Published in Development on September 01, 2003
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
Continuous single-cell imaging of blood generation from haemogenic endothelium. Nature (2009) 4.32
Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol (2008) 4.04
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature (2009) 3.88
Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development (2007) 3.26
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin. Proc Natl Acad Sci U S A (2004) 2.88
Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell (2008) 2.77
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67
Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood (2006) 2.66
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood (2005) 2.65
Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development (2007) 2.33
CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development (2008) 2.22
The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell (2012) 1.96
Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression. Blood (2006) 1.90
Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development. Cell Stem Cell (2009) 1.85
Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos. Development (2010) 1.81
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood (2011) 1.79
Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol (2011) 1.76
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell (2011) 1.76
Human endothelial progenitor cells. Cold Spring Harb Perspect Med (2012) 1.68
Clonal analysis identifies hemogenic endothelium as the source of the blood-endothelial common lineage in the mouse embryo. Blood (2014) 1.56
Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A (2011) 1.55
Novel role for EKLF in megakaryocyte lineage commitment. Blood (2007) 1.53
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells. Blood (2009) 1.51
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood (2006) 1.48
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region. J Exp Med (2011) 1.48
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. J Exp Med (2005) 1.44
Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level. Nat Commun (2013) 1.35
A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo. Blood (2011) 1.34
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (2008) 1.30
Hematopoietic stem and progenitor cell trafficking. Trends Immunol (2011) 1.29
Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood (2006) 1.25
CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells. Blood (2011) 1.23
Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells (2012) 1.17
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. Blood (2013) 1.14
Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells. Blood Cells Mol Dis (2013) 1.11
Hematopoietic stem cell emergence in the conceptus and the role of Runx1. Int J Dev Biol (2010) 1.11
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood (2007) 1.10
The embryonic origins of erythropoiesis in mammals. Blood (2012) 1.09
Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol (2008) 1.07
Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor. Stem Cell Reports (2014) 1.06
A short history of hemogenic endothelium. Blood Cells Mol Dis (2013) 1.05
Friend virus utilizes the BMP4-dependent stress erythropoiesis pathway to induce erythroleukemia. J Virol (2007) 1.04
Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. Cell Rep (2014) 1.04
Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells (2012) 1.03
Tracing haematopoietic stem cell formation at single-cell resolution. Nature (2016) 1.03
Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo. Cell Rep (2015) 1.01
Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis. Blood (2008) 1.01
Hardwiring Stem Cell Communication through Tissue Structure. Cell (2016) 0.97
A critical role for endoglin in the emergence of blood during embryonic development. Blood (2012) 0.95
Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development. Proc Natl Acad Sci U S A (2009) 0.93
Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity. Stem Cells (2015) 0.92
Ontogeny of Tissue-Resident Macrophages. Front Immunol (2015) 0.91
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium. PLoS One (2013) 0.90
The transcriptional programme controlled by Runx1 during early embryonic blood development. Dev Biol (2012) 0.90
Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection. Stem Cells Dev (2014) 0.89
Ex vivo time-lapse confocal imaging of the mouse embryo aorta. Nat Protoc (2011) 0.88
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood (2015) 0.88
Stepwise development of hematopoietic stem cells from embryonic stem cells. PLoS One (2009) 0.88
Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation. Blood (2012) 0.87
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development. PLoS One (2012) 0.85
Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open (2013) 0.85
Plasticity and maintenance of hematopoietic stem cells during development. Recent Pat Biotechnol (2011) 0.85
Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells. Stem Cell Res Ther (2013) 0.85
Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this. Development (2014) 0.84
