Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.

PubWeight™: 2.45‹?› | Rank: Top 2%

🔗 View Article (PMC 2929732)

Published in J Clin Invest on August 25, 2010

Authors

Xingshen Sun1, Hongshu Sui, John T Fisher, Ziying Yan, Xiaoming Liu, Hyung-Ju Cho, Nam Soo Joo, Yulong Zhang, Weihong Zhou, Yaling Yi, Joann M Kinyon, Diana C Lei-Butters, Michelle A Griffin, Paul Naumann, Meihui Luo, Jill Ascher, Kai Wang, Timothy Frana, Jeffrey J Wine, David K Meyerholz, John F Engelhardt

Author Affiliations

1: Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

Articles citing this

(truncated to the top 100)

Origins of cystic fibrosis lung disease. N Engl J Med (2015) 2.97

The AAV vector toolkit: poised at the clinical crossroads. Mol Ther (2012) 2.53

Cystic fibrosis: a mucosal immunodeficiency syndrome. Nat Med (2012) 2.03

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01

Modifier genes in Mendelian disorders: the example of cystic fibrosis. Ann N Y Acad Sci (2010) 1.87

Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell (2012) 1.72

Cystic fibrosis genetics: from molecular understanding to clinical application. Nat Rev Genet (2014) 1.70

ATP secretion in the male reproductive tract: essential role of CFTR. J Physiol (2012) 1.57

Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A (2014) 1.47

Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. J Clin Invest (2012) 1.40

Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance. Proc Natl Acad Sci U S A (2011) 1.36

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest (2013) 1.30

Unstressing intemperate models: how cold stress undermines mouse modeling. J Exp Med (2012) 1.30

Cystic fibrosis transmembrane regulator correctors and potentiators. Cold Spring Harb Perspect Med (2013) 1.20

CFTR, mucins, and mucus obstruction in cystic fibrosis. Cold Spring Harb Perspect Med (2012) 1.15

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation. Mucosal Immunol (2012) 1.09

Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol (2014) 1.09

Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. Development (2013) 1.09

Advances in cell and gene-based therapies for cystic fibrosis lung disease. Mol Ther (2012) 1.08

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Mol Biol Cell (2012) 1.07

The innate immune function of airway epithelial cells in inflammatory lung disease. Eur Respir J (2015) 1.05

New animal models of cystic fibrosis: what are they teaching us? Curr Opin Pulm Med (2011) 1.03

Defective fluid secretion from submucosal glands of nasal turbinates from CFTR-/- and CFTR (ΔF508/ΔF508) pigs. PLoS One (2011) 1.02

The secret life of CFTR as a calcium-activated chloride channel. J Physiol (2013) 1.01

Comparative biology of cystic fibrosis animal models. Methods Mol Biol (2011) 1.01

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell (2016) 1.01

Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. PLoS One (2014) 0.99

The cystic fibrosis intestine. Cold Spring Harb Perspect Med (2013) 0.98

Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. Am J Respir Cell Mol Biol (2014) 0.97

Role of tyrosine phosphorylation in the muscarinic activation of the cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem (2013) 0.96

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. J Clin Invest (2011) 0.95

The blood-epididymis barrier and inflammation. Spermatogenesis (2014) 0.94

Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clin Sci (Lond) (2015) 0.94

A little CFTR goes a long way: CFTR-dependent sweat secretion from G551D and R117H-5T cystic fibrosis subjects taking ivacaftor. PLoS One (2014) 0.94

The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease. Nat Biotechnol (2014) 0.94

Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. Am J Respir Crit Care Med (2012) 0.94

Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs. Am J Respir Cell Mol Biol (2015) 0.94

Mucociliary transport in porcine trachea: differential effects of inhibiting chloride and bicarbonate secretion. Am J Physiol Lung Cell Mol Physiol (2012) 0.93

Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. Am J Pathol (2014) 0.93

Swine models of cystic fibrosis reveal male reproductive tract phenotype at birth. Biol Reprod (2011) 0.93

Cystic fibrosis therapeutics: the road ahead. Chest (2013) 0.91

Genetic therapies for cystic fibrosis lung disease. Hum Mol Genet (2011) 0.91

Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep (2015) 0.90

Fixing cystic fibrosis by correcting CFTR domain assembly. J Cell Biol (2012) 0.90

Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets. Am J Respir Cell Mol Biol (2013) 0.88

Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia. J Biomed Biotechnol (2011) 0.88

Lentiviral vector gene transfer to porcine airways. Mol Ther Nucleic Acids (2012) 0.87

