Published in Lancet on June 07, 2003
On the nucleation of amyloid beta-protein monomer folding. Protein Sci (2005) 2.47
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat Neurosci (2015) 1.60
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Biochemistry (2008) 1.54
Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci (2014) 1.47
Proteolytic degradation of amyloid β-protein. Cold Spring Harb Perspect Med (2012) 1.46
Alzheimer's disease: synapses gone cold. Mol Neurodegener (2011) 1.43
beta-Amyloid degradation and Alzheimer's disease. J Biomed Biotechnol (2006) 1.35
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol Dis (2008) 1.23
APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Struct Funct (2009) 1.20
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. EMBO Mol Med (2011) 1.11
Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease. Front Aging Neurosci (2013) 0.94
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. Am J Pathol (2008) 0.93
Polymorphic triple beta-sheet structures contribute to amide hydrogen/deuterium (H/D) exchange protection in the Alzheimer amyloid beta42 peptide. J Biol Chem (2011) 0.91
Gene therapy in Alzheimer's disease - potential for disease modification. J Cell Mol Med (2010) 0.90
Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells. J Biol Chem (2010) 0.87
Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front Aging Neurosci (2014) 0.85
Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxid Med Cell Longev (2016) 0.84
Hereditary and sporadic forms of abeta-cerebrovascular amyloidosis and relevant transgenic mouse models. Int J Mol Sci (2009) 0.82
Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapy. Clin Dev Immunol (2013) 0.81
Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease. Proc Jpn Acad Ser B Phys Biol Sci (2013) 0.80
Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide. J Biol Chem (2017) 0.75
Long-term neprilysin inhibition - implications for ARNIs. Nat Rev Cardiol (2016) 0.75
Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun (2016) 0.75
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron (2013) 3.27
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
19F and 1H MRI detection of amyloid beta plaques in vivo. Nat Neurosci (2005) 2.44
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci (2007) 1.85
Potent amyloidogenicity and pathogenicity of Aβ43. Nat Neurosci (2011) 1.76
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci (2004) 1.65
Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide. Bioessays (2014) 1.61
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest (2005) 1.56
Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacol Ther (2005) 1.54
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat Med (2005) 1.49
beta-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem (2005) 1.48
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J Neurosci Res (2002) 1.43
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry (2006) 1.41
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem (2006) 1.37
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. J Biol Chem (2005) 1.34
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry (2004) 1.32
Aβ secretion and plaque formation depend on autophagy. Cell Rep (2013) 1.32
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem (2005) 1.25
Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS One (2011) 1.23
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiol Dis (2006) 1.23
Oxidized neprilysin in aging and Alzheimer's disease brains. Biochem Biophys Res Commun (2003) 1.21
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. J Biol Chem (2006) 1.21
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1). J Biol Chem (2002) 1.20
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci (2011) 1.19
Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. FASEB J (2011) 1.18
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry (2008) 1.18
Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus (2003) 1.15
Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res (2002) 1.14
Comprehensive behavioral phenotyping of calpastatin-knockout mice. Mol Brain (2008) 1.11
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion. Biochem Biophys Res Commun (2006) 1.10
Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging (2006) 1.10
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. J Biol Chem (2008) 1.07
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Hum Mol Genet (2009) 1.07
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology. Nat Commun (2012) 1.05
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J (2003) 1.04
Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. J Biol Chem (2009) 1.04
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Biochim Biophys Acta (2006) 1.04
Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production. J Neurochem (2007) 1.02
Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques. Eur J Med Chem (2004) 1.02
BACE1 interacts with lipid raft proteins. J Neurosci Res (2006) 1.01
Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochim Biophys Acta (2005) 1.00
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta Neuropathol (2010) 0.98
Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. J Biol Chem (2006) 0.98
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. J Neurosci Res (2006) 0.95
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain. Neurobiol Aging (2005) 0.95
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease. Ann Neurol (2005) 0.94
Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behav Brain Res (2005) 0.94
Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease. Acta Neuropathol (2014) 0.94
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons. J Biol Chem (2004) 0.93
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol (2013) 0.93
Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen. J Immunol (2008) 0.93
Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Sci Rep (2013) 0.93
SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes. J Cell Sci (2005) 0.92
Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. J Neurochem (2011) 0.91
BACE1 interacts with nicastrin. Biochem Biophys Res Commun (2002) 0.91
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. J Neurochem (2005) 0.91
Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Exp Neurol (2012) 0.91
Gene therapy in Alzheimer's disease - potential for disease modification. J Cell Mol Med (2010) 0.90
Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Res (2005) 0.90
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. FEBS Lett (2005) 0.90
Activation of calpain-1 in human carotid artery atherosclerotic lesions. BMC Cardiovasc Disord (2009) 0.90
Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3). Hum Mol Genet (2012) 0.89
Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J (2003) 0.87
Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory. J Pharmacol Exp Ther (2005) 0.87
Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci (2012) 0.87
Capillary CAA and perivascular Aβ-deposition: two distinct features of Alzheimer's disease pathology. J Neurol Sci (2010) 0.87
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol (2005) 0.86
Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis. J Immunol (2013) 0.86
CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease. Neurobiol Dis (2009) 0.86
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nat Commun (2013) 0.84
Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol (2011) 0.84
Sialylation enhances the secretion of neurotoxic amyloid-beta peptides. J Neurochem (2006) 0.84
Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase. Glycoconj J (2004) 0.83
Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein. Brain Res Mol Brain Res (2002) 0.83
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates. Biochemistry (2013) 0.83
Spatial resolution of calpain-catalyzed proteolysis in focal cerebral ischemia. Brain Res (2005) 0.83
Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells. Brain Res (2002) 0.83
Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neurosci Lett (2005) 0.82
Involvement of calpain in osteoclastic bone resorption. J Biochem (2005) 0.82
Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. Int J Alzheimers Dis (2009) 0.82
An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model. FASEB J (2011) 0.81
Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. J Neurosci Res (2010) 0.81
KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett (2004) 0.81
In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons. Brain Res Mol Brain Res (2002) 0.81
Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites. J Neurosci (2011) 0.81
Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain. Brain Res (2003) 0.81
Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells. J Neurosci Res (2009) 0.80
Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons. Neurosci Lett (2002) 0.80
[Amyloid-beta peptide metabolism and Alzheimer's disease]. Nihon Yakurigaku Zasshi (2003) 0.80
Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism. Sci Aging Knowledge Environ (2003) 0.79
Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1. Brain Res (2006) 0.79
New mouse model of Alzheimer's. ACS Chem Neurosci (2014) 0.79