Published in J Neurosci on June 15, 2003
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A (2004) 5.65
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron (2006) 5.48
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci (2005) 4.71
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron (2004) 3.21
Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol (2004) 1.71
Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A (2008) 1.66
Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proc Natl Acad Sci U S A (2004) 1.58
Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci (2009) 1.52
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain (2008) 1.42
Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease. PLoS One (2010) 1.41
CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 1.37
Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice. J Neurochem (2010) 1.33
Target identification for CNS diseases by transcriptional profiling. Neuropsychopharmacology (2008) 1.32
Single cell gene expression profiling in Alzheimer's disease. NeuroRx (2006) 1.22
Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci (2010) 1.17
Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain. J Neuroinflammation (2013) 1.13
Genes and pathways underlying regional and cell type changes in Alzheimer's disease. Genome Med (2013) 1.12
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet (2011) 1.12
An epigenetic hypothesis of aging-related cognitive dysfunction. Front Aging Neurosci (2010) 1.11
A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease. Curr Alzheimer Res (2007) 1.10
Failures to reconsolidate memory in a mouse model of Alzheimer's disease. Neurobiol Learn Mem (2009) 1.08
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease. Nat Neurosci (2012) 1.08
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry (2013) 1.03
Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability. Curr Genomics (2010) 0.97
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease. Br J Pharmacol (2011) 0.96
Fluorescent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. J Neurosci Methods (2009) 0.95
Mechanisms of age-related cognitive change and targets for intervention: epigenetics. J Gerontol A Biol Sci Med Sci (2012) 0.93
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2010) 0.93
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol Neurodegener (2006) 0.92
The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice. Pharmacogenomics J (2008) 0.92
Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice. J Neuroinflammation (2013) 0.91
Amyloid-β oligomers induce differential gene expression in adult human brain slices. J Biol Chem (2012) 0.91
Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration. Neurobiol Dis (2013) 0.90
Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. BMC Neurosci (2005) 0.89
Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling. Physiol Genomics (2009) 0.88
Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice. Front Cell Neurosci (2012) 0.87
Independent effects of intra- and extracellular Abeta on learning-related gene expression. Am J Pathol (2009) 0.87
Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity. Neural Plast (2012) 0.86
Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities. Front Cell Neurosci (2013) 0.86
Nuclear receptors in neurodegenerative diseases. Neurobiol Dis (2014) 0.85
Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing. Front Aging Neurosci (2014) 0.83
Advances on the understanding of the origins of synaptic pathology in AD. Curr Genomics (2007) 0.83
Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection. Neurobiol Dis (2006) 0.83
Dissecting gene expression at the blood-brain barrier. Front Neurosci (2014) 0.83
A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1. Front Neurol (2013) 0.81
The role of activity in synaptic degeneration in a protein misfolding disease, prion disease. PLoS One (2012) 0.81
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A (2016) 0.80
Modifications of hippocampal circuits and early disruption of adult neurogenesis in the tg2576 mouse model of Alzheimer's disease. PLoS One (2013) 0.80
Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory. Philos Trans R Soc Lond B Biol Sci (2013) 0.80
Age-related changes in Egr1 transcription and DNA methylation within the hippocampus. Hippocampus (2016) 0.80
Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice. Neuroscience (2010) 0.79
Reconstructing the Hsp90/Tau Machine. Curr Enzym Inhib (2013) 0.79
ARG3.1/ARC expression in hippocampal dentate gyrus astrocytes: ultrastructural evidence and co-localization with glial fibrillary acidic protein. J Cell Mol Med (2008) 0.79
Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty. PLoS One (2013) 0.78
CART treatment improves memory and synaptic structure in APP/PS1 mice. Sci Rep (2015) 0.78
REGION-SPECIFIC NEURON AND SYNAPSE LOSS IN THE HIPPOCAMPUS OF APP(SL)/PS1 KNOCK-IN MICE. Transl Neurosci (2013) 0.77
Epigenetic and pharmacological regulation of the amyloid-degrading enzyme neprilysin results in modulation of cognitive functions in mammals. Dokl Biol Sci (2011) 0.76
Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease. Behav Brain Res (2016) 0.76
Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease. Front Cell Neurosci (2015) 0.75
The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells. Oxid Med Cell Longev (2017) 0.75
Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. Nat Biotechnol (2012) 7.37
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell (2011) 6.82
Regulatory networks define phenotypic classes of human stem cell lines. Nature (2008) 4.98
Global analysis of X-chromosome dosage compensation. J Biol (2006) 3.78
A bioinformatic assay for pluripotency in human cells. Nat Methods (2011) 3.66
Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell (2011) 3.32
Research capacity. Enabling the genomic revolution in Africa. Science (2014) 3.05
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A (2009) 2.96
Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell (2012) 2.94
Human embryonic stem cells have a unique epigenetic signature. Genome Res (2006) 2.89
Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J Neuroinflammation (2004) 2.67
Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence. Stem Cells (2008) 2.52
A call for standardized naming and reporting of human ESC and iPSC lines. Cell Stem Cell (2011) 2.48
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci (2003) 2.44
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. J Neurosci (2004) 2.38
Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice. Nat Protoc (2006) 2.12
Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Neurosci (2002) 2.03
Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA⋅TTC triplet repeat instability. Cell Stem Cell (2010) 2.02
Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models. Neurobiol Aging (2004) 1.97
Gene therapy: can neural stem cells deliver? Nat Rev Neurosci (2006) 1.95
A call to standardize teratoma assays used to define human pluripotent cell lines. Cell Stem Cell (2010) 1.93
Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods (2012) 1.91
Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J Neuropathol Exp Neurol (2005) 1.90
Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Exp Neurol (2002) 1.89
Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J Neurosci (2006) 1.79
Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS One (2011) 1.75
Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol Dis (2004) 1.73
New insights into chimpanzees, tools, and termites from the Congo Basin. Am Nat (2004) 1.71
Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A (2008) 1.66
Assessing self-renewal and differentiation in human embryonic stem cell lines. Stem Cells (2005) 1.58
Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice. Exp Neurol (2004) 1.58
Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines. BMC Dev Biol (2006) 1.58
Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell (2008) 1.57
Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies. Alzheimers Res Ther (2011) 1.43
Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J Neurosci (2010) 1.42
LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. J Neuroinflammation (2010) 1.40
Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice. J Neuroimmune Pharmacol (2007) 1.32
Induced pluripotent stem cells from highly endangered species. Nat Methods (2011) 1.24
The functions of microRNAs in pluripotency and reprogramming. Nat Cell Biol (2012) 1.23
Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain. Nat Protoc (2006) 1.18
Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging. Magn Reson Med (2004) 1.17
Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice. Mol Ther (2008) 1.17
Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis. Cell Res (2011) 1.17
Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiol Aging (2013) 1.16
Diverse microglial responses after intrahippocampal administration of lipopolysaccharide. Glia (2006) 1.16
Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology (2006) 1.15
Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain. J Neuroinflammation (2013) 1.13
Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. J Neurochem (2004) 1.13
Genomic instability in pluripotent stem cells: implications for clinical applications. J Biol Chem (2013) 1.13
Differentiation of neural lineage cells from human pluripotent stem cells. Methods (2008) 1.13
DNA methylation in embryonic stem cells. J Cell Biochem (2010) 1.11
Epigenetic therapy for Friedreich ataxia. Ann Neurol (2014) 1.11
Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease. J Neuropathol Exp Neurol (2003) 1.10
Highly parallel genome-wide expression analysis of single mammalian cells. PLoS One (2012) 1.10
Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. PLoS One (2011) 1.10
Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice. FEBS J (2009) 1.08
Biochemical and histochemical evidence of nonspecific binding of alpha7nAChR antibodies to mouse brain tissue. J Histochem Cytochem (2004) 1.08
NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells. Stem Cells Dev (2005) 1.08
BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state. Development (2013) 1.07
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther (2014) 1.05
Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage. Proc Natl Acad Sci U S A (2007) 1.04
Isolation of human embryonic stem cell-derived teratomas for the assessment of pluripotency. Curr Protoc Stem Cell Biol (2007) 1.04
Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. J Neurosci Methods (2010) 1.02
Restricted ethnic diversity in human embryonic stem cell lines. Nat Methods (2010) 1.02
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy. Neurobiol Aging (2013) 1.02
Transcriptome coexpression map of human embryonic stem cells. BMC Genomics (2006) 1.01
Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. ASN Neuro (2011) 1.01
Beyond fraud--stem-cell research continues. N Engl J Med (2006) 1.00
Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies. BMC Neurosci (2007) 1.00
Preparation of autogenic human feeder cells for growth of human embryonic stem cells. Curr Protoc Stem Cell Biol (2008) 0.98
Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. J Neuroinflammation (2006) 0.97
Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice. BMC Neurosci (2004) 0.97
Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. J Neuroinflammation (2011) 0.95
Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One (2011) 0.92
Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus. Stem Cells Dev (2011) 0.92
Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions. J Cell Sci (2013) 0.92
The ACTCellerate initiative: large-scale combinatorial cloning of novel human embryonic stem cell derivatives. Regen Med (2008) 0.91
Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. PLoS One (2013) 0.90