Published in Nucleic Acids Res on January 30, 2006
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair (Amst) (2007) 2.43
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci (2008) 2.24
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle (2008) 1.83
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. Semin Cancer Biol (2010) 1.44
Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst) (2008) 1.20
Involvement of oxidatively damaged DNA and repair in cancer development and aging. Am J Transl Res (2010) 1.12
RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA). J Biol Chem (2008) 1.06
Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing. Biochemistry (2008) 1.04
Acetylation regulates WRN catalytic activities and affects base excision DNA repair. PLoS One (2008) 0.96
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ. J Biol Chem (2012) 0.96
Human RECQL5 participates in the removal of endogenous DNA damage. Mol Biol Cell (2012) 0.92
Human RECQL5beta stimulates flap endonuclease 1. Nucleic Acids Res (2010) 0.91
Base excision repair in the mammalian brain: implication for age related neurodegeneration. Mech Ageing Dev (2013) 0.90
FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Mol Cancer Res (2010) 0.90
Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells. J Biol Chem (2011) 0.90
Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic Acids Res (2007) 0.89
From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing. Cell Mol Life Sci (2007) 0.89
Helicases as prospective targets for anti-cancer therapy. Anticancer Agents Med Chem (2008) 0.88
The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage. Toxicol Sci (2009) 0.88
Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity. Biochemistry (2011) 0.84
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases. DNA Repair (Amst) (2010) 0.84
The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling. Oncogene (2011) 0.84
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage. Nucleic Acids Res (2012) 0.84
Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability. Crit Rev Biochem Mol Biol (2013) 0.84
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation. DNA Repair (Amst) (2008) 0.82
The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro. Age (Dordr) (2012) 0.82
The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA. DNA Repair (Amst) (2010) 0.82
Ku80-deleted cells are defective at base excision repair. Mutat Res (2013) 0.82
The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer. Oncotarget (2016) 0.81
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. DNA Repair (Amst) (2013) 0.81
The role of DNA exonucleases in protecting genome stability and their impact on ageing. Age (Dordr) (2011) 0.81
A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair. Nucleic Acids Res (2009) 0.81
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. DNA Repair (Amst) (2014) 0.80
WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts. BMC Cardiovasc Disord (2008) 0.79
Mechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand. PLoS One (2009) 0.79
8p deletion is strongly linked to poor prognosis in breast cancer. Cancer Biol Ther (2015) 0.77
Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis. Life Sci (2015) 0.77
The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair. Nucleic Acids Res (2016) 0.76
Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine in DNA pol λ-knockdown cells. Genes Environ (2015) 0.76
Application of the microfluidic-assisted replication track analysis to measure DNA repair in human and mouse cells. Methods (2016) 0.75
Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal. Nucleic Acids Res (2014) 0.75
Crosstalk between the nucleolus and the DNA damage response. Mol Biosyst (2017) 0.75
Recent Advances in Understanding Werner Syndrome. F1000Res (2017) 0.75
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res (2001) 4.47
Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci U S A (1997) 4.40
Repairing DNA-methylation damage. Nat Rev Mol Cell Biol (2004) 2.85
An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA. Nature (2002) 2.58
Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem (1999) 2.26
Homologous recombination resolution defect in werner syndrome. Mol Cell Biol (2002) 2.21
The 3' 5' exonucleases. Nat Rev Mol Cell Biol (2002) 2.07
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. EMBO J (1999) 2.04
Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. J Biol Chem (1998) 1.93
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum Mol Genet (2000) 1.93
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease. J Biol Chem (1998) 1.90
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. Nucleic Acids Res (1999) 1.90
Methylation-induced blocks to in vitro DNA replication. Mutat Res (1985) 1.89
Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase. Hum Genet (1999) 1.71
Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev (2001) 1.61
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. J Biol Chem (2004) 1.59
Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. J Biol Chem (2000) 1.58
Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. J Biol Chem (2001) 1.56
DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. J Biol Chem (2001) 1.50
Werner syndrome cells are sensitive to DNA cross-linking drugs. FASEB J (2001) 1.48
Characterization of the human and mouse WRN 3'-->5' exonuclease. Nucleic Acids Res (2000) 1.46
The fidelity of DNA polymerase beta during distributive and processive DNA synthesis. J Biol Chem (1999) 1.46
Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic Biol Med (2005) 1.42
Oxidants are a major contributor to aging. Ann N Y Acad Sci (1992) 1.41
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis (2003) 1.37
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem (2004) 1.36
Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease. J Mol Biol (2000) 1.33
Mutagenesis by alkylating agents: coding properties for DNA polymerase of poly (dC) template containing 3-methylcytosine. Biochimie (1983) 1.28
Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. DNA Repair (Amst) (2002) 1.26
Werner protein protects nonproliferating cells from oxidative DNA damage. Mol Cell Biol (2005) 1.26
Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases. J Biol Chem (2000) 1.25
Werner and Bloom helicases are involved in DNA repair in a complementary fashion. Oncogene (2002) 1.22
Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle. Anal Biochem (1984) 1.21
