Published in N Engl J Med on May 20, 2003
National Emphysema Treatment Trial (NETT) | NCT00000606
Endobronchial Valve for Emphysema Palliation Trial (VENT) | NCT00129584
Allogeneic MSC Treatment for Pulmonary Emphysema | NCT04918706
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. Can Respir J (2007) 4.27
Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med (2006) 3.71
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
The minimal important difference of exercise tests in severe COPD. Eur Respir J (2010) 3.27
Comparison of plethysmographic and helium dilution lung volumes: which is best for COPD? Chest (2009) 2.98
Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med (2007) 2.77
Lung volume reduction surgery since the National Emphysema Treatment Trial: study of Society of Thoracic Surgeons Database. J Thorac Cardiovasc Surg (2014) 2.64
State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 2.60
Reproducibility and validity of lung density measures from cardiac CT Scans--The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Acad Radiol (2009) 2.35
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax (2012) 2.15
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology. Am J Respir Crit Care Med (2007) 2.04
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98
Chronotropic incompetence predicts mortality in severe obstructive pulmonary disease. Respir Physiol Neurobiol (2013) 1.97
Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med (2007) 1.94
CT metrics of airway disease and emphysema in severe COPD. Chest (2009) 1.81
The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med (2007) 1.68
The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery. Am J Respir Crit Care Med (2011) 1.64
Lung volume reduction coil treatment for patients with severe emphysema: a European multicentre trial. Thorax (2014) 1.62
Combined corticosteroid and long-acting beta-agonist in one inhaler versus inhaled steroids for chronic obstructive pulmonary disease. Cochrane Database Syst Rev (2007) 1.59
Pilot study of a cell phone-based exercise persistence intervention post-rehabilitation for COPD. Int J Chron Obstruct Pulmon Dis (2009) 1.53
Phenotype of Spirometric Impairment in an Aging Population. Am J Respir Crit Care Med (2016) 1.48
Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax (2014) 1.48
A randomised trial of lung sealant versus medical therapy for advanced emphysema. Eur Respir J (2015) 1.45
Collateral ventilation. Thorax (2006) 1.42
Pulmonary function is associated with distal aortic calcium, not proximal aortic distensibility. MESA lung study. COPD (2011) 1.41
Impact of pulmonary hypertension on exercise performance in patients with interstitial lung disease undergoing evaluation for lung transplantation. Respirology (2014) 1.41
Validity of chronic obstructive pulmonary disease diagnoses in a large administrative database. Can Respir J (2012) 1.39
Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med (2010) 1.36
Awake nonresectional lung volume reduction surgery. Ann Surg (2006) 1.27
Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. Respir Res (2007) 1.27
Epidemiology and clinical impact of major comorbidities in patients with COPD. Int J Chron Obstruct Pulmon Dis (2014) 1.23
Physical activity, health status and risk of hospitalization in patients with severe chronic obstructive pulmonary disease. Respiration (2010) 1.22
Airway wall attenuation: a biomarker of airway disease in subjects with COPD. J Appl Physiol (1985) (2009) 1.18
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol (2011) 1.17
Characterization of outcomes 1 year after endoscopic thermal vapor ablation for patients with heterogeneous emphysema. Int J Chron Obstruct Pulmon Dis (2012) 1.15
Bullous disease of the lung and cannabis smoking: insufficient evidence for a causative link. J R Soc Med (2006) 1.15
A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2005) 1.14
Guidelines for diagnosis and management of chronic obstructive pulmonary disease: Joint ICS/NCCP (I) recommendations. Lung India (2013) 1.13
Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample. The MESA lung study. Ann Am Thorac Soc (2014) 1.11
3He diffusion MRI of the lung. Acad Radiol (2005) 1.11
Changing the burden of COPD mortality. Int J Chron Obstruct Pulmon Dis (2006) 1.11
Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One (2011) 1.11
Long-term oxygen treatment in chronic obstructive pulmonary disease: recommendations for future research: an NHLBI workshop report. Am J Respir Crit Care Med (2006) 1.10
Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. Respir Res (2010) 1.10
The history of COPD. Int J Chron Obstruct Pulmon Dis (2006) 1.08
Chronic obstructive pulmonary disease: lobe-based visual assessment of volumetric CT by Using standard images--comparison with quantitative CT and pulmonary function test in the COPDGene study. Radiology (2012) 1.07
Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study. Respir Res (2010) 1.07
Relation of interlobar collaterals to radiological heterogeneity in severe emphysema. Thorax (2006) 1.07
Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD. Eur Respir J (2010) 1.06
Longitudinal change in the BODE index predicts mortality in severe emphysema. Am J Respir Crit Care Med (2008) 1.05
Free-living physical activity in COPD: assessment with accelerometer and activity checklist. J Rehabil Res Dev (2009) 1.05
Physiological and computed tomographic predictors of outcome from lung volume reduction surgery. Am J Respir Crit Care Med (2009) 1.04
Diagnostic imaging in COPD. Semin Respir Crit Care Med (2010) 1.03
Large-scale international validation of the ADO index in subjects with COPD: an individual subject data analysis of 10 cohorts. BMJ Open (2012) 1.03
A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med (2015) 1.02
Chronic obstructive pulmonary disease. Indian J Med Res (2013) 1.02
Emphysema: time to say farewell to therapeutic nihilism. Thorax (2014) 1.01
Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease. Respir Res (2012) 1.01
Use of pedometer and Internet-mediated walking program in patients with chronic obstructive pulmonary disease. J Rehabil Res Dev (2010) 1.00
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. Am J Respir Cell Mol Biol (2009) 0.98
Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J (2008) 0.98
Effect of lung volume reduction surgery on resting pulmonary hemodynamics in severe emphysema. Am J Respir Crit Care Med (2007) 0.97
Endoscopic volume reduction in COPD- a critical review. Dtsch Arztebl Int (2014) 0.97
Design of the Endobronchial Valve for Emphysema Palliation Trial (VENT): a non-surgical method of lung volume reduction. BMC Pulm Med (2007) 0.96
Lung deflation and oxygen pulse in COPD: results from the NETT randomized trial. Respir Med (2011) 0.96
Bronchoscopic lung volume reduction in severe emphysema. Proc Am Thorac Soc (2008) 0.96
Physiologic basis for improved pulmonary function after lung volume reduction. Proc Am Thorac Soc (2008) 0.96
Caring for the older person with chronic obstructive pulmonary disease. JAMA (2012) 0.96
COPD: what is the unmet need? Br J Pharmacol (2008) 0.95
Automated lobar quantification of emphysema in patients with severe COPD. Eur Radiol (2008) 0.95
Efficacy and safety of endobronchial valves for advanced emphysema: a meta analysis. J Thorac Dis (2015) 0.95
Automatic lung lobe segmentation using particles, thin plate splines, and maximum a posteriori estimation. Med Image Comput Comput Assist Interv (2010) 0.94
Emphysema lung lobe volume reduction: effects on the ipsilateral and contralateral lobes. Eur Radiol (2012) 0.94
Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2014) 0.94
Efficacy of bronchoscopic lung volume reduction: a meta-analysis. Int J Chron Obstruct Pulmon Dis (2014) 0.94
Abandonment of high-dose chemotherapy/hematopoietic cell transplants for breast cancer following negative trial results. Health Serv Res (2011) 0.94
Lung volume reduction surgery: technique, operative mortality, and morbidity. Proc Am Thorac Soc (2008) 0.94
National Emphysema Treatment Trial: the major outcomes of lung volume reduction surgery in severe emphysema. Proc Am Thorac Soc (2008) 0.93
Cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers. Int J Environ Res Public Health (2011) 0.93
The National Emphysema Treatment Trial--how strong is the evidence? N Engl J Med (2003) 0.93
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD (2011) 0.93
Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med (2014) 0.93
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet (2013) 0.92
Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis. Drug Des Devel Ther (2011) 0.92
Bronchoscopic interventions for severe COPD. J Thorac Dis (2014) 0.92
National Emphysema Treatment Trial state of the art: genetics of emphysema. Proc Am Thorac Soc (2008) 0.92
