Published in Nat Cell Biol on June 01, 2003
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer (2009) 12.92
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J (2008) 6.32
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol (2004) 5.46
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A (2006) 4.56
Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov (2011) 4.05
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell (2008) 3.91
Class I PI3K in oncogenic cellular transformation. Oncogene (2008) 3.90
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev (2004) 3.59
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol (2008) 3.50
The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci U S A (2005) 3.49
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol (2006) 3.33
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol (2004) 3.20
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol (2013) 3.11
Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03
Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84
mTOR kinase structure, mechanism and regulation. Nature (2013) 2.80
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell (2013) 2.79
Regulation of mTORC1 by amino acids. Trends Cell Biol (2014) 2.64
Targeting protein prenylation for cancer therapy. Nat Rev Cancer (2011) 2.60
Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One (2009) 2.54
Nutrient-sensing mechanisms and pathways. Nature (2015) 2.46
Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol (2004) 2.37
Tuberous sclerosis complex proteins control axon formation. Genes Dev (2008) 2.33
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J (2007) 2.27
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell (2012) 2.22
Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer Cell (2014) 2.15
The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. Oncogene (2009) 2.14
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One (2007) 2.07
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A (2006) 2.06
Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell (2009) 2.03
Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci U S A (2008) 2.02
Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia (2009) 1.98
Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci U S A (2008) 1.97
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol Cell Biol (2006) 1.82
Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum Mol Genet (2009) 1.79
Rheb is essential for murine development. Mol Cell Biol (2011) 1.76
Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res (2010) 1.76
Myocardial AKT: the omnipresent nexus. Physiol Rev (2011) 1.76
mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev (2012) 1.74
Lymphangioleiomyomatosis: what do we know and what are we looking for? Eur Respir Rev (2011) 1.73
Nutrient signaling to mTOR and cell growth. Trends Biochem Sci (2013) 1.68
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein. J Biol Chem (2009) 1.67
Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev (2011) 1.66
Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer (2008) 1.62
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev (2008) 1.61
Regulation of mTORC1 by the Rab and Arf GTPases. J Biol Chem (2010) 1.60
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev (2004) 1.57
Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol (2005) 1.55
Regulation of mTORC1 by PI3K signaling. Trends Cell Biol (2015) 1.54
Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. Hum Mol Genet (2010) 1.53
Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest (2010) 1.52
Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. J Biol Chem (2010) 1.52
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem (2007) 1.52
The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. J Virol (2010) 1.49
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J (2005) 1.47
Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans. Am J Respir Cell Mol Biol (2006) 1.47
Emerging role of autophagy in kidney function, diseases and aging. Autophagy (2012) 1.43
Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation. PLoS Biol (2016) 1.42
Autophagy: controlling cell fate in rheumatic diseases. Nat Rev Rheumatol (2016) 1.42
Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res (2009) 1.41
Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol Cell Biol (2003) 1.41
Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proc Natl Acad Sci U S A (2009) 1.40
Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors. Cell Cycle (2008) 1.40
Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol (2005) 1.39
PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects. Cell Cycle (2009) 1.38
mTORC2 is required for proliferation and survival of TSC2-null cells. Mol Cell Biol (2011) 1.36
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. Curr Genomics (2007) 1.33
The complexes of mammalian target of rapamycin. Curr Protein Pept Sci (2010) 1.33
Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell (2011) 1.31
The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway. Hum Mol Genet (2008) 1.30
Rag proteins regulate amino-acid-induced mTORC1 signalling. Biochem Soc Trans (2009) 1.29
Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. PLoS One (2013) 1.29
RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem (2008) 1.28
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med (2010) 1.28
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J (2008) 1.28
Tuberous sclerosis complex: neurological, renal and pulmonary manifestations. Neuropediatrics (2011) 1.27
Updates of mTOR inhibitors. Anticancer Agents Med Chem (2010) 1.27
Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb. Mol Cell Biol (2009) 1.25
Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. Am J Respir Cell Mol Biol (2006) 1.24
mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability. J Biol Chem (2009) 1.24
Mechanisms of TSC-mediated control of synapse assembly and axon guidance. PLoS One (2007) 1.23
Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner. Mol Cell Biol (2007) 1.23
Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. Cancer Res (2010) 1.23
Airway smooth muscle growth in asthma: proliferation, hypertrophy, and migration. Proc Am Thorac Soc (2008) 1.23
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death Differ (2010) 1.22
Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp Gerontol (2010) 1.21
Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem J (2003) 1.21
Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner. Proc Natl Acad Sci U S A (2011) 1.20
Constitutively active Rheb induces oncogenic transformation. Oncogene (2008) 1.20
Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell (2005) 10.61
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (2003) 7.43
The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell (2008) 5.58
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell (2009) 5.57
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol (2002) 5.37
Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol (2003) 5.01
Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev Cell (2002) 4.85
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev (2003) 4.68
Expression of Yes-associated protein in common solid tumors. Hum Pathol (2008) 4.61
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell (2010) 4.47
