Published in Proc Am Thorac Soc on September 15, 2008
Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol (2010) 3.22
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
The human airway epithelial basal cell transcriptome. PLoS One (2011) 1.69
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cell Mol Life Sci (2010) 1.66
Lung adenocarcinoma subtypes based on expression of human airway basal cell genes. Eur Respir J (2013) 1.59
The cell biology of asthma. J Cell Biol (2014) 1.40
Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol (2010) 1.40
RNA-Seq quantification of the human small airway epithelium transcriptome. BMC Genomics (2012) 1.28
Mesenchymal cell survival in airway and interstitial pulmonary fibrosis. Fibrogenesis Tissue Repair (2010) 1.17
EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype. Proc Natl Acad Sci U S A (2013) 1.16
Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PLoS One (2011) 1.13
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. Pflugers Arch (2010) 1.08
Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression. Hum Mol Genet (2013) 1.08
The role of vimentin intermediate filaments in the progression of lung cancer. Am J Respir Cell Mol Biol (2014) 1.08
Rho-associated protein kinase inhibition enhances airway epithelial Basal-cell proliferation and lentivirus transduction. Am J Respir Cell Mol Biol (2013) 1.07
Neurotrophins in lung health and disease. Expert Rev Respir Med (2010) 1.05
Patterning and plasticity in development of the respiratory lineage. Dev Dyn (2010) 1.05
Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected]. Proc Natl Acad Sci U S A (2013) 1.01
Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells. Ann Am Thorac Soc (2014) 1.00
Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity. Respir Res (2013) 0.96
Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cell Mol Life Sci (2012) 0.95
Claudins: Gatekeepers of lung epithelial function. Semin Cell Dev Biol (2015) 0.94
Brain-derived neurotrophic factor in the airways. Pharmacol Ther (2014) 0.94
Cilia dysfunction in lung disease. Annu Rev Physiol (2014) 0.94
Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 0.94
Smoking-induced CXCL14 expression in the human airway epithelium links chronic obstructive pulmonary disease to lung cancer. Am J Respir Cell Mol Biol (2013) 0.93
The rabbit as a model for studying lung disease and stem cell therapy. Biomed Res Int (2013) 0.91
Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer. Stem Cells (2013) 0.90
FOXJ1 prevents cilia growth inhibition by cigarette smoke in human airway epithelium in vitro. Am J Respir Cell Mol Biol (2014) 0.90
Early host responses of seasonal and pandemic influenza A viruses in primary well-differentiated human lung epithelial cells. PLoS One (2013) 0.89
Airway basal cells. The "smoking gun" of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 0.88
Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition. Am J Physiol Lung Cell Mol Physiol (2014) 0.88
Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy. Proc Natl Acad Sci U S A (2015) 0.88
Smoking accelerates aging of the small airway epithelium. Respir Res (2014) 0.87
Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. PLoS One (2014) 0.87
Site-specific differences in gene expression of secreted proteins in the mouse lung: comparison of methods to show differences by location. J Histochem Cytochem (2010) 0.87
Bone marrow cells expressing clara cell secretory protein increase epithelial repair after ablation of pulmonary clara cells. Mol Ther (2013) 0.87
GemC1 controls multiciliogenesis in the airway epithelium. EMBO Rep (2016) 0.86
Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells. Part Fibre Toxicol (2012) 0.85
Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model. Physiol Rep (2015) 0.84
3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively. Chem Res Toxicol (2010) 0.84
Comparative evaluation of miRNA expression between in vitro and in vivo airway epithelium demonstrates widespread differences. Am J Pathol (2013) 0.83
Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp Lung Res (2012) 0.83
Artificial lung basics: fundamental challenges, alternative designs and future innovations. Organogenesis (2011) 0.83
Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure. Part Fibre Toxicol (2013) 0.83
Airway epithelial wounds in rhesus monkey generate ionic currents that guide cell migration to promote healing. J Appl Physiol (1985) (2011) 0.82
EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium. Stem Cells (2016) 0.82
4-Hydroxynonenal regulates mitochondrial function in human small airway epithelial cells. Oncotarget (2015) 0.82
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. EMBO Rep (2014) 0.81
Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis. Front Pharmacol (2016) 0.80
ATP4a is required for development and function of the Xenopus mucociliary epidermis - a potential model to study proton pump inhibitor-associated pneumonia. Dev Biol (2015) 0.79
Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci (2015) 0.79
Growth and differentiation of primary and passaged equine bronchial epithelial cells under conventional and air-liquid-interface culture conditions. BMC Vet Res (2011) 0.79
Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS One (2015) 0.79
Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines. Physiol Rep (2013) 0.79
Smoking-dependent Distal-to-Proximal Repatterning of the Adult Human Small Airway Epithelium. Am J Respir Crit Care Med (2017) 0.79
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C. Antimicrob Agents Chemother (2013) 0.78
Reconstituted human upper airway epithelium as 3-d in vitro model for nasal polyposis. PLoS One (2014) 0.78
In vitro culturing of ciliary respiratory cells--a model for studies of genetic diseases. J Appl Genet (2010) 0.78
Detection of a novel stem cell probably involved in normal turnover of the lung airway epithelium. J Cell Mol Med (2015) 0.77
Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype. Am J Respir Cell Mol Biol (2016) 0.77
Bronchoalveolar lavage and other methods to define the human respiratory tract milieu in health and disease. Lung (2011) 0.77
Depletion of bone marrow CCSP-expressing cells delays airway regeneration. Mol Ther (2014) 0.77
Coronaviruses and the human airway: a universal system for virus-host interaction studies. Virol J (2016) 0.75
What we can learn from a tadpole about ciliopathies and airway diseases - Using systems biology in Xenopus to study cilia and mucociliary epithelia. Genesis (2017) 0.75
Pendrin, an anion exchanger on lung epithelial cells, could be a novel target for lipopolysaccharide-induced acute lung injury mice. Am J Transl Res (2016) 0.75
Epithelial Sodium and Chloride Channels and Asthma. Chin Med J (Engl) (2015) 0.75
JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium. Stem Cell Rev (2016) 0.75
A mixture of carcinoid tumors, extensive neuroendocrine proliferation, and multiple pulmonary sclerosing hemangiomas. World J Surg Oncol (2014) 0.75
Agonist binding to β-adrenergic receptors on human airway epithelial cells inhibits migration and wound repair. Am J Physiol Cell Physiol (2015) 0.75
The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue. Cell Biosci (2015) 0.75
Analysis of Cell Turnover in the Bronchiolar Epithelium Through the Normal Aging Process. Lung (2016) 0.75
Temporal dynamics of ovine airway epithelial cell differentiation at an air-liquid interface. PLoS One (2017) 0.75
Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A (2009) 7.24
Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy. Nat Med (2002) 5.07
Well-differentiated human airway epithelial cell cultures. Methods Mol Med (2005) 4.66
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
Lung development and repair: contribution of the ciliated lineage. Proc Natl Acad Sci U S A (2006) 3.57
Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. J Clin Invest (2008) 3.33
Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. Dis Model Mech (2010) 3.17
Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell (2011) 2.95
Type 2 alveolar cells are stem cells in adult lung. J Clin Invest (2013) 2.93
Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. J Virol (2002) 2.77
Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem (2009) 2.59
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J Clin Invest (2010) 2.45
Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 2.42
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest (2008) 2.42
Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. J Biol Chem (2002) 2.23
Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors. Nat Biotechnol (2005) 2.16
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Am J Respir Crit Care Med (2009) 2.15
Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types. Clin Cancer Res (2010) 2.15
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn (2005) 2.13
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol (2006) 2.12
Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol (2004) 2.04
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circ Res (2004) 1.98
Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing. Nat Biotechnol (2002) 1.96
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol (2003) 1.82
A subset of mouse tracheal epithelial basal cells generates large colonies in vitro. Am J Physiol Lung Cell Mol Physiol (2003) 1.80
Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. J Virol (2002) 1.77
Terminal N-linked galactose is the primary receptor for adeno-associated virus 9. J Biol Chem (2011) 1.73
Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc Natl Acad Sci U S A (2013) 1.73
Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation. PLoS One (2012) 1.72
Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol (2003) 1.72
Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. J Immunol (2006) 1.68
Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest (2008) 1.64
Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR. PLoS One (2011) 1.58
PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter. J Cell Sci (2005) 1.58
Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiol Genomics (2006) 1.57
Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes. PLoS One (2013) 1.52
Signaling components of redox active endosomes: the redoxosomes. Antioxid Redox Signal (2009) 1.50
Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49