Six-minute walk distance in patients with severe end-stage COPD: association with survival after inpatient pulmonary rehabilitation. J Cardiopulm Rehabil Prev (2010) 0.92
The Saudi Guidelines for the Diagnosis and Management of COPD. Ann Thorac Med (2014) 0.92
Considering usual medical care in clinical trial design. PLoS Med (2009) 0.91
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease. Thorax (2011) 0.91
Pulmonary rehabilitation in idiopathic pulmonary fibrosis: a call for continued investigation. Respir Med (2008) 0.91
Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest (2008) 0.91
Distribution of Pneumocystis jirovecii in lungs from colonized COPD patients. Diagn Microbiol Infect Dis (2011) 0.91
Effect of endobronchial valve therapy on pulmonary perfusion and ventilation distribution. PLoS One (2015) 0.90
Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2010) 0.90
Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med (2006) 9.17
Benefits and harms of CT screening for lung cancer: a systematic review. JAMA (2012) 8.71
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med (2000) 8.32
DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med (2008) 5.87
Patients at high risk of death after lung-volume-reduction surgery. N Engl J Med (2001) 5.76
Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N Engl J Med (2000) 5.65
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med (2008) 5.62
American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol (2009) 4.95
Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer. J Urol (2003) 4.66
A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. N Engl J Med (2016) 3.99
Non-small cell lung cancer. J Natl Compr Canc Netw (2010) 3.93
Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med (2006) 3.71
Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clin Cancer Res (2010) 3.56
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore) (2004) 3.32
Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer Res (2004) 3.29
Dasty2, an Ajax protein DAS client. Bioinformatics (2008) 3.26
BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2011) 3.23
2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer. J Clin Oncol (2011) 3.21
Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med (2002) 3.16
Strategies to prevent central line-associated bloodstream infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 3.13
Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach. Clin Gastroenterol Hepatol (2004) 3.10
FAQs about the GOLD 2011 assessment proposal of COPD: a comparative analysis of four different cohorts. Eur Respir J (2013) 2.87
Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. Am J Respir Crit Care Med (2007) 2.86
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol (2008) 2.86
Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med (2007) 2.77
Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide. Clin Cancer Res (2011) 2.59
Non-small cell lung cancer, version 2.2013. J Natl Compr Canc Netw (2013) 2.56
Long-term follow-up of patients receiving lung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group. Ann Thorac Surg (2006) 2.53
In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors. Clin Cancer Res (2002) 2.48
Non-small cell lung cancer. J Natl Compr Canc Netw (2012) 2.40
Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients. Hepatology (2002) 2.37
A compendium of strategies to prevent healthcare-associated infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 2.32
Strategies to prevent catheter-associated urinary tract infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 2.30
Retracted Expression of concern: Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. Am J Respir Crit Care Med (2009) 2.28
Early identification of atopy in the prediction of persistent asthma in children. Lancet (2008) 2.27
Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 2.22
Asthma morbidity during pregnancy can be predicted by severity classification. J Allergy Clin Immunol (2003) 2.22
Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype. Clin Cancer Res (2005) 2.21
Fluorodeoxyglucose uptake of primary non-small cell lung cancer at positron emission tomography: new contrary data on prognostic role. Clin Cancer Res (2007) 2.14
Minimally invasive resection of early lung cancers. Oncology (Williston Park) (2015) 2.04
Management of centrally located non-small-cell carcinoma. Oncology (Williston Park) (2014) 2.04
Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and length. Am J Respir Crit Care Med (2003) 2.03
