Published in J Biol Chem on June 06, 2003
DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma (2009) 2.13
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA (2008) 1.76
Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev (2007) 1.69
DNA methyltransferases: a novel target for prevention and therapy. Front Oncol (2014) 1.62
Solving the Dnmt2 enigma. Chromosoma (2010) 1.59
Cigarette smoking and DNA methylation. Front Genet (2013) 1.48
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Oncogene (2006) 1.46
Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci U S A (2013) 1.43
Characterization of cytosine methylated regions and 5-cytosine DNA methyltransferase (Ehmeth) in the protozoan parasite Entamoeba histolytica. Nucleic Acids Res (2004) 1.36
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2. PLoS One (2011) 1.13
Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy. Curr Genomics (2009) 1.11
The structure, function and evolution of proteins that bind DNA and RNA. Nat Rev Mol Cell Biol (2014) 1.10
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Res (2012) 1.07
A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity. PLoS Pathog (2010) 1.05
Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation. Nat Genet (2010) 1.03
Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Curr Med Chem (2010) 0.99
Evolution of gene sequence in response to chromosomal location. Genetics (2007) 0.97
Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the Southern Chinese population. Int J Mol Sci (2012) 0.97
MiRNAs, epigenetics, and cancer. Mamm Genome (2008) 0.96
Evolution of dnmt-2 and mbd-2-like genes in the free-living nematodes Pristionchus pacificus, Caenorhabditis elegans and Caenorhabditis briggsae. Nucleic Acids Res (2004) 0.96
DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases. J Biol Chem (2013) 0.95
Transgene-induced CCWGG methylation does not alter CG methylation patterning in human kidney cells. Nucleic Acids Res (2005) 0.95
The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis. PLoS One (2008) 0.92
The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1. BMC Biochem (2005) 0.91
Epigenetic control of nuclear architecture. Cell Mol Life Sci (2007) 0.90
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond. Front Genet (2013) 0.90
Programming the genome in embryonic and somatic stem cells. J Cell Mol Med (2007) 0.85
In vitro tRNA methylation assay with the Entamoeba histolytica DNA and tRNA methyltransferase Dnmt2 (Ehmeth) enzyme. J Vis Exp (2010) 0.84
A real-time assay for CpG-specific cytosine-C5 methyltransferase activity. Nucleic Acids Res (2010) 0.84
The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. Nucleic Acids Res (2014) 0.82
Epigenetic Basis for the Differentiation Potential of Mesenchymal and Embryonic Stem Cells. Transfus Med Hemother (2008) 0.82
Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix. Gene Ther Mol Biol (2005) 0.79
Structure analysis of Entamoeba histolytica DNMT2 (EhMeth). PLoS One (2012) 0.78
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated? Front Genet (2015) 0.78
Prolonged Effects of Silver Nanoparticles on p53/p21 Pathway-Mediated Proliferation, DNA Damage Response, and Methylation Parameters in HT22 Hippocampal Neuronal Cells. Mol Neurobiol (2016) 0.77
Reviving the RNA World: An Insight into the Appearance of RNA Methyltransferases. Front Genet (2016) 0.76
Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6. J Biol Chem (2016) 0.75
Crystallization and preliminary crystallographic analysis of the (cytosine-5)-DNA methyltransferase NlaX from Neisseria lactamica. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.75
Cross-Talk between Dnmt2-Dependent tRNA Methylation and Queuosine Modification. Biomolecules (2017) 0.75
Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma. World J Gastroenterol (2016) 0.75
Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Front Genet (2014) 0.75
Genomic DNA Methylation Analyses Reveal the Distinct Profiles in Castor Bean Seeds with Persistent Endosperms. Plant Physiol (2016) 0.75
Linking epigenetic function to electrostatics: The DNMT2 structural model example. PLoS One (2017) 0.75
Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression. Redox Biol (2017) 0.75
How do lncRNAs regulate transcription? Sci Adv (2017) 0.75
Expression level and immunolocalization of de novo methyltransferase 3 protein (TuDNMT3) in adult females and males of the two-spotted spider mite, Tetranychus urticae. Exp Appl Acarol (2015) 0.75
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
Cyclical DNA methylation of a transcriptionally active promoter. Nature (2008) 7.62
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res (2003) 7.56
Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol (2008) 3.53
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem (2010) 3.03
BISMA--fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC Bioinformatics (2010) 2.60
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res (2010) 2.39
Structure and function of mammalian DNA methyltransferases. Chembiochem (2010) 2.39
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet (2009) 2.37
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. J Biol Chem (2005) 2.28
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites. J Biol Chem (2004) 2.08
Chromatin targeting of de novo DNA methyltransferases by the PWWP domain. J Biol Chem (2004) 2.02
Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. J Mol Biol (2006) 1.93
Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. J Biol Chem (2002) 1.85
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA (2008) 1.76
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9. Hum Mol Genet (2011) 1.67
Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome. J Mol Biol (2005) 1.65
Non-imprinted allele-specific DNA methylation on human autosomes. Genome Biol (2009) 1.64
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res (2006) 1.52
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res (2008) 1.46
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur J Biochem (2002) 1.39
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell (2005) 1.36
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase. Nucleic Acids Res (2006) 1.36
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol (2008) 1.34
Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase. Chem Biol (2011) 1.33
Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase. J Mol Biol (2006) 1.27
DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones. Methods Mol Biol (2009) 1.26
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases. Biochemistry (2005) 1.26
Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics (2011) 1.26
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res (2011) 1.24
Bisulfite sequencing Data Presentation and Compilation (BDPC) web server--a useful tool for DNA methylation analysis. Nucleic Acids Res (2008) 1.19
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. J Mol Biol (2012) 1.17
Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L. J Biol Chem (2011) 1.14
Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails. BMC Biochem (2011) 1.13
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2. PLoS One (2011) 1.13
Proteomic changes in maize roots after short-term adjustment to saline growth conditions. Proteomics (2010) 1.11
On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family. J Mol Biol (2009) 1.09
The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. J Biol Chem (2013) 1.08
Developing a programmed restriction endonuclease for highly specific DNA cleavage. Nucleic Acids Res (2005) 1.07
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Res (2012) 1.07
Staphylococcus aureus ClpC ATPase is a late growth phase effector of metabolism and persistence. Proteomics (2009) 1.05
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum Mol Genet (2006) 1.05
Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme. J Mol Biol (2003) 1.04
Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins. Mol Biosyst (2008) 1.03
Fhl-1, a new key protein in pulmonary hypertension. Circulation (2008) 1.03
DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat (2012) 1.01
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One (2010) 0.99
Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther (2004) 0.99
The Escherichia coli dam DNA methyltransferase modifies DNA in a highly processive reaction. J Mol Biol (2002) 0.97
Stopped-flow and mutational analysis of base flipping by the Escherichia coli Dam DNA-(adenine-N6)-methyltransferase. J Mol Biol (2004) 0.95
Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Mol Endocrinol (2007) 0.92
Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase. Anal Biochem (2005) 0.90
Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs. J Proteome Res (2011) 0.90
A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening. J Biomol Screen (2009) 0.90
Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group. Chembiochem (2007) 0.90
Mapping of protein-protein interaction sites by the 'absence of interference' approach. J Mol Biol (2007) 0.90
Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic Acids Res (2011) 0.90
Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain. Chembiochem (2014) 0.89
Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chem Biol (2012) 0.89
Detection and analysis of enzymatic DNA methylation of oligonucleotide substrates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Anal Biochem (2003) 0.88
Identification of novel inhibitors of DNA methylation by screening of a chemical library. ACS Chem Biol (2013) 0.88
New clustering module in BDPC bisulfite sequencing data presentation and compilation web application for DNA methylation analyses. Biotechniques (2009) 0.88
C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development. Chembiochem (2011) 0.88
Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA). Nucleic Acids Res (2013) 0.87
A fluorescence-based supramolecular tandem assay for monitoring lysine methyltransferase activity in homogeneous solution. Chemistry (2012) 0.87
Continuous enzymatic assay for histone lysine methyltransferases. Biotechniques (2007) 0.87
Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. Int J Cancer (2008) 0.87
Structural and biochemical characterization of a new Mg(2+) binding site near Tyr94 in the restriction endonuclease PvuII. J Mol Biol (2003) 0.86
A fluorimetric assay for on-line detection of DNA cleavage by restriction endonucleases. J Biotechnol (2002) 0.86
Silencing of gene expression by targeted DNA methylation: concepts and approaches. Methods Mol Biol (2010) 0.86
Reading and writing DNA methylation. Nat Struct Mol Biol (2008) 0.86
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. FEBS J (2011) 0.85
The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site. J Biol Chem (2007) 0.85
The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues. Biochimie (2012) 0.85
The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins (2009) 0.85
Rapid synthesis of new DNMT inhibitors derivatives of procainamide. Chembiochem (2011) 0.84
Impact of 7,8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a. Biochemistry (2009) 0.84
German human methylome project started. Cancer Res (2006) 0.83
Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics (2007) 0.83
Probing the DNA interface of the EcoRV DNA-(adenine-N6)-methyltransferase by site-directed mutagenesis, fluorescence spectroscopy, and UV cross-linking. Biochemistry (2002) 0.82
Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle. J Biol Chem (2007) 0.81
Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1. J Med Chem (2014) 0.81
The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner. Nucleic Acids Res (2011) 0.81
Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution. J Mol Biol (2009) 0.80
Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase. Biochemistry (2012) 0.80
DNA methyltransferase assays. Methods Mol Biol (2011) 0.80
Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase. FEBS Lett (2012) 0.80
Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. ChemMedChem (2014) 0.80
Specificity of DNA triple helix formation analyzed by a FRET assay. BMC Biochem (2002) 0.80
Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation. Chembiochem (2011) 0.80
Non-radioactive protein lysine methyltransferase microplate assay based on reading domains. ChemMedChem (2013) 0.79
Eimeria bovis-induced modulation of the host cell proteome at the meront I stage. Mol Biochem Parasitol (2010) 0.79
DNMT1-associated DNA methylation changes in cancer. Cell Cycle (2015) 0.79
High-throughput purification of polyHis-tagged recombinant fusion proteins. Methods Mol Biol (2003) 0.79
Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase. Chembiochem (2011) 0.78
Genomic imprinting--the struggle of the genders at the molecular level. Angew Chem Int Ed Engl (2013) 0.78
Methylation sensitivity of restriction enzymes interacting with GATC sites. Biotechniques (2003) 0.78
The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. BMC Biochem (2011) 0.78
Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension. Proteomics (2013) 0.77
Transition from EcoDam to T4Dam DNA recognition mechanism without loss of activity and specificity. Chembiochem (2009) 0.76