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. J Biol Chem (2003) 1.19
Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. J Mol Biol (2002) 1.19
The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells. Nucleic Acids Res (2005) 1.16
Regulation of WRN helicase activity in human base excision repair. J Biol Chem (2004) 1.15
Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus. J Mol Biol (2002) 1.14
Delayed DNA joining at 3' mismatches by human DNA ligases. Nucleic Acids Res (1999) 1.06
The E249K mutator mutant of DNA polymerase beta extends mispaired termini. J Biol Chem (1999) 1.06
Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents. Mutat Res (2003) 1.02
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) (2004) 0.99
Weak strand displacement activity enables human DNA polymerase beta to expand CAG/CTG triplet repeats at strand breaks. J Biol Chem (2002) 0.99
Human diseases deficient in RecQ helicases. Biochimie (2003) 0.94
DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation. Biochem Biophys Res Commun (2004) 0.82
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res (2006) 4.20
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (2006) 3.37
AP endonuclease-independent DNA base excision repair in human cells. Mol Cell (2004) 3.37
Structure and mechanism of DNA polymerase Beta. Chem Rev (2006) 3.30
Population Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets. Popul Health Metr (2011) 3.21
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature (2007) 3.03
Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. Structure (2003) 2.77
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell (2004) 2.60
In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc Natl Acad Sci U S A (2004) 2.59
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50
The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33
Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity. Structure (2004) 2.10
The X family portrait: structural insights into biological functions of X family polymerases. DNA Repair (Amst) (2007) 1.98
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J Biol Chem (2003) 1.95
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Mol Cell (2008) 1.88
XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell Res (2008) 1.87
DNA repair mechanisms in dividing and non-dividing cells. DNA Repair (Amst) (2013) 1.85
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Personalized exposure assessment: promising approaches for human environmental health research. Environ Health Perspect (2005) 1.83
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell (2006) 1.79
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One (2011) 1.78
Structural insights into the origins of DNA polymerase fidelity. Structure (2003) 1.74
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. J Biol Chem (2005) 1.72
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70
XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Res (2004) 1.70
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J Biol Chem (2002) 1.68
Is the use of arch bars or interdental wire fixation necessary for successful outcomes in the open reduction and internal fixation of mandibular angle fractures? J Oral Maxillofac Surg (2008) 1.64
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64
Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A (2003) 1.64
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J Biol Chem (2005) 1.63
Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates. J Biol Chem (2004) 1.62
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state. Biochemistry (2007) 1.61
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry (2007) 1.61
Effects of Hatha yoga and Omkar meditation on cardiorespiratory performance, psychologic profile, and melatonin secretion. J Altern Complement Med (2004) 1.61
Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes. Proc Natl Acad Sci U S A (2003) 1.60
Observing a DNA polymerase choose right from wrong. Cell (2013) 1.60
Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. DNA Repair (Amst) (2003) 1.59
Estimating the effect of human base excision repair protein variants on the repair of oxidative DNA base damage. Cancer Epidemiol Biomarkers Prev (2006) 1.59
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res (2005) 1.59
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. J Biol Chem (2004) 1.59
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proc Natl Acad Sci U S A (2006) 1.56
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. J Am Chem Soc (2004) 1.55
Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes. Mutat Res (2003) 1.53
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A (2011) 1.52
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging (2005) 1.52
A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Mol Cancer Res (2007) 1.52
Comparison of three incisions to repair complete unilateral cleft lip. Plast Reconstr Surg (2010) 1.51
HMGB1 is a cofactor in mammalian base excision repair. Mol Cell (2007) 1.49
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. J Biol Chem (2002) 1.48
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. J Am Chem Soc (2007) 1.48
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet (2003) 1.46
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA Repair (Amst) (2006) 1.45
Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se. J Mol Biol (2002) 1.43
Substrate channeling in mammalian base excision repair pathways: passing the baton. J Biol Chem (2010) 1.43
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells (2008) 1.43
Erythropoietin levels in lowlanders and high-altitude natives at 3450 m. Aviat Space Environ Med (2007) 1.42
Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta. Biochemistry (2004) 1.42
Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides. J Med Chem (2012) 1.42
Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. J Biol Chem (2001) 1.42
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic Biol Med (2005) 1.42
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci (2006) 1.42
Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev (2013) 1.41
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Biochemistry (2006) 1.40
Functional characterization of Candida albicans ABC transporter Cdr1p. Eukaryot Cell (2003) 1.40
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc (2009) 1.38
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38