Racial disparities among patients with lung cancer who were recommended operative therapy. Arch Surg (2009) 2.02
Inadequate use of asthma medication in the United States: results of the asthma in America national population survey. J Allergy Clin Immunol (2002) 1.98
Carotid-femoral pulse wave velocity assessment by two different methods: implications for risk assessment. J Hypertens (2015) 1.98
The effects of pulmonary rehabilitation in the national emphysema treatment trial. Chest (2005) 1.94
Imaging of subsquamous Barrett's epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study. Gastrointest Endosc (2009) 1.92
The burden of asthma in the United States: level and distribution are dependent on interpretation of the national asthma education and prevention program guidelines. Am J Respir Crit Care Med (2002) 1.92
Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci Transl Med (2011) 1.87
Strategies to prevent clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 1.84
Strategies to prevent ventilator-associated pneumonia in acute care hospitals. Infect Control Hosp Epidemiol (2008) 1.81
Asthma during pregnancy. Obstet Gynecol (2004) 1.79
Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema. N Engl J Med (2003) 1.79
Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma. Clin Cancer Res (2003) 1.79
Multi-modality mediastinal staging for lung cancer among medicare beneficiaries. J Thorac Oncol (2009) 1.76
Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med (2009) 1.74
Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging (2003) 1.72
Phase II, randomized, placebo-controlled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkers. J Clin Oncol (2009) 1.71
Patient and surgical factors influencing air leak after lung volume reduction surgery: lessons learned from the National Emphysema Treatment Trial. Ann Thorac Surg (2006) 1.71
Non-small cell lung cancer, version 1.2015. J Natl Compr Canc Netw (2014) 1.71
Non-small cell lung cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw (2006) 1.68
The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med (2007) 1.68
Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals. Infect Control Hosp Epidemiol (2008) 1.66
Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. J Natl Cancer Inst (2007) 1.65
Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest. Cell Stem Cell (2012) 1.60
Contrasting crustal production and rapid mantle transitions beneath back-arc ridges. Nature (2011) 1.60
Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med (2005) 1.58
Impaired lung homeostasis in neonatal mice exposed to cigarette smoke. Am J Respir Cell Mol Biol (2007) 1.56
Statement on the care of the child with chronic lung disease of infancy and childhood. Am J Respir Crit Care Med (2003) 1.54
Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet Neurol (2012) 1.54
Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naïve prostate cancer. Clin Cancer Res (2006) 1.50
Association of central and peripheral pulse pressure with intermediate cardiovascular phenotypes. J Hypertens (2012) 1.49
Enhanced Caenorhabditis elegans locomotion in a structured microfluidic environment. PLoS One (2008) 1.49
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med (2013) 1.49
Sleep-disordered breathing in Hispanic/Latino individuals of diverse backgrounds. The Hispanic Community Health Study/Study of Latinos. Am J Respir Crit Care Med (2014) 1.49
Predictors of operative mortality and cardiopulmonary morbidity in the National Emphysema Treatment Trial. J Thorac Cardiovasc Surg (2005) 1.46
Nocturnal blood pressure and progression to end-stage renal disease or death in nondiabetic chronic kidney disease stages 3 and 4. J Hypertens (2010) 1.43
Weight gain after lung reduction surgery is related to improved lung function and ventilatory efficiency. Am J Respir Crit Care Med (2012) 1.43
Genome-wide association study of short-acting β2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. Am J Respir Crit Care Med (2015) 1.42
Oral valacyclovir as prophylaxis against herpes simplex virus reactivation during high dose chemotherapy for leukemia. Leuk Lymphoma (2004) 1.41
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. J Clin Oncol (2009) 1.41
Clinical significance of radiologic characterizations in COPD. COPD (2009) 1.41
Relationship between non-small cell lung cancer FDG uptake at PET, tumor histology, and Ki-67 proliferation index. J Thorac Oncol (2008) 1.39