Published in Mar Drugs on March 31, 2010
Drug discovery targeting cell division proteins, microtubules and FtsZ. Bioorg Med Chem (2014) 0.86
Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors. Mar Drugs (2012) 0.83
Metabolomic tools for secondary metabolite discovery from marine microbial symbionts. Mar Drugs (2014) 0.80
Synthesis and SAR of Lehualide B: a marine-derived natural product with potent anti-multiple myeloma activity. ACS Chem Biol (2013) 0.80
Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Porifera and Coelenterata. World J Clin Oncol (2011) 0.79
Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads. Nat Prod Rep (2014) 0.77
Axonal Transport and Neurodegeneration: How Marine Drugs Can Be Used for the Development of Therapeutics. Mar Drugs (2016) 0.75
Ethyl acetate extract from marine sponge Hyattella cribriformis exhibit potent anticancer activity by promoting tubulin polymerization as evidenced mitotic arrest and induction of apoptosis. Pharmacogn Mag (2015) 0.75
Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ. J Nat Prod (2017) 0.75
Antiproliferative and Proapoptotic Activities of Marine Sponge Hyrtios erectus Extract on Breast Carcinoma Cell Line (MCF-7). Pharmacogn Mag (2017) 0.75
Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science (2001) 24.48
The genetic landscape of a cell. Science (2010) 16.52
Natural products as sources of new drugs over the last 25 years. J Nat Prod (2007) 13.98
Microtubules as a target for anticancer drugs. Nat Rev Cancer (2004) 13.93
Promotion of microtubule assembly in vitro by taxol. Nature (1979) 12.73
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc (1971) 8.56
Paclitaxel (taxol) N Engl J Med (1995) 5.79
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A (2004) 5.10
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature (2007) 4.70
Mediation of c-Myc-induced apoptosis by p53. Science (1994) 4.45
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res (1995) 4.11
Drug development from marine natural products. Nat Rev Drug Discov (2008) 4.08
Impact of natural products on developing new anti-cancer agents. Chem Rev (2009) 3.99
Marine natural products. Nat Prod Rep (2009) 3.41
Drugs from the deep: marine natural products as drug candidates. Drug Discov Today (2003) 3.32
Clinical toxicities encountered with paclitaxel (Taxol). Semin Oncol (1993) 3.18
Taxol suppresses dynamics of individual microtubules in living human tumor cells. Mol Biol Cell (1999) 3.14
Marine natural products as anticancer drugs. Mol Cancer Ther (2005) 2.93
A network view of disease and compound screening. Nat Rev Drug Discov (2009) 2.90
Chemistry. The renaissance of natural products as drug candidates. Science (2005) 2.83
Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol (1998) 2.78
Structure of tubulin at 6.5 A and location of the taxol-binding site. Nature (1995) 2.62
Marine sponges as pharmacy. Mar Biotechnol (NY) (2005) 2.49
Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Mol Cell (2005) 2.17
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu Rev Cell Dev Biol (2000) 2.12
Targeting microtubules for cancer chemotherapy. Curr Med Chem Anticancer Agents (2005) 2.10
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nat Rev Drug Discov (2009) 2.08
Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp. J Org Chem (2000) 2.04
Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity. Cancer Res (2003) 2.01
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proc Natl Acad Sci U S A (2005) 2.00
Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition. Biochemistry (1993) 1.99
Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci U S A (2006) 1.96
Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity. Cancer Res (2002) 1.69
A three-hybrid system for detecting small ligand-protein receptor interactions. Proc Natl Acad Sci U S A (1996) 1.61
Tubulin-interactive natural products as anticancer agents. J Nat Prod (2009) 1.59
Total syntheses of (+)-zampanolide and (+)-dactylolide exploiting a unified strategy. J Am Chem Soc (2002) 1.56
Microtubule active agents: beyond the taxane frontier. Clin Cancer Res (2008) 1.49
Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines. Cancer Res (2004) 1.45
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. Biochemistry (2002) 1.45
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol (2006) 1.36
Total synthesis of (+)-peloruside A. Org Lett (2005) 1.35
Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine. Apoptosis (2001) 1.32
Enantioselective total synthesis of peloruside A: a potent microtubule stabilizer. Org Lett (2008) 1.31
Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin. Proc Natl Acad Sci U S A (2003) 1.30
Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A. Angew Chem Int Ed Engl (2003) 1.30
Antitumor activity and mechanism of action of the novel marine natural products mycalamide-A and -B and onnamide. Cancer Res (1989) 1.26