Cystic fibrosis and other respiratory diseases of impaired mucus clearance. Toxicol Pathol (2007) 1.46
Redox modifier genes in amyotrophic lateral sclerosis in mice. J Clin Invest (2007) 1.46
Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci U S A (2012) 1.46
Retracted Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. Am J Respir Cell Mol Biol (2010) 1.44
Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia. PLoS Pathog (2012) 1.43
Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. J Clin Invest (2012) 1.40
Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces. J Immunol (2005) 1.38
Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J Biol Chem (2002) 1.38
Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol (2009) 1.37
Cytokine secretion by cystic fibrosis airway epithelial cells. Am J Respir Crit Care Med (2003) 1.34
Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2002) 1.32
Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem (2003) 1.30
Transcellular thiocyanate transport by human airway epithelia. J Physiol (2004) 1.30
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. J Biol Chem (2005) 1.28
rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion. Mol Ther (2006) 1.28
DiffSplice: the genome-wide detection of differential splicing events with RNA-seq. Nucleic Acids Res (2012) 1.28
Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia. Am J Respir Cell Mol Biol (2006) 1.28
Second-strand genome conversion of adeno-associated virus type 2 (AAV-2) and AAV-5 is not rate limiting following apical infection of polarized human airway epithelia. J Virol (2003) 1.28
Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem (2011) 1.26
Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. Stem Cells (2012) 1.26
PITX2 and beta-catenin interactions regulate Lef-1 isoform expression. Mol Cell Biol (2007) 1.26
The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett (2006) 1.23
Human nasal and tracheo-bronchial respiratory epithelial cell culture. Methods Mol Biol (2013) 1.23
Unique biologic properties of recombinant AAV1 transduction in polarized human airway epithelia. J Biol Chem (2006) 1.21
Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes. J Virol (2005) 1.21
Evidence for a superoxide permeability pathway in endosomal membranes. Mol Cell Biol (2008) 1.21
Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane. J Biol Chem (2009) 1.21
Mucins and their O-Glycans from human bronchial epithelial cell cultures. Am J Physiol Lung Cell Mol Physiol (2004) 1.20
A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med (2003) 1.16
Consequences of DNA-dependent protein kinase catalytic subunit deficiency on recombinant adeno-associated virus genome circularization and heterodimerization in muscle tissue. J Virol (2003) 1.16
Cloned ferrets produced by somatic cell nuclear transfer. Dev Biol (2006) 1.15
Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol (2009) 1.15
Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium. Am J Respir Crit Care Med (2004) 1.14
Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. Mol Microbiol (2011) 1.14
Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype. Am J Respir Crit Care Med (2014) 1.14
IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest (2004) 1.13
Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. Antioxid Redox Signal (2009) 1.13
The glandular stem/progenitor cell niche in airway development and repair. Proc Am Thorac Soc (2008) 1.13
Species-specific differences in mouse and human airway epithelial biology of recombinant adeno-associated virus transduction. Am J Respir Cell Mol Biol (2005) 1.12
Stem cells in the lung. Methods Enzymol (2006) 1.10
Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling. J Biol Chem (2010) 1.08
SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis. Am J Respir Cell Mol Biol (2005) 1.08
Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy. Proc Natl Acad Sci U S A (2010) 1.07
Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. Br J Pharmacol (2012) 1.06
β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci (2012) 1.05
Airway epithelial cell tolerance to Pseudomonas aeruginosa. Respir Res (2005) 1.05
Epithelial kinetics in mouse heterotopic tracheal allografts. Am J Transplant (2002) 1.04
Spliceosome-mediated RNA trans-splicing with recombinant adeno-associated virus partially restores cystic fibrosis transmembrane conductance regulator function to polarized human cystic fibrosis airway epithelial cells. Hum Gene Ther (2005) 1.04
Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion. J Cell Sci (2002) 1.03
New animal models of cystic fibrosis: what are they teaching us? Curr Opin Pulm Med (2011) 1.03
Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD. J Hepatol (2004) 1.03
Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice. Am J Physiol Lung Cell Mol Physiol (2006) 1.02
Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury. Biochem J (2008) 1.02
Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. J Biol Chem (2009) 1.02
Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol (2007) 1.02
C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology (2004) 1.02
Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. Proc Am Thorac Soc (2008) 1.02