Published in BMC Biochem on August 31, 2011
Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol (2012) 2.76
Interpreting the language of histone and DNA modifications. Biochim Biophys Acta (2014) 1.80
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol (2012) 1.77
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol Cell (2013) 1.70
PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol (2012) 1.37
Peptide microarrays to interrogate the "histone code". Methods Enzymol (2012) 1.13
A combination of H2A.Z and H4 acetylation recruits Brd2 to chromatin during transcriptional activation. PLoS Genet (2012) 1.02
Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. Am J Transl Res (2013) 1.01
Histones: at the crossroads of peptide and protein chemistry. Chem Rev (2014) 1.01
Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation. J Biol Chem (2012) 1.00
PELP1 oncogenic functions involve CARM1 regulation. Carcinogenesis (2013) 0.99
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PLoS One (2013) 0.88
Application of histone modification-specific interaction domains as an alternative to antibodies. Genome Res (2014) 0.88
ChIP-less analysis of chromatin states. Epigenetics Chromatin (2014) 0.87
SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. Cell Commun Signal (2012) 0.82
Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays. J Biol Chem (2016) 0.77
Reader domain specificity and lysine demethylase-4 family function. Nat Commun (2016) 0.76
Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics Chromatin (2017) 0.75
Application of recombinant TAF3 PHD domain instead of anti-H3K4me3 antibody. Epigenetics Chromatin (2016) 0.75
ArrayNinja: An Open Source Platform for Unified Planning and Analysis of Microarray Experiments. Methods Enzymol (2016) 0.75
Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state. Epigenetics Chromatin (2017) 0.75
Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites. Nat Commun (2017) 0.75
Chromatin modifications and their function. Cell (2007) 55.98
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
The complex language of chromatin regulation during transcription. Nature (2007) 16.97
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science (2002) 8.08
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature (2004) 6.72
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40
Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat Struct Mol Biol (2007) 3.77
Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol (2008) 3.53
The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications. J Immunol Methods (2002) 3.52
The language of histone crosstalk. Cell (2010) 3.18
The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell (2008) 3.05
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem (2010) 3.03
Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell (2004) 2.99
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature (2009) 2.83
Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol (2008) 2.64
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. EMBO Rep (2009) 2.50
Readers of histone modifications. Cell Res (2011) 2.40
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res (2010) 2.39
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nat Struct Mol Biol (2007) 2.22
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion. Nat Protoc (2007) 2.08
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nat Struct Mol Biol (2011) 1.79
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9. Hum Mol Genet (2011) 1.67
Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS One (2009) 1.66
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res (2009) 1.49
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol (2008) 1.34
Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase. Chem Biol (2011) 1.33
Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J (2010) 1.27
Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics (2011) 1.26
Synthesis of peptide arrays using SPOT-technology and the CelluSpots-method. Methods Mol Biol (2009) 1.13
Analysis of protein kinase substrate specificity by the use of peptide libraries on cellulose paper (SPOT-method). Methods Mol Biol (1998) 1.04
Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J Mol Biol (2011) 1.04
Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. J Proteome Res (2010) 0.98
Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2. FEBS Lett (2010) 0.97
Profiling of generic anti-phosphopeptide antibodies and kinases with peptide microarrays using radioactive and fluorescence-based assays. Mol Divers (2004) 0.93
CelluSpots: a reproducible means of making peptide arrays for the determination of SH2 domain binding specificity. Methods Mol Biol (2009) 0.90
Characterizing and optimizing protease/peptide inhibitor interactions, a new application for spot synthesis. J Biochem (2000) 0.88
Antibody epitope mapping using SPOT peptide arrays. Methods Mol Biol (2009) 0.84
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
Cyclical DNA methylation of a transcriptionally active promoter. Nature (2008) 7.62
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res (2003) 7.56
Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol (2008) 3.53
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem (2010) 3.03
BISMA--fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC Bioinformatics (2010) 2.60
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res (2010) 2.39
Structure and function of mammalian DNA methyltransferases. Chembiochem (2010) 2.39
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet (2009) 2.37
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. J Biol Chem (2005) 2.28
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites. J Biol Chem (2004) 2.08
Chromatin targeting of de novo DNA methyltransferases by the PWWP domain. J Biol Chem (2004) 2.02
Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase. J Mol Biol (2006) 1.93
Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. J Biol Chem (2002) 1.85
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA (2008) 1.76
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9. Hum Mol Genet (2011) 1.67
Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome. J Mol Biol (2005) 1.65
Non-imprinted allele-specific DNA methylation on human autosomes. Genome Biol (2009) 1.64
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res (2006) 1.52
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res (2008) 1.46
The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity. J Biol Chem (2003) 1.46
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur J Biochem (2002) 1.39
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase. Nucleic Acids Res (2006) 1.36
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell (2005) 1.36
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol (2008) 1.34
Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase. Chem Biol (2011) 1.33
Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase. J Mol Biol (2006) 1.27
DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones. Methods Mol Biol (2009) 1.26
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases. Biochemistry (2005) 1.26
Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics (2011) 1.26
Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res (2011) 1.24
Bisulfite sequencing Data Presentation and Compilation (BDPC) web server--a useful tool for DNA methylation analysis. Nucleic Acids Res (2008) 1.19
Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. J Mol Biol (2012) 1.17
Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L. J Biol Chem (2011) 1.14
On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2. PLoS One (2011) 1.13
On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family. J Mol Biol (2009) 1.09
The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. J Biol Chem (2013) 1.08
Developing a programmed restriction endonuclease for highly specific DNA cleavage. Nucleic Acids Res (2005) 1.07
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Res (2012) 1.07
Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum Mol Genet (2006) 1.05
Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme. J Mol Biol (2003) 1.04
Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins. Mol Biosyst (2008) 1.03
DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat (2012) 1.01
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One (2010) 0.99
Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther (2004) 0.99
The Escherichia coli dam DNA methyltransferase modifies DNA in a highly processive reaction. J Mol Biol (2002) 0.97
Stopped-flow and mutational analysis of base flipping by the Escherichia coli Dam DNA-(adenine-N6)-methyltransferase. J Mol Biol (2004) 0.95
Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Mol Endocrinol (2007) 0.92
Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase. Anal Biochem (2005) 0.90
A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening. J Biomol Screen (2009) 0.90
Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group. Chembiochem (2007) 0.90
Mapping of protein-protein interaction sites by the 'absence of interference' approach. J Mol Biol (2007) 0.90
Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic Acids Res (2011) 0.90
Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain. Chembiochem (2014) 0.89
Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chem Biol (2012) 0.89
Detection and analysis of enzymatic DNA methylation of oligonucleotide substrates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Anal Biochem (2003) 0.88
New clustering module in BDPC bisulfite sequencing data presentation and compilation web application for DNA methylation analyses. Biotechniques (2009) 0.88
Identification of novel inhibitors of DNA methylation by screening of a chemical library. ACS Chem Biol (2013) 0.88
C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development. Chembiochem (2011) 0.88
Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA). Nucleic Acids Res (2013) 0.87
A fluorescence-based supramolecular tandem assay for monitoring lysine methyltransferase activity in homogeneous solution. Chemistry (2012) 0.87
Continuous enzymatic assay for histone lysine methyltransferases. Biotechniques (2007) 0.87
Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. Int J Cancer (2008) 0.87
Structural and biochemical characterization of a new Mg(2+) binding site near Tyr94 in the restriction endonuclease PvuII. J Mol Biol (2003) 0.86
Silencing of gene expression by targeted DNA methylation: concepts and approaches. Methods Mol Biol (2010) 0.86
A fluorimetric assay for on-line detection of DNA cleavage by restriction endonucleases. J Biotechnol (2002) 0.86
Reading and writing DNA methylation. Nat Struct Mol Biol (2008) 0.86
The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site. J Biol Chem (2007) 0.85
The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues. Biochimie (2012) 0.85
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. FEBS J (2011) 0.85
The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins (2009) 0.85
Impact of 7,8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a. Biochemistry (2009) 0.84
Rapid synthesis of new DNMT inhibitors derivatives of procainamide. Chembiochem (2011) 0.84
German human methylome project started. Cancer Res (2006) 0.83
Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics (2007) 0.83
Probing the DNA interface of the EcoRV DNA-(adenine-N6)-methyltransferase by site-directed mutagenesis, fluorescence spectroscopy, and UV cross-linking. Biochemistry (2002) 0.82
Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle. J Biol Chem (2007) 0.81
Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1. J Med Chem (2014) 0.81
The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner. Nucleic Acids Res (2011) 0.81
Specificity of DNA triple helix formation analyzed by a FRET assay. BMC Biochem (2002) 0.80
Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. ChemMedChem (2014) 0.80
Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase. FEBS Lett (2012) 0.80
Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution. J Mol Biol (2009) 0.80
Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation. Chembiochem (2011) 0.80
DNA methyltransferase assays. Methods Mol Biol (2011) 0.80
Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase. Biochemistry (2012) 0.80