Published in Exp Gerontol on December 02, 2010
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Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
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Rapamycin extends life- and health span because it slows aging. Aging (Albany NY) (2013) 1.19
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Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY) (2011) 1.10
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) (2012) 1.05
Age-specific variation in immune response in Drosophila melanogaster has a genetic basis. Genetics (2012) 1.05
Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet (2012) 0.99
Germline energetics, aging, and female infertility. Cell Metab (2013) 0.97
Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell (2014) 0.94
Big mice die young but large animals live longer. Aging (Albany NY) (2013) 0.93
Dietary effects on cuticular hydrocarbons and sexual attractiveness in Drosophila. PLoS One (2012) 0.91
Involvement of redox state in the aging of Drosophila melanogaster. Antioxid Redox Signal (2013) 0.91
Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. Cell Metab (2015) 0.91
Joint inhibition of TOR and JNK pathways interacts to extend the lifespan of Brachionus manjavacas (Rotifera). Exp Gerontol (2014) 0.91
Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. RNA Biol (2013) 0.89
Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life. PLoS One (2015) 0.88
Mitochondrial maintenance failure in aging and role of sexual dimorphism. Arch Biochem Biophys (2014) 0.86
Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. Endocrinology (2014) 0.84
SIN3 is critical for stress resistance and modulates adult lifespan. Aging (Albany NY) (2014) 0.83
Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster. Biomol Ther (Seoul) (2013) 0.83
MTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer. Cell Cycle (2013) 0.82
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget (2012) 0.82
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Autophagy drives epidermal deterioration in a Drosophila model of tissue aging. Aging (Albany NY) (2013) 0.81
Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function. J Immunol (2013) 0.81
The effects of Rpd3 on fly metabolism, health, and longevity. Exp Gerontol (2016) 0.80
Molecular mechanisms of aging and immune system regulation in Drosophila. Int J Mol Sci (2012) 0.80
RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity. Aging (Albany NY) (2015) 0.79
Invertebrate models for coenzyme q10 deficiency. Mol Syndromol (2014) 0.77
Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul) (2016) 0.77
Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP. PLoS One (2015) 0.77
Dietary restriction and lifespan: Lessons from invertebrate models. Ageing Res Rev (2016) 0.77
TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia. PLoS One (2015) 0.76
Genome-wide transcriptomics of aging in the rotifer Brachionus manjavacas, an emerging model system. BMC Genomics (2017) 0.75
microRNA-496 - A new, potentially aging-relevant regulator of mTOR. Cell Cycle (2016) 0.75
Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila. Biomol Ther (Seoul) (2015) 0.75
Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling. EXCLI J (2015) 0.75
Regulation of Drosophila Lifespan by bellwether Promoter Alleles. Sci Rep (2017) 0.75
Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity. Eur J Appl Physiol (2017) 0.75
The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome. Aging (Albany NY) (2017) 0.75
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Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol (2004) 12.12
mTOR and cancer: insights into a complex relationship. Nat Rev Cancer (2006) 11.86
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
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Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science (1991) 10.16
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Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell (2004) 8.53
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab (2008) 6.60
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol (2003) 6.32
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell (2007) 5.67
A nutrient sensor mechanism controls Drosophila growth. Cell (2003) 5.61
Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev (2000) 5.53
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol (2002) 5.37
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development (2004) 5.27
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell (2001) 5.14
Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol (2003) 5.01
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab (2006) 4.98
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Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (2004) 4.70
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev (2001) 4.68
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol (2003) 4.67
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
Lifespan and reproduction in Drosophila: New insights from nutritional geometry. Proc Natl Acad Sci U S A (2008) 4.43
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Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol (2005) 4.30
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol (2003) 4.20
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell (2009) 4.20
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab (2010) 4.11
Remote control of insulin secretion by fat cells in Drosophila. Cell Metab (2009) 4.10
An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell (2009) 4.07
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev (2000) 4.05
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell (2005) 4.02
Rapamycin decelerates cellular senescence. Cell Cycle (2009) 3.97
Rheb fills a GAP between TSC and TOR. Trends Biochem Sci (2003) 3.90
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science (2010) 3.86
Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet (2007) 3.83
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell (2007) 3.78
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol (2004) 3.72
Dietary restriction in long-lived dwarf flies. Science (2002) 3.71
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med (2007) 3.66
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev (2004) 3.59
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell (2008) 3.58
Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol (2007) 3.47
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy (2007) 3.45
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle (2008) 3.37
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MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol (2007) 3.19
Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science (2002) 3.19
Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev (2007) 3.18
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The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol (2001) 2.73
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet (2009) 2.60
The TOR pathway couples nutrition and developmental timing in Drosophila. Dev Cell (2008) 2.52
mTOR and the control of whole body metabolism. Curr Opin Cell Biol (2009) 2.52
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol (2002) 2.51
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Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell (2003) 2.29
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev (2005) 2.28
TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J Cell Biol (2006) 2.24
Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Proc Natl Acad Sci U S A (2005) 2.23
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle (2006) 2.23
Complexity of the TOR signaling network. Trends Cell Biol (2006) 2.21
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daf-16 protects the nematode Caenorhabditis elegans during food deprivation. J Gerontol A Biol Sci Med Sci (2006) 2.06
Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila. Curr Biol (2010) 2.03
The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell (2002) 2.01
Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell Metab (2006) 1.99
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell (2009) 4.20
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell (2007) 3.78
Allocrine modulation of feeding behavior by the Sex Peptide of Drosophila. Curr Biol (2006) 3.01
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A role for S6 kinase and serotonin in postmating dietary switch and balance of nutrients in D. melanogaster. Curr Biol (2010) 1.63
Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell (2013) 1.60
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Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab (2010) 1.46
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab (2011) 1.39
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci (2008) 1.36
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab (2012) 1.34
A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet (2009) 1.29
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell (2012) 1.08
TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev (2010) 1.07
Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One (2011) 1.06
Dietary restriction and aging, 2009. Aging Cell (2010) 1.03
High carbohydrate-low protein consumption maximizes Drosophila lifespan. Exp Gerontol (2013) 1.02
The hypoxic response and aging. Cell Cycle (2009) 1.00
Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster. PLoS Genet (2010) 0.99
Cell signaling. Aging is RSKy business. Science (2009) 0.94
Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell (2009) 0.93
Drosophila melanogaster as an emerging translational model of human nephrolithiasis. J Urol (2013) 0.91
Circadian clocks and metabolism: the nutrient-sensing AKT and TOR pathways make the link. Curr Biol (2010) 0.90
Rapamycin: killing two birds with one stone. Aging (Albany NY) (2011) 0.89
Microcomposition of human urinary calculi using advanced imaging techniques. J Urol (2012) 0.85
Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans. Aging Cell (2014) 0.82
Ubiquitin ligases join the field of dietary restriction in C.elegans. Aging (Albany NY) (2009) 0.78
Strontium substitution for calcium in lithogenesis. J Urol (2012) 0.76