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev (2012) 4.19
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat Cell Biol (2005) 3.80
Filling out the Hippo pathway. Nat Rev Mol Cell Biol (2007) 3.46
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev (2010) 3.02
Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell (2010) 2.96
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A (2010) 2.43
Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell (2008) 2.40
EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell (2010) 2.34
EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development (2009) 2.18
Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell (2013) 2.16
Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Dev Cell (2004) 2.02
The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development (2010) 1.93
Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature (2011) 1.89
Why size matters: altering cell size. Curr Opin Genet Dev (2002) 1.83
Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing. Cell (2004) 1.76
A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing. Development (2002) 1.76
Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol (2007) 1.70
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev (2002) 1.69
dMyc is required for larval growth and endoreplication in Drosophila. Development (2004) 1.69
Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev (2004) 1.57
A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell (2007) 1.55
Drosophila target of rapamycin kinase functions as a multimer. Genetics (2005) 1.50
Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol (2004) 1.50
The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Dev Cell (2013) 1.43
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev (2013) 1.40
TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. J Cell Biol (2009) 1.38
The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis. Development (2002) 1.34
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes Dev (2014) 1.30
Intestinal stem cell function in Drosophila and mice. Curr Opin Genet Dev (2012) 1.30
The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth. EMBO J (2005) 1.25
Structural and functional analysis of the YAP-binding domain of human TEAD2. Proc Natl Acad Sci U S A (2010) 1.24
Intestinal stem cells in the adult Drosophila midgut. Exp Cell Res (2011) 1.23
Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. J Cell Biol (2007) 1.20
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem (2012) 1.18
Fat flies expanded the hippo pathway: a matter of size control. Sci STKE (2007) 1.16
Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology (2012) 1.15
The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway. Int J Gastrointest Cancer (2006) 1.14
Premetazoan origin of the hippo signaling pathway. Cell Rep (2011) 1.12
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol Cell Biol (2005) 1.11
Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. BMC Cell Biol (2010) 1.09
Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol (2007) 1.05
Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression. Mol Syst Biol (2007) 1.04
How size is controlled: from Hippos to Yorkies. Nat Cell Biol (2007) 1.00
Flow cytometric analysis of Drosophila cells. Methods Mol Biol (2008) 1.00
Endoreplication. Cold Spring Harb Perspect Biol (2013) 0.97
Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress. Cell Cycle (2012) 0.97
Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure (2013) 0.95
Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development. Genes Cells (2008) 0.94
Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing. Dev Biol (2007) 0.93
RNA expression profiling from FACS-isolated cells of the Drosophila intestine. Curr Protoc Stem Cell Biol (2013) 0.93
Yorkie and Scalloped: partners in growth activation. Dev Cell (2008) 0.93
A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol (2010) 0.92
Cyclin D does not provide essential Cdk4-independent functions in Drosophila. Genetics (2004) 0.92
Proliferative control in Drosophila stem cells. Curr Opin Cell Biol (2008) 0.92
Functional properties of a recombinant chimeric plasminogen activator with platelet-targeted fibrinolytic and anticoagulant potential. Mol Genet Metab (2004) 0.91
Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila. Dev Biol (2009) 0.90
Controlling cell division in yeast and animals: does size matter? J Biol (2003) 0.89
Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One (2012) 0.89
The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Genetics (2005) 0.89
Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies. Hum Pathol (2012) 0.88
The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding. BMC Cancer (2013) 0.87
Earthworms: sources of antimicrobial and anticancer molecules. Adv Exp Med Biol (2004) 0.87
LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2). Mol Cell Biol (2012) 0.86
Proteomic comparison between human young and old brains by two-dimensional gel electrophoresis and identification of proteins. Int J Dev Neurosci (2003) 0.85
Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta Neuropathol (2011) 0.83
The molecular chaperone Hsp90 is required for cell cycle exit in Drosophila melanogaster. PLoS Genet (2013) 0.82
Combinatorial control of temporal gene expression in the Drosophila wing by enhancers and core promoters. BMC Genomics (2012) 0.82
The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila. PLoS One (2012) 0.81
Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila. Cell Cycle (2006) 0.80
Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila. Dev Biol (2012) 0.80
Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA. Hear Res (2013) 0.79
Hunting complex differential gene interaction patterns across molecular contexts. Nucleic Acids Res (2014) 0.79
Comparative proteome analysis of human temporal cortex lobes by two-dimensional electrophoresis and identification of selected common proteins. Neurochem Res (2002) 0.78
Temporal regulation of Dpp signaling output in the Drosophila wing. Dev Dyn (2014) 0.77
Expression and characterization of ARSP1 from Eisenia fetida. Comp Biochem Physiol C Toxicol Pharmacol (2004) 0.77
Effect of metallothionein on cell viability and its interactions with cadmium and zinc in HEK293 cells. Cell Biol Int (2005) 0.77
Proteomic analysis of corticobasal degeneration: a case study of corticobasal degeneration at the proteome level. J Neuropsychiatry Clin Neurosci (2005) 0.77
EndoGI modulates Notch signaling and axon guidance in Drosophila. Mech Dev (2010) 0.76
Stimulating cROSstalk between commensal bacteria and intestinal stem cells. EMBO J (2013) 0.76
Bacterial expression and purification of biologically active human TFF3. Peptides (2004) 0.76
Drosophila PRL-1 is a growth inhibitor that counteracts the function of the Src oncogene. PLoS One (2013) 0.76
Chewing the fat; regulating autophagy in Drosophila. Dev Cell (2004) 0.76
[Protective effect of extra metallothioneins from rabbit liver induced by zinc on toxicity of lead in rat primary hepatocyte culture]. Wei Sheng Yan Jiu (2002) 0.75
Tracking protein turnover and degradation by microscopy: photo-switchable versus time-encoded fluorescent proteins. Open Biol (2014) 0.75
A potential thrombus diagnosis reagent based on P-selectin monoclonal antibody SZ-51 light chain. Thromb Res (2008) 0.75