Published in Blood on June 05, 2003
Multilayered specification of the T-cell lineage fate. Immunol Rev (2010) 1.32
The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood (2005) 1.21
Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood (2009) 1.15
PRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling. Mol Cell Biol (2010) 1.14
PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate. Biochem J (2008) 1.11
CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding. Nucleic Acids Res (2009) 1.07
Molecular and developmental biology of the hemangioblast. Dev Dyn (2008) 0.99
Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice. Cell Mol Gastroenterol Hepatol (2015) 0.97
The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis. Blood (2010) 0.93
The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors. Biochem J (2009) 0.92
The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus. J Virol (2005) 0.92
Gene expression programs of mouse endothelial cells in kidney development and disease. PLoS One (2010) 0.90
Interaction between Hhex and SOX13 modulates Wnt/TCF activity. J Biol Chem (2009) 0.90
Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex. Oncogene (2014) 0.85
Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation. Stem Cells (2015) 0.81
Study of intermolecular contacts in the proline-rich homeodomain (PRH)-DNA complex using molecular dynamics simulations. Eur Biophys J (2012) 0.78
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a. Genes Dev (2016) 0.78
PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response. J Hematol Oncol (2016) 0.76
Hhex Is Necessary for the Hepatic Differentiation of Mouse ES Cells and Acts via Vegf Signaling. PLoS One (2016) 0.75
Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion. Cell Biosci (2016) 0.75
Study of base pair mutations in proline-rich homeodomain (PRH)-DNA complexes using molecular dynamics. Eur Biophys J (2013) 0.75
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development (2004) 4.72
The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2008) 3.46
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development (2003) 3.09
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet (2013) 2.76
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med (2008) 2.72
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A (2009) 2.51
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
Heterozygous mutations of OTX2 cause severe ocular malformations. Am J Hum Genet (2005) 2.26
The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. Proc Natl Acad Sci U S A (2005) 2.15
In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis (2005) 2.08
A low fT3 level as a prognostic marker in patients with acute myocardial infarctions. Intern Med (2012) 2.02
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining. Proc Natl Acad Sci U S A (2010) 1.94
Trend and disease burden of bacillary dysentery in China (1991-2000). Bull World Health Organ (2006) 1.93
High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A (2011) 1.87
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res (2007) 1.82
Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential. Cell Stem Cell (2013) 1.80
Selective regulation of arterial branching morphogenesis by synectin. Dev Cell (2006) 1.77
Metnase mediates chromosome decatenation in acute leukemia cells. Blood (2009) 1.74
Drug Repurposing from an Academic Perspective. Drug Discov Today Ther Strateg (2011) 1.68
More forks on the road to replication stress recovery. J Mol Cell Biol (2011) 1.64
The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Proc Natl Acad Sci U S A (2002) 1.52
Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells (2012) 1.52
PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood (2004) 1.47
Synthetic lethality: exploiting the addiction of cancer to DNA repair. Blood (2011) 1.42
Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J Immunol (2002) 1.39
The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation. Nucleic Acids Res (2008) 1.38
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A (2011) 1.36
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining. DNA Repair (Amst) (2008) 1.35
Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev (2005) 1.35
SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development. J Clin Endocrinol Metab (2008) 1.34
Preoperative biliary drainage for obstructive jaundice. Cochrane Database Syst Rev (2008) 1.32
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood (2009) 1.29
Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping. Neuroimage (2010) 1.24
Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer. Cancer Res (2007) 1.24
Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells. Hum Gene Ther (2004) 1.23
Critical roles of lysosomal acid lipase in myelopoiesis. Am J Pathol (2010) 1.22
Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res (2010) 1.21
A synthesized pheromone induces upstream movement in female sea lamprey and summons them into traps. Proc Natl Acad Sci U S A (2009) 1.20
CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum. Plant Mol Biol (2014) 1.20
Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers. Biomaterials (2009) 1.20
Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells. PLoS One (2009) 1.20
Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA mutation in 16 Chinese families: implication for early detection and prevention of deafness. Biochem Biophys Res Commun (2006) 1.19
Delayed arteriogenesis in hypercholesterolemic mice. Circulation (2005) 1.19
PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption. J Clin Endocrinol Metab (2012) 1.19
Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors. Proc Natl Acad Sci U S A (2009) 1.17
Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells. Exp Hematol (2004) 1.16
The chemokine CXCL14 (BRAK) stimulates activated NK cell migration: implications for the downregulation of CXCL14 in malignancy. Exp Hematol (2006) 1.12
Nell-1 protein promotes bone formation in a sheep spinal fusion model. Tissue Eng Part A (2011) 1.10
Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med (2005) 1.09
Integrase-defective lentiviral vectors as a delivery platform for targeted modification of adenosine deaminase locus. Mol Ther (2013) 1.08
Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development (2007) 1.07
Primary endothelial cells isolated from the yolk sac and para-aortic splanchnopleura support the expansion of adult marrow stem cells in vitro. Blood (2003) 1.07
Metnase/SETMAR: a domesticated primate transposase that enhances DNA repair, replication, and decatenation. Genetica (2010) 1.06
Mechanisms of leukemia translocations. Curr Opin Hematol (2008) 1.06
Transcriptional termination sequences in the mouse serum albumin gene. RNA (2006) 1.06
Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells. J Cancer Res Clin Oncol (2010) 1.05
11-deoxycortisol is a corticosteroid hormone in the lamprey. Proc Natl Acad Sci U S A (2010) 1.04
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol (2012) 1.04
Pre-operative biliary drainage for obstructive jaundice. Cochrane Database Syst Rev (2012) 1.03
Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol (2008) 1.03
Evaluation of primitive murine hematopoietic stem and progenitor cell transduction in vitro and in vivo by recombinant adeno-associated virus vector serotypes 1 through 5. Hum Gene Ther (2006) 1.02
The Nell-1 growth factor stimulates bone formation by purified human perivascular cells. Tissue Eng Part A (2011) 1.02
Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy. Cancer Res (2012) 1.01
Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med (2013) 1.01
Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4. Blood (2005) 1.00
Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Mol Ther (2013) 1.00
ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion. Cardiovasc Diabetol (2012) 0.99
Expression levels of the human DNA repair protein metnase influence lentiviral genomic integration. Biochimie (2008) 0.99
Methylation of p15INK4b and expression of ANRIL on chromosome 9p21 are associated with coronary artery disease. PLoS One (2012) 0.98
Characterization of a novel bile alcohol sulfate released by sexually mature male sea lamprey (Petromyzon marinus). PLoS One (2013) 0.97
Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol (2009) 0.97
The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Cancer Res (2011) 0.97
Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech (2008) 0.97
Vaspin attenuates high glucose-induced vascular smooth muscle cells proliferation and chemokinesis by inhibiting the MAPK, PI3K/Akt, and NF-κB signaling pathways. Atherosclerosis (2013) 0.96
Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey. Proc Natl Acad Sci U S A (2012) 0.96
PARP1 is required for chromosomal translocations. Blood (2013) 0.96
The use of BMP-2 coupled - Nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects. Biomaterials (2010) 0.96
Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. Blood (2002) 0.96
The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site. Biochim Biophys Acta (2012) 0.95
Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db/db mice by inhibiting the NF-κB pathway. Diab Vasc Dis Res (2014) 0.95
Developmental mechanisms directing early anterior forebrain specification in vertebrates. Cell Mol Life Sci (2013) 0.94
The sea lamprey Petromyzon marinus genome reveals the early origin of several chemosensory receptor families in the vertebrate lineage. BMC Evol Biol (2009) 0.94
Cell wall composition contributes to the control of transpiration efficiency in Arabidopsis thaliana. Plant J (2010) 0.94
Gender differences in adolescent substance abuse. Curr Psychiatry Rep (2009) 0.92
The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart. J Biol Chem (2014) 0.92
Insight from the lamprey genome: glimpsing early vertebrate development via neuroendocrine-associated genes and shared synteny of gonadotropin-releasing hormone (GnRH). Gen Comp Endocrinol (2013) 0.92
Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. Stem Cells (2004) 0.91
HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain. Development (2011) 0.91
MicroRNAs regulate bone metabolism. J Bone Miner Metab (2013) 0.91
Glomerular territories in the olfactory bulb from the larval stage of the sea lamprey Petromyzon marinus. J Comp Neurol (2003) 0.90
Male sea lampreys, Petromyzon marinus L., excrete a sex pheromone from gill epithelia. Biol Reprod (2003) 0.89