Published in Cancer Cell on June 01, 2003
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Mol Cell Biol (2004) 2.53
KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol (2009) 1.97
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol (2016) 1.76
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion. Arterioscler Thromb Vasc Biol (2011) 1.54
The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Proc Natl Acad Sci U S A (2005) 1.43
Salvador-Warts-Hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins. Dev Cell (2015) 1.42
Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. Cancer Res (2008) 1.41
Transcriptional networks and cellular senescence in human mammary fibroblasts. Mol Biol Cell (2004) 1.38
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Blood (2005) 1.38
Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology (2008) 1.33
High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study. Br J Cancer (2008) 1.29
Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation. J Virol (2004) 1.25
Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer. Mol Cancer (2005) 1.14
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development (2005) 1.12
ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling. Mol Cell Biol (2011) 1.11
ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling. Blood (2009) 1.09
Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma. Br J Cancer (2007) 1.09
Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. Cancer Res (2010) 1.09
Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma. Am J Pathol (2006) 1.08
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer. BMC Genomics (2007) 1.05
Regulation of the retinoblastoma proteins by the human herpesviruses. Cell Div (2009) 1.02
BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1. BMC Immunol (2005) 1.02
Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem (2010) 1.01
ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. Cancer Res (2010) 1.01
Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. Kidney Int (2011) 1.00
Identification of novel Notch target genes in T cell leukaemia. Mol Cancer (2009) 1.00
Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. Diabetes (2011) 0.98
Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear. Dev Dyn (2011) 0.98
Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo. Oncogene (2008) 0.97
Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. J Biol Chem (2008) 0.97
Overexpression of inhibitor of DNA-binding (ID)-1 protein related to angiogenesis in tumor advancement of ovarian cancers. BMC Cancer (2009) 0.96
Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC Clin Pathol (2005) 0.96
Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer. Cancer Med (2012) 0.95
Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2013) 0.95
Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells. Islets (2011) 0.94
Retracted Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells. J Biol Chem (2011) 0.93
COX-2 overexpression increases malignant potential of human glioma cells through Id1. Oncotarget (2014) 0.93
Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells. Carcinogenesis (2009) 0.92
Signal transducer and activator of transcription 5a mediates mammary ductal branching and proliferation in the nulliparous mouse. Endocrinology (2010) 0.92
ID1 promotes breast cancer metastasis by S100A9 regulation. Mol Cancer Res (2014) 0.92
Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. Am J Pathol (2011) 0.92
Id2 is dispensable for Myc-induced epidermal neoplasia. Mol Cell Biol (2004) 0.90
TGF-beta repression of Id2 induces apoptosis in gut epithelial cells. Oncogene (2009) 0.89
Inhibitor of differentiation 4 (ID4): From development to cancer. Biochim Biophys Acta (2014) 0.89
The ID proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation. Virology (2008) 0.89
Id1 promotes tumor cell migration in nonsmall cell lung cancers. J Oncol (2010) 0.88
Exit from arsenite-induced mitotic arrest is p53 dependent. Environ Health Perspect (2006) 0.88
USF1/2 transcription factor DNA-binding activity is induced during rat Sertoli cell differentiation. Biol Reprod (2008) 0.86
ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma. BMC Cancer (2013) 0.85
Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis. Carcinogenesis (2009) 0.85
Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol Cancer (2013) 0.85
Activated β-catenin forces N2A cell-derived neurons back to tumor-like neuroblasts and positively correlates with a risk for human neuroblastoma. Int J Biol Sci (2012) 0.85
Targeting Id1 reduces proliferation and invasion in aggressive human salivary gland cancer cells. BMC Cancer (2013) 0.85
Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids (2012) 0.84
Snail interacts with Id2 in the regulation of TNF-α-induced cancer cell invasion and migration in OSCC. Am J Cancer Res (2015) 0.84
The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma. Mol Cancer Res (2011) 0.84
A genetic strategy for combined screening and localized imaging of breast cancer. Mol Imaging Biol (2011) 0.84
Effect of selenium nanoparticles with different sizes in primary cultured intestinal epithelial cells of crucian carp, Carassius auratus gibelio. Int J Nanomedicine (2013) 0.83
Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1. Br J Cancer (2009) 0.83
Id1 delays senescence of primary human melanocytes. Mol Carcinog (2008) 0.82
Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis. PLoS Pathog (2014) 0.82
High Id1 expression, a generally negative prognostic factor, paradoxically predicts a favorable prognosis for adjuvant paclitaxel plus cisplatin therapy in surgically treated lung cancer patients. Oncotarget (2014) 0.81
Follicle-stimulating hormone (FSH) transiently blocks FSH receptor transcription by increasing inhibitor of deoxyribonucleic acid binding/differentiation-2 and decreasing upstream stimulatory factor expression in rat Sertoli cells. Endocrinology (2009) 0.81
ID1 regulates U87 human cell proliferation and invasion. Oncol Lett (2013) 0.80
Upstream stimulatory factor induces Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation. Biol Reprod (2011) 0.80
A mechanism linking Id2-TGFβ crosstalk to reversible adaptive plasticity in neuroblastoma. PLoS One (2013) 0.80
Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity. Biochimie (2015) 0.80
Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner. Mol Cancer (2014) 0.80
Probasin promoter-driven expression of ID1 is not sufficient for carcinogenesis in rodent prostate. J Histochem Cytochem (2009) 0.80
Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. Int J Biol Sci (2010) 0.79
Downregulation of Id1 by small interfering RNA in gastric cancer inhibits cell growth via the Akt pathway. Mol Med Rep (2012) 0.79
Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth. Cancer Res (2016) 0.79
Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer. Cancer Prev Res (Phila) (2015) 0.79
The Id-protein family in developmental and cancer-associated pathways. Cell Commun Signal (2017) 0.78
Drug efficacy testing in mice. Curr Top Microbiol Immunol (2012) 0.78
Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells. PLoS One (2015) 0.78
Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. FASEB J (2015) 0.77
Daxx inhibits muscle differentiation by repressing E2A-mediated transcription. J Cell Biochem (2009) 0.77
The dietary compounds resveratrol and genistein induce activating transcription factor 3 while suppressing inhibitor of DNA binding/differentiation-1. J Med Food (2011) 0.77
Id transcriptional regulators in adipogenesis and adipose tissue metabolism. Front Biosci (Landmark Ed) (2014) 0.77
Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21(Cip1/Waf1). Cell Death Dis (2016) 0.77
Cancer imaging: Gene transcription-based imaging and therapeutic systems. Int J Biochem Cell Biol (2012) 0.77
Increased expression of Id1 and Id3 promotes tumorigenicity by enhancing angiogenesis and suppressing apoptosis in small cell lung cancer. Genes Cancer (2014) 0.77
Inheritance of susceptibility to induction of nephroblastomas in the Noble rat. Differentiation (2009) 0.77
The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells. Sci Rep (2016) 0.77
ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes. Histochem Cell Biol (2013) 0.76
A novel role for the deubiquitinase USP1 in the control of centrosome duplication. Cell Cycle (2016) 0.76
Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation. Development (2015) 0.75
Id-1, Id-2, and Id-3 co-expression correlates with prognosis in stage I and II lung adenocarcinoma patients treated with surgery and adjuvant chemotherapy. Exp Biol Med (Maywood) (2016) 0.75
Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1α. Biomed Res Int (2016) 0.75
Effects of an 11-nm DMSA-coated iron nanoparticle on the gene expression profile of two human cell lines, THP-1 and HepG2. J Nanobiotechnology (2015) 0.75
Id2a is required for hepatic outgrowth during liver development in zebrafish. Mech Dev (2015) 0.75
Interacting mechanism of ID3 HLH domain towards E2A/E12 transcription factor - An Insight through molecular dynamics and docking approach. Biochem Biophys Rep (2015) 0.75
Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol (2003) 3.40
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38
Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One (2007) 2.77
Toward a molecular classification of melanoma. J Clin Oncol (2007) 1.95
Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion. Am J Pathol (2002) 1.72
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol (2005) 1.52
Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. Cancer Cell (2002) 1.42
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A (2011) 1.30
Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas. J Invest Dermatol (2013) 1.22
Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor. J Am Chem Soc (2005) 1.14
Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors. Cancer Cell (2003) 1.08
Melanoma biomarkers: current status and vision for the future. Nat Clin Pract Oncol (2008) 1.05
MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell (2013) 1.05
A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis (2012) 1.01
Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression. Cancer Res (2011) 0.98
Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. J Invest Dermatol (2013) 0.96
Selective HAT inhibitors as mechanistic tools for protein acetylation. Methods Enzymol (2004) 0.91
Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem (2005) 0.90
Id1 promotes tumor cell migration in nonsmall cell lung cancers. J Oncol (2010) 0.88
Id1 expression is transcriptionally regulated in radial growth phase melanomas. Int J Cancer (2007) 0.86
Wiring the angiogenic switch: Ras, Myc, and Thrombospondin-1. Cancer Cell (2003) 0.85
BRAF kinase in melanoma development and progression. Expert Rev Mol Med (2008) 0.85
High-efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system. J Invest Dermatol (2004) 0.84
DNA repair gene variants in relation to overall cancer risk: a population-based study. Carcinogenesis (2012) 0.84
Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction. Cancer Res (2011) 0.84
Global analysis of BRAFV600E target genes in human melanocytes identifies matrix metalloproteinase-1 as a critical mediator of melanoma growth. J Invest Dermatol (2011) 0.83
Neuropilin-2: a novel biomarker for malignant melanoma? Hum Pathol (2011) 0.83
Cigarette smoking and malignant melanoma: a case-control study. J Am Acad Dermatol (2010) 0.82
Id1 delays senescence of primary human melanocytes. Mol Carcinog (2008) 0.82
The association between skin characteristics and skin cancer prevention behaviors. Cancer Epidemiol Biomarkers Prev (2009) 0.82
A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiol (2012) 0.82
MicroRNAs as an emerging target for melanoma therapy. J Invest Dermatol (2013) 0.81
A community-based study of nucleotide excision repair polymorphisms in relation to the risk of non-melanoma skin cancer. J Invest Dermatol (2012) 0.81
Nonspecific enhancement of gene expression by compounds identified in high-throughput cell-based screening. Biotechniques (2004) 0.79
Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration. Pigment Cell Melanoma Res (2013) 0.78
Glyceraldehyde-3-phosphate dehydrogenase expression is altered by hypoxia in melanoma cells and primary human melanocytes. Melanoma Res (2010) 0.77
Quantitative measurement of circulating lymphoid-specific helicase (HELLS) gene transcript: a potential serum biomarker for melanoma metastasis. Pigment Cell Melanoma Res (2010) 0.76
A simple engineered platform reveals different modes of tumor-microenvironmental cell interaction. Biofabrication (2015) 0.75
A Rare Case of Immune Reconstitution Inflammatory Syndrome Development in an Immunocompromised Patient with Progressive Multifocal Leukoencephalopathy and Multicentric Castleman's Disease. Case Rep Neurol Med (2013) 0.75
Neuropilin-2 promotes melanoma growth and progression in vivo. Melanoma Res (2016) 0.75