Variation in MSRA modifies risk of neonatal intestinal obstruction in cystic fibrosis. PLoS Genet (2012) 0.86

Why mouse airway submucosal gland serous cells do not secrete fluid in response to cAMP stimulation. J Biol Chem (2012) 0.85

The challenges and promises of new therapies for cystic fibrosis. J Exp Med (2012) 0.85

Development of ferret as a human lung cancer model by injecting 4-(Nmethyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Lung Cancer (2013) 0.84

Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology. Am J Physiol Gastrointest Liver Physiol (2015) 0.84

Comparative processing and function of human and ferret cystic fibrosis transmembrane conductance regulator. J Biol Chem (2012) 0.84

Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy. Hum Gene Ther Clin Dev (2015) 0.84

Molecular characterization of the small nonstructural proteins of parvovirus Aleutian mink disease virus (AMDV) during infection. Virology (2014) 0.83

The cystic fibrosis of exocrine pancreas. Cold Spring Harb Perspect Med (2013) 0.83

Generation of Lung Epithelium from Pluripotent Stem Cells. Curr Pathobiol Rep (2013) 0.83

Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independent. Respir Res (2011) 0.82

The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases. Biochem J (2012) 0.82

Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea. Proc Natl Acad Sci U S A (2014) 0.81

The cystic fibrosis gene: a molecular genetic perspective. Cold Spring Harb Perspect Med (2013) 0.81

Quantitative proteomics reveals an altered cystic fibrosis in vitro bronchial epithelial secretome. Am J Respir Cell Mol Biol (2015) 0.81

Cystic fibrosis: an inherited disease affecting mucin-producing organs. Int J Biochem Cell Biol (2014) 0.81

Transgenic animals may help resolve a sticky situation in cystic fibrosis. J Clin Invest (2010) 0.81

A ferret model of COPD-related chronic bronchitis. JCI Insight (2016) 0.81

Ferret lung transplant: an orthotopic model of obliterative bronchiolitis. Am J Transplant (2012) 0.80

Transduction of ferret airway epithelia using a pre-treatment and lentiviral gene vector. BMC Pulm Med (2014) 0.80

Genetically modified species in research: Opportunities and challenges for the histology core laboratory. J Histotechnol (2012) 0.79

Hybrid nonviral/viral vector systems for improved piggyBac DNA transposon in vivo delivery. Mol Ther (2015) 0.79

Loss of cftr function leads to pancreatic destruction in larval zebrafish. Dev Biol (2015) 0.79

Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors. Mol Ther Nucleic Acids (2013) 0.79

Pancreatic pathophysiology in cystic fibrosis. J Pathol (2015) 0.79

Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets. PLoS One (2014) 0.79

Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins. PLoS One (2015) 0.79

Effects of airway surface liquid pH on host defense in cystic fibrosis. Int J Biochem Cell Biol (2014) 0.79

Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium. Am J Physiol Gastrointest Liver Physiol (2015) 0.79

The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3. Dis Model Mech (2012) 0.78

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis. Rev Physiol Biochem Pharmacol (2016) 0.78

Thyroid glands from pigs with cystic fibrosis, old issues new ways. Exp Physiol (2010) 0.78

Animal models of adrenocortical tumorigenesis. Mol Cell Endocrinol (2011) 0.78

Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating. J Physiol (2015) 0.78

PATHOPHYSIOLOGIC EVALUATION OF THE TRANSGENIC CFTR "GUT-CORRECTED" PORCINE MODEL OF CYSTIC FIBROSIS. Am J Physiol Lung Cell Mol Physiol (2016) 0.78

Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance. Am J Respir Cell Mol Biol (2016) 0.77

Barriers to inhaled gene therapy of obstructive lung diseases: A review. J Control Release (2016) 0.77

Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions. Hum Gene Ther (2013) 0.77

NETs and CF Lung Disease: Current Status and Future Prospects. Antibiotics (Basel) (2015) 0.77

Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA. PLoS One (2014) 0.77

Porcine nasal epithelial cultures for studies of cystic fibrosis sinusitis. Int Forum Allergy Rhinol (2014) 0.77

The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa. BMC Physiol (2012) 0.76

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences. Biomed Res Int (2016) 0.76

Prevalence of meconium ileus marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. Genet Med (2015) 0.76

Gene delivery to the airway. Curr Protoc Hum Genet (2013) 0.76

Burkholderia cepacia Complex Vaccines: Where Do We Go from here? Vaccines (Basel) (2016) 0.75

Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel. Sci Rep (2016) 0.75

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. J Innate Immun (2016) 0.75

A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret. J Hered (2015) 0.75

The magnitude of ivacaftor effects on fluid secretion via R117H-CFTR channels: Human in vivo measurements. PLoS One (2017) 0.75

Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators Inflamm (2016) 0.75

Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers. Hum Gene Ther (2015) 0.75

Lessons learned from the cystic fibrosis pig. Theriogenology (2016) 0.75

Articles cited by this

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science (1989) 40.22

Cystic fibrosis. N Engl J Med (2005) 8.09

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28

Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med (2005) 5.51

Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet (1992) 4.12

Pathology of cystic fibrosis review of the literature and comparison with 146 autopsied cases. Perspect Pediatr Pathol (1975) 3.03

Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR. Science (1994) 2.24

Cystic fibrosis mouse models. Am J Respir Cell Mol Biol (2006) 1.98

Submucosal glands and airway defense. Proc Am Thorac Soc (2004) 1.76

Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis. Gastroenterology (2006) 1.71

Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest (2008) 1.64

Malabsorption of bile acids in children with cystic fibrosis. N Engl J Med (1973) 1.63

Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions. J Lipid Res (1992) 1.62

Processing and function of CFTR-DeltaF508 are species-dependent. Proc Natl Acad Sci U S A (2007) 1.62

Prevalence of liver disease in cystic fibrosis. Arch Dis Child (1991) 1.61

The distribution and structure of cells in the tracheal epithelium of the mouse. Cell Tissue Res (1980) 1.58

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic. J Cell Biol (2009) 1.54

Ultrastructure of the nonciliated bronchiolar epithelial (Clara) cell of mammalian lung. III. A study of man with comparison of 15 mammalian species. Exp Lung Res (1980) 1.53

Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis. J Clin Invest (2007) 1.50

Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49

Optical method for quantifying rates of mucus secretion from single submucosal glands. Am J Physiol Lung Cell Mol Physiol (2001) 1.47

Natural history of liver disease in cystic fibrosis. Hepatology (1999) 1.40

A comparative study of mammalian tracheal mucous glands. J Anat (2000) 1.39

Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J (2004) 1.35

Cystic fibrosis of the pancreas. Morphologic findings in infants with and without diagnostic pancreatic lesions. Arch Pathol (1973) 1.26

CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse. Am J Physiol (1994) 1.20

Quantitation of the secretory cells of the ferret tracheobronchial tree. J Anat (1986) 1.18

Ferret nutrition. Vet Clin North Am Exot Anim Pract (1999) 1.16

Cloned ferrets produced by somatic cell nuclear transfer. Dev Biol (2006) 1.15

Bile acids: trying to understand their chemistry and biology with the hope of helping patients. Hepatology (2009) 1.14

Effects of ursodeoxycholic acid treatment on nutrition and liver function in patients with cystic fibrosis and longstanding cholestasis. Gut (1990) 1.09

Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic events. Am J Physiol Gastrointest Liver Physiol (2004) 1.07

Intestinal bile salts in cystic fibrosis: studies in the patient and experimental animal. Arch Dis Child (1979) 1.04

A method for staining both gram-positive and gram-negative bacteria in sections. J Pathol Bacteriol (1947) 1.03

Normal vas deferens in fetuses with cystic fibrosis. J Urol (1997) 0.98

Morphological changes in the vas deferens and expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in control, deltaF508 and knock-out CFTR mice during postnatal life. Mol Reprod Dev (2000) 0.93

In vivo analysis of fluid transport in cystic fibrosis airway epithelia of bronchial xenografts. Am J Physiol (1996) 0.88

Bile acid metabolism in children with cystic fibrosis. Acta Paediatr Scand Suppl (1985) 0.88

Effects of a proton-pump inhibitor in cystic fibrosis. Acta Paediatr (1998) 0.85

Omeprazole, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymes. Eur J Pediatr (2003) 0.85

Cystic fibrosis as a cause of infertility. Reprod Biol (2004) 0.85

Ursodeoxycholic acid improves cholestasis in infants with cystic fibrosis. Ann Pharmacother (1997) 0.82

The normal upper gastrointestinal examination in the ferret. Vet Radiol Ultrasound (2003) 0.80

Articles by these authors

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38

Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Genotype, haplotype and copy-number variation in worldwide human populations. Nature (2008) 12.40

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol (2013) 7.97

The microRNA spectrum in 12 body fluids. Clin Chem (2010) 6.82

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28

A test of enhancing model accuracy in high-throughput crystallography. J Struct Funct Genomics (2005) 5.96

Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA (2012) 5.16

Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy. Nat Med (2002) 5.07

Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39

Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am J Psychiatry (2011) 4.29

Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms. Nucleic Acids Res (2008) 4.22

Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18

Copy number variation at 1q21.1 associated with neuroblastoma. Nature (2009) 4.10

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A (2011) 3.87

Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol (2009) 3.78

Reverse engineering cellular networks. Nat Protoc (2006) 3.67

Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43

A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42

Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36

Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. J Clin Invest (2008) 3.33

Ethics and scientific publication. Adv Physiol Educ (2005) 3.26

The landscape of recombination in African Americans. Nature (2011) 3.06

From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99

A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas. Mol Syst Biol (2008) 2.99

Origins of cystic fibrosis lung disease. N Engl J Med (2015) 2.97

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol (2010) 2.92

Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. J Virol (2002) 2.77

Safety and efficacy of warfarin plus aspirin combination therapy for giant coronary artery aneurysm secondary to Kawasaki disease: a meta-analysis. Cardiology (2014) 2.64

Comparative analysis of microarray normalization procedures: effects on reverse engineering gene networks. Bioinformatics (2007) 2.63

Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nat Genet (2013) 2.62

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology (2012) 2.58

Denoising array-based comparative genomic hybridization data using wavelets. Biostatistics (2005) 2.56

Extracellular microRNA: a new source of biomarkers. Mutat Res (2011) 2.55

The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53

A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24. J Pediatr (2009) 2.44

LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States. Am J Ophthalmol (2007) 2.43

wANNOVAR: annotating genetic variants for personal genomes via the web. J Med Genet (2012) 2.43

Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int (2005) 2.42

Photoselective vaporization with the green light laser vs transurethral resection of the prostate for treating benign prostate hyperplasia: a systematic review and meta-analysis. BJU Int (2012) 2.42

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest (2008) 2.42

Complexity of the microRNA repertoire revealed by next-generation sequencing. RNA (2010) 2.38

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37

The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) (2009) 2.34

Improved exome prioritization of disease genes through cross-species phenotype comparison. Genome Res (2013) 2.24

Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Mol Cell Proteomics (2008) 2.24

Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. J Biol Chem (2002) 2.23

A microsatellite-based, gene-rich linkage map reveals genome structure, function and evolution in Gossypium. Genetics (2007) 2.23

Exploring techniques for vision based human activity recognition: methods, systems, and evaluation. Sensors (Basel) (2013) 2.22

Synthesis of the H-cluster framework of iron-only hydrogenase. Nature (2005) 2.17

Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors. Nat Biotechnol (2005) 2.16

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15

Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Am J Respir Crit Care Med (2009) 2.15

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res (2013) 2.12

Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol (2006) 2.12

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A (2011) 2.12

Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD. Am J Kidney Dis (2006) 2.09

Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency. Cell Stem Cell (2013) 2.04

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01

Copy number variation of multiple genes at Rhg1 mediates nematode resistance in soybean. Science (2012) 2.01

Gene-function wiki would let biologists pool worldwide resources. Nature (2006) 2.01

Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circ Res (2004) 1.98

Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Hum Mutat (2011) 1.98

A model to predict antiviral treatment in HBeAg negative chronic hepatitis B with alanine aminotransferase≤2 upper limit of normal. Liver Int (2013) 1.97

Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing. Nat Biotechnol (2002) 1.96

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95

Airway epithelial cells: current concepts and challenges. Proc Am Thorac Soc (2008) 1.90

Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol (2010) 1.88

Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood (2011) 1.78

Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. J Virol (2002) 1.77

Submucosal glands and airway defense. Proc Am Thorac Soc (2004) 1.76

Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol (2003) 1.72

Bioartificial sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN Channel reduces the dependence on electronic pacemaker in a sick-sinus syndrome model. Circulation (2006) 1.70

Causes of alternative pathway dysregulation in dense deposit disease. Clin J Am Soc Nephrol (2012) 1.70

Isolation and characterization of methicillin-resistant Staphylococcus aureus from pork farms and visiting veterinary students. PLoS One (2013) 1.69

An inducible model of abacterial prostatitis induces antigen specific inflammatory and proliferative changes in the murine prostate. Prostate (2011) 1.68

Absent secretion to vasoactive intestinal peptide in cystic fibrosis airway glands. J Biol Chem (2002) 1.66

Air trapping and airflow obstruction in newborn cystic fibrosis piglets. Am J Respir Crit Care Med (2013) 1.65

Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest (2008) 1.64