Published in J Virol on July 01, 2003
Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors. J Virol (2004) 3.65
Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. J Clin Invest (2009) 1.54
Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus. J Virol (2008) 1.50
Unique biologic properties of recombinant AAV1 transduction in polarized human airway epithelia. J Biol Chem (2006) 1.21
Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction. J Virol (2010) 1.21
Intracellular viral processing, not single-stranded DNA accumulation, is crucial for recombinant adeno-associated virus transduction. J Virol (2004) 1.17
Species-specific differences in mouse and human airway epithelial biology of recombinant adeno-associated virus transduction. Am J Respir Cell Mol Biol (2005) 1.12
Adeno-associated virus: a key to the human genome? Future Virol (2010) 1.03
Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates. Mol Ther (2007) 0.96
Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions. J Virol (2004) 0.96
Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo. Hum Gene Ther (2007) 0.95
Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus. J Virol (2014) 0.93
Enhanced real-time monitoring of adeno-associated virus trafficking by virus-quantum dot conjugates. ACS Nano (2011) 0.90
Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction. J Virol (2014) 0.87
AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. PLoS Pathog (2011) 0.87
Self-complementary adeno-associated viral vectors for gene therapy of hemophilia B: progress and challenges. Expert Rev Hematol (2011) 0.87
Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy. Hum Gene Ther Clin Dev (2015) 0.84
Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus. J Virol (2011) 0.84
Cellular unfolded protein response against viruses used in gene therapy. Front Microbiol (2014) 0.83
Mechanistic insights into the enhancement of adeno-associated virus transduction by proteasome inhibitors. J Virol (2013) 0.82
Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PLoS One (2012) 0.79
Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors. PLoS One (2013) 0.78
Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia. Mol Ther Nucleic Acids (2012) 0.78
Parvovirus particles and movement in the cellular cytoplasm and effects of the cytoskeleton. Virology (2014) 0.76
CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. JCI Insight (2016) 0.75
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol (1996) 6.22
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol (1987) 4.57
Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther (2001) 4.35
Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus. J Clin Invest (2000) 3.57
Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. J Biol Chem (2001) 3.15
Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. J Virol (2000) 3.00
Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors. J Virol (2001) 2.95
Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. J Virol (2002) 2.77
Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia. Hum Gene Ther (1998) 2.00
Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins. J Clin Invest (2002) 1.63
A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease. Hum Gene Ther (2001) 1.58
Transduction of well-differentiated airway epithelium by recombinant adeno-associated virus is limited by vector entry. J Virol (1999) 1.55
Gene therapy in cystic fibrosis. Chest (2001) 1.19
Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy. Nat Med (2002) 5.07
Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. J Clin Invest (2008) 3.33
Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. J Virol (2002) 2.77
Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res (2004) 2.69
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J Clin Invest (2010) 2.45
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest (2008) 2.42
Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. J Biol Chem (2002) 2.23
Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors. Nat Biotechnol (2005) 2.16
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Am J Respir Crit Care Med (2009) 2.15
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol (2006) 2.12
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circ Res (2004) 1.98
Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing. Nat Biotechnol (2002) 1.96
Airway epithelial cells: current concepts and challenges. Proc Am Thorac Soc (2008) 1.90
Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. J Virol (2002) 1.77
Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol (2003) 1.72
Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest (2008) 1.64
PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter. J Cell Sci (2005) 1.58
Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiol Genomics (2006) 1.57
Signaling components of redox active endosomes: the redoxosomes. Antioxid Redox Signal (2009) 1.50
Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49
Redox modifier genes in amyotrophic lateral sclerosis in mice. J Clin Invest (2007) 1.46
Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia. PLoS Pathog (2012) 1.43
Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am J Physiol Lung Cell Mol Physiol (2007) 1.42
Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. J Clin Invest (2012) 1.40
Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J Biol Chem (2002) 1.38
Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood (2010) 1.31
Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem (2003) 1.30
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem (2005) 1.28
rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion. Mol Ther (2006) 1.28
Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia. Am J Respir Cell Mol Biol (2006) 1.28
Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem (2011) 1.26
PITX2 and beta-catenin interactions regulate Lef-1 isoform expression. Mol Cell Biol (2007) 1.26
Unique biologic properties of recombinant AAV1 transduction in polarized human airway epithelia. J Biol Chem (2006) 1.21
Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes. J Virol (2005) 1.21
Evidence for a superoxide permeability pathway in endosomal membranes. Mol Cell Biol (2008) 1.21
Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane. J Biol Chem (2009) 1.21
Consequences of DNA-dependent protein kinase catalytic subunit deficiency on recombinant adeno-associated virus genome circularization and heterodimerization in muscle tissue. J Virol (2003) 1.16
Cloned ferrets produced by somatic cell nuclear transfer. Dev Biol (2006) 1.15
IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest (2004) 1.13
Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. Antioxid Redox Signal (2009) 1.13
The glandular stem/progenitor cell niche in airway development and repair. Proc Am Thorac Soc (2008) 1.13
Species-specific differences in mouse and human airway epithelial biology of recombinant adeno-associated virus transduction. Am J Respir Cell Mol Biol (2005) 1.12
Stem cells in the lung. Methods Enzymol (2006) 1.10
Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation (2004) 1.07
Spliceosome-mediated RNA trans-splicing with recombinant adeno-associated virus partially restores cystic fibrosis transmembrane conductance regulator function to polarized human cystic fibrosis airway epithelial cells. Hum Gene Ther (2005) 1.04
Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion. J Cell Sci (2002) 1.03
New animal models of cystic fibrosis: what are they teaching us? Curr Opin Pulm Med (2011) 1.03
Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD. J Hepatol (2004) 1.03
Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol (2007) 1.02
Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury. Biochem J (2008) 1.02
Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway. Mol Ther (2004) 1.01
Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Mol Ther (2009) 1.01
Comparative biology of cystic fibrosis animal models. Methods Mol Biol (2011) 1.01
Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. Am J Physiol Lung Cell Mol Physiol (2004) 1.00
BMP signaling controls PASMC KV channel expression in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol (2005) 0.99
Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats. Hypertension (2007) 0.99
Endothelin-1 stimulates arterial VCAM-1 expression via NADPH oxidase-derived superoxide in mineralocorticoid hypertension. Hypertension (2003) 0.98
Current status of gene therapy for inherited lung diseases. Annu Rev Physiol (2002) 0.98
Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. Am J Respir Cell Mol Biol (2014) 0.97
Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates. Mol Ther (2007) 0.96
Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions. J Virol (2004) 0.96
Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Lab Invest (2008) 0.96
CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. J Clin Invest (2011) 0.95
Progress toward generating a ferret model of cystic fibrosis by somatic cell nuclear transfer. Reprod Biol Endocrinol (2003) 0.95
Recombinant AAV-mediated gene delivery using dual vector heterodimerization. Methods Enzymol (2002) 0.95
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem (2004) 0.95
Airway glandular development and stem cells. Curr Top Dev Biol (2004) 0.95
Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo. Hum Gene Ther (2007) 0.95
Nitric oxide and protein nitration in the cystic fibrosis airway. Arch Biochem Biophys (2002) 0.94
Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. Am J Respir Crit Care Med (2012) 0.94
Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. J Invest Dermatol (2004) 0.94
Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs. Am J Respir Cell Mol Biol (2015) 0.94
In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia. J Virol (2013) 0.92
Manifestations of cystic fibrosis diagnosed in adulthood. Curr Opin Pulm Med (2005) 0.92
Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity. J Biol Chem (2011) 0.91