Published in Mol Cell Biol on July 01, 2003
HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature (2008) 14.17
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11
RNA processing and its regulation: global insights into biological networks. Nat Rev Genet (2010) 5.34
Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat Biotechnol (2011) 3.18
Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol (2007) 2.71
Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. Science (2010) 2.69
HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley Interdiscip Rev RNA (2010) 2.59
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev (2005) 2.38
Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling. Neuron (2010) 2.08
Nova autoregulation reveals dual functions in neuronal splicing. EMBO J (2005) 1.97
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Rep (2014) 1.78
A comprehensive computational characterization of conserved mammalian intronic sequences reveals conserved motifs associated with constitutive and alternative splicing. Genome Res (2007) 1.58
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Hum Mol Genet (2009) 1.53
The function of introns. Front Genet (2012) 1.42
A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators. Mol Biol Cell (2006) 1.31
RNA protein interaction in neurons. Annu Rev Neurosci (2013) 1.31
Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. Proc Natl Acad Sci U S A (2009) 1.27
Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mRNA. Mol Cell Biol (2007) 1.27
Evolution of Nova-dependent splicing regulation in the brain. PLoS Genet (2007) 1.23
Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. Endocr Rev (2008) 1.18
Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts. RNA (2011) 1.14
Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1gamma gene. Nucleic Acids Res (2007) 1.11
Defects in translational regulation contributing to human cognitive and behavioral disease. Curr Opin Genet Dev (2011) 1.09
The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite. Front Neural Circuits (2010) 1.05
Prediction of clustered RNA-binding protein motif sites in the mammalian genome. Nucleic Acids Res (2013) 1.05
ELAV multimerizes on conserved AU4-6 motifs important for ewg splicing regulation. Mol Cell Biol (2005) 1.04
Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences. Biochim Biophys Acta (2012) 1.04
PIPE-CLIP: a comprehensive online tool for CLIP-seq data analysis. Genome Biol (2014) 1.03
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife (2013) 1.03
The function of spliceosome components in open mitosis. Nucleus (2010) 1.01
Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1. Structure (2011) 1.01
Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes. Genetics (2005) 1.01
The CUGBP2 splicing factor regulates an ensemble of branchpoints from perimeter binding sites with implications for autoregulation. PLoS Genet (2009) 0.99
Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand. Hum Genet (2010) 0.97
Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members. Nucleic Acids Res (2010) 0.95
Determination and augmentation of RNA sequence specificity of the Nova K-homology domains. Nucleic Acids Res (2004) 0.90
Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA. J Biol Chem (2011) 0.85
The intronic GABRG2 mutation, IVS6+2T->G, associated with childhood absence epilepsy altered subunit mRNA intron splicing, activated nonsense-mediated decay, and produced a stable truncated γ2 subunit. J Neurosci (2012) 0.85
Impaired surface αβγ GABA(A) receptor expression in familial epilepsy due to a GABRG2 frameshift mutation. Neurobiol Dis (2012) 0.84
Nova1 is a master regulator of alternative splicing in pancreatic beta cells. Nucleic Acids Res (2014) 0.83
The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels. Channels (Austin) (2010) 0.82
Guardian of Genetic Messenger-RNA-Binding Proteins. Biomolecules (2016) 0.80
RNA regulation in neurologic disease and cancer. Cancer Res Treat (2010) 0.80
Alternative Splicing of a Novel Inducible Exon Diversifies the CASK Guanylate Kinase Domain. J Nucleic Acids (2012) 0.79
Nova-1 mediates glucocorticoid-induced inhibition of pre-mRNA splicing of gonadotropin-releasing hormone transcripts. J Biol Chem (2009) 0.78
Dynamic expression pattern of neuro-oncological ventral antigen 1 (Nova1) in the rat brain after focal cerebral ischemia/reperfusion insults. J Histochem Cytochem (2012) 0.78
Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression. PLoS One (2015) 0.77
Does conservation account for splicing patterns? BMC Genomics (2016) 0.75
RNA binding protein Nova1 promotes tumor growth in vivo and its potential mechanism as an oncogene may due to its interaction with GABAA Receptor-γ2. J Biomed Sci (2016) 0.75
The salmonid myostatin gene family: a novel model for investigating mechanisms that influence duplicate gene fate. BMC Evol Biol (2012) 0.75
17β-estradiol regulates the RNA-binding protein Nova1, which then regulates the alternative splicing of estrogen receptor β in the aging female rat brain. Neurobiol Aging (2017) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol (1997) 10.26
