Published in J Virol on September 09, 2009
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Nat Rev Microbiol (2013) 1.88
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother (2012) 1.56
Structure of hepatitis C virus polymerase in complex with primer-template RNA. J Virol (2012) 1.39
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A. PLoS Pathog (2013) 1.28
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem (2010) 1.14
RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells. PLoS Pathog (2010) 1.10
A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes. J Virol (2011) 1.07
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains. Proc Natl Acad Sci U S A (2012) 1.07
Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions. J Virol (2010) 1.01
Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA. J Virol (2011) 0.96
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner. J Virol (2010) 0.95
A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A. PLoS One (2011) 0.94
Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3. PLoS One (2011) 0.89
Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A. J Biol Chem (2012) 0.87
Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis. J Virol (2012) 0.87
Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405. J Virol (2012) 0.86
A weak neutralizing antibody response to hepatitis C virus envelope glycoprotein enhances virus infection. PLoS One (2011) 0.85
Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication. J Virol (2014) 0.83
Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS One (2013) 0.82
Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. J Virol (2011) 0.78
Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance. Antimicrob Agents Chemother (2014) 0.78
The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase. Virus Res (2014) 0.76
Initiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template. Biochemistry (2014) 0.76
C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex. PLoS One (2016) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr (2002) 53.61
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science (1999) 24.31
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56
Complete replication of hepatitis C virus in cell culture. Science (2005) 18.59
Efficient initiation of HCV RNA replication in cell culture. Science (2000) 15.12
Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon. Gastroenterology (2003) 7.35
Physiological concentrations of purines and pyrimidines. Mol Cell Biochem (1994) 6.95
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A (2006) 6.87
Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations. J Virol (2001) 6.71
Mutations in hepatitis C virus RNAs conferring cell culture adaptation. J Virol (2001) 6.37
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J (1996) 5.47
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol (1997) 4.71
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells. Proc Natl Acad Sci U S A (2006) 4.54
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J Virol (2003) 4.52
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol (1999) 4.37
Hepatitis C virus: an infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras. Virology (1999) 4.04
A mechanism for initiating RNA-dependent RNA polymerization. Nature (2001) 3.99
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci U S A (1999) 3.77
Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication. J Virol (2005) 3.21
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure (1999) 3.04
Quantitative analysis of the hepatitis C virus replication complex. J Virol (2005) 2.91
Novel insights into hepatitis C virus replication and persistence. Adv Virus Res (2004) 2.81
RNA synthesis in a cage--structural studies of reovirus polymerase lambda3. Cell (2002) 2.74
De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus. J Virol (2000) 2.65
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol (2002) 2.61
A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication. J Virol (2004) 2.36
Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol (2007) 2.29
De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase. J Virol (2000) 2.19
A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA. J Virol (1999) 2.16
Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase. J Virol (2000) 1.91
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem (2005) 1.87
Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus. Virology (1998) 1.81
Selective stimulation of hepatitis C virus and pestivirus NS5B RNA polymerase activity by GTP. J Biol Chem (1999) 1.67
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog (2009) 1.56
Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol (2007) 1.44
The essential role of C-terminal residues in regulating the activity of hepatitis C virus RNA-dependent RNA polymerase. Biochim Biophys Acta (2002) 1.39
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication. J Virol (2004) 1.36
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase. J Biol Chem (2008) 1.35
Domain identification by iterative analysis of error-scaled difference distance matrices. Acta Crystallogr D Biol Crystallogr (2004) 1.30
Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis. J Mol Biol (2003) 1.28
Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals. J Virol (2002) 1.27
Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesis. J Biol Chem (2002) 1.18
The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells. J Virol (2007) 1.16
Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction. Biochemistry (2006) 1.15
Functional analysis of RNA binding by the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem (2005) 1.03
Hepatitis C virus NS5B polymerase exhibits distinct nucleotide requirements for initiation and elongation. J Biol Chem (2008) 1.03
Analysis of RNA by northern and slot blot hybridization. Curr Protoc Mol Biol (2004) 0.94
Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain. Arch Virol (2009) 0.84
Analysis of mutant NS5B proteins encoded by isolates from chimpanzees chronically infected following clonal HCV RNA inoculation. Virology (2003) 0.80
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol (2003) 5.41
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol (2002) 5.21
Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G. Science (2006) 4.11
Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol (2006) 3.75
Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees. Proc Natl Acad Sci U S A (2002) 3.43
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe (2011) 3.05
Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G. Science (2007) 2.97
Quantitative analysis of the hepatitis C virus replication complex. J Virol (2005) 2.91
Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology (2002) 2.53
The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology (2010) 2.52
The birnavirus crystal structure reveals structural relationships among icosahedral viruses. Cell (2005) 2.44
Assembly of infectious hepatitis C virus particles. Trends Microbiol (2010) 2.36
Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol (2007) 2.29
96-Channel receive-only head coil for 3 Tesla: design optimization and evaluation. Magn Reson Med (2009) 2.21
A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C. J Virol Methods (2003) 1.96
Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog (2009) 1.94
Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology (2010) 1.92
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection. Nat Rev Microbiol (2013) 1.88
Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci U S A (2010) 1.67
Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology (2011) 1.64
Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. J Biol Chem (2005) 1.63
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations. PLoS Pathog (2009) 1.56
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. J Virol (2002) 1.56
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem (2011) 1.54
Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication. Hepatology (2012) 1.49
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest (2009) 1.46
Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol (2007) 1.44
Diagnostic value of routine clinical parameters in acute myocardial infarction: a comparison to delayed contrast enhanced magnetic resonance imaging. Delayed enhancement and routine clinical parameters after myocardial infarction. Int J Cardiovasc Imaging (2003) 1.44
Dissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell line. J Virol (2005) 1.41
Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology (2008) 1.40
Role of annexin A2 in the production of infectious hepatitis C virus particles. J Virol (2010) 1.38
Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy. Gastroenterology (2006) 1.37
Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology (2007) 1.36
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication. J Virol (2004) 1.36
Hepatitis C virus RNA replication is resistant to tumour necrosis factor-alpha. J Gen Virol (2003) 1.29
Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency. J Virol (2011) 1.28
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A. PLoS Pathog (2013) 1.28
Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe (2012) 1.24
Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells. Gastroenterology (2005) 1.24
A target on the move: innate and adaptive immune escape strategies of hepatitis C virus. Antiviral Res (2006) 1.19
Characterization of a membrane-associated trimeric low-pH-induced Form of the class II viral fusion protein E from tick-borne encephalitis virus and its crystallization. J Virol (2004) 1.19
Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J Gen Virol (2007) 1.17
A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1. J Neurosci (2009) 1.15
Hepatitis C virus replication cycle. J Hepatol (2010) 1.15
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem (2010) 1.14
A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes. J Virol (2011) 1.07
Dynamic contrast-enhanced myocardial perfusion imaging using saturation-prepared TrueFISP. J Magn Reson Imaging (2002) 1.05
Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF. Cell Transplant (2008) 1.05
Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle. PLoS Pathog (2013) 1.02
Detection of lesions in multiple sclerosis by 2D FLAIR and single-slab 3D FLAIR sequences at 3.0 T: initial results. Eur Radiol (2006) 0.99
Characterization of monomeric intermediates during VSV glycoprotein structural transition. PLoS Pathog (2012) 0.98
Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo. Gastroenterology (2012) 0.96
Structural basis of ligand recognition in 5-HT3 receptors. EMBO Rep (2012) 0.96
Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation. J Mol Biol (2007) 0.96
Relationships between structure and interaction kinetics for HIV-1 protease inhibitors. J Med Chem (2002) 0.95
An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors. J Mol Biol (2011) 0.93
Structure of the Triatoma virus capsid. Acta Crystallogr D Biol Crystallogr (2013) 0.93
Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3. FEBS J (2007) 0.92
Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology (2011) 0.91
Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination. PLoS One (2013) 0.91
Kinetic and thermodynamic characterization of HIV-1 protease inhibitors. J Mol Recognit (2004) 0.91
Intermediate conformations during viral fusion glycoprotein structural transition. Curr Opin Virol (2013) 0.91
Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors. J Med Chem (2006) 0.90
Bile acids specifically increase hepatitis C virus RNA-replication. PLoS One (2012) 0.90
Experimental models to study the immunobiology of hepatitis C virus. J Gen Virol (2010) 0.90
Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening. J Med Chem (2011) 0.89
Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor. Anal Biochem (2009) 0.89
Annexin A2 as a differential diagnostic marker of hepatocellular tumors. Pathol Res Pract (2010) 0.89
Relationships between hepatitis C virus replication and CXCL-8 production in vitro. J Virol (2006) 0.89
In praise of impurity: 30S ribosomal S15 protein-assisted crystallization of turnip yellow mosaic virus proteinase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.88
A compact viral processing proteinase/ubiquitin hydrolase from the OTU family. PLoS Pathog (2013) 0.87
Telemetric ICP measurement with the first CE-approved device: data from animal experiments and initial clinical experiences. Acta Neurochir Suppl (2012) 0.87
Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential. J Hepatol (2012) 0.86
Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library. J Med Chem (2008) 0.86
Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance. J Med Chem (2006) 0.86
Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B. Hepatology (2013) 0.86
Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor. J Biol Chem (2002) 0.86
Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405. J Virol (2012) 0.86
Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope. PLoS Pathog (2012) 0.85
Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3. Antivir Ther (2007) 0.85
Scaffolds for protein crystallisation. Acta Crystallogr D Biol Crystallogr (2002) 0.84
Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-Length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals. Bioorg Med Chem (2003) 0.84
Unusual self-assembly properties of Norovirus Newbury2 virus-like particles. Arch Biochem Biophys (2013) 0.84
Norovirus capsid proteins self-assemble through biphasic kinetics via long-lived stave-like intermediates. J Am Chem Soc (2013) 0.84
On the active site protonation state in aspartic proteases: implications for drug design. Curr Pharm Des (2013) 0.84
Microstructural alterations of silicone catheters in an animal experiment: histopathology and SEM findings. Acta Neurochir Suppl (2012) 0.83
Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants. Antiviral Res (2003) 0.83
Deconstruction of non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1 for exploration of the optimization landscape of fragments. J Med Chem (2011) 0.83