The roles of intersubunit interactions in exosome stability.

A protein interaction framework for human mRNA degradation. Genome Res (2004) 2.25

Whole-genome analysis of mRNA decay in Plasmodium falciparum reveals a global lengthening of mRNA half-life during the intra-erythrocytic development cycle. Genome Biol (2007) 2.03

Subunit architecture of multimeric complexes isolated directly from cells. EMBO Rep (2006) 1.75

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res (2009) 1.68

A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells. Nucleic Acids Res (2008) 1.46

Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Mol Biol Cell (2006) 1.33

The RNA-binding protein TbDRBD3 regulates the stability of a specific subset of mRNAs in trypanosomes. Nucleic Acids Res (2008) 1.32

The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X. Traffic (2008) 1.22

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. RNA (2007) 1.22

A role for the exosome in the in vivo degradation of unstable mRNAs. RNA (2003) 1.15

Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. RNA (2010) 1.08

Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes. Eukaryot Cell (2007) 1.05

Core exosome-independent roles for Rrp6 in cell cycle progression. Mol Biol Cell (2009) 1.05

The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradation. RNA (2013) 1.02

The exozyme model: a continuum of functionally distinct complexes. RNA (2010) 0.98

Trypanosome MTR4 is involved in rRNA processing. Nucleic Acids Res (2007) 0.96

Characterization of deadenylation in trypanosome extracts and its inhibition by poly(A)-binding protein Pab1p. RNA (2004) 0.96

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nat Commun (2014) 0.94

Deadenylation-independent stage-specific mRNA degradation in Leishmania. Nucleic Acids Res (2008) 0.92

Interdependent nucleocytoplasmic trafficking and interactions of Dis3 with Rrp6, the core exosome and importin-alpha3. Traffic (2009) 0.92

Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks. Nucleic Acids Res (2014) 0.92

Rapid decay of unstable Leishmania mRNAs bearing a conserved retroposon signature 3'-UTR motif is initiated by a site-specific endonucleolytic cleavage without prior deadenylation. Nucleic Acids Res (2010) 0.89

3'-End polishing of the kinetoplastid spliced leader RNA is performed by SNIP, a 3'-->5' exonuclease with a Motley assortment of small RNA substrates. Mol Cell Biol (2004) 0.84

Pronounced and extensive microtubule defects in a Saccharomyces cerevisiae DIS3 mutant. Yeast (2011) 0.84

Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. Nucleic Acids Res (2010) 0.84

The CAF1-NOT complex of trypanosomes. Front Genet (2014) 0.82

Depletion of the Trypanosome Pumilio domain protein PUF2 or of some other essential proteins causes transcriptome changes related to coding region length. Eukaryot Cell (2014) 0.82

A global profiling of uncapped mRNAs under cold stress reveals specific decay patterns and endonucleolytic cleavages in Brachypodium distachyon. Genome Biol (2013) 0.82

RRP41L, a putative core subunit of the exosome, plays an important role in seed germination and early seedling growth in Arabidopsis. Plant Physiol (2012) 0.80

Depletion of trypanosome CTR9 leads to gene expression defects. PLoS One (2012) 0.80

Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast. Genetics (2016) 0.77

Identification and analysis of the RNA degrading complexes and machinery of Giardia lamblia using an in silico approach. BMC Genomics (2011) 0.77

RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates. PLoS One (2014) 0.77

Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in Trypanosoma brucei. PLoS One (2014) 0.76

RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism. J Biol Chem (2016) 0.75

Exosomal Protein Deficiencies: How Abnormal RNA Metabolism Results in Childhood-Onset Neurological Diseases. J Neuromuscul Dis (2015) 0.75

The nuclear proteome of Trypanosoma brucei. PLoS One (2017) 0.75

The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64

In search of antisense. Trends Biochem Sci (2004) 3.93

Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature (2012) 3.92

A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Nat Genet (2008) 3.62

Antisense transcripts in the human genome. Trends Genet (2002) 3.33

Tissue specificity and the human protein interaction network. Mol Syst Biol (2009) 3.20

