Published in Biochemistry on October 26, 2004
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO J (2012) 2.72
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Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif. J Biol Chem (2010) 1.21
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Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. J Biol Chem (2014) 1.06
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Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production. Structure (2014) 0.93
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. J Biol Chem (2013) 0.92
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Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease. Curr Neuropharmacol (2011) 0.89
Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase. Front Physiol (2014) 0.87
Toward the structure of presenilin/γ-secretase and presenilin homologs. Biochim Biophys Acta (2013) 0.87
Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping. EMBO J (2016) 0.86
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Stable insertion of Alzheimer Abeta peptide into the ER membrane strongly correlates with its length. FEBS Lett (2007) 0.82
γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells. J Biol Chem (2013) 0.82
γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production. Int J Alzheimers Dis (2012) 0.82
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Biological function of Presenilin and its role in AD pathogenesis. Transl Neurodegener (2013) 0.81
CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation. PLoS One (2008) 0.79
EVALUATION OF HOW CIGARETTE SMOKE IS A DIRECT RISK FACTOR FOR ALZHEIMER'S DISEASE. Technol Innov (2012) 0.79
Mechanism of intramembrane cleavage of alcadeins by γ-secretase. PLoS One (2013) 0.78
Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ. Biochemistry (2016) 0.77
Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation. PLoS One (2013) 0.77
Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem (2015) 0.77
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease. Alzheimers Res Ther (2016) 0.76
Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice. Front Mol Neurosci (2017) 0.75
Unlocking truths of γ-secretase in Alzheimer's disease: what is the translational potential? Future Neurol (2015) 0.75
Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models. Acta Neuropathol Commun (2016) 0.75
Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast. Anal Biochem (2007) 0.75
Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice. J Neuroimmunol (2016) 0.75
APP Function and Lipids: A Bidirectional Link. Front Mol Neurosci (2017) 0.75
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells. Acta Neuropathol Commun (2015) 0.75
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron (2013) 3.27
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J Neurosci (2009) 2.49
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
19F and 1H MRI detection of amyloid beta plaques in vivo. Nat Neurosci (2005) 2.44
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells (2005) 1.86
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci (2007) 1.85
Potent amyloidogenicity and pathogenicity of Aβ43. Nat Neurosci (2011) 1.76
Active gamma-secretase complexes contain only one of each component. J Biol Chem (2007) 1.69
Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. J Biol Chem (2006) 1.66
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci (2004) 1.65
Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide. Bioessays (2014) 1.61
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest (2005) 1.56
Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacol Ther (2005) 1.54
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat Med (2005) 1.49
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem (2003) 1.49
beta-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem (2005) 1.48
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J Neurosci Res (2002) 1.43
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry (2006) 1.41
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem (2006) 1.37
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. J Biol Chem (2005) 1.34
Aβ secretion and plaque formation depend on autophagy. Cell Rep (2013) 1.32
Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Hum Mol Genet (2006) 1.27
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 1.27
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem (2005) 1.25
Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS One (2011) 1.23
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiol Dis (2006) 1.23
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One (2013) 1.23
Oxidized neprilysin in aging and Alzheimer's disease brains. Biochem Biophys Res Commun (2003) 1.21
The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. J Biol Chem (2006) 1.21
Emergence of cooperation in public goods games. Proc Biol Sci (2009) 1.20
Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1). J Biol Chem (2002) 1.20
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Cell Rep (2013) 1.20
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci (2011) 1.19
Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. FASEB J (2011) 1.18
Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry (2008) 1.18
Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry (2003) 1.15
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. Hum Mol Genet (2007) 1.15
Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus (2003) 1.15
Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res (2002) 1.14
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics (2009) 1.12
DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry (2006) 1.12
Comprehensive behavioral phenotyping of calpastatin-knockout mice. Mol Brain (2008) 1.11
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion. Biochem Biophys Res Commun (2006) 1.10
Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging (2006) 1.10
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. J Biol Chem (2008) 1.07
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Hum Mol Genet (2009) 1.07
Alzheimer's disease: beta-Amyloid protein and tau. J Neurosci Res (2002) 1.06
Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation. Lancet (2003) 1.05
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology. Nat Commun (2012) 1.05
Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. J Biol Chem (2009) 1.04
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J (2003) 1.04
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Biochim Biophys Acta (2006) 1.04
Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. J Biol Chem (2008) 1.04
Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production. J Neurochem (2007) 1.02
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry (2003) 1.02
Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques. Eur J Med Chem (2004) 1.02
BACE1 interacts with lipid raft proteins. J Neurosci Res (2006) 1.01
Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochim Biophys Acta (2005) 1.00
Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol Dis (2005) 1.00
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes Cells (2011) 0.99
Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. J Biol Chem (2006) 0.98
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta Neuropathol (2010) 0.98
Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. J Biol Chem (2007) 0.97
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. EMBO Mol Med (2012) 0.96
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. J Biol Chem (2005) 0.96
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain. Neurobiol Aging (2005) 0.95
Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. J Biol Chem (2004) 0.95
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. J Neurosci Res (2006) 0.95
Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behav Brain Res (2005) 0.94
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease. Ann Neurol (2005) 0.94
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Cell Signal (2009) 0.94
Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease. Acta Neuropathol (2014) 0.94
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons. J Biol Chem (2004) 0.93
Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen. J Immunol (2008) 0.93
Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol (2013) 0.93
Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Sci Rep (2013) 0.93
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. J Biol Chem (2013) 0.92
SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes. J Cell Sci (2005) 0.92
BACE1 interacts with nicastrin. Biochem Biophys Res Commun (2002) 0.91
Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Exp Neurol (2012) 0.91
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. J Neurochem (2005) 0.91
Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. J Neurochem (2011) 0.91
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. FEBS Lett (2005) 0.90