Generating human hematopoietic stem cells in vitro -exploring endothelial to hematopoietic transition as a portal for stemness acquisition. FEBS Lett (2016) 0.84
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood (2010) 0.84
Developmental niches for embryonic erythroid cells. Blood Cells Mol Dis (2010) 0.84
Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells (2014) 0.83
Serum- and stromal cell-free hypoxic generation of embryonic stem cell-derived hematopoietic cells in vitro, capable of multilineage repopulation of immunocompetent mice. Stem Cells Transl Med (2012) 0.82
The balance of positive and negative effects of TGF-β signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells. Stem Cells Dev (2013) 0.82
DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo. Blood (2013) 0.80
Making Blood: The Haematopoietic Niche throughout Ontogeny. Stem Cells Int (2015) 0.80
Mapping mouse hemangioblast maturation from headfold stages. Dev Biol (2012) 0.80
Development and differentiation of the erythroid lineage in mammals. Dev Comp Immunol (2015) 0.80
Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation. PLoS One (2012) 0.80
In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation. Stem Cell Reports (2015) 0.80
Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis. Stem Cells (2013) 0.80
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells. Nat Commun (2016) 0.79
The modern primitives: applying new technological approaches to explore the biology of the earliest red blood cells. ISRN Hematol (2013) 0.79
The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development. Stem Cells (2010) 0.79
Vasculogenic and hematopoietic cellular progenitors are scattered within the prenatal mouse heart. Histochem Cell Biol (2014) 0.79
A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17. Stem Cell Reports (2015) 0.79
Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development. J Biol Chem (2014) 0.79
Platelet-rich plasma and adipose-derived mesenchymal stem cells for regenerative medicine-associated treatments in bottlenose dolphins (Tursiops truncatus). PLoS One (2014) 0.78
Interferon-α signaling promotes embryonic HSC maturation. Blood (2016) 0.78
Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications. Stem Cells Int (2015) 0.77
Early hematopoiesis and macrophage development. Semin Immunol (2016) 0.77
Common developmental pathway for primitive erythrocytes and multipotent hematopoietic progenitors in early mouse development. Stem Cell Reports (2013) 0.77
Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo. Exp Hematol (2017) 0.76
Novel methods for determining hematopoietic stem and progenitor cell emergence in the murine yolk sac. Int J Dev Biol (2010) 0.76
The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development. Cell Rep (2016) 0.76
Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems. Front Biol (Beijing) (2014) 0.75
F4/80(+) Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo. J Immunol Res (2016) 0.75
Developing HSCs become Notch independent by the end of maturation in the AGM region. Blood (2016) 0.75
Generation and Analysis of GATA2(w/eGFP) Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis. Stem Cell Reports (2016) 0.75
Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood (2004) 7.21
Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol (2008) 4.07
Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol (2007) 3.42
The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell (2008) 3.09
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet (2013) 2.76
Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood (2004) 2.76
Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. Blood (2005) 2.72
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood (2004) 2.35
All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood (2007) 2.31
Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity. Am J Physiol Lung Cell Mol Physiol (2007) 2.21
Injury of the renal microvascular endothelium alters barrier function after ischemia. Am J Physiol Renal Physiol (2003) 2.19
Flow cytometric identification and functional characterization of immature and mature circulating endothelial cells. Arterioscler Thromb Vasc Biol (2012) 2.07
A low fT3 level as a prognostic marker in patients with acute myocardial infarctions. Intern Med (2012) 2.02
Trend and disease burden of bacillary dysentery in China (1991-2000). Bull World Health Organ (2006) 1.93
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. Am J Pathol (2008) 1.90
High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A (2011) 1.87
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res (2007) 1.82
Ontogeny of CD24 in the human kidney. Kidney Int (2010) 1.81
Selective regulation of arterial branching morphogenesis by synectin. Dev Cell (2006) 1.77
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence. Blood (2012) 1.72
Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells. Exp Hematol (2010) 1.63
Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A. J Mol Cell Cardiol (2002) 1.62
Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A (2011) 1.55
Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci U S A (2005) 1.50
