Published in Biochem Biophys Res Commun on November 30, 1992
Flow-mediated endothelial mechanotransduction. Physiol Rev (1995) 10.13
Nitric oxide synthases in mammals. Biochem J (1994) 6.50
Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci U S A (1993) 2.94
Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (1993) 2.18
Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology. Antioxid Redox Signal (2010) 1.63
Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review. Mol Med (1998) 1.62
Nitric oxide and bone. Immunology (2001) 1.60
NO as a signalling molecule in the nervous system. Br J Pharmacol (2002) 1.46
Structural studies of constitutive nitric oxide synthases with diatomic ligands bound. J Biol Inorg Chem (2006) 1.28
Nitric oxide: a mediator in rat tubular hypoxia/reoxygenation injury. Proc Natl Acad Sci U S A (1994) 1.20
Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br J Pharmacol (1995) 1.12
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. Biochemistry (2009) 1.07
Role of nitric oxide in the circulatory failure and organ injury in a rodent model of gram-positive shock. Br J Pharmacol (1996) 1.05
Nitric oxide inhibits capacitative Ca2+ entry and enhances endoplasmic reticulum Ca2+ uptake in bovine vascular endothelial cells. J Physiol (2002) 1.04
Heme coordination of NO in NO synthase. Proc Natl Acad Sci U S A (1994) 0.97
Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity. Biochem J (1999) 0.89
GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP. Am J Physiol Lung Cell Mol Physiol (2009) 0.88
Comparison of the effects of hydroxocobalamin and oxyhaemoglobin on responses to NO, EDRF and the nitrergic transmitter. Br J Pharmacol (1996) 0.88
Functional reconstitution in Escherichia coli of the yeast mitochondrial matrix peptidase from its two inactive subunits. Proc Natl Acad Sci U S A (1993) 0.87
Metabolic engineering of microorganisms for the production of L-arginine and its derivatives. Microb Cell Fact (2014) 0.87
Regulation of nerve growth factor release by nitric oxide through cyclic GMP pathway in cortical glial cells. Mol Pharmacol (1999) 0.86
Arginine-based inhibitors of nitric oxide synthase: therapeutic potential and challenges. Mediators Inflamm (2012) 0.86
Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. Environ Health Perspect (1998) 0.85
Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax (1999) 0.85
Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide. Interdiscip Toxicol (2011) 0.84
Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. Biochemistry (2012) 0.83
Neuronal nitric oxide synthase expression is induced in neocortical astrocytes after spreading depression. J Cereb Blood Flow Metab (1998) 0.83
Nitric oxide can acutely modulate its biosynthesis through a negative feedback mechanism on L-arginine transport in cardiac myocytes. Am J Physiol Cell Physiol (2010) 0.82
Effect of nitric oxide gas on the generation of nitric oxide by isolated blood vessels: implications for inhalation therapy. Br J Pharmacol (1994) 0.78
Effect of ischemia in vivo and oxygen-glucose deprivation in vitro on NOS pools in the spinal cord: comparative study. Cell Mol Neurobiol (2006) 0.76
Dexamethasone worsens nitric oxide inhibition-induced hypertension and renal dysfunction. Am J Hypertens (2000) 0.75
The effect of a spinal cord hemisection on changes in nitric oxide synthase pools in the site of injury and in regions located far away from the injured site. Cell Mol Neurobiol (2006) 0.75
Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther (1981) 6.71
The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annu Rev Pharmacol Toxicol (1985) 3.29
Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin. J Pharmacol Exp Ther (1981) 3.14
Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther (1986) 2.64
Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med (1992) 2.56
Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol (1993) 2.53
Activation of purified guanylate cyclase by nitric oxide requires heme. Comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung. Biochim Biophys Acta (1982) 2.00
Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms. J Biol Chem (1986) 1.86
Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery. J Pharmacol Exp Ther (1984) 1.85
Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension (1991) 1.77
Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite. Can J Physiol Pharmacol (1981) 1.74
Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols. Biochim Biophys Acta (1980) 1.74
Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase. Proc Natl Acad Sci U S A (1994) 1.71
Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation. Mol Pharmacol (1983) 1.68
IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells. Am J Physiol Cell Physiol (2000) 1.67
Bioregulation of lysosomal enzyme secretion from human neutrophils: roles of guanosine 3':5'-monophosphate and calcium in stimulus-secretion coupling. Proc Natl Acad Sci U S A (1975) 1.65
Activation of purified soluble guanylate cyclase by protoporphyrin IX. Proc Natl Acad Sci U S A (1982) 1.64
Hormonal control of lysosomal enzyme release from human neutrophils. Effects of autonomic agents on enzyme release, phagocytosis, and cylic nucleotide levels. J Exp Med (1974) 1.58
Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc Natl Acad Sci U S A (2001) 1.58
Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide. Biochem Biophys Res Commun (1995) 1.57
Nitric oxide and atherosclerosis. Nitric Oxide (2001) 1.57
Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J Biol Chem (1984) 1.55
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production. Am J Physiol (1996) 1.50
Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. Biochem Biophys Res Commun (1992) 1.50
Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res (1993) 1.48
Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones. Proc Natl Acad Sci U S A (1974) 1.48
Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO. Biochem Biophys Res Commun (1993) 1.44
Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am J Physiol (1992) 1.41
Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide. Biochem Biophys Res Commun (1990) 1.41
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci U S A (2001) 1.39
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A (1992) 1.39
Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX. Arch Biochem Biophys (1982) 1.38
Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro. Neuroscience (1994) 1.36
Possible involvement of S-nitrosothiols in the activation of guanylate cyclase by nitroso compounds. FEBS Lett (1980) 1.36
Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides. Science (1973) 1.34
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B. Proc Natl Acad Sci U S A (1996) 1.32
Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N'-nitrosonornicotine and nitric oxide. J Pharmacol Exp Ther (1980) 1.31
Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. J Immunol (1993) 1.30
Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. Biochem Biophys Res Commun (1989) 1.29
Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem Biophys Res Commun (1993) 1.29
A spectrophotometric assay for nitrate using NADPH oxidation by Aspergillus nitrate reductase. Anal Biochem (1993) 1.29
Endothelium-derived nitric oxide relaxes nonvascular smooth muscle. Eur J Pharmacol (1989) 1.27
Nonphagocytic release of neutral protease and beta-glucuronidase from human neutrophils. Regulation by autonomic neurohormones and cyclic nucleotides. Arthritis Rheum (1974) 1.27
Nitric oxide-cyclic GMP signal transduction system. Methods Enzymol (1996) 1.23
Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP. J Pharmacol Exp Ther (1984) 1.23
Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J Biol Chem (2001) 1.22
Differences in responsiveness of intrapulmonary artery and vein to arachidonic acid: mechanism of arterial relaxation involves cyclic guanosine 3':5'-monophosphate and cyclic adenosine 3':5'-monophosphate. J Pharmacol Exp Ther (1985) 1.20
Breakdown of noncollagenous chondromucoprotein matrix by leukocyte lysosome granule lysates from guinea pig, rabbit, and human. Clin Immunol Immunopathol (1973) 1.18
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein. Proc Natl Acad Sci U S A (1990) 1.17
Neutral protease release from human leukocytes regulated by neurohormones and cyclic nucleotides. Nat New Biol (1973) 1.16
Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc Natl Acad Sci U S A (1999) 1.16
Mediation of immunologic discharge of lysosomal enzymes from human neutrophils by guanosine 3',5'-monophosphate. Requirement of calcium, and inhibition by adenosine 3',5'-monophosphate. J Exp Med (1974) 1.15
An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity. Proc Natl Acad Sci U S A (2001) 1.14
Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis. J Biol Chem (1995) 1.13
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. J Biol Chem (1982) 1.12
L-arginine inhibits balloon catheter-induced intimal hyperplasia. Biochem Biophys Res Commun (1993) 1.11
Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes. J Biol Chem (1984) 1.11
Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc Natl Acad Sci U S A (2000) 1.11
Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro. Biochem Pharmacol (1971) 1.10
Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J Immunol (1998) 1.10
Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis. Biochem Pharmacol (1972) 1.10
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. Am Heart J (2004) 1.10
Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proc Natl Acad Sci U S A (2001) 1.09
Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release. J Pharmacol Exp Ther (1991) 1.08
Release of neutral protease and beta-glucuronidase from human neutrophils in the presence of cartilage treated with various immunologic reactants. J Immunol (1974) 1.08
Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept. Adv Cyclic Nucleotide Protein Phosphorylation Res (1984) 1.06
Microcirculation and oxidative stress. Free Radic Res (2007) 1.06
Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein. Circ Res (1987) 1.05
NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation. Biochem Biophys Res Commun (1990) 1.05
Condensed expirate nitrite as a home marker for acute asthma. Lancet (1995) 1.04
Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J Urol (1992) 1.03
Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochem Biophys Res Commun (1992) 1.03
Dissimilarities between methylene blue and cyanide on relaxation and cyclic GMP formation in endothelium-intact intrapulmonary artery caused by nitrogen oxide-containing vasodilators and acetylcholine. J Pharmacol Exp Ther (1986) 1.03
L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation. Biochem Biophys Res Commun (1989) 1.02
Enzyme release from guinea-pig polymorphonuclear leucocyte lysosomes inhibited in vitro by anti-inflammatory drugs. Nat New Biol (1972) 1.02
Regulation of lysosomal enzyme secretion: role in inflammation. Agents Actions (1974) 1.02
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. Am J Physiol (1998) 1.01
Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues. Science (1977) 1.01
Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J Immunol (1974) 1.01
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J Biol Chem (2001) 1.01
Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site -SH groups and both substrate and activator. Arch Biochem Biophys (1981) 1.01
Atriopeptin II relaxes and elevates cGMP in bovine pulmonary artery but not vein. J Appl Physiol (1985) (1986) 1.01
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide. J Biol Chem (1994) 1.01
Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation. Biochem Biophys Res Commun (1999) 1.00
Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds. Adv Pharmacol (1995) 0.99
Bidirectional regulation of lysosomal enzyme secretion and phagocytosis in human neutrophils by guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate. Proc Soc Exp Biol Med (1976) 0.99
Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver. Biochem Biophys Res Commun (1978) 0.98
Hormonal control of neutrophil lysosomal enzyme release: effect of epinephrine on adenosine 3',5'-monophosphate. Science (1974) 0.98
Dissimilar effects of anti-inflammatory drugs on stability of lysosomes from peritoneal and circulating leukocytes and liver. Biochem Pharmacol (1971) 0.98
Appearance and concentrations of catecholamines and their biosynthesis in the embryonic and developing chick. J Pharmacol Exp Ther (1968) 0.98
Acute arterial thrombosis causes endothelial dysfunction: a new paradigm for thrombolytic therapy. J Vasc Surg (2001) 0.97
Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes. Neuroscience (1995) 0.97
Preservation of structural integrity of liver lysosomes and membrane-stabilizing action of anti-inflammatory drugs, catecholamines and cyclic adenosine monophosphate in isotonic salt media. Biochem Pharmacol (1973) 0.96
The requriement of sympathetic innervation for the active transport of norepinephrine by the heart. J Pharmacol Exp Ther (1968) 0.95
Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. Am J Physiol (1993) 0.95
Release of enzymes from a rat liver lysosome fraction: inhibition by catecholamines and cyclic3', 5'-adenosine monophosphate, stimulation by cholinergic agents and cyclic 3', 5'-guanosine monophosphate. J Pharmacol Exp Ther (1973) 0.94
Catechol-O-methyl transferase and monoamine oxidase activities in the heart and liver of the embryonic and developing chick. J Pharmacol Exp Ther (1968) 0.93
Physiological release of nitric oxide is dependent on the level of vascular tone. Eur J Pharmacol (1990) 0.92
Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide. Proc Natl Acad Sci U S A (2001) 0.92