Predicting mutation outcome from early stochastic variation in genetic interaction partners. Nature (2011) 2.56

Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Cell (2009) 2.32

A protein interaction framework for human mRNA degradation. Genome Res (2004) 2.25

Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis. Plant Cell (2008) 2.16

Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling. EMBO J (2009) 2.13

A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei. Mol Biochem Parasitol (2005) 2.10

Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans. Science (2011) 1.98

Evolutionary plasticity of genetic interaction networks. Nat Genet (2008) 1.97

The use of edge-betweenness clustering to investigate biological function in protein interaction networks. BMC Bioinformatics (2005) 1.97

A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Genomics (2006) 1.88

Rapid selection of transgenic C. elegans using antibiotic resistance. Nat Methods (2010) 1.80

The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. Hum Mol Genet (2004) 1.77

Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb. Cell (2008) 1.75

The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J Biol Chem (2007) 1.69

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res (2009) 1.68

Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons. BMC Genomics (2009) 1.68

TbMP81 is required for RNA editing in Trypanosoma brucei. EMBO J (2002) 1.65

Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2(alpha) phosphorylation at Thr169. J Cell Sci (2008) 1.64

Predicting genetic modifier loci using functional gene networks. Genome Res (2010) 1.59

Hepatitis C virus mutation affects proteasomal epitope processing. J Clin Invest (2004) 1.58

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics (2004) 1.56

Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei. Proteomics (2006) 1.53

RNA-binding domain proteins in Kinetoplastids: a comparative analysis. Eukaryot Cell (2005) 1.52

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain. J Biol Chem (2004) 1.50

Messenger RNA processing sites in Trypanosoma brucei. Mol Biochem Parasitol (2005) 1.47

A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells. Nucleic Acids Res (2008) 1.46

Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model. Mol Microbiol (2006) 1.42

Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans. Genome Biol (2007) 1.41

Trypanosoma brucei PUF9 regulates mRNAs for proteins involved in replicative processes over the cell cycle. PLoS Pathog (2009) 1.41

Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii. EMBO J (2002) 1.40

Expression of the RNA recognition motif protein RBP10 promotes a bloodstream-form transcript pattern in Trypanosoma brucei. Mol Microbiol (2012) 1.38

Widespread conservation of genetic redundancy during a billion years of eukaryotic evolution. Trends Genet (2008) 1.36

Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake. Mol Cell Proteomics (2006) 1.33

Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol (2006) 1.30

The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Curr Biol (2007) 1.27

Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome. PLoS Genet (2011) 1.27

Control and regulation of gene expression: quantitative analysis of the expression of phosphoglycerate kinase in bloodstream form Trypanosoma brucei. J Biol Chem (2007) 1.18

Regulated expression of glycosomal phosphoglycerate kinase in Trypanosoma brucei. Mol Biochem Parasitol (2006) 1.18

Substrate specificity, localization, and essential role of the glutathione peroxidase-type tryparedoxin peroxidases in Trypanosoma brucei. J Biol Chem (2005) 1.18

Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradation. RNA (2006) 1.17

The transcriptomes of Trypanosoma brucei Lister 427 and TREU927 bloodstream and procyclic trypomastigotes. Mol Biochem Parasitol (2005) 1.17

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. Biochem J (2009) 1.15

The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury. Mol Microbiol (2004) 1.15

Expression of the human RNA-binding protein HuR in Trypanosoma brucei increases the abundance of mRNAs containing AU-rich regulatory elements. Nucleic Acids Res (2002) 1.15

A role for the exosome in the in vivo degradation of unstable mRNAs. RNA (2003) 1.15

Human genes with CpG island promoters have a distinct transcription-associated chromatin organization. Genome Biol (2012) 1.13

The role of the 5'-3' exoribonuclease XRNA in transcriptome-wide mRNA degradation. RNA (2011) 1.13

Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion. Proc Natl Acad Sci U S A (2013) 1.13

Predicting phenotypic variation in yeast from individual genome sequences. Nat Genet (2011) 1.12

Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease pim1. Mol Cell Biol (2006) 1.12

The cell cycle regulated transcriptome of Trypanosoma brucei. PLoS One (2011) 1.09

Human epidermal stem cell function is regulated by circadian oscillations. Cell Stem Cell (2013) 1.09

Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray. Mol Biochem Parasitol (2002) 1.09

A simple principle concerning the robustness of protein complex activity to changes in gene expression. BMC Syst Biol (2008) 1.09

The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes. J Cell Sci (2010) 1.06

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation. FEBS Lett (2010) 1.06

Functional analysis of Trypanosoma brucei PUF1. Mol Biochem Parasitol (2006) 1.05

Gliotoxin production by clinical and environmental Aspergillus fumigatus strains. Int J Med Microbiol (2007) 1.04

Post-transcriptional regulation of the trypanosome heat shock response by a zinc finger protein. PLoS Pathog (2013) 1.04

The Leishmania tarentolae exosome: purification and structural analysis by electron microscopy. Mol Biochem Parasitol (2008) 1.03

The subcellular localisation of trypanosome RRP6 and its association with the exosome. Mol Biochem Parasitol (2006) 1.02

The roles of 3'-exoribonucleases and the exosome in trypanosome mRNA degradation. RNA (2013) 1.02

EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. J Cell Sci (2008) 1.01

The role of deadenylation in the degradation of unstable mRNAs in trypanosomes. Nucleic Acids Res (2009) 1.01

The role of protein quality control in mitochondrial protein homeostasis under oxidative stress. Proteomics (2010) 1.00

Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity. J Exp Med (2002) 1.00

Generating transgenic nematodes by bombardment and antibiotic selection. Nat Methods (2012) 0.99

Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase. FEBS J (2005) 0.98

Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem (2012) 0.97

Depletion of GIM5 causes cellular fragility, a decreased glycosome number, and reduced levels of ether-linked phospholipids in trypanosomes. J Biol Chem (2003) 0.97

The centriolar satellite protein SSX2IP promotes centrosome maturation. J Cell Biol (2013) 0.96

Epigenetic epistatic interactions constrain the evolution of gene expression. Mol Syst Biol (2013) 0.96

Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex. Dev Cell (2012) 0.96

Characterization and developmentally regulated localization of the mitochondrial carrier protein homologue MCP6 from Trypanosoma brucei. Eukaryot Cell (2006) 0.96

A domino effect in drug action: from metabolic assault towards parasite differentiation. Mol Microbiol (2010) 0.95

Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels. Mol Microbiol (2014) 0.95

Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis. Int J Biol Sci (2010) 0.93

An RNAi screen of the RRM-domain proteins of Trypanosoma brucei. Mol Biochem Parasitol (2008) 0.92

Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks. Nucleic Acids Res (2014) 0.92

Mitochondrial carrier family inventory of Trypanosoma brucei brucei: Identification, expression and subcellular localisation. Mol Biochem Parasitol (2009) 0.92

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Cell Cycle (2015) 0.92

Glutathionylation of trypanosomal thiol redox proteins. J Biol Chem (2007) 0.92

Inferring gene function from evolutionary change in signatures of translation efficiency. Genome Biol (2014) 0.91

Candida species fail to produce the immunosuppressive secondary metabolite gliotoxin in vitro. FEMS Yeast Res (2007) 0.90

Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei. Biochem J (2007) 0.90

Two-hybrid reporter vectors for gap repair cloning. Biotechniques (2005) 0.89

O-glycosylation of the non-canonical T-cadherin from rabbit skeletal muscle by single mannose residues. FEBS Lett (2013) 0.88

Is there a classical nonsense-mediated decay pathway in trypanosomes? PLoS One (2011) 0.88

Trypanosomes as a model to investigate mRNA decay pathways. Methods Enzymol (2008) 0.87

The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation. J Biol Chem (2001) 0.87

Conserved noncoding elements and the evolution of animal body plans. Bioessays (2009) 0.87

The Trypanosoma brucei zinc finger protein ZC3H18 is involved in differentiation. Mol Biochem Parasitol (2011) 0.87

5,000 RNAi experiments on a chip. Nat Methods (2004) 0.86