Exon recognition in vertebrate splicing. J Biol Chem (1995) 10.08
Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci (2000) 7.54
Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res (2002) 6.71
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature (1982) 6.56
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell (2001) 6.50
Characterization of a beta-actin mRNA zipcode-binding protein. Mol Cell Biol (1997) 5.21
Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet (2002) 4.97
Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron (2000) 4.24
mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end. Cell (1997) 4.03
A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev (1997) 3.88
Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. Cell (1995) 3.71
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. Cell (2000) 3.59
Alternative RNA splicing in the nervous system. Prog Neurobiol (2001) 3.38
Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes Dev (1994) 3.20
Meiosis-specific RNA splicing in yeast. Cell (1991) 3.15
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A (2000) 3.11
hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Mol Cell Biol (1999) 3.06
Selection of splice sites in pre-mRNAs with short internal exons. Mol Cell Biol (1991) 3.02
The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol (1997) 2.93
Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J (1995) 2.87
Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron (1993) 2.81
The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. Mol Cell Biol (1997) 2.69
A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol Cell Biol (1997) 2.66
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain. Proc Natl Acad Sci U S A (1996) 2.52
Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats. Mol Cell Biol (1998) 2.51
Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3' untranslated region. EMBO J (1994) 2.47
Neuron-specific alternative splicing of nonmuscle myosin II heavy chain-B pre-mRNA requires a cis-acting intron sequence. J Biol Chem (1996) 2.24
Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA. RNA (1996) 2.16
A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates. Curr Biol (1998) 2.06
Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol (1999) 2.05
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain. Proc Natl Acad Sci U S A (2000) 1.92
Common themes in the function of transcription and splicing enhancers. Curr Opin Cell Biol (1997) 1.92
Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes Dev (1995) 1.89
Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol (1997) 1.83
Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proc Natl Acad Sci U S A (1997) 1.82
Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. RNA (1999) 1.78
Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol (1995) 1.75
Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. Structure (1999) 1.59
Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron (1994) 1.59
Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain. Neuron (1997) 1.58
The splice of life: alternative splicing and neurological disease. Nat Rev Neurosci (2001) 1.57
Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site. Proc Natl Acad Sci U S A (1990) 1.53
Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science (1995) 1.41
Essential nucleotides direct neuron-specific splicing of gamma 2 pre-mRNA. RNA (1996) 1.31
Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration. Annu Rev Neurosci (2001) 1.29
The KH domains of Xenopus Vg1RBP mediate RNA binding and self-association. RNA (2002) 1.26
Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing. J Neurochem (1991) 1.18
Alternative splicing generates two isoforms of the alpha 2 subunit of the inhibitory glycine receptor. FEBS Lett (1991) 1.15
UUCAC- and vera-dependent localization of VegT RNA in Xenopus oocytes. Curr Biol (2002) 1.11
An intronic downstream enhancer promotes 3' splice site usage of a neural cell-specific exon. J Biol Chem (2000) 1.10
A consensus RNA signal that directs germ layer determinants to the vegetal cortex of Xenopus oocytes. Dev Biol (2002) 1.06
Dopamine D2 receptors in signal transduction and behavior. Crit Rev Neurobiol (1997) 1.03
Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor. Neuropharmacology (1999) 1.01
Role of dimerization in KH/RNA complexes: the example of Nova KH3. Biochemistry (2002) 1.00
Cell- and stage-specific splicing events resolved in specialized neurons of the rat cerebellum. RNA (1996) 0.98
Immunocytochemical localization of gamma 2 short and gamma 2 long subunits of the GABAA receptor in the rat brain. J Neurosci (1994) 0.91
Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines. Pharmacol Biochem Behav (2000) 0.86
Differential expression of two forms of GABAA receptor gamma 2-subunit in mice. Brain Res Bull (1991) 0.84
A novel bipartite intronic splicing enhancer promotes the inclusion of a mini-exon in the AMP deaminase 1 gene. J Biol Chem (2001) 0.84
Differential Localization of Two Alternatively Spliced GABAA Receptor gamma2-Subunit mRNAs in the Chick Brain. Eur J Neurosci (1992) 0.80
