novel doxycycline derivatives immobilized on different surface plasmon resonance biosensor surfaces. Bioanalysis (2010) 0.75
The mevalonate auxotrophic mutant of Staphylococcus aureus can adapt to mevalonate depletion. Antimicrob Agents Chemother (2013) 0.75
Protein expression can be monitored in yeast by peptide-mediated induction of TetR-controlled gene expression. J Biotechnol (2012) 0.75
Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems. Bioorg Med Chem (2010) 0.75
Pressure effect on the structure of the Tet repressor protein TetR(B). Photochem Photobiol Sci (2002) 0.75