Roles of spleen and liver in development of the murine hematopoietic system. Exp Hematol (2002) 1.49
Extracellular matrix scaffolds are repopulated by bone marrow-derived cells in a mouse model of achilles tendon reconstruction. J Orthop Res (2006) 1.49
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability. Blood (2007) 1.48
PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Blood (2004) 1.47
Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A (2009) 1.47
Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway. FASEB J (2009) 1.45
Liver metastases: 3D shape-based analysis of CT scans for detection of local recurrence after radiofrequency ablation. Radiology (2006) 1.45
Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors. Differentiation (2009) 1.45
Renal tumors: MR imaging-guided percutaneous cryotherapy--initial experience in 23 patients. Radiology (2005) 1.45
Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry. Blood (2003) 1.45
Blood island formation: longstanding observations and modern interpretations. Exp Hematol (2005) 1.44
Endothelial progenitor cells: quo vadis? J Mol Cell Cardiol (2010) 1.41
Rac2 concentrations in umbilical cord neutrophils. Biol Neonate (2006) 1.39
Isolation and characterization of endothelial progenitor cells from human blood. Curr Protoc Stem Cell Biol (2008) 1.36
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood (2003) 1.36
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
Definitive hematopoietic commitment within the embryonic vascular endothelial-cadherin(+) population. Exp Hematol (2002) 1.35
Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev (2005) 1.35
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. J Clin Invest (2011) 1.35
Clonogenic endothelial progenitor cells are sensitive to oxidative stress. Stem Cells (2006) 1.34
Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation. J Am Chem Soc (2007) 1.34
Preoperative biliary drainage for obstructive jaundice. Cochrane Database Syst Rev (2008) 1.32
Cord blood stem and progenitor cells. Methods Enzymol (2006) 1.29
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood (2009) 1.29
Endothelial colony-forming cell role in neoangiogenesis and tissue repair. Curr Opin Organ Transplant (2010) 1.27
Comparison of percutaneous and surgical approaches to renal tumor ablation: metaanalysis of effectiveness and complication rates. J Vasc Interv Radiol (2008) 1.26
Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation. Tissue Eng Part A (2011) 1.26
Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells. Hum Gene Ther (2004) 1.23
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood (2006) 1.22
Critical roles of lysosomal acid lipase in myelopoiesis. Am J Pathol (2010) 1.22
A synthesized pheromone induces upstream movement in female sea lamprey and summons them into traps. Proc Natl Acad Sci U S A (2009) 1.20
CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum. Plant Mol Biol (2014) 1.20
Biomimetic apatite-coated alginate/chitosan microparticles as osteogenic protein carriers. Biomaterials (2009) 1.20
Delayed arteriogenesis in hypercholesterolemic mice. Circulation (2005) 1.19
Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA mutation in 16 Chinese families: implication for early detection and prevention of deafness. Biochem Biophys Res Commun (2006) 1.19
Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming. Stem Cells (2013) 1.19
Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering. Biomaterials (2013) 1.16
Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells. Exp Hematol (2004) 1.16
Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells. Hum Mol Genet (2006) 1.15
Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag (2006) 1.14
Developmental biology: Birth of the blood cell. Nature (2009) 1.11
Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice. Am J Physiol Lung Cell Mol Physiol (2009) 1.11
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood (2007) 1.10
Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. Tissue Eng Part A (2009) 1.10
Nell-1 protein promotes bone formation in a sheep spinal fusion model. Tissue Eng Part A (2011) 1.10
Endothelial progenitor cells and cardiovascular cell-based therapies. Cytotherapy (2009) 1.09
Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med (2005) 1.09
Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med (2010) 1.09
A hydrogel derived from decellularized dermal extracellular matrix. Biomaterials (2012) 1.08
Pluripotent stem cells identified in multiple murine tissues. Ann N Y Acad Sci (2003) 1.08
Circulating and tissue resident endothelial progenitor cells. J Cell Physiol (2014) 1.07
Neonatal neutrophils: the good, the bad, and the ugly. Clin Perinatol (2004) 1.07
Primary endothelial cells isolated from the yolk sac and para-aortic splanchnopleura support the expansion of adult marrow stem cells in vitro. Blood (2003) 1.07
Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood. Pediatr Res (2008) 1.06
Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells. J Cancer Res Clin Oncol (2010) 1.05
Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells. Angiogenesis (2009) 1.04