Published in Neurobiol Dis on September 07, 2006
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem (2009) 1.57
Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia. Neuropsychopharmacology (2011) 1.42
Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett (2009) 1.23
Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease. ACS Chem Neurosci (2012) 1.22
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). J Med Chem (2014) 1.17
M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons. J Neurosci (2009) 1.15
M1 and M4 receptors modulate hippocampal pyramidal neurons. J Neurophysiol (2010) 1.07
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. EMBO J (2010) 1.05
Discovery of ML326: The first sub-micromolar, selective M5 PAM. Bioorg Med Chem Lett (2013) 0.97
A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment. Psychopharmacology (Berl) (2011) 0.91
Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency. PLoS One (2009) 0.87
Novel allosteric effects of amiodarone at the muscarinic M5 receptor. J Pharmacol Exp Ther (2010) 0.87
Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits. Front Behav Neurosci (2011) 0.79
Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complement Altern Med (2012) 0.78
Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation. J Phys Chem B (2011) 0.78
Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients. Sci Rep (2011) 0.77
Investigation of the mechanisms mediating MDMA "Ecstasy"-induced increases in cerebro-cortical perfusion determined by btASL MRI. Psychopharmacology (Berl) (2014) 0.77
Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins. Mol Brain (2016) 0.76
Provisional hypotheses for the molecular genetics of cognitive development: imaging genetic pathways in the anterior cingulate cortex. Biol Psychol (2007) 0.75
Synthesis of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one. Tetrahedron Lett (2015) 0.75
Resveratrol Increases Serum BDNF Concentrations and Reduces Vascular Smooth Muscle Cells Contractility via a NOS-3-Independent Mechanism. Biomed Res Int (2017) 0.75
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci (2008) 6.13
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell (2002) 5.69
Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci (2007) 4.34
Innate versus learned odour processing in the mouse olfactory bulb. Nature (2007) 4.19
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell (2003) 3.96
Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83
Initiation and synergistic fibrillization of tau and alpha-synuclein. Science (2003) 3.76
Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells. Development (2004) 3.68
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron (2013) 3.27
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci (2006) 2.87
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab (2006) 2.82
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain (2008) 2.55
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J Clin Invest (2007) 2.45
19F and 1H MRI detection of amyloid beta plaques in vivo. Nat Neurosci (2005) 2.44
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Engineering GPCR signaling pathways with RASSLs. Nat Methods (2008) 2.29
Results of 2 years of treatment with as-needed ranibizumab reinjection for polypoidal choroidal vasculopathy. Br J Ophthalmol (2013) 2.26
Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci (2002) 2.25
Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell (2005) 2.21
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell (2003) 2.11
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron (2005) 2.11
Aluminum induces tau aggregation in vitro but not in vivo. J Alzheimers Dis (2007) 2.10
Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106. Biol Psychiatry (2008) 2.06
Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol (2012) 1.95
A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A (2009) 1.90
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest (2008) 1.86
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci (2007) 1.85
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol (2007) 1.83
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell (2007) 1.82
Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion. Proc Natl Acad Sci U S A (2013) 1.82
Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation (2004) 1.80
Potent amyloidogenicity and pathogenicity of Aβ43. Nat Neurosci (2011) 1.76
Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem Res (2003) 1.75
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice. Hum Mol Genet (2002) 1.73
The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis. J Immunol (2002) 1.71
Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron (2002) 1.71
Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis (2006) 1.67
Granular tau oligomers as intermediates of tau filaments. Biochemistry (2007) 1.67
Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol (2005) 1.66
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A (2002) 1.66
In vivo evidence of CHIP up-regulation attenuating tau aggregation. J Neurochem (2005) 1.66
Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation. J Biol Chem (2007) 1.65
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci (2004) 1.65
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem (2003) 1.64
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol (2007) 1.63
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J Neurosci (2004) 1.63
PPARalpha protects proximal tubular cells from acute fatty acid toxicity. J Am Soc Nephrol (2007) 1.62
A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology (2013) 1.62
Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide. Bioessays (2014) 1.61
Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proc Natl Acad Sci U S A (2007) 1.58
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci (2007) 1.58
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest (2005) 1.56
Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Proc Natl Acad Sci U S A (2002) 1.55
Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacol Ther (2005) 1.54
M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. J Neurosci (2004) 1.53
High-efficiency CAG-FLPe deleter mice in C57BL/6J background. Exp Anim (2006) 1.53
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. J Neurosci (2002) 1.53
A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J Biol Chem (2006) 1.52
Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. J Neurosci (2005) 1.52
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51
Immunohistochemical detection of immunoglobulins and complements in formaldehyde-fixed and paraffin-embedded renal biopsy tissues; an adjunct for diagnosis of glomerulonephritis. Nephrology (Carlton) (2005) 1.50
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat Med (2005) 1.49
Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neurosci Res (2006) 1.49
beta-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem (2005) 1.48
Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography. J Cereb Blood Flow Metab (2003) 1.47
Auditory-visual speech perception examined by fMRI and PET. Neurosci Res (2003) 1.47
Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum. J Neurosci (2010) 1.47
Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.47
Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci (2002) 1.47
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. J Neurosci (2004) 1.46
Human cerebral circulation: positron emission tomography studies. Ann Nucl Med (2005) 1.46
Faithful expression of imprinted genes in cloned mice. Science (2002) 1.45
Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes (2004) 1.44
Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J Neurosci Res (2002) 1.43
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci (2002) 1.42
GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J Neurosci (2007) 1.41
Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. J Neurosci (2007) 1.41
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry (2006) 1.41
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci (2003) 1.41