A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) 14.63
HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature (2008) 14.17
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature (2009) 14.07
De novo gene disruptions in children on the autistic spectrum. Neuron (2012) 9.69
CLIP identifies Nova-regulated RNA networks in the brain. Science (2003) 8.88
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell (2011) 8.46
An RNA map predicting Nova-dependent splicing regulation. Nature (2006) 7.63
Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58
CLIP: a method for identifying protein-RNA interaction sites in living cells. Methods (2005) 6.26
RNA processing and its regulation: global insights into biological networks. Nat Rev Genet (2010) 5.34
Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat Biotechnol (2011) 3.18
An alternative mode of microRNA target recognition. Nat Struct Mol Biol (2012) 2.77
Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. Science (2010) 2.69
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol Cell (2012) 2.54
Splicing regulation in neurologic disease. Neuron (2006) 2.46
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev (2005) 2.38
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells. J Neurosci (2004) 2.20
Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling. Neuron (2010) 2.08
RNA binding proteins and the regulation of neuronal synaptic plasticity. Curr Opin Neurobiol (2006) 2.08
Nova autoregulation reveals dual functions in neuronal splicing. EMBO J (2005) 1.97
EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J (2012) 1.91
CLIP: crosslinking and immunoprecipitation of in vivo RNA targets of RNA-binding proteins. Methods Mol Biol (2008) 1.79
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron (2012) 1.78
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev (2012) 1.70
Paraneoplastic neurological degenerations: keys to tumour immunity. Nat Rev Cancer (2004) 1.55
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Hum Mol Genet (2009) 1.53
Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction. Nat Struct Mol Biol (2011) 1.38
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J (2002) 1.38
Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell (2005) 1.36
A mouse model of the human Fragile X syndrome I304N mutation. PLoS Genet (2009) 1.36
Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. PLoS Biol (2005) 1.35
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron (2012) 1.27
Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing. Proc Natl Acad Sci U S A (2009) 1.27
Evolution of Nova-dependent splicing regulation in the brain. PLoS Genet (2007) 1.23
Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells. J Biol Chem (2004) 1.22
The fragile X mental retardation protein, FMRP, recognizes G-quartets. Ment Retard Dev Disabil Res Rev (2004) 1.14
IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation. J Immunol (2006) 1.13
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood (2006) 1.13
Neuroimmunology of the paraneoplastic neurological degenerations. Curr Opin Immunol (2004) 1.08
Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. J Clin Invest (2009) 1.08
The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite. Front Neural Circuits (2010) 1.05
Prediction of clustered RNA-binding protein motif sites in the mammalian genome. Nucleic Acids Res (2013) 1.05
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife (2013) 1.03
Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1. Structure (2011) 1.01
A T-cell receptor associated with naturally occurring human tumor immunity. Proc Natl Acad Sci U S A (2007) 0.96
Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens. Arch Neurol (2012) 0.95
The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells. PLoS One (2010) 0.94
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice. Hum Mol Genet (2013) 0.92
Functional and mechanistic insights from genome-wide studies of splicing regulation in the brain. Adv Exp Med Biol (2007) 0.91
Observing the invisible: successful tumor immunity in humans. Nat Immunol (2003) 0.90
Determination and augmentation of RNA sequence specificity of the Nova K-homology domains. Nucleic Acids Res (2004) 0.90
Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer. PLoS One (2010) 0.88
Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neurosci Lett (2004) 0.86
Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo. Elife (2013) 0.85
Tolerance to the neuron-specific paraneoplastic HuD antigen. PLoS One (2009) 0.85
The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels. Channels (Austin) (2010) 0.82
T cells targeting a neuronal paraneoplastic antigen mediate tumor rejection and trigger CNS autoimmunity with humoral activation. Eur J Immunol (2014) 0.79
Ri/Nova gene-associated paraneoplastic subacute motor neuronopathy. Muscle Nerve (2013) 0.77
NMDA receptor as a target in paraneoplastic encephalitis. Ann Neurol (2007) 0.76
Erratum: Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Nat Protoc (2016) 0.75
Autoimmune encephalopathy: the spectrum widens. Ann Neurol (2009) 0.75
Turkey must end violent response to protests. Science (2013) 0.75