Published in Mol Cell Biol on March 01, 2004
Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol (2006) 1.42
Cardiovascular development and the colonizing cardiac neural crest lineage. ScientificWorldJournal (2007) 1.26
Retracted siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells. J Exp Clin Cancer Res (2008) 1.01
The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas. Oncotarget (2011) 1.00
Genetic analysis of myc and telomerase interactions in vivo. Mol Cell Biol (2006) 0.89
Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis. Carcinogenesis (2009) 0.85
The Id-protein family in developmental and cancer-associated pathways. Cell Commun Signal (2017) 0.78
The Smad7-Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-β. J Cell Sci (2013) 0.78
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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 6.50
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30
Getting under the skin of epidermal morphogenesis. Nat Rev Genet (2002) 4.54
Id proteins in development, cell cycle and cancer. Trends Cell Biol (2003) 4.53
Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell (1999) 4.38
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature (2001) 4.14
Extra-embryonic function of Rb is essential for embryonic development and viability. Nature (2003) 3.92
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Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc Natl Acad Sci U S A (2002) 3.55
Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature (2000) 3.36
Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem (1999) 3.17
Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol Cell Biol (1997) 2.71
Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol (1998) 2.64
Identification of c-myc responsive genes using rat cDNA microarray. Cancer Res (2000) 2.62
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Id proteins in cell growth and tumorigenesis. Cancer Cell (2003) 2.38
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Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J Biol Chem (1994) 2.09
The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res (1994) 2.07
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Id proteins in cell cycle control and cellular senescence. Oncogene (2001) 1.88
Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol (1996) 1.81
Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J Biol Chem (1997) 1.76
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A (2003) 1.74
The Id proteins and angiogenesis. Oncogene (2001) 1.70
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Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis. Dev Dyn (1996) 1.57
Disentangling the MYC web. Proc Natl Acad Sci U S A (2002) 1.47
Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis. Dev Dyn (1997) 1.44
Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J (1999) 1.37
Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma. Cancer Res (2002) 1.36
Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth. Cancer Res (2000) 1.35
A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors. Oncogene (2001) 1.31
Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma. Oncogene (2003) 1.27
Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res (2000) 1.21
Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. Mol Cell Biol (2001) 1.13
Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. J Biol Chem (2003) 1.11
Id gene expression as a key mediator of tumor cell biology. Cancer Res (1999) 1.07
Role of Id proteins in embryonic and tumor angiogenesis. Trends Cardiovasc Med (2001) 1.04
Doxorubicin represses the function of the myogenic helix-loop-helix transcription factor MyoD. Involvement of Id gene induction. J Biol Chem (1994) 0.96
ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Oncogene (2003) 0.88
Regulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor. Mol Cell Biol (2001) 0.87
ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas. Cancer Res (2003) 0.85
Gene expression of markers associated with proliferation and differentiation in human keratinocytes cultured from epidermis and from buccal mucosa. Arch Oral Biol (1995) 0.81
Expression of Id2 mRNA in neuroblastoma and normal ganglion. Eur J Surg Oncol (2003) 0.77
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res (2007) 6.57
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci U S A (2005) 6.54
Modeling the therapeutic efficacy of p53 restoration in tumors. Cell (2006) 5.95
Modelling Myc inhibition as a cancer therapy. Nature (2008) 5.81
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell (2002) 5.29
Distinct thresholds govern Myc's biological output in vivo. Cancer Cell (2008) 4.16
A matter of life and death. Cancer Cell (2002) 4.07
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med (2007) 3.11
p53--a Jack of all trades but master of none. Nat Rev Cancer (2009) 2.96
Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature (2010) 2.51
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell (2006) 2.32
Temporal dissection of p53 function in vitro and in vivo. Nat Genet (2005) 2.19
Endogenous Myc maintains the tumor microenvironment. Genes Dev (2011) 2.16
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev (2006) 1.87
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. Blood (2011) 1.84
MYC-dependent regulation and prognostic role of CIP2A in gastric cancer. J Natl Cancer Inst (2009) 1.80
Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res (2008) 1.75
The ups and downs of Myc biology. Curr Opin Genet Dev (2009) 1.70
A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr Biol (2009) 1.70
Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes (2007) 1.67
Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. Cancer Res (2006) 1.64
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev (2013) 1.60
Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme. J Magn Reson Imaging (2002) 1.59
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res (2004) 1.48
Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res (2003) 1.46
Id4 regulates neural progenitor proliferation and differentiation in vivo. Development (2004) 1.45
c-Myc functionally cooperates with Bax to induce apoptosis. Mol Cell Biol (2002) 1.43
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res (2006) 1.42
Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo. Neuro Oncol (2011) 1.38
Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia. Oncogene (2004) 1.32
The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell (2002) 1.24
Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation. Mol Cell Biol (2009) 1.21
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife (2013) 1.20
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov (2013) 1.17
Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J Biol Chem (2006) 1.16
The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J Gen Virol (2004) 1.14
Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage. J Biol Chem (2004) 1.11
Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms. Cancer Cell (2006) 1.11
Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev (2011) 1.11
The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. PLoS One (2011) 1.10
Genetics of glioblastoma: a window into its imaging and histopathologic variability. Radiographics (2011) 1.06
Testing of new agents in childhood cancer preclinical models: meeting summary. Clin Cancer Res (2002) 1.03
The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Res (2008) 1.02
ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver. J Biol Chem (2009) 1.01
The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res (2004) 0.98
Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis. J Neurosci (2008) 0.96
Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim. Mol Cancer Ther (2007) 0.96
A head holder for magnetic resonance imaging that allows the stereotaxic alignment of spontaneously occurring intracranial mouse tumors. J Neurosci Methods (2002) 0.96
Finding cancer's weakest link. Oncotarget (2011) 0.96
Inhibitor of DNA binding 4 (ID4) regulation of adipocyte differentiation and adipose tissue formation in mice. J Biol Chem (2010) 0.94
Exploratory Visual Analysis of statistical results from microarray experiments comparing high and low grade glioma. Cancer Inform (2007) 0.93
Modeling pharmacological inhibition of mast cell degranulation as a therapy for insulinoma. Neoplasia (2011) 0.92
p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells. Stem Cells (2011) 0.91
Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment. J Neurooncol (2007) 0.90
Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors. J Clin Invest (2013) 0.90
PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells. J Biol Chem (2008) 0.89
Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors. Cancer Res (2003) 0.87
KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo. Cell Cycle (2014) 0.87
All things to all people. Cell (2012) 0.85
Nursing some sense out of Myc. J Biol (2009) 0.85
Prognostic significance of an apoptotic index and apoptosis/proliferation ratio for patients with high-grade astrocytomas. Neuro Oncol (2002) 0.85
Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. Cancer Res (2008) 0.84
Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation. J Biol Chem (2009) 0.83
Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma. PLoS One (2013) 0.82
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A (2013) 0.82
Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development. Stem Cells (2013) 0.78
Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment. Cancer Res (2014) 0.78
Diffuse encephaloventriculitis and substantial leukoencephalopathy after intraventricular administration of recombinant adenovirus. Neurol Res (2005) 0.78
Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation. Cancer Res (2013) 0.77
Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities. J Pediatr Hematol Oncol (2016) 0.75
Molecular mechanisms of neuronal cell death: implications for nuclear factors responding to cAMP and phorbol esters. Mol Cell Neurosci (2002) 0.75
Can a small-molecular gadolinium contrast agent be applied successfully with dynamic MRI to quantitatively define brain tumor microvascular responses to angiogenesis inhibition? Acad Radiol (2002) 0.75