PubRank

David M Wilson

Author PubWeight™ 128.15‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res 2006 4.20
2 A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 2012 4.08
3 Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol 2008 1.95
4 DNA repair mechanisms in dividing and non-dividing cells. DNA Repair (Amst) 2013 1.85
5 XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Res 2004 1.70
6 Is the use of arch bars or interdental wire fixation necessary for successful outcomes in the open reduction and internal fixation of mandibular angle fractures? J Oral Maxillofac Surg 2008 1.64
7 Estimating the effect of human base excision repair protein variants on the repair of oxidative DNA base damage. Cancer Epidemiol Biomarkers Prev 2006 1.59
8 Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res 2005 1.59
9 Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes. Mutat Res 2003 1.53
10 Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A 2011 1.52
11 A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Mol Cancer Res 2007 1.52
12 Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides. J Med Chem 2012 1.42
13 Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med 2012 1.42
14 Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic Biol Med 2005 1.42
15 Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev 2013 1.41
16 Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc 2009 1.38
17 Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice. PLoS Genet 2009 1.37
18 Overview of base excision repair biochemistry. Curr Mol Pharmacol 2012 1.36
19 Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol 2010 1.35
20 Human apurinic/apyrimidinic endonuclease 1. Antioxid Redox Signal 2013 1.34
21 The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res 2006 1.34
22 Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 2009 1.32
23 Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. Nucleic Acids Res 2004 1.31
24 GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther 2007 1.30
25 Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) 2008 1.27
26 Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB J 2010 1.25
27 Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett 2012 1.24
28 Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging 2011 1.23
29 Pathways for repairing and tolerating the spectrum of oxidative DNA lesions. Cancer Lett 2012 1.20
30 Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. J Mol Biol 2002 1.19
31 Aprataxin localizes to mitochondria and preserves mitochondrial function. Proc Natl Acad Sci U S A 2011 1.19
32 Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision. J Mol Biol 2008 1.19
33 Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism. Magn Reson Med 2010 1.18
34 Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res 2009 1.18
35 Direct and indirect roles of RECQL4 in modulating base excision repair capacity. Hum Mol Genet 2009 1.18
36 Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates. Nucleic Acids Res 2007 1.18
37 The involvement of DNA-damage and -repair defects in neurological dysfunction. Am J Hum Genet 2008 1.17
38 Molecular interactions of human Exo1 with DNA. Nucleic Acids Res 2002 1.16
39 Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. Cancer Res 2006 1.15
40 Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate 2013 1.15
41 Regulation of WRN helicase activity in human base excision repair. J Biol Chem 2004 1.15
42 Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas. Cancer Res 2012 1.13
43 Inhibition of Ape1 nuclease activity by lead, iron, and cadmium. Environ Health Perspect 2004 1.13
44 (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg Med Chem Lett 2005 1.12
45 Human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage. Nucleic Acids Res 2008 1.12
46 The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett 2005 1.07
47 XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes. J Exp Med 2011 1.06
48 Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era? Mol Cell Biol 2009 1.05
49 XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage. Environ Mol Mutagen 2011 1.05
50 Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int J Cancer 2012 1.04
51 A quantitative model of human DNA base excision repair. I. Mechanistic insights. Nucleic Acids Res 2002 1.04
52 Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. Nucleic Acids Res 2010 1.04
53 Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA. DNA Repair (Amst) 2004 1.02
54 A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Res 2009 1.00
55 XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair. J Cell Biochem 2005 0.99
56 XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells. Environ Mol Mutagen 2007 0.98
57 Modulation of DNA base excision repair during neuronal differentiation. Neurobiol Aging 2013 0.97
58 Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair (Amst) 2010 0.96
59 Repair of persistent strand breaks in the mitochondrial genome. Mech Ageing Dev 2011 0.96
60 Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice. Hum Mol Genet 2012 0.96
61 Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation. Nucleic Acids Res 2012 0.94
62 XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Nucleic Acids Res 2008 0.94
63 WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. Mech Ageing Dev 2006 0.94
64 XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility. Nucleic Acids Res 2011 0.94
65 Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem 2012 0.93
66 The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency. Mech Ageing Dev 2011 0.93
67 Human RECQL5 participates in the removal of endogenous DNA damage. Mol Biol Cell 2012 0.92
68 Nucleotide sequence and DNA secondary structure, as well as replication protein A, modulate the single-stranded abasic endonuclease activity of APE1. J Biol Chem 2005 0.92
69 The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. DNA Repair (Amst) 2012 0.92
70 Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med 2013 0.91
71 Disparity between DNA base excision repair in yeast and mammals: translational implications. Cancer Res 2003 0.91
72 The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats. Biochemistry 2012 0.91
73 In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging 2011 0.91
74 Base excision repair in the mammalian brain: implication for age related neurodegeneration. Mech Ageing Dev 2013 0.90
75 Diffusion MR of hyperpolarized 13C molecules in solution. Analyst 2013 0.90
76 Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients. Mech Ageing Dev 2004 0.90
77 Validity of protein-osmolality versus protein-creatinine ratios in the estimation of quantitative proteinuria from random samples of urine in children. Am J Kidney Dis 2003 0.90
78 Nucleic acid binding activity of human Cockayne syndrome B protein and identification of Ca(2+) as a novel metal cofactor. J Mol Biol 2009 0.89
79 Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1. Neurosurgery 2009 0.89
80 Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. Nucleic Acids Res 2010 0.88
81 A new in vivo screening paradigm to accelerate antimalarial drug discovery. PLoS One 2013 0.86
82 Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1. J Mol Biol 2003 0.86
83 S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity. J Mol Biol 2011 0.86
84 Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats. Biochem Pharmacol 2007 0.86
85 Somatostatin receptor-binding peptides suitable for tumor radiotherapy with Re-188 or Re-186. Chemistry and initial biological studies. J Med Chem 2007 0.86
86 Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1. Mol Carcinog 2007 0.86
87 The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett 2008 0.86
88 Targeting DNA repair proteins for cancer treatment. Cell Mol Life Sci 2010 0.86
89 DNA damage levels and biochemical repair capacities associated with XRCC1 deficiency. Biochemistry 2005 0.86
90 The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. J Biol Chem 2012 0.85
91 Effect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complex. Biophys J 2005 0.85
92 4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists. J Med Chem 2007 0.85
93 Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One 2011 0.85
94 Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds. Bioorg Med Chem 2010 0.85
95 Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability. DNA Repair (Amst) 2003 0.84
96 Functional assessment of population and tumor-associated APE1 protein variants. PLoS One 2013 0.84
97 Partial resection of the hyoid apparatus during surgical treatment of ectopic thyroid carcinomas in dogs: 5 cases (2011-2013). J Am Vet Med Assoc 2014 0.84
98 Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040. Psychopharmacology (Berl) 2008 0.84
99 Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1. J Mol Biol 2011 0.84
100 Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. Analyst 2012 0.83
101 NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks. J Biol Chem 2013 0.83
102 Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection. PLoS One 2012 0.81
103 (13)C MR reporter probe system using dynamic nuclear polarization. NMR Biomed 2010 0.81
104 Oxidative DNA damage background estimated by a system model of base excision repair. Free Radic Biol Med 2004 0.81
105 Comparison of the mechanical behaviors of locked and nonlocked plate/screw fixation applied to experimentally induced rotational osteotomies in canine ilia. Vet Surg 2011 0.80
106 Differential neural representation of oral ethanol by central taste-sensitive neurons in ethanol-preferring and genetically heterogeneous rats. J Neurophysiol 2011 0.80
107 Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy. Oncotarget 2014 0.80
108 Network biology as a new approach to drug discovery. Curr Opin Drug Discov Devel 2010 0.80
109 Plant-incorporated Bacillus thuringiensis resistance for control of fall armyworm and corn earworm (Lepidoptera: Noctuidae) in corn. J Econ Entomol 2004 0.80
110 Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb) 2015 0.78
111 A comparison of two pairing procedures to establish praise as a reinforcer. J Appl Behav Anal 2012 0.78
112 Antimalarial drug discovery: recent progress and future directions. Prog Med Chem 2013 0.77
113 (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg Med Chem Lett 2005 0.77
114 The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement. Bioorg Med Chem Lett 2012 0.76
115 Special issue on the segmental progeria Cockayne syndrome. Mech Ageing Dev 2013 0.76
116 The mitochondrial genome: dynamics, mechanisms of repair, and a target in disease and therapy. Environ Mol Mutagen 2010 0.75
117 Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry. PLoS One 2013 0.75
118 Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity. DNA Repair (Amst) 2003 0.75
119 The role of genetic association studies in identifying new drug targets. Curr Opin Drug Discov Devel 2008 0.75
120 Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition. Bioorg Med Chem Lett 2012 0.75
121 Changes in fungi and mycotoxins in pearl millet under controlled storage conditions. Mycopathologia 2007 0.75
122 Does supplementary reinforcement of stereotypy facilitate extinction? J Appl Behav Anal 2013 0.75
123 Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine. Bioorg Med Chem Lett 2010 0.75
124 The importance of target validation in drug discovery and development. Curr Opin Drug Discov Devel 2009 0.75