A unique mode of microtubule stabilization induced by peloruside A. J Mol Biol (2008) 1.25
Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents. Nat Prod Rep (2007) 1.24
Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry (2002) 1.19
Spatial and temporal variability of cytotoxic metabolites in populations of the New Zealand sponge Mycale hentscheli. J Chem Ecol (2005) 1.18
Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest. Cancer Res (2003) 1.17
Total synthesis of (+)-zampanolide. J Am Chem Soc (2001) 1.17
Clinical status of anti-cancer agents derived from marine sources. Anticancer Agents Med Chem (2008) 1.17
Macrolactonization via Ti(IV)-mediated epoxy-acid coupling: a total synthesis of (-)-dactylolide [and zampanolide]. J Am Chem Soc (2003) 1.15
Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol). Cancer Res (1998) 1.15
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res (2004) 1.13
Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. J Med Chem (2009) 1.13
Total synthesis of mycalamide A. J Am Chem Soc (2005) 1.12
An expedient total synthesis of (-)-dactylolide and formal synthesis of (-)-zampanolide. Org Lett (2005) 1.11
The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry (1999) 1.10
Total synthesis of (+)-mycalamide A. Org Lett (2006) 1.05
Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines. Mol Pharm (2007) 1.03
Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species. J Nat Prod (2000) 1.02
An aldol-based synthesis of (+)-peloruside a, a potent microtubule stabilizing agent. J Am Chem Soc (2009) 1.02
NMR determination of the bioactive conformation of peloruside A bound to microtubules. J Am Chem Soc (2006) 1.00
Total synthesis of mycalamide A and 7-epi-mycalamide A. Org Lett (2000) 1.00
Producing drugs from marine sponges. Biotechnol Adv (2003) 0.99
A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products. J Nat Prod (2009) 0.98
Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity. J Org Chem (2010) 0.96
Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J Biol Chem (2009) 0.96
Novel agents that target tublin and related elements. Semin Oncol (2006) 0.95
Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob Agents Chemother (2009) 0.95
Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. Biochemistry (2009) 0.94
Cytotoxicity of pederin and some of its derivatives on cultured mammalian cells. Experientia (1966) 0.93
Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine. Bioorg Med Chem Lett (2004) 0.93
Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia species. J Nat Prod (2002) 0.92
The in vitro biological activities of synthetic 18-O-methyl mycalamide B, 10-epi-18-O-methyl mycalamide B and pederin. Anticancer Drug Des (1997) 0.92
Total synthesis of (-)-zampanolide and questionable existence of (-)-dactylolide as the elusive biosynthetic precursor of (-)-zampanolide in an Okinawan sponge. Org Lett (2009) 0.91
Mycalamides C and D, cytotoxic compounds from the marine sponge Stylinos n. species. J Nat Prod (2000) 0.91
Marine macrolides, a promising source of antitumor compounds. Anticancer Agents Med Chem (2009) 0.91
Strategies for the synthesis of the novel antitumor agent peloruside A. Curr Opin Drug Discov Devel (2008) 0.89
Marine toxins: an overview. Prog Mol Subcell Biol (2009) 0.89
Antibiotics and compounds affecting tanslation by eukaryotic ribosomes. Specific enhancement of aminoacyl-tRNA binding by methylaxnthines. Mol Cell Biochem (1976) 0.88
High-throughput gene silencing using cell arrays. Oncogene (2004) 0.88
Total synthesis of (-)-dactylolide and formal synthesis of (-)-zampanolide via target oriented beta-C-glycoside formation. J Org Chem (2008) 0.87
Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells. Apoptosis (2004) 0.86
Convergent total synthesis of (+)-mycalamide A. J Org Chem (2006) 0.85
Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A. Methods Enzymol (2007) 0.85
Yeast as a screening tool. Drug Discov Today Technol (2005) 0.85
Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation. Mol Cancer Ther (2003) 0.83
The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C. Anticancer Drug Des (2002) 0.83
Personal recollections on the early development of taxol. J Nat Prod (2004) 0.82
Onnamide F: a new nematocide from a southern Australian marine sponge, Trachycladus laevispirulifer. J Nat Prod (2001) 0.82
Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7. Invest New Drugs (2010) 0.82
Toxins affecting actin filaments and microtubules. Prog Mol Subcell Biol (2009) 0.81
Chemical prospectors scour the seas for promising drugs. Science (1994) 0.80
Microbial secondary metabolites play important roles in medicine; prospects for discovery of new drugs. Perspect Biol Med (1997) 0.80
Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A. J Leukoc Biol (2009) 0.79
Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells. Invest New Drugs (2010) 0.76
Marine natural products. Nat Prod Rep (2010) 3.68
Marine natural products. Nat Prod Rep (2009) 3.41
