Base excision repair in the mammalian brain: implication for age related neurodegeneration.

PubWeight™: 0.90‹?›

🔗 View Article (PMC 3834072)

Published in Mech Ageing Dev on May 02, 2013

Authors

Peter Sykora1, David M Wilson, Vilhelm A Bohr

Author Affiliations

1: Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, United States.

Articles citing this

Human apurinic/apyrimidinic endonuclease 1. Antioxid Redox Signal (2013) 1.34

Recognition and repair of chemically heterogeneous structures at DNA ends. Environ Mol Mutagen (2014) 1.00

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. Nucleic Acids Res (2014) 0.96

Base excision repair capacity in informing healthspan. Carcinogenesis (2014) 0.84

Chromatin modifications associated with DNA double-strand breaks repair as potential targets for neurological diseases. Neurotherapeutics (2013) 0.81

Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators. Aging Dis (2013) 0.78

Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7. Drug Des Devel Ther (2015) 0.77

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease. Aging Cell (2016) 0.76

Behavioral and Neurochemical Deficits in Aging Rats with Increased Neonatal Iron Intake: Silibinin's Neuroprotection by Maintaining Redox Balance. Front Aging Neurosci (2015) 0.75

Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models. PLoS One (2014) 0.75

Aging in the cerebellum and hippocampus and associated behaviors over the adult life span of CB6F1 mice. Neuroscience (2013) 0.75

DNA damage in the oligodendrocyte lineage and its role in brain aging. Mech Ageing Dev (2016) 0.75

Genome instability in Alzheimer disease. Mech Ageing Dev (2016) 0.75

The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders. Int J Mol Sci (2017) 0.75

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells. Nucleic Acids Res (2017) 0.75

Articles cited by this

A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A (1999) 4.28

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A (1996) 3.34

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature (2005) 2.98

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86

Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol (1988) 2.78

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA. Nature (2002) 2.58

Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res (2001) 2.04

The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol Cell Biol (1999) 1.94

Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res (1998) 1.83

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta. EMBO J (2000) 1.70

The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst) (2005) 1.64

Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64

Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2. DNA Repair (Amst) (2005) 1.62

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo. Proc Natl Acad Sci U S A (2010) 1.61

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging (2005) 1.52

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature (2011) 1.45

Cellular bases of brain energy metabolism and their relevance to functional brain imaging: evidence for a prominent role of astrocytes. Cereb Cortex (1996) 1.44

Chick-embryo DNA polymerase gamma. Identity of gamma-polymerases purified from nuclei and mitochondria. Eur J Biochem (1977) 1.34

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res (2006) 1.34

Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet (2009) 1.32

Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons. Cancer Res (2008) 1.25

Mitochondrial DNA ligase III function is independent of Xrcc1. Nucleic Acids Res (2000) 1.24

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. DNA Repair (Amst) (2009) 1.24

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein. DNA Repair (Amst) (2006) 1.23

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria. Proc Natl Acad Sci U S A (2010) 1.23

The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage. Prog Mol Biol Transl Sci (2012) 1.22

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest (2004) 1.22

Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. J Mol Biol (2002) 1.19

Aprataxin localizes to mitochondria and preserves mitochondrial function. Proc Natl Acad Sci U S A (2011) 1.19

Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity. Nucleic Acids Res (2005) 1.16

Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev (2012) 1.13

Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. J Alzheimers Dis (2011) 1.13

DNA polymerase beta is critical for mouse meiotic synapsis. EMBO J (2009) 1.09

Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions. J Cereb Blood Flow Metab (2010) 1.09

Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res (2002) 1.07

Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains. DNA Repair (Amst) (2008) 1.07

Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. Proc Natl Acad Sci U S A (2010) 1.05

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia. Proc Natl Acad Sci U S A (2011) 1.04

Early decrease of apurinic/apyrimidinic endonuclease expression after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab (1999) 1.01

Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J Biol Chem (2010) 1.01

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice. Proc Natl Acad Sci U S A (2012) 1.01

Exchangeability of mammalian DNA ligases between base excision repair pathways. Biochemistry (2004) 1.01

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid. J Neurosci (2006) 0.99

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience (2006) 0.98

The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation. DNA Repair (Amst) (2011) 0.98

Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair. J Biol Chem (2004) 0.98

Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells. Cell Rep (2012) 0.97

Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosis. Stroke (1999) 0.97

Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage. Mutat Res (2012) 0.96

Repair of persistent strand breaks in the mitochondrial genome. Mech Ageing Dev (2011) 0.96

Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injury. Neurobiol Dis (2001) 0.96

DNA ligase I gene expression during differentiation and cell proliferation. Nucleic Acids Res (1992) 0.96

Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimer's hippocampus. Neuroreport (1998) 0.95

XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility. Nucleic Acids Res (2011) 0.94

DNA polymerase-beta may be the main player for defective DNA repair in aging rat neurons. Ann N Y Acad Sci (2001) 0.93

Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons. Brain Res Mol Brain Res (1997) 0.91

DNA polymerase beta-catalyzed-PCNA independent long patch base excision repair synthesis: a mechanism for repair of oxidatively damaged DNA ends in post-mitotic brain. J Neurochem (2008) 0.91

Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription. Hum Mol Genet (2006) 0.90

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death. FASEB J (2002) 0.90

Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates. Proc Natl Acad Sci U S A (2012) 0.89

Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest. Brain Res Mol Brain Res (1997) 0.89

p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Mol Cell Biol (2004) 0.88

APE/Ref-1 responses to ischemia in rat brain. Neuroreport (1998) 0.87

Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity. DNA Repair (Amst) (2009) 0.87

Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity. DNA Repair (Amst) (2005) 0.87

Mitochondrial DNA ligase function in Saccharomyces cerevisiae. Nucleic Acids Res (2001) 0.86

Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains. Brain Res Dev Brain Res (1995) 0.85

Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities. DNA Repair (Amst) (2012) 0.85

DNA polymerase beta is critical for genomic stability of sperm cells. DNA Repair (Amst) (2011) 0.84

APE1/Ref-1 in Alzheimer's disease: an immunohistochemical study. Neurosci Lett (2009) 0.83

Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts. J Biol Chem (1997) 0.82

Age-dependent decline of DNA base excision repair activity in rat cortical neurons. Mech Ageing Dev (2012) 0.82

Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Cell Death Differ (2005) 0.82

Decreased mutant frequency in embryonic brain of DNA polymerase beta null mice. Mutagenesis (2006) 0.82

Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice. Neuroscience (1999) 0.81

Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair. Nucleic Acids Res (2011) 0.81

Base excision repair activities in organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation. DNA Repair (Amst) (2008) 0.81

Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice. Biochem Biophys Res Commun (2007) 0.80

APE/Ref-1 responses to oxidative stress in aged rats. J Neurosci Res (1998) 0.79

DNA-polymerase alpha, beta, delta and epsilon activities in isolated neuronal and astroglial cell fractions from developing and aging rat cerebral cortex. Int J Dev Neurosci (2002) 0.79

Loss of base excision repair in aging rat neurons and its restoration by DNA polymerase beta. Brain Res Mol Brain Res (2000) 0.79

Changes of DNA ligase in developing rat brain. J Biochem (1977) 0.78

Articles by these authors

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res (2006) 4.20

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08

Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50

The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43

Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42

No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33

Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95

DNA repair mechanisms in dividing and non-dividing cells. DNA Repair (Amst) (2013) 1.85

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84

Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84

The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84

Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82

SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70

XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Res (2004) 1.70

Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68

Is the use of arch bars or interdental wire fixation necessary for successful outcomes in the open reduction and internal fixation of mandibular angle fractures? J Oral Maxillofac Surg (2008) 1.64

Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64

Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A (2003) 1.64

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64

Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62

Estimating the effect of human base excision repair protein variants on the repair of oxidative DNA base damage. Cancer Epidemiol Biomarkers Prev (2006) 1.59

Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res (2005) 1.59

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56

DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55

Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes. Mutat Res (2003) 1.53

Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A (2011) 1.52

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging (2005) 1.52

A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Mol Cancer Res (2007) 1.52

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48

Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet (2003) 1.46

Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells (2008) 1.43

Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides. J Med Chem (2012) 1.42

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42

Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic Biol Med (2005) 1.42

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci (2006) 1.42

Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev (2013) 1.41

Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39

Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc (2009) 1.38

Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress. FASEB J (2003) 1.38

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38

Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice. PLoS Genet (2009) 1.37

Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol (2003) 1.37

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis (2003) 1.37

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem (2004) 1.36

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging. Mech Ageing Dev (2008) 1.36

Overview of base excision repair biochemistry. Curr Mol Pharmacol (2012) 1.36

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol (2010) 1.35

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35

Junction of RecQ helicase biochemistry and human disease. J Biol Chem (2004) 1.34

Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging. Biogerontology (2008) 1.34

Human apurinic/apyrimidinic endonuclease 1. Antioxid Redox Signal (2013) 1.34

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res (2006) 1.34

p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene (2004) 1.33

The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life. Mech Ageing Dev (2003) 1.33

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One (2009) 1.32

Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) (2008) 1.31

Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. Nucleic Acids Res (2004) 1.31

Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress. Mol Cell Biol (2005) 1.31

The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther (2007) 1.30

Base excision repair capacity in mitochondria and nuclei: tissue-specific variations. FASEB J (2002) 1.27

Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) (2008) 1.27

WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem (2003) 1.27

Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26

Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB J (2010) 1.25

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett (2012) 1.24

Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B. Oncogene (2002) 1.24

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol (2003) 1.23

Pathways and functions of the Werner syndrome protein. Mech Ageing Dev (2005) 1.23

Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging (2011) 1.23

The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA. J Biol Chem (2002) 1.22

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res (2002) 1.22

A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092. J Cell Sci (2002) 1.21

Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein. DNA Repair (Amst) (2002) 1.21

Pathways for repairing and tolerating the spectrum of oxidative DNA lesions. Cancer Lett (2012) 1.20

Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. Aging Cell (2011) 1.20

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. J Biol Chem (2003) 1.19

Mitochondrial DNA repair and association with aging--an update. Exp Gerontol (2010) 1.19

Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice. DNA Repair (Amst) (2008) 1.19

Aprataxin localizes to mitochondria and preserves mitochondrial function. Proc Natl Acad Sci U S A (2011) 1.19

Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision. J Mol Biol (2008) 1.19

Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. J Mol Biol (2002) 1.19

Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism. Magn Reson Med (2010) 1.18

Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res (2009) 1.18

Direct and indirect roles of RECQL4 in modulating base excision repair capacity. Hum Mol Genet (2009) 1.18