Published in PLoS One on September 16, 2013
Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease. Front Aging Neurosci (2013) 0.94
Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. PLoS One (2014) 0.84
Mutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disorders. Clin Interv Aging (2015) 0.77
Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. Int J Mol Sci (2016) 0.75
Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease. Front Mol Neurosci (2016) 0.75
Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain. J Biol Chem (2016) 0.75
Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 13.12
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Altered histone acetylation is associated with age-dependent memory impairment in mice. Science (2010) 6.38
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem (2001) 4.45
Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science (2004) 4.25
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron (2005) 3.83
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci (2001) 3.56
Memory reconsolidation mediates the strengthening of memories by additional learning. Nat Neurosci (2008) 3.03
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci (2004) 2.07
C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. FASEB J (2003) 1.90
Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. J Neurosci (2003) 1.76
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A (2007) 1.61
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain. J Cell Biol (2005) 1.59
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog Neurobiol (2008) 1.58
Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease. PLoS One (2010) 1.41
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A (2010) 1.38
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep (2008) 1.27
The physiology of the β-amyloid precursor protein intracellular domain AICD. J Neurochem (2011) 1.26
Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. J Cell Sci (2009) 1.26
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem (2010) 1.21
Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdala. Learn Mem (2010) 1.19
Functions of the APP gene family in the nervous system: insights from mouse models. Exp Brain Res (2011) 1.05
Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway. PLoS One (2011) 1.03
Nuclear signalling by membrane protein intracellular domains: the AICD enigma. Cell Signal (2011) 0.98
Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment. J Alzheimers Dis (2012) 0.98
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. FASEB J (2009) 0.96
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling. EMBO Rep (2011) 0.94
Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. J Biol Chem (2011) 0.89
Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells. Gene (2003) 0.89
γ-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib. J Alzheimers Dis (2011) 0.87
Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease. Exp Neurol (1997) 0.86
The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells. Int J Cancer (2011) 0.83
Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport. Acta Neuropathol (2011) 0.82
Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation. Neurochem Int (2005) 0.80
Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J (2004) 2.94
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol (2006) 1.68
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem (2008) 1.54
Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int (2009) 1.39
Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin. Am J Physiol Endocrinol Metab (2009) 1.38
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. J Neurosci (2005) 1.35
PART is part of Alzheimer disease. Acta Neuropathol (2015) 1.31
A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. Proc Natl Acad Sci U S A (2009) 1.30
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Commun (2009) 1.28
Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice. Am J Pathol (2007) 1.26
Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. J Biol Chem (2002) 1.25
Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia. Biochem J (2009) 1.20
Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. Int J Cancer (2003) 1.18
Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J Neurochem (2004) 1.18
Expression of BORIS in melanoma: lack of association with MAGE-A1 activation. Int J Cancer (2008) 1.18
MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription. Nucleic Acids Res (2004) 1.17
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease. Acta Neuropathol (2001) 1.15
Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1. Neurobiol Dis (2004) 1.14
Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration. J Biol Chem (2012) 1.13
Role of TRPC1 channel in skeletal muscle function. Am J Physiol Cell Physiol (2009) 1.11
Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. J Biol Chem (2006) 1.07
Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury. Exp Neurol (2012) 1.07
Monoclonal anti-MAGE-3 CTL responses in melanoma patients displaying tumor regression after vaccination with a recombinant canarypox virus. J Immunol (2003) 1.05
Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model. PLoS One (2012) 1.04
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes. Ann Neurol (2012) 1.02
Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice. Am J Pathol (2012) 1.00
Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. J Biol Chem (2006) 1.00
Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse. Neurobiol Aging (2011) 0.99
Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice. J Neurotrauma (2012) 0.98
Photoreceptor proteins as cancer-retina antigens. Int J Cancer (2007) 0.97
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. FASEB J (2009) 0.96
Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets. J Clin Endocrinol Metab (2010) 0.95
Essential role of TRPV2 ion channel in the sensitivity of dystrophic muscle to eccentric contractions. FEBS Lett (2009) 0.94
Network excitability dysfunction in Alzheimer's disease: insights from in vitro and in vivo models. Rev Neurosci (2010) 0.94
Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models. Biochim Biophys Acta (2004) 0.92
Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion. J Neurotrauma (2013) 0.91
Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. J Alzheimers Dis (2010) 0.91
Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol (2013) 0.91
Amyloid precursor protein controls cholesterol turnover needed for neuronal activity. EMBO Mol Med (2013) 0.91
Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3. J Biol Chem (2005) 0.91
Epigenetic hierarchy within the MAGEA1 cancer-germline gene: promoter DNA methylation dictates local histone modifications. PLoS One (2013) 0.90
What is the role of amyloid precursor protein dimerization? Cell Adh Migr (2010) 0.90
Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus. Hum Mol Genet (2012) 0.89
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice. Acta Neuropathol (2015) 0.88
Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations. J Neurosci (2009) 0.88
Multifaceted role of galectin-3 on human glioblastoma cell motility. Biochem Biophys Res Commun (2004) 0.87
Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta. Biochem Biophys Res Commun (2007) 0.87
Structural features of the KPI domain control APP dimerization, trafficking, and processing. FASEB J (2011) 0.87
Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells. J Neurochem (2006) 0.87
Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells. Biochim Biophys Acta (2008) 0.86
Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model. Am J Pathol (2011) 0.85
Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells. Neurosci Lett (2005) 0.84
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity. J Biol Chem (2004) 0.84
Hexafluorobenzene in comparison with perfluoro-15-crown-5-ether for repeated monitoring of oxygenation using 19F MRI in a mouse model. Magn Reson Med (2012) 0.84
Fe65 does not stabilize AICD during activation of transcription in a luciferase assay. Biochem Biophys Res Commun (2007) 0.83
DNA methylation-associated repression of cancer-germline genes in human embryonic and adult stem cells. Stem Cells (2009) 0.83
Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes. Mol Neurodegener (2014) 0.83
Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells. Exp Dermatol (2010) 0.82
Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model. Biochem Soc Trans (2010) 0.82
Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury. Int J Pharm (2013) 0.82
Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport. Acta Neuropathol (2011) 0.82
Silencing of cancer-germline genes in human preimplantation embryos: evidence for active de novo DNA methylation in stem cells. Biochem Biophys Res Commun (2011) 0.81
Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(Kip1) and calbindin in the fetal and neonatal feline cerebellar cortex. Vet J (2012) 0.80
The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. PLoS One (2012) 0.80
From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein. J Neurochem (2013) 0.79
Gamma-secretase inhibitor activity of a Pterocarpus erinaceus extract. Neurodegener Dis (2013) 0.79
Identification of feline panleukopenia virus proteins expressed in Purkinje cell nuclei of cats with cerebellar hypoplasia. Vet J (2012) 0.79
Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain (2014) 0.79
Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation. Epigenetics (2012) 0.79
Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity. J Neurosci Res (2006) 0.78
Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668. Neurobiol Aging (2010) 0.78
Cell surface targeting of VPAC1 receptors: evidence for implication of a quality control system and the proteasome. Biochim Biophys Acta (2008) 0.78