Marine natural products. Nat Prod Rep (2010) 3.22
Marine natural products. Nat Prod Rep (2008) 2.73
Marine natural products. Nat Prod Rep (2005) 2.51
Marine natural products. Nat Prod Rep (2007) 2.21
Marine natural products. Nat Prod Rep (2006) 2.01
Marine natural products. Nat Prod Rep (2004) 1.90
Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity. Cancer Res (2002) 1.69
Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines. Cancer Res (2004) 1.45
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol (2006) 1.36
Spongian diterpenoids from marine sponges. Nat Prod Rep (2006) 1.26
Marine natural products. Nat Prod Rep (2003) 1.19
Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis. J Med Chem (2009) 1.13
Chemical reactions on surface molecules attached to silicon quantum dots. J Am Chem Soc (2010) 1.10
Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. J Biol Chem (2011) 1.07
Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines. Mol Pharm (2007) 1.03
NMR determination of the bioactive conformation of peloruside A bound to microtubules. J Am Chem Soc (2006) 1.00
Structural basis of microtubule stabilization by laulimalide and peloruside A. Angew Chem Int Ed Engl (2014) 0.99
Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity. J Org Chem (2010) 0.96
Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp. J Org Chem (2002) 0.96
Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules. Chem Biol (2012) 0.95
Spatial and temporal variability of the bacterial community in different chemotypes of the New Zealand marine sponge Mycale hentscheli. FEMS Microbiol Ecol (2010) 0.92
Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues. Org Biomol Chem (2011) 0.88
Sized controlled synthesis, purification, and cell studies with silicon quantum dots. Nanoscale (2011) 0.85
Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity. Chembiochem (2010) 0.85
Mollisosides A, B1, and B2: minor triterpene glycosides from the New Zealand and South Australian sea cucumber Australostichopus mollis. J Nat Prod (2005) 0.84
Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes. Mol Cancer Ther (2011) 0.84
Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells. Cancer Chemother Pharmacol (2010) 0.82
Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7. Invest New Drugs (2010) 0.82
Microtubule-stabilizing agents delay the onset of EAE through inhibition of migration. Immunol Cell Biol (2013) 0.81
Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp. J Nat Prod (2011) 0.80
Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A. J Leukoc Biol (2009) 0.79
Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells. Pharm Res (2012) 0.79
The agminosides: naturally acetylated glycolipids from the New Zealand marine sponge Raspailia agminata. J Nat Prod (2010) 0.78
βII-tubulin and βIII-tubulin mediate sensitivity to peloruside A and laulimalide, but not paclitaxel or vinblastine, in human ovarian carcinoma cells. Mol Cancer Ther (2011) 0.77
Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent. Methods Cell Biol (2013) 0.77
Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A. Invest New Drugs (2015) 0.76
Clathriol, a novel polyoxygenated 14beta steroid isolated from the New Zealand marine sponge Clathria lissosclera. J Nat Prod (2002) 0.76
Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells. Invest New Drugs (2010) 0.76
Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease. Nat Prod Rep (2016) 0.76
Molecular basis for fungicidal action of neothyonidioside, a triterpene glycoside from the sea cucumber, Australostichopus mollis. Mol Biosyst (2012) 0.75
Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. Mar Drugs (2012) 0.75
Structurally diverse hamigerans from the New Zealand marine sponge Hamigera tarangaensis: NMR-directed isolation, structure elucidation and antifungal activity. Org Biomol Chem (2013) 0.75
Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae. Gene (2012) 0.75
The protein synthesis inhibitors mycalamides A and E have limited susceptibility toward the drug efflux network. J Biochem Mol Toxicol (2011) 0.75
Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding. Curr Cancer Drug Targets (2014) 0.75
Lipophilic toxicity from the marine dinoflagellate Karenia brevisulcata: use of the brevetoxin neuroblastoma assay to assess toxin presence and concentration. Toxicon (2005) 0.75
13C NMR analysis of 3,6-dihydro-2H-pyrans: assignment of remote stereochemistry using axial shielding effects. J Org Chem (2014) 0.75
Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae. Mol Biosyst (2014) 0.75
The Oxeatamides: nitrogenous spongian diterpenes from the New Zealand marine sponge Darwinella oxeata. J Nat Prod (2014) 0.75
Heptanosides from galactose-derived oxepenes via stereoselective addition reactions. J Org Chem (2009) 0.75
Hydrothermal oxidation of waste lipids, protein, and starch from New Zealand meat- and vegetable-processing plants. Water Environ Res (2006) 0.75