Published in J Mol Biol on July 18, 2003
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol (2007) 2.65
Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. J Virol (2003) 2.63
The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc Natl Acad Sci U S A (2004) 2.05
Structural and functional analysis of hepatitis C virus strain JFH1 polymerase. J Virol (2009) 1.17
General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues. Antimicrob Agents Chemother (2006) 1.15
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem (2010) 1.14
Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses (2010) 1.07
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother (2007) 1.03
Hepatitis C virus NS5B polymerase exhibits distinct nucleotide requirements for initiation and elongation. J Biol Chem (2008) 1.03
Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions. J Virol (2010) 1.01
A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A. PLoS One (2011) 0.94
Recombinant viral RdRps can initiate RNA synthesis from circular templates. RNA (2005) 0.93
De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities. J Virol (2004) 0.93
Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase. J Virol (2005) 0.93
Nontemplated terminal nucleotidyltransferase activity of double-stranded RNA bacteriophage phi6 RNA-dependent RNA polymerase. J Virol (2008) 0.90
Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2010) 0.86
Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines. Antimicrob Agents Chemother (2009) 0.85
Repair of the tRNA-like CCA sequence in a multipartite positive-strand RNA virus. J Virol (2005) 0.85
Hydrophobic and charged residues in the C-terminal arm of hepatitis C virus RNA-dependent RNA polymerase regulate initiation and elongation. J Virol (2014) 0.78
Structure and function of the Zika virus full-length NS5 protein. Nat Commun (2017) 0.78
Purification and Biochemical Characterisation of Rabbit Calicivirus RNA-Dependent RNA Polymerases and Identification of Non-Nucleoside Inhibitors. Viruses (2016) 0.77
Initiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template. Biochemistry (2014) 0.76
Subgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases. Nucleic Acids Res (2014) 0.76
C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex. PLoS One (2016) 0.75
The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure (2010) 2.29
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat Struct Mol Biol (2012) 2.18
Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy. Clin Microbiol Rev (2003) 1.95
Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus. EMBO J (2003) 1.91
Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2002) 1.89
Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation. J Biol Chem (2006) 1.73
The severe acute respiratory syndrome coronavirus Nsp15 protein is an endoribonuclease that prefers manganese as a cofactor. J Virol (2004) 1.67
Core-controlled polymorphism in virus-like particles. Proc Natl Acad Sci U S A (2007) 1.66
Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J Biol Chem (2007) 1.49
Replication studies using genotype 1a subgenomic hepatitis C virus replicons. J Virol (2003) 1.42
Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor. Antimicrob Agents Chemother (2003) 1.40
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase. J Biol Chem (2008) 1.35
Nanoparticle-templated assembly of viral protein cages. Nano Lett (2006) 1.33
Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. J Biol Chem (2008) 1.33
Quantum dot encapsulation in viral capsids. Nano Lett (2006) 1.31
Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. Respir Res (2009) 1.29
Self-assembled virus-like particles with magnetic cores. Nano Lett (2007) 1.28
Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals. J Virol (2002) 1.27
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. J Biol Chem (2007) 1.27
Requirements for de novo initiation of RNA synthesis by recombinant flaviviral RNA-dependent RNA polymerases. J Virol (2002) 1.27
What is disrupting IFN-alpha's antiviral activity? Trends Biotechnol (2004) 1.25
Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate. Nucleic Acids Res (2010) 1.25
RNA recognition and cleavage by the SARS coronavirus endoribonuclease. J Mol Biol (2006) 1.18
Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J Virol (2010) 1.15
Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives. J Biol Chem (2003) 1.15
Enhancer-like activity of a brome mosaic virus RNA promoter. J Virol (2003) 1.13
Role of surface charge density in nanoparticle-templated assembly of bromovirus protein cages. ACS Nano (2010) 1.12
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem (2006) 1.09
LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs. PLoS One (2011) 1.08
Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. J Biol Chem (2007) 1.07
VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay. J Virol (2011) 1.06
Gold nanoparticles as spectroscopic enhancers for in vitro studies on single viruses. J Am Chem Soc (2003) 1.06
Deleterious role of TLR3 during hyperoxia-induced acute lung injury. Am J Respir Crit Care Med (2008) 1.05
Brome mosaic virus capsid protein regulates accumulation of viral replication proteins by binding to the replicase assembly RNA element. RNA (2009) 1.05
Norovirus RNA synthesis is modulated by an interaction between the viral RNA-dependent RNA polymerase and the major capsid protein, VP1. J Virol (2012) 1.04
An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs. J Mol Biol (2012) 1.04
Functional analysis of RNA binding by the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2005) 1.03
Toll-like receptor 9 can be expressed at the cell surface of distinct populations of tonsils and human peripheral blood mononuclear cells. Infect Immun (2004) 1.03
Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease. J Virol (2007) 1.00
A pathway analysis of poly(I:C)-induced global gene expression change in human peripheral blood mononuclear cells. Physiol Genomics (2006) 1.00
Template sequence near the initiation nucleotide can modulate brome mosaic virus RNA accumulation in plant protoplasts. J Virol (2004) 0.99
Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated inflammatory diseases. J Interferon Cytokine Res (2006) 0.99
Replication-independent long-distance trafficking by viral RNAs in Nicotiana benthamiana. Plant Cell (2007) 0.98
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother (2011) 0.98
Packaging of gold particles in viral capsids. J Nanosci Nanotechnol (2005) 0.98
Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization. J Biol Chem (2012) 0.98
Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3. Mol Cell Biol (2008) 0.97
RNA binding by the brome mosaic virus capsid protein and the regulation of viral RNA accumulation. J Mol Biol (2009) 0.97
Susceptibilities of herpes simplex viruses to penciclovir and acyclovir in eight cell lines. Antimicrob Agents Chemother (2002) 0.96
Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A. Hepatology (2009) 0.95
Self-assembly approaches to nanomaterial encapsulation in viral protein cages. J Mater Chem (2008) 0.95
Requirements for brome mosaic virus subgenomic RNA synthesis in vivo and replicase-core promoter interactions in vitro. J Virol (2004) 0.95
The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly(I:C) through a FPRL1-dependent pathway. J Biol Chem (2013) 0.94
Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase. Virology (2003) 0.93
Pokeweed antiviral protein inhibits brome mosaic virus replication in plant cells. J Biol Chem (2005) 0.92
Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1. J Biol Chem (2010) 0.92
Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function. Virol J (2006) 0.91
Synergistic effects of mutations and nanoparticle templating in the self-assembly of cowpea chlorotic mottle virus capsids. Nano Lett (2009) 0.90
The cytoplasmic domain of the F protein of Human respiratory syncytial virus is not required for cell fusion. J Gen Virol (2006) 0.90
Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3. PLoS One (2011) 0.89
Self-assembly of brome mosaic virus capsids: insights from shorter time-scale experiments. J Phys Chem A (2008) 0.89
Structures of the compact helical core domains of feline calicivirus and murine norovirus VPg proteins. J Virol (2013) 0.89
Brome mosaic virus RNA syntheses in vitro and in barley protoplasts. J Virol (2003) 0.89
Down modulation of human TLR3 function by a monoclonal antibody. Cell Immunol (2007) 0.88
Effects of amino-acid substitutions in the Brome mosaic virus capsid protein on RNA encapsidation. Mol Plant Microbe Interact (2010) 0.88
Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif. J Virol (2009) 0.88
Use of a novel cell-based fusion reporter assay to explore the host range of human respiratory syncytial virus F protein. Virol J (2005) 0.87
Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes. Antiviral Res (2009) 0.86
Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture. Bioorg Med Chem Lett (2005) 0.86
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase. Bioorg Med Chem Lett (2009) 0.86
Prediction and validation of the unexplored RNA-binding protein atlas of the human proteome. Proteins (2013) 0.86
The tripartite virions of the brome mosaic virus have distinct physical properties that affect the timing of the infection process. J Virol (2014) 0.85
Relationship between the loss of neutralizing antibody binding and fusion activity of the F protein of human respiratory syncytial virus. Virol J (2007) 0.84
A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5' terminal sequence of the hepatitis C virus RNA. Mol Cell Proteomics (2013) 0.83
Identification and characterization of novel bone marrow myeloid DEC205+Gr-1+ cell subsets that differentially express chemokine and TLRs. J Immunol (2007) 0.83
Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation. PLoS One (2013) 0.82
Biomedicines to reduce inflammation but not viral load in chronic HCV--what's the sense? Trends Biotechnol (2004) 0.82
RNA binding by the NS3 protease of the hepatitis C virus. Virus Res (2012) 0.82
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations. BMC Infect Dis (2002) 0.82
Sequence requirements for the development of a chimeric HCV replicon system. Virus Res (2004) 0.82
Mapping cooperative activity of the hepatitis C virus RNA-dependent RNA polymerase using genotype 1a-1b chimeras. Biochem Biophys Res Commun (2004) 0.82
The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein. J Virol (2012) 0.81
Selective repression of translation by the brome mosaic virus 1a RNA replication protein. J Virol (2006) 0.81
Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I. PLoS One (2010) 0.81
RNA synthesis by the brome mosaic virus RNA-dependent RNA polymerase in human cells reveals requirements for de novo initiation and protein-protein interaction. J Virol (2012) 0.81
Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity. Bioorg Med Chem Lett (2007) 0.81
Kinetic profile of a heterocyclic HCV replicon RNA synthesis inhibitor. Biochem Biophys Res Commun (2003) 0.81
Identification and functional characterization of the nascent RNA contacting residues of the hepatitis C virus RNA-dependent RNA polymerase. RNA (2012) 0.81
An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Bioorg Med Chem Lett (2006) 0.80
Cell-penetrating peptides derived from viral capsid proteins. Mol Plant Microbe Interact (2011) 0.79
Factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analogues. J Clin Virol (2006) 0.79
Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors. Bioorg Med Chem